Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies
Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The pro...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gong, Junbo [verfasserIn] Zhang, Dejiang [verfasserIn] Ran, Yuanyuan [verfasserIn] Zhang, Keke [verfasserIn] Du, Shichao [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Frontiers of chemical engineering in China - Beijing : Higher Education Press, 2007, 11(2017), 2 vom: 14. März, Seite 220-230 |
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| Übergeordnetes Werk: |
volume:11 ; year:2017 ; number:2 ; day:14 ; month:03 ; pages:220-230 |
| Links: |
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| DOI / URN: |
10.1007/s11705-017-1624-4 |
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| 520 | |a Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. | ||
| 650 | 4 | |a clindamycin phosphate |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a solvate |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a crystal structure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a thermal stability |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a moisture stability |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zhang, Dejiang |e verfasserin |4 aut | |
| 700 | 1 | |a Ran, Yuanyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Keke |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Shichao |e verfasserin |4 aut | |
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10.1007/s11705-017-1624-4 doi (DE-627)SPR021950695 (SPR)s11705-017-1624-4-e DE-627 ger DE-627 rakwb eng 540 ASE Gong, Junbo verfasserin aut Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. clindamycin phosphate (dpeaa)DE-He213 solvate (dpeaa)DE-He213 crystal structure (dpeaa)DE-He213 thermal stability (dpeaa)DE-He213 moisture stability (dpeaa)DE-He213 Zhang, Dejiang verfasserin aut Ran, Yuanyuan verfasserin aut Zhang, Keke verfasserin aut Du, Shichao verfasserin aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 11(2017), 2 vom: 14. März, Seite 220-230 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:11 year:2017 number:2 day:14 month:03 pages:220-230 https://dx.doi.org/10.1007/s11705-017-1624-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 11 2017 2 14 03 220-230 |
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10.1007/s11705-017-1624-4 doi (DE-627)SPR021950695 (SPR)s11705-017-1624-4-e DE-627 ger DE-627 rakwb eng 540 ASE Gong, Junbo verfasserin aut Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. clindamycin phosphate (dpeaa)DE-He213 solvate (dpeaa)DE-He213 crystal structure (dpeaa)DE-He213 thermal stability (dpeaa)DE-He213 moisture stability (dpeaa)DE-He213 Zhang, Dejiang verfasserin aut Ran, Yuanyuan verfasserin aut Zhang, Keke verfasserin aut Du, Shichao verfasserin aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 11(2017), 2 vom: 14. März, Seite 220-230 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:11 year:2017 number:2 day:14 month:03 pages:220-230 https://dx.doi.org/10.1007/s11705-017-1624-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 11 2017 2 14 03 220-230 |
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10.1007/s11705-017-1624-4 doi (DE-627)SPR021950695 (SPR)s11705-017-1624-4-e DE-627 ger DE-627 rakwb eng 540 ASE Gong, Junbo verfasserin aut Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. clindamycin phosphate (dpeaa)DE-He213 solvate (dpeaa)DE-He213 crystal structure (dpeaa)DE-He213 thermal stability (dpeaa)DE-He213 moisture stability (dpeaa)DE-He213 Zhang, Dejiang verfasserin aut Ran, Yuanyuan verfasserin aut Zhang, Keke verfasserin aut Du, Shichao verfasserin aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 11(2017), 2 vom: 14. März, Seite 220-230 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:11 year:2017 number:2 day:14 month:03 pages:220-230 https://dx.doi.org/10.1007/s11705-017-1624-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 11 2017 2 14 03 220-230 |
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10.1007/s11705-017-1624-4 doi (DE-627)SPR021950695 (SPR)s11705-017-1624-4-e DE-627 ger DE-627 rakwb eng 540 ASE Gong, Junbo verfasserin aut Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. clindamycin phosphate (dpeaa)DE-He213 solvate (dpeaa)DE-He213 crystal structure (dpeaa)DE-He213 thermal stability (dpeaa)DE-He213 moisture stability (dpeaa)DE-He213 Zhang, Dejiang verfasserin aut Ran, Yuanyuan verfasserin aut Zhang, Keke verfasserin aut Du, Shichao verfasserin aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 11(2017), 2 vom: 14. März, Seite 220-230 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:11 year:2017 number:2 day:14 month:03 pages:220-230 https://dx.doi.org/10.1007/s11705-017-1624-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 11 2017 2 14 03 220-230 |
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10.1007/s11705-017-1624-4 doi (DE-627)SPR021950695 (SPR)s11705-017-1624-4-e DE-627 ger DE-627 rakwb eng 540 ASE Gong, Junbo verfasserin aut Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. clindamycin phosphate (dpeaa)DE-He213 solvate (dpeaa)DE-He213 crystal structure (dpeaa)DE-He213 thermal stability (dpeaa)DE-He213 moisture stability (dpeaa)DE-He213 Zhang, Dejiang verfasserin aut Ran, Yuanyuan verfasserin aut Zhang, Keke verfasserin aut Du, Shichao verfasserin aut Enthalten in Frontiers of chemical engineering in China Beijing : Higher Education Press, 2007 11(2017), 2 vom: 14. März, Seite 220-230 (DE-627)545787602 (DE-600)2388862-3 1673-7474 nnns volume:11 year:2017 number:2 day:14 month:03 pages:220-230 https://dx.doi.org/10.1007/s11705-017-1624-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 11 2017 2 14 03 220-230 |
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The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. 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Gong, Junbo |
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Gong, Junbo ddc 540 misc clindamycin phosphate misc solvate misc crystal structure misc thermal stability misc moisture stability Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies |
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Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies |
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Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies |
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solvates and polymorphs of clindamycin phosphate: structural, thermal stability and moisture stability studies |
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Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies |
| abstract |
Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. |
| abstractGer |
Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. |
| abstract_unstemmed |
Abstract Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied. |
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