Metachondromatosis: more than just multiple osteochondromas

Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of...
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Autor*in:	Fisher, Thomas J. [verfasserIn] Williams, Nicole Morris, Lloyd Cundy, Peter J.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Metachondromatosis Review Case report Osteochondroma Enchondromatosis

Anmerkung:	© EPOS 2013

Übergeordnetes Werk:	Enthalten in: Journal of children's orthopaedics - London : Sage, 2007, 7(2013), 6 vom: 21. Sept., Seite 455-464
Übergeordnetes Werk:	volume:7 ; year:2013 ; number:6 ; day:21 ; month:09 ; pages:455-464

Links:	Volltext

DOI / URN:	10.1007/s11832-013-0526-3

Katalog-ID:	SPR022620311

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520			\|a Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention.
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allfields	10.1007/s11832-013-0526-3 doi (DE-627)SPR022620311 (SPR)s11832-013-0526-3-e DE-627 ger DE-627 rakwb eng Fisher, Thomas J. verfasserin aut Metachondromatosis: more than just multiple osteochondromas 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © EPOS 2013 Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. Metachondromatosis (dpeaa)DE-He213 Review (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Osteochondroma (dpeaa)DE-He213 Enchondromatosis (dpeaa)DE-He213 Williams, Nicole aut Morris, Lloyd aut Cundy, Peter J. aut Enthalten in Journal of children's orthopaedics London : Sage, 2007 7(2013), 6 vom: 21. Sept., Seite 455-464 (DE-627)523858221 (DE-600)2268264-8 1863-2548 nnns volume:7 year:2013 number:6 day:21 month:09 pages:455-464 https://dx.doi.org/10.1007/s11832-013-0526-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2057 GBV_ILN_2190 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 6 21 09 455-464
spelling	10.1007/s11832-013-0526-3 doi (DE-627)SPR022620311 (SPR)s11832-013-0526-3-e DE-627 ger DE-627 rakwb eng Fisher, Thomas J. verfasserin aut Metachondromatosis: more than just multiple osteochondromas 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © EPOS 2013 Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. Metachondromatosis (dpeaa)DE-He213 Review (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Osteochondroma (dpeaa)DE-He213 Enchondromatosis (dpeaa)DE-He213 Williams, Nicole aut Morris, Lloyd aut Cundy, Peter J. aut Enthalten in Journal of children's orthopaedics London : Sage, 2007 7(2013), 6 vom: 21. Sept., Seite 455-464 (DE-627)523858221 (DE-600)2268264-8 1863-2548 nnns volume:7 year:2013 number:6 day:21 month:09 pages:455-464 https://dx.doi.org/10.1007/s11832-013-0526-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2057 GBV_ILN_2190 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 6 21 09 455-464
allfields_unstemmed	10.1007/s11832-013-0526-3 doi (DE-627)SPR022620311 (SPR)s11832-013-0526-3-e DE-627 ger DE-627 rakwb eng Fisher, Thomas J. verfasserin aut Metachondromatosis: more than just multiple osteochondromas 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © EPOS 2013 Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. Metachondromatosis (dpeaa)DE-He213 Review (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Osteochondroma (dpeaa)DE-He213 Enchondromatosis (dpeaa)DE-He213 Williams, Nicole aut Morris, Lloyd aut Cundy, Peter J. aut Enthalten in Journal of children's orthopaedics London : Sage, 2007 7(2013), 6 vom: 21. Sept., Seite 455-464 (DE-627)523858221 (DE-600)2268264-8 1863-2548 nnns volume:7 year:2013 number:6 day:21 month:09 pages:455-464 https://dx.doi.org/10.1007/s11832-013-0526-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2057 GBV_ILN_2190 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 6 21 09 455-464
allfieldsGer	10.1007/s11832-013-0526-3 doi (DE-627)SPR022620311 (SPR)s11832-013-0526-3-e DE-627 ger DE-627 rakwb eng Fisher, Thomas J. verfasserin aut Metachondromatosis: more than just multiple osteochondromas 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © EPOS 2013 Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. Metachondromatosis (dpeaa)DE-He213 Review (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Osteochondroma (dpeaa)DE-He213 Enchondromatosis (dpeaa)DE-He213 Williams, Nicole aut Morris, Lloyd aut Cundy, Peter J. aut Enthalten in Journal of children's orthopaedics London : Sage, 2007 7(2013), 6 vom: 21. Sept., Seite 455-464 (DE-627)523858221 (DE-600)2268264-8 1863-2548 nnns volume:7 year:2013 number:6 day:21 month:09 pages:455-464 https://dx.doi.org/10.1007/s11832-013-0526-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2057 GBV_ILN_2190 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 6 21 09 455-464
allfieldsSound	10.1007/s11832-013-0526-3 doi (DE-627)SPR022620311 (SPR)s11832-013-0526-3-e DE-627 ger DE-627 rakwb eng Fisher, Thomas J. verfasserin aut Metachondromatosis: more than just multiple osteochondromas 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © EPOS 2013 Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. Metachondromatosis (dpeaa)DE-He213 Review (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Osteochondroma (dpeaa)DE-He213 Enchondromatosis (dpeaa)DE-He213 Williams, Nicole aut Morris, Lloyd aut Cundy, Peter J. aut Enthalten in Journal of children's orthopaedics London : Sage, 2007 7(2013), 6 vom: 21. Sept., Seite 455-464 (DE-627)523858221 (DE-600)2268264-8 1863-2548 nnns volume:7 year:2013 number:6 day:21 month:09 pages:455-464 https://dx.doi.org/10.1007/s11832-013-0526-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2057 GBV_ILN_2190 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 6 21 09 455-464
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Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. 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author	Fisher, Thomas J.
spellingShingle	Fisher, Thomas J. misc Metachondromatosis misc Review misc Case report misc Osteochondroma misc Enchondromatosis Metachondromatosis: more than just multiple osteochondromas
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topic_title	Metachondromatosis: more than just multiple osteochondromas Metachondromatosis (dpeaa)DE-He213 Review (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Osteochondroma (dpeaa)DE-He213 Enchondromatosis (dpeaa)DE-He213
topic	misc Metachondromatosis misc Review misc Case report misc Osteochondroma misc Enchondromatosis
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title	Metachondromatosis: more than just multiple osteochondromas
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title_full	Metachondromatosis: more than just multiple osteochondromas
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author_browse	Fisher, Thomas J. Williams, Nicole Morris, Lloyd Cundy, Peter J.
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title_sort	metachondromatosis: more than just multiple osteochondromas
title_auth	Metachondromatosis: more than just multiple osteochondromas
abstract	Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. © EPOS 2013
abstractGer	Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. © EPOS 2013
abstract_unstemmed	Introduction Metachondromatosis is a rare genetic disease of osteochondroma and enchondroma formation, caused by loss of function of the PTPN11 gene. It is distinct from other similar conditions such as multiple osteochondromas and hereditary multiple exostoses by the distribution and orientation of lesions, and pattern of inheritance. Lesions typically occur in hands, feet, femora, tibiae and the pelvis. Lesions are typically reported to regress in adulthood. Methods We reviewed the current literature on metachondromatosis, and present four new cases in a family with metachondromatosis. Results Long-term follow up data reveal spontaneous regression of lesions by skeletal maturity. Complications may include nerve palsy due to the mass effect of lesions, avascular necrosis of the femoral head and angular deformity of long bones. Histopathological analysis has demonstrated that lesions in metachondromatosis are a mix of osteochondromas and enchondromas; however, one case of chondrosarcoma has been reported. Conclusion Lesions associated with metachondromatosis may cause a variety of complications due to mass effects; however, they are often asymptomatic, cause cosmetic concerns and, importantly, most regress spontaneously. Regular clinical review with selective imaging to monitor for such complications is appropriate, but uncomplicated lesions are unlikely to require surgical intervention. © EPOS 2013
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title_short	Metachondromatosis: more than just multiple osteochondromas
url	https://dx.doi.org/10.1007/s11832-013-0526-3
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Metachondromatosis: more than just multiple osteochondromas

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