Systematic analysis of genes involved in oral cancer metastasis to lymph nodes

Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This s...
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Autor*in:	Zhang, Xing’an [verfasserIn] Zhang, Lanfang Tan, Xiaoyao Lin, Ying Han, Xinsheng Wang, Huadong Ming, Huawei Li, Qiujiang Liu, Kang Feng, Gang

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Oral cancer Metastasis CCND1 JUN SPP1

Anmerkung:	© The Author(s) 2018

Übergeordnetes Werk:	Enthalten in: Cellular & molecular biology letters - London : BioMed Central, 1996, 23(2018), 1 vom: 15. Nov.
Übergeordnetes Werk:	volume:23 ; year:2018 ; number:1 ; day:15 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s11658-018-0120-2

Katalog-ID:	SPR021345309

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allfields	10.1186/s11658-018-0120-2 doi (DE-627)SPR021345309 (SPR)s11658-018-0120-2-e DE-627 ger DE-627 rakwb eng Zhang, Xing’an verfasserin aut Systematic analysis of genes involved in oral cancer metastasis to lymph nodes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. Oral cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 CCND1 (dpeaa)DE-He213 JUN (dpeaa)DE-He213 SPP1 (dpeaa)DE-He213 Zhang, Lanfang aut Tan, Xiaoyao aut Lin, Ying aut Han, Xinsheng aut Wang, Huadong aut Ming, Huawei aut Li, Qiujiang aut Liu, Kang aut Feng, Gang aut Enthalten in Cellular & molecular biology letters London : BioMed Central, 1996 23(2018), 1 vom: 15. Nov. (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:23 year:2018 number:1 day:15 month:11 https://dx.doi.org/10.1186/s11658-018-0120-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2018 1 15 11
spelling	10.1186/s11658-018-0120-2 doi (DE-627)SPR021345309 (SPR)s11658-018-0120-2-e DE-627 ger DE-627 rakwb eng Zhang, Xing’an verfasserin aut Systematic analysis of genes involved in oral cancer metastasis to lymph nodes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. Oral cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 CCND1 (dpeaa)DE-He213 JUN (dpeaa)DE-He213 SPP1 (dpeaa)DE-He213 Zhang, Lanfang aut Tan, Xiaoyao aut Lin, Ying aut Han, Xinsheng aut Wang, Huadong aut Ming, Huawei aut Li, Qiujiang aut Liu, Kang aut Feng, Gang aut Enthalten in Cellular & molecular biology letters London : BioMed Central, 1996 23(2018), 1 vom: 15. Nov. (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:23 year:2018 number:1 day:15 month:11 https://dx.doi.org/10.1186/s11658-018-0120-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2018 1 15 11
allfields_unstemmed	10.1186/s11658-018-0120-2 doi (DE-627)SPR021345309 (SPR)s11658-018-0120-2-e DE-627 ger DE-627 rakwb eng Zhang, Xing’an verfasserin aut Systematic analysis of genes involved in oral cancer metastasis to lymph nodes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. Oral cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 CCND1 (dpeaa)DE-He213 JUN (dpeaa)DE-He213 SPP1 (dpeaa)DE-He213 Zhang, Lanfang aut Tan, Xiaoyao aut Lin, Ying aut Han, Xinsheng aut Wang, Huadong aut Ming, Huawei aut Li, Qiujiang aut Liu, Kang aut Feng, Gang aut Enthalten in Cellular & molecular biology letters London : BioMed Central, 1996 23(2018), 1 vom: 15. Nov. (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:23 year:2018 number:1 day:15 month:11 https://dx.doi.org/10.1186/s11658-018-0120-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2018 1 15 11
allfieldsGer	10.1186/s11658-018-0120-2 doi (DE-627)SPR021345309 (SPR)s11658-018-0120-2-e DE-627 ger DE-627 rakwb eng Zhang, Xing’an verfasserin aut Systematic analysis of genes involved in oral cancer metastasis to lymph nodes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. Oral cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 CCND1 (dpeaa)DE-He213 JUN (dpeaa)DE-He213 SPP1 (dpeaa)DE-He213 Zhang, Lanfang aut Tan, Xiaoyao aut Lin, Ying aut Han, Xinsheng aut Wang, Huadong aut Ming, Huawei aut Li, Qiujiang aut Liu, Kang aut Feng, Gang aut Enthalten in Cellular & molecular biology letters London : BioMed Central, 1996 23(2018), 1 vom: 15. Nov. (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:23 year:2018 number:1 day:15 month:11 https://dx.doi.org/10.1186/s11658-018-0120-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2018 1 15 11
