Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity
Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further incre...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Karpova, L. V. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Anmerkung: |
© MAIK Nauka 2008 |
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| Übergeordnetes Werk: |
Enthalten in: Biochemistry (Moscow) - Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007, 2(2008), 2 vom: Juni, Seite 156-160 |
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| Übergeordnetes Werk: |
volume:2 ; year:2008 ; number:2 ; month:06 ; pages:156-160 |
| Links: |
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| DOI / URN: |
10.1134/S1990747808020104 |
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| Katalog-ID: |
SPR02259065X |
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| 024 | 7 | |a 10.1134/S1990747808020104 |2 doi | |
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| 041 | |a eng | ||
| 100 | 1 | |a Karpova, L. V. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity |
| 264 | 1 | |c 2008 | |
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| 500 | |a © MAIK Nauka 2008 | ||
| 520 | |a Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. | ||
| 650 | 4 | |a NMDA |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a NMDA Receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ouabain |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Supplement Series |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phosphorylated Form |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Akkuratov, E. E. |4 aut | |
| 700 | 1 | |a Bulygina, E. R. |4 aut | |
| 700 | 1 | |a Boldyrev, A. A. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochemistry (Moscow) |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 |g 2(2008), 2 vom: Juni, Seite 156-160 |w (DE-627)546011217 |w (DE-600)2390072-6 |x 1990-7494 |7 nnns |
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| 856 | 4 | 0 | |u https://dx.doi.org/10.1134/S1990747808020104 |z lizenzpflichtig |3 Volltext |
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| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
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| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
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| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2110 | ||
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| 912 | |a GBV_ILN_2112 | ||
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| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2119 | ||
| 912 | |a GBV_ILN_2122 | ||
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| 912 | |a GBV_ILN_4307 | ||
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| 951 | |a AR | ||
| 952 | |d 2 |j 2008 |e 2 |c 06 |h 156-160 | ||
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10.1134/S1990747808020104 doi (DE-627)SPR02259065X (SPR)S1990747808020104-e DE-627 ger DE-627 rakwb eng Karpova, L. V. verfasserin aut Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © MAIK Nauka 2008 Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. NMDA (dpeaa)DE-He213 NMDA Receptor (dpeaa)DE-He213 Ouabain (dpeaa)DE-He213 Supplement Series (dpeaa)DE-He213 Phosphorylated Form (dpeaa)DE-He213 Akkuratov, E. E. aut Bulygina, E. R. aut Boldyrev, A. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 2(2008), 2 vom: Juni, Seite 156-160 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:2 year:2008 number:2 month:06 pages:156-160 https://dx.doi.org/10.1134/S1990747808020104 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 2 06 156-160 |
| spelling |
10.1134/S1990747808020104 doi (DE-627)SPR02259065X (SPR)S1990747808020104-e DE-627 ger DE-627 rakwb eng Karpova, L. V. verfasserin aut Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © MAIK Nauka 2008 Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. NMDA (dpeaa)DE-He213 NMDA Receptor (dpeaa)DE-He213 Ouabain (dpeaa)DE-He213 Supplement Series (dpeaa)DE-He213 Phosphorylated Form (dpeaa)DE-He213 Akkuratov, E. E. aut Bulygina, E. R. aut Boldyrev, A. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 2(2008), 2 vom: Juni, Seite 156-160 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:2 year:2008 number:2 month:06 pages:156-160 https://dx.doi.org/10.1134/S1990747808020104 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 2 06 156-160 |
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10.1134/S1990747808020104 doi (DE-627)SPR02259065X (SPR)S1990747808020104-e DE-627 ger DE-627 rakwb eng Karpova, L. V. verfasserin aut Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © MAIK Nauka 2008 Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. NMDA (dpeaa)DE-He213 NMDA Receptor (dpeaa)DE-He213 Ouabain (dpeaa)DE-He213 Supplement Series (dpeaa)DE-He213 Phosphorylated Form (dpeaa)DE-He213 Akkuratov, E. E. aut Bulygina, E. R. aut Boldyrev, A. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 2(2008), 2 vom: Juni, Seite 156-160 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:2 year:2008 number:2 month:06 pages:156-160 https://dx.doi.org/10.1134/S1990747808020104 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 2 06 156-160 |
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10.1134/S1990747808020104 doi (DE-627)SPR02259065X (SPR)S1990747808020104-e DE-627 ger DE-627 rakwb eng Karpova, L. V. verfasserin aut Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © MAIK Nauka 2008 Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. NMDA (dpeaa)DE-He213 NMDA Receptor (dpeaa)DE-He213 Ouabain (dpeaa)DE-He213 Supplement Series (dpeaa)DE-He213 Phosphorylated Form (dpeaa)DE-He213 Akkuratov, E. E. aut Bulygina, E. R. aut Boldyrev, A. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 2(2008), 2 vom: Juni, Seite 156-160 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:2 year:2008 number:2 month:06 pages:156-160 https://dx.doi.org/10.1134/S1990747808020104 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 2 06 156-160 |
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Karpova, L. V. misc NMDA misc NMDA Receptor misc Ouabain misc Supplement Series misc Phosphorylated Form Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity |
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Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity NMDA (dpeaa)DE-He213 NMDA Receptor (dpeaa)DE-He213 Ouabain (dpeaa)DE-He213 Supplement Series (dpeaa)DE-He213 Phosphorylated Form (dpeaa)DE-He213 |
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Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity |
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Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity |
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Karpova, L. V. |
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Karpova, L. V. Akkuratov, E. E. Bulygina, E. R. Boldyrev, A. A. |
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| title_sort |
ouabain-sensitive and ouabain-resistant isoforms of $ na^{+} $,$ k^{+} $-atpase in cerebellar granule cells control map kinase activity |
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Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity |
| abstract |
Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. © MAIK Nauka 2008 |
| abstractGer |
Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. © MAIK Nauka 2008 |
| abstract_unstemmed |
Abstract Three-hour incubation of rat cerebellar granule cells with 0.1 μM ouabain increases intracellular levels of $ Ca^{2+} $ ions and reactive oxygen species (ROS) resulting in pronounced activation of Mitogen-Activated Protein Kinase (MAPK). Higher concentrations of ouabain induce further increases in MAPK activity. The activating effect of ouabain is attenuated by the NMDA-receptor antagonists MK-801 and D-AP5. The data obtained suggest that similar to NMDA receptors ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase are actively involved in intracellular signaling cascades controlling proliferative activity of neuronal cells. © MAIK Nauka 2008 |
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Ouabain-sensitive and ouabain-resistant isoforms of $ Na^{+} $,$ K^{+} $-ATPase in cerebellar granule cells control MAP kinase activity |
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2024-07-03T13:52:41.826Z |
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