Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study

Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thi...
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Autor*in:	Bernard, Charlotte [verfasserIn] Catheline, Gwénaëlle [verfasserIn] Dilharreguy, Bixente [verfasserIn] Couffinhal, Thierry [verfasserIn] Ledure, Sylvain [verfasserIn] Lassalle-Lagadec, Saioa [verfasserIn] Callaert, Dorothée [verfasserIn] Allard, Michèle [verfasserIn] Sibon, Igor [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Acute coronary syndrome Cognitive impairment Executive functioning Structural MRI Resting-state Functional MRI

Übergeordnetes Werk:	Enthalten in: Brain imaging and behavior - New York, NY [u.a.] : Springer, 2007, 10(2015), 3 vom: 20. Nov., Seite 893-900
Übergeordnetes Werk:	volume:10 ; year:2015 ; number:3 ; day:20 ; month:11 ; pages:893-900

Links:	Volltext

DOI / URN:	10.1007/s11682-015-9483-4

Katalog-ID:	SPR022239049

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520			\|a Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders.
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650		4	\|a Cognitive impairment \|7 (dpeaa)DE-He213
650		4	\|a Executive functioning \|7 (dpeaa)DE-He213
650		4	\|a Structural MRI \|7 (dpeaa)DE-He213
650		4	\|a Resting-state \|7 (dpeaa)DE-He213
650		4	\|a Functional MRI \|7 (dpeaa)DE-He213
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700	1		\|a Ledure, Sylvain \|e verfasserin \|4 aut
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700	1		\|a Callaert, Dorothée \|e verfasserin \|4 aut
700	1		\|a Allard, Michèle \|e verfasserin \|4 aut
700	1		\|a Sibon, Igor \|e verfasserin \|4 aut
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allfields	10.1007/s11682-015-9483-4 doi (DE-627)SPR022239049 (SPR)s11682-015-9483-4-e DE-627 ger DE-627 rakwb eng 150 ASE 44.90 bkl Bernard, Charlotte verfasserin aut Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders. Acute coronary syndrome (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functioning (dpeaa)DE-He213 Structural MRI (dpeaa)DE-He213 Resting-state (dpeaa)DE-He213 Functional MRI (dpeaa)DE-He213 Catheline, Gwénaëlle verfasserin aut Dilharreguy, Bixente verfasserin aut Couffinhal, Thierry verfasserin aut Ledure, Sylvain verfasserin aut Lassalle-Lagadec, Saioa verfasserin aut Callaert, Dorothée verfasserin aut Allard, Michèle verfasserin aut Sibon, Igor verfasserin aut Enthalten in Brain imaging and behavior New York, NY [u.a.] : Springer, 2007 10(2015), 3 vom: 20. Nov., Seite 893-900 (DE-627)537878033 (DE-600)2377165-3 1931-7565 nnns volume:10 year:2015 number:3 day:20 month:11 pages:893-900 https://dx.doi.org/10.1007/s11682-015-9483-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 10 2015 3 20 11 893-900
spelling	10.1007/s11682-015-9483-4 doi (DE-627)SPR022239049 (SPR)s11682-015-9483-4-e DE-627 ger DE-627 rakwb eng 150 ASE 44.90 bkl Bernard, Charlotte verfasserin aut Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders. Acute coronary syndrome (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functioning (dpeaa)DE-He213 Structural MRI (dpeaa)DE-He213 Resting-state (dpeaa)DE-He213 Functional MRI (dpeaa)DE-He213 Catheline, Gwénaëlle verfasserin aut Dilharreguy, Bixente verfasserin aut Couffinhal, Thierry verfasserin aut Ledure, Sylvain verfasserin aut Lassalle-Lagadec, Saioa verfasserin aut Callaert, Dorothée verfasserin aut Allard, Michèle verfasserin aut Sibon, Igor verfasserin aut Enthalten in Brain imaging and behavior New York, NY [u.a.] : Springer, 2007 10(2015), 3 vom: 20. Nov., Seite 893-900 (DE-627)537878033 (DE-600)2377165-3 1931-7565 nnns volume:10 year:2015 number:3 day:20 month:11 pages:893-900 https://dx.doi.org/10.1007/s11682-015-9483-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 10 2015 3 20 11 893-900
