Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma

Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The M...
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Autor*in:	Nemoto, Miho Watanabe [verfasserIn] Iwai, Yuma Togasaki, Gentaro Kurokawa, Marie Harada, Rintarou Kobayashi, Hiroki Uno, Takashi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Image-guided brachytherapy MRI Cervical cancer

Anmerkung:	© Japan Radiological Society 2017

Übergeordnetes Werk:	Enthalten in: Radiation medicine - Tokyo : Springer, 1999, 35(2017), 12 vom: 16. Okt., Seite 760-765
Übergeordnetes Werk:	volume:35 ; year:2017 ; number:12 ; day:16 ; month:10 ; pages:760-765

Links:	Volltext

DOI / URN:	10.1007/s11604-017-0690-3

Katalog-ID:	SPR021039178

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520			\|a Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation.
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allfields	10.1007/s11604-017-0690-3 doi (DE-627)SPR021039178 (SPR)s11604-017-0690-3-e DE-627 ger DE-627 rakwb eng Nemoto, Miho Watanabe verfasserin (orcid)0000-0003-0962-4429 aut Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2017 Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. Image-guided brachytherapy (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Iwai, Yuma aut Togasaki, Gentaro aut Kurokawa, Marie aut Harada, Rintarou aut Kobayashi, Hiroki aut Uno, Takashi aut Enthalten in Radiation medicine Tokyo : Springer, 1999 35(2017), 12 vom: 16. Okt., Seite 760-765 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:35 year:2017 number:12 day:16 month:10 pages:760-765 https://dx.doi.org/10.1007/s11604-017-0690-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 35 2017 12 16 10 760-765
spelling	10.1007/s11604-017-0690-3 doi (DE-627)SPR021039178 (SPR)s11604-017-0690-3-e DE-627 ger DE-627 rakwb eng Nemoto, Miho Watanabe verfasserin (orcid)0000-0003-0962-4429 aut Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2017 Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. Image-guided brachytherapy (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Iwai, Yuma aut Togasaki, Gentaro aut Kurokawa, Marie aut Harada, Rintarou aut Kobayashi, Hiroki aut Uno, Takashi aut Enthalten in Radiation medicine Tokyo : Springer, 1999 35(2017), 12 vom: 16. Okt., Seite 760-765 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:35 year:2017 number:12 day:16 month:10 pages:760-765 https://dx.doi.org/10.1007/s11604-017-0690-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 35 2017 12 16 10 760-765
allfields_unstemmed	10.1007/s11604-017-0690-3 doi (DE-627)SPR021039178 (SPR)s11604-017-0690-3-e DE-627 ger DE-627 rakwb eng Nemoto, Miho Watanabe verfasserin (orcid)0000-0003-0962-4429 aut Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2017 Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. Image-guided brachytherapy (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Iwai, Yuma aut Togasaki, Gentaro aut Kurokawa, Marie aut Harada, Rintarou aut Kobayashi, Hiroki aut Uno, Takashi aut Enthalten in Radiation medicine Tokyo : Springer, 1999 35(2017), 12 vom: 16. Okt., Seite 760-765 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:35 year:2017 number:12 day:16 month:10 pages:760-765 https://dx.doi.org/10.1007/s11604-017-0690-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 35 2017 12 16 10 760-765
allfieldsGer	10.1007/s11604-017-0690-3 doi (DE-627)SPR021039178 (SPR)s11604-017-0690-3-e DE-627 ger DE-627 rakwb eng Nemoto, Miho Watanabe verfasserin (orcid)0000-0003-0962-4429 aut Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2017 Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. Image-guided brachytherapy (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Iwai, Yuma aut Togasaki, Gentaro aut Kurokawa, Marie aut Harada, Rintarou aut Kobayashi, Hiroki aut Uno, Takashi aut Enthalten in Radiation medicine Tokyo : Springer, 1999 35(2017), 12 vom: 16. Okt., Seite 760-765 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:35 year:2017 number:12 day:16 month:10 pages:760-765 https://dx.doi.org/10.1007/s11604-017-0690-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 35 2017 12 16 10 760-765
