Late-onset CMV disease following CMV prophylaxis

Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prop...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Donnelly, C. [verfasserIn] Kennedy, F. Keane, C. Schaffer, K. McCormick, P. A.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Cytomegalovirus Liver transplant Valganciclovir Ganciclovir Cytomegalovirus prophylaxis Late-onset cytomegalovirus

Anmerkung:	© Royal Academy of Medicine in Ireland 2009

Übergeordnetes Werk:	Enthalten in: Irish journal of medical science - London : Springer, 1922, 178(2009), 3 vom: 02. Apr., Seite 333-336
Übergeordnetes Werk:	