allfieldsSound	10.1186/s11658-018-0120-2 doi (DE-627)SPR021345309 (SPR)s11658-018-0120-2-e DE-627 ger DE-627 rakwb eng Zhang, Xing’an verfasserin aut Systematic analysis of genes involved in oral cancer metastasis to lymph nodes 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. Oral cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 CCND1 (dpeaa)DE-He213 JUN (dpeaa)DE-He213 SPP1 (dpeaa)DE-He213 Zhang, Lanfang aut Tan, Xiaoyao aut Lin, Ying aut Han, Xinsheng aut Wang, Huadong aut Ming, Huawei aut Li, Qiujiang aut Liu, Kang aut Feng, Gang aut Enthalten in Cellular & molecular biology letters London : BioMed Central, 1996 23(2018), 1 vom: 15. Nov. (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:23 year:2018 number:1 day:15 month:11 https://dx.doi.org/10.1186/s11658-018-0120-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2018 1 15 11
language	English
source	Enthalten in Cellular & molecular biology letters 23(2018), 1 vom: 15. Nov. volume:23 year:2018 number:1 day:15 month:11
sourceStr	Enthalten in Cellular & molecular biology letters 23(2018), 1 vom: 15. Nov. volume:23 year:2018 number:1 day:15 month:11
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institution	findex.gbv.de
topic_facet	Oral cancer Metastasis CCND1 JUN SPP1
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container_title	Cellular & molecular biology letters
authorswithroles_txt_mv	Zhang, Xing’an @@aut@@ Zhang, Lanfang @@aut@@ Tan, Xiaoyao @@aut@@ Lin, Ying @@aut@@ Han, Xinsheng @@aut@@ Wang, Huadong @@aut@@ Ming, Huawei @@aut@@ Li, Qiujiang @@aut@@ Liu, Kang @@aut@@ Feng, Gang @@aut@@
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author	Zhang, Xing’an
spellingShingle	Zhang, Xing’an misc Oral cancer misc Metastasis misc CCND1 misc JUN misc SPP1 Systematic analysis of genes involved in oral cancer metastasis to lymph nodes
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topic_title	Systematic analysis of genes involved in oral cancer metastasis to lymph nodes Oral cancer (dpeaa)DE-He213 Metastasis (dpeaa)DE-He213 CCND1 (dpeaa)DE-He213 JUN (dpeaa)DE-He213 SPP1 (dpeaa)DE-He213
topic	misc Oral cancer misc Metastasis misc CCND1 misc JUN misc SPP1
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title	Systematic analysis of genes involved in oral cancer metastasis to lymph nodes
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title_full	Systematic analysis of genes involved in oral cancer metastasis to lymph nodes
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author_browse	Zhang, Xing’an Zhang, Lanfang Tan, Xiaoyao Lin, Ying Han, Xinsheng Wang, Huadong Ming, Huawei Li, Qiujiang Liu, Kang Feng, Gang
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title_sort	systematic analysis of genes involved in oral cancer metastasis to lymph nodes
title_auth	Systematic analysis of genes involved in oral cancer metastasis to lymph nodes
abstract	Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. © The Author(s) 2018
abstractGer	Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. © The Author(s) 2018
abstract_unstemmed	Abstract Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying critical regulatory genes are important for the treatment of this disease. This study aimed to identify differentially expressed genes (gene signature) and pathways that contribute to oral cancer metastasis to lymph nodes. The GSE70604-associated study compared gene profiles in lymph nodes with metastasis of oral cancer to those of normal lymph nodes. The GSE2280-associated study compared gene profiles in primary tumor of oral cancer with lymph node metastasis to those in tumors without lymph node metastasis. There are 28 common differentially expressed genes (DEGs) showing consistent changes in both datasets in overlapping analysis. GO biological process and KEGG pathway analysis of these 28 DEGs identified the gene signature CCND1, JUN and SPP1, which are categorized as key regulatory genes involved in the focal adhesion pathway. Silencing expression of CCND1, JUN and SPP1 in the human oral cancer cell line OECM-1 confirmed that those genes play essential roles in oral cancer cell invasion. Analysis of clinical samples of oral cancer found a strong correlation of these genes with short survival, especially JUN expression associated with metastasis. Our study identified a unique gene signature – CCND1, JUN and SPP1 – which may be involved in oral cancer lymph node metastasis. © The Author(s) 2018
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Systematic analysis of genes involved in oral cancer metastasis to lymph nodes
url	https://dx.doi.org/10.1186/s11658-018-0120-2
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author2	Zhang, Lanfang Tan, Xiaoyao Lin, Ying Han, Xinsheng Wang, Huadong Ming, Huawei Li, Qiujiang Liu, Kang Feng, Gang
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up_date	2024-07-03T21:59:25.284Z
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Systematic analysis of genes involved in oral cancer metastasis to lymph nodes

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