allfieldsSound	10.1007/s11604-017-0690-3 doi (DE-627)SPR021039178 (SPR)s11604-017-0690-3-e DE-627 ger DE-627 rakwb eng Nemoto, Miho Watanabe verfasserin (orcid)0000-0003-0962-4429 aut Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2017 Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. Image-guided brachytherapy (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Iwai, Yuma aut Togasaki, Gentaro aut Kurokawa, Marie aut Harada, Rintarou aut Kobayashi, Hiroki aut Uno, Takashi aut Enthalten in Radiation medicine Tokyo : Springer, 1999 35(2017), 12 vom: 16. Okt., Seite 760-765 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:35 year:2017 number:12 day:16 month:10 pages:760-765 https://dx.doi.org/10.1007/s11604-017-0690-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 35 2017 12 16 10 760-765
language	English
source	Enthalten in Radiation medicine 35(2017), 12 vom: 16. Okt., Seite 760-765 volume:35 year:2017 number:12 day:16 month:10 pages:760-765
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authorswithroles_txt_mv	Nemoto, Miho Watanabe @@aut@@ Iwai, Yuma @@aut@@ Togasaki, Gentaro @@aut@@ Kurokawa, Marie @@aut@@ Harada, Rintarou @@aut@@ Kobayashi, Hiroki @@aut@@ Uno, Takashi @@aut@@
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Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. 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author	Nemoto, Miho Watanabe
spellingShingle	Nemoto, Miho Watanabe misc Image-guided brachytherapy misc MRI misc Cervical cancer Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma
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topic_title	Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma Image-guided brachytherapy (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213
topic	misc Image-guided brachytherapy misc MRI misc Cervical cancer
topic_unstemmed	misc Image-guided brachytherapy misc MRI misc Cervical cancer
topic_browse	misc Image-guided brachytherapy misc MRI misc Cervical cancer
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title	Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma
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title_full	Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma
author_sort	Nemoto, Miho Watanabe
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author_browse	Nemoto, Miho Watanabe Iwai, Yuma Togasaki, Gentaro Kurokawa, Marie Harada, Rintarou Kobayashi, Hiroki Uno, Takashi
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title_sort	preliminary results of a new workflow for mri/ct-based image-guided brachytherapy in cervical carcinoma
title_auth	Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma
abstract	Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. © Japan Radiological Society 2017
abstractGer	Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. © Japan Radiological Society 2017
abstract_unstemmed	Purpose We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. Conclusion Our described method of MRI-guided IGBT offers a practical option for the benefits of target delineation. © Japan Radiological Society 2017
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702
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title_short	Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma
url	https://dx.doi.org/10.1007/s11604-017-0690-3
remote_bool	true
author2	Iwai, Yuma Togasaki, Gentaro Kurokawa, Marie Harada, Rintarou Kobayashi, Hiroki Uno, Takashi
author2Str	Iwai, Yuma Togasaki, Gentaro Kurokawa, Marie Harada, Rintarou Kobayashi, Hiroki Uno, Takashi
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up_date	2024-07-03T19:55:01.007Z
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Materials and methods The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained. The MR image set was registered to the subsequent brachytherapy treatment planning CT using the applicator for rigid body registration. To demonstrate the registration quality, we used here the Dice index as a measurement of tandem delineation overlap between CT and MRI. Results The median Dice index was 0.879 (range 0.610–0.932), which indicated that the contours on CT and MRI fitted well. With this combination method, the median D90 of HR CTV and the calculated D2 $ cm^{3} $ of the bladder, rectum, and sigmoid in each fraction were 7.2 (4.0–10.4), 5.9 (2.3–7.7), 4.0 (1.9–6.7), and 3.8 (0.6–7.2) Gy, respectively. 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Preliminary results of a new workflow for MRI/CT-based image-guided brachytherapy in cervical carcinoma

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