allfields_unstemmed	10.1007/s11682-015-9483-4 doi (DE-627)SPR022239049 (SPR)s11682-015-9483-4-e DE-627 ger DE-627 rakwb eng 150 ASE 44.90 bkl Bernard, Charlotte verfasserin aut Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders. Acute coronary syndrome (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functioning (dpeaa)DE-He213 Structural MRI (dpeaa)DE-He213 Resting-state (dpeaa)DE-He213 Functional MRI (dpeaa)DE-He213 Catheline, Gwénaëlle verfasserin aut Dilharreguy, Bixente verfasserin aut Couffinhal, Thierry verfasserin aut Ledure, Sylvain verfasserin aut Lassalle-Lagadec, Saioa verfasserin aut Callaert, Dorothée verfasserin aut Allard, Michèle verfasserin aut Sibon, Igor verfasserin aut Enthalten in Brain imaging and behavior New York, NY [u.a.] : Springer, 2007 10(2015), 3 vom: 20. Nov., Seite 893-900 (DE-627)537878033 (DE-600)2377165-3 1931-7565 nnns volume:10 year:2015 number:3 day:20 month:11 pages:893-900 https://dx.doi.org/10.1007/s11682-015-9483-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 10 2015 3 20 11 893-900
allfieldsGer	10.1007/s11682-015-9483-4 doi (DE-627)SPR022239049 (SPR)s11682-015-9483-4-e DE-627 ger DE-627 rakwb eng 150 ASE 44.90 bkl Bernard, Charlotte verfasserin aut Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders. Acute coronary syndrome (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functioning (dpeaa)DE-He213 Structural MRI (dpeaa)DE-He213 Resting-state (dpeaa)DE-He213 Functional MRI (dpeaa)DE-He213 Catheline, Gwénaëlle verfasserin aut Dilharreguy, Bixente verfasserin aut Couffinhal, Thierry verfasserin aut Ledure, Sylvain verfasserin aut Lassalle-Lagadec, Saioa verfasserin aut Callaert, Dorothée verfasserin aut Allard, Michèle verfasserin aut Sibon, Igor verfasserin aut Enthalten in Brain imaging and behavior New York, NY [u.a.] : Springer, 2007 10(2015), 3 vom: 20. Nov., Seite 893-900 (DE-627)537878033 (DE-600)2377165-3 1931-7565 nnns volume:10 year:2015 number:3 day:20 month:11 pages:893-900 https://dx.doi.org/10.1007/s11682-015-9483-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 10 2015 3 20 11 893-900
allfieldsSound	10.1007/s11682-015-9483-4 doi (DE-627)SPR022239049 (SPR)s11682-015-9483-4-e DE-627 ger DE-627 rakwb eng 150 ASE 44.90 bkl Bernard, Charlotte verfasserin aut Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders. Acute coronary syndrome (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functioning (dpeaa)DE-He213 Structural MRI (dpeaa)DE-He213 Resting-state (dpeaa)DE-He213 Functional MRI (dpeaa)DE-He213 Catheline, Gwénaëlle verfasserin aut Dilharreguy, Bixente verfasserin aut Couffinhal, Thierry verfasserin aut Ledure, Sylvain verfasserin aut Lassalle-Lagadec, Saioa verfasserin aut Callaert, Dorothée verfasserin aut Allard, Michèle verfasserin aut Sibon, Igor verfasserin aut Enthalten in Brain imaging and behavior New York, NY [u.a.] : Springer, 2007 10(2015), 3 vom: 20. Nov., Seite 893-900 (DE-627)537878033 (DE-600)2377165-3 1931-7565 nnns volume:10 year:2015 number:3 day:20 month:11 pages:893-900 https://dx.doi.org/10.1007/s11682-015-9483-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 10 2015 3 20 11 893-900
language	English
source	Enthalten in Brain imaging and behavior 10(2015), 3 vom: 20. Nov., Seite 893-900 volume:10 year:2015 number:3 day:20 month:11 pages:893-900
sourceStr	Enthalten in Brain imaging and behavior 10(2015), 3 vom: 20. Nov., Seite 893-900 volume:10 year:2015 number:3 day:20 month:11 pages:893-900
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Acute coronary syndrome Cognitive impairment Executive functioning Structural MRI Resting-state Functional MRI
dewey-raw	150
isfreeaccess_bool	false
container_title	Brain imaging and behavior
authorswithroles_txt_mv	Bernard, Charlotte @@aut@@ Catheline, Gwénaëlle @@aut@@ Dilharreguy, Bixente @@aut@@ Couffinhal, Thierry @@aut@@ Ledure, Sylvain @@aut@@ Lassalle-Lagadec, Saioa @@aut@@ Callaert, Dorothée @@aut@@ Allard, Michèle @@aut@@ Sibon, Igor @@aut@@
publishDateDaySort_date	2015-11-20T00:00:00Z
hierarchy_top_id	537878033
dewey-sort	3150
id	SPR022239049
language_de	englisch
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author	Bernard, Charlotte
spellingShingle	Bernard, Charlotte ddc 150 bkl 44.90 misc Acute coronary syndrome misc Cognitive impairment misc Executive functioning misc Structural MRI misc Resting-state misc Functional MRI Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study
authorStr	Bernard, Charlotte
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topic_title	150 ASE 44.90 bkl Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study Acute coronary syndrome (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functioning (dpeaa)DE-He213 Structural MRI (dpeaa)DE-He213 Resting-state (dpeaa)DE-He213 Functional MRI (dpeaa)DE-He213
topic	ddc 150 bkl 44.90 misc Acute coronary syndrome misc Cognitive impairment misc Executive functioning misc Structural MRI misc Resting-state misc Functional MRI
topic_unstemmed	ddc 150 bkl 44.90 misc Acute coronary syndrome misc Cognitive impairment misc Executive functioning misc Structural MRI misc Resting-state misc Functional MRI
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title	Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study
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title_full	Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study
author_sort	Bernard, Charlotte
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author_browse	Bernard, Charlotte Catheline, Gwénaëlle Dilharreguy, Bixente Couffinhal, Thierry Ledure, Sylvain Lassalle-Lagadec, Saioa Callaert, Dorothée Allard, Michèle Sibon, Igor
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title_sort	cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal mri study
title_auth	Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study
abstract	Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders.
abstractGer	Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders.
abstract_unstemmed	Abstract Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recruited 4 ± 1 months after a first ACS. Executive functions were evaluated with the Trail-Making-Test-B (TMTB) at baseline (ie 4 ± 1 months after ACS) and 6 months later (ie 10 ± 1 months after ACS). Using both time-points, we identified 3 groups of patients according to normative data based on age, gender and education level: 15 ‘cognitively normal’ patients without impairment at each follow-up, 10 ‘transient impaired’ patients with an impairment only at baseline and 8 ‘impairing’ patients with an impairment only at follow-up. We explored, in the whole-brain, the structural integrity using Voxel-Based Morphometry and Tract-Based Spatial Statistics and the resting-state functional connectivity using Network-Based Statistics. No structural difference was observed between impaired and cognitively normal patients. At the functional level, compared to the ‘cognitively normal’ group, the ‘transient impaired’ patients presented an increased functional connectivity in a network centered on middle-orbito-frontal regions, whereas the ‘impairing’ patients presented only a non-significant decrease of functional connectivity. Executive dysfunction in ACS patients is associated to functional but no structural characteristics, particularly to an increased functional connectivity in cognitive networks in transient impaired patients. Further studies with larger sample size are needed to confirm these results and to determine if these patients could be at higher risk for developing permanent cognitive disorders.
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container_issue	3
title_short	Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study
url	https://dx.doi.org/10.1007/s11682-015-9483-4
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author2	Catheline, Gwénaëlle Dilharreguy, Bixente Couffinhal, Thierry Ledure, Sylvain Lassalle-Lagadec, Saioa Callaert, Dorothée Allard, Michèle Sibon, Igor
author2Str	Catheline, Gwénaëlle Dilharreguy, Bixente Couffinhal, Thierry Ledure, Sylvain Lassalle-Lagadec, Saioa Callaert, Dorothée Allard, Michèle Sibon, Igor
ppnlink	537878033
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s11682-015-9483-4
up_date	2024-07-04T02:23:20.697Z
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Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study

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