Specific issues of mitochondrial fragmentation (Fission)
Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of fil...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zorov, D. B. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Anmerkung: |
© Pleiades Publishing, Ltd. 2015 |
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| Übergeordnetes Werk: |
Enthalten in: Biochemistry (Moscow) - Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007, 9(2015), 4 vom: Okt., Seite 278-284 |
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| Übergeordnetes Werk: |
volume:9 ; year:2015 ; number:4 ; month:10 ; pages:278-284 |
| Links: |
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| DOI / URN: |
10.1134/S1990747815050219 |
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| Katalog-ID: |
SPR022594973 |
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| 100 | 1 | |a Zorov, D. B. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Specific issues of mitochondrial fragmentation (Fission) |
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| 520 | |a Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. | ||
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| 650 | 4 | |a fragmentation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a fission |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a reactive oxygen species |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Vorobjev, I. A. |4 aut | |
| 700 | 1 | |a Plotnikov, E. Y. |4 aut | |
| 700 | 1 | |a Silachev, D. N. |4 aut | |
| 700 | 1 | |a Zorova, L. D. |4 aut | |
| 700 | 1 | |a Pevzner, I. B. |4 aut | |
| 700 | 1 | |a Babenko, V. A. |4 aut | |
| 700 | 1 | |a Zorov, S. D. |4 aut | |
| 700 | 1 | |a Jankauskas, S. S. |4 aut | |
| 700 | 1 | |a Popkov, V. A. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochemistry (Moscow) |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 |g 9(2015), 4 vom: Okt., Seite 278-284 |w (DE-627)546011217 |w (DE-600)2390072-6 |x 1990-7494 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:2015 |g number:4 |g month:10 |g pages:278-284 |
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10.1134/S1990747815050219 doi (DE-627)SPR022594973 (SPR)S1990747815050219-e DE-627 ger DE-627 rakwb eng Zorov, D. B. verfasserin aut Specific issues of mitochondrial fragmentation (Fission) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2015 Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. mitochondria (dpeaa)DE-He213 fragmentation (dpeaa)DE-He213 fission (dpeaa)DE-He213 reactive oxygen species (dpeaa)DE-He213 Vorobjev, I. A. aut Plotnikov, E. Y. aut Silachev, D. N. aut Zorova, L. D. aut Pevzner, I. B. aut Babenko, V. A. aut Zorov, S. D. aut Jankauskas, S. S. aut Popkov, V. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 9(2015), 4 vom: Okt., Seite 278-284 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:9 year:2015 number:4 month:10 pages:278-284 https://dx.doi.org/10.1134/S1990747815050219 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2015 4 10 278-284 |
| spelling |
10.1134/S1990747815050219 doi (DE-627)SPR022594973 (SPR)S1990747815050219-e DE-627 ger DE-627 rakwb eng Zorov, D. B. verfasserin aut Specific issues of mitochondrial fragmentation (Fission) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2015 Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. mitochondria (dpeaa)DE-He213 fragmentation (dpeaa)DE-He213 fission (dpeaa)DE-He213 reactive oxygen species (dpeaa)DE-He213 Vorobjev, I. A. aut Plotnikov, E. Y. aut Silachev, D. N. aut Zorova, L. D. aut Pevzner, I. B. aut Babenko, V. A. aut Zorov, S. D. aut Jankauskas, S. S. aut Popkov, V. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 9(2015), 4 vom: Okt., Seite 278-284 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:9 year:2015 number:4 month:10 pages:278-284 https://dx.doi.org/10.1134/S1990747815050219 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2015 4 10 278-284 |
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10.1134/S1990747815050219 doi (DE-627)SPR022594973 (SPR)S1990747815050219-e DE-627 ger DE-627 rakwb eng Zorov, D. B. verfasserin aut Specific issues of mitochondrial fragmentation (Fission) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2015 Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. mitochondria (dpeaa)DE-He213 fragmentation (dpeaa)DE-He213 fission (dpeaa)DE-He213 reactive oxygen species (dpeaa)DE-He213 Vorobjev, I. A. aut Plotnikov, E. Y. aut Silachev, D. N. aut Zorova, L. D. aut Pevzner, I. B. aut Babenko, V. A. aut Zorov, S. D. aut Jankauskas, S. S. aut Popkov, V. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 9(2015), 4 vom: Okt., Seite 278-284 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:9 year:2015 number:4 month:10 pages:278-284 https://dx.doi.org/10.1134/S1990747815050219 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2015 4 10 278-284 |
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10.1134/S1990747815050219 doi (DE-627)SPR022594973 (SPR)S1990747815050219-e DE-627 ger DE-627 rakwb eng Zorov, D. B. verfasserin aut Specific issues of mitochondrial fragmentation (Fission) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2015 Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. mitochondria (dpeaa)DE-He213 fragmentation (dpeaa)DE-He213 fission (dpeaa)DE-He213 reactive oxygen species (dpeaa)DE-He213 Vorobjev, I. A. aut Plotnikov, E. Y. aut Silachev, D. N. aut Zorova, L. D. aut Pevzner, I. B. aut Babenko, V. A. aut Zorov, S. D. aut Jankauskas, S. S. aut Popkov, V. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 9(2015), 4 vom: Okt., Seite 278-284 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:9 year:2015 number:4 month:10 pages:278-284 https://dx.doi.org/10.1134/S1990747815050219 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2015 4 10 278-284 |
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10.1134/S1990747815050219 doi (DE-627)SPR022594973 (SPR)S1990747815050219-e DE-627 ger DE-627 rakwb eng Zorov, D. B. verfasserin aut Specific issues of mitochondrial fragmentation (Fission) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2015 Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. mitochondria (dpeaa)DE-He213 fragmentation (dpeaa)DE-He213 fission (dpeaa)DE-He213 reactive oxygen species (dpeaa)DE-He213 Vorobjev, I. A. aut Plotnikov, E. Y. aut Silachev, D. N. aut Zorova, L. D. aut Pevzner, I. B. aut Babenko, V. A. aut Zorov, S. D. aut Jankauskas, S. S. aut Popkov, V. A. aut Enthalten in Biochemistry (Moscow) Dordrecht [u.a.] : Springer Science + Business Media B.V, 2007 9(2015), 4 vom: Okt., Seite 278-284 (DE-627)546011217 (DE-600)2390072-6 1990-7494 nnns volume:9 year:2015 number:4 month:10 pages:278-284 https://dx.doi.org/10.1134/S1990747815050219 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2015 4 10 278-284 |
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Enthalten in Biochemistry (Moscow) 9(2015), 4 vom: Okt., Seite 278-284 volume:9 year:2015 number:4 month:10 pages:278-284 |
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Enthalten in Biochemistry (Moscow) 9(2015), 4 vom: Okt., Seite 278-284 volume:9 year:2015 number:4 month:10 pages:278-284 |
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Zorov, D. B. @@aut@@ Vorobjev, I. A. @@aut@@ Plotnikov, E. Y. @@aut@@ Silachev, D. N. @@aut@@ Zorova, L. D. @@aut@@ Pevzner, I. B. @@aut@@ Babenko, V. A. @@aut@@ Zorov, S. D. @@aut@@ Jankauskas, S. S. @@aut@@ Popkov, V. A. @@aut@@ |
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Zorov, D. B. |
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Zorov, D. B. misc mitochondria misc fragmentation misc fission misc reactive oxygen species Specific issues of mitochondrial fragmentation (Fission) |
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Specific issues of mitochondrial fragmentation (Fission) mitochondria (dpeaa)DE-He213 fragmentation (dpeaa)DE-He213 fission (dpeaa)DE-He213 reactive oxygen species (dpeaa)DE-He213 |
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Zorov, D. B. Vorobjev, I. A. Plotnikov, E. Y. Silachev, D. N. Zorova, L. D. Pevzner, I. B. Babenko, V. A. Zorov, S. D. Jankauskas, S. S. Popkov, V. A. |
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specific issues of mitochondrial fragmentation (fission) |
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Specific issues of mitochondrial fragmentation (Fission) |
| abstract |
Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. © Pleiades Publishing, Ltd. 2015 |
| abstractGer |
Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. © Pleiades Publishing, Ltd. 2015 |
| abstract_unstemmed |
Abstract In 1983 we discovered a phenomenon of the total fragmentation (fission) of the entire mitochondrial population in a cell following the exposure to a mitochondrial inhibitor. Further experiments showed that a wide range of substances acting on mitochondria can cause the transformation of filamentous structures to small globular vesicles (the thread–grain transition). Fragmentation of mitochondria clearly begins with the formation of a septum formed by the inner mitochondrial membranes, leading to the division of mitochondria into a number of compartments, not necessarily of the same configuration. Visible signs of fragmentation of the mitochondrial reticulum appeared after an hour of the exposure to mitochondrial inhibitors; the process of mitochondrial fission was markedly accelerated and developed within seconds when the cells stained with fluorescent probes were exposed to excitation light and were affected photodynamically. The crucial role of reactive oxygen species in the initiation of the process of mitochondrial fission is proposed. Before the formation of septa, local enlightenment of mitochondrial matrix (local swelling) can be observed, which indicates the possibility of the existence of intramitochondrial skeleton that maintains the shape of the mitochondria. The septum formation and fragmentation gives rise to different populations of mitochondria. Apparently, this is a part of the mechanism of mitochondrial quality control and elimination of damaged mitochondria. © Pleiades Publishing, Ltd. 2015 |
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Specific issues of mitochondrial fragmentation (Fission) |
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Vorobjev, I. A. Plotnikov, E. Y. Silachev, D. N. Zorova, L. D. Pevzner, I. B. Babenko, V. A. Zorov, S. D. Jankauskas, S. S. Popkov, V. A. |
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Vorobjev, I. A. Plotnikov, E. Y. Silachev, D. N. Zorova, L. D. Pevzner, I. B. Babenko, V. A. Zorov, S. D. Jankauskas, S. S. Popkov, V. A. |
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| score |
7.4016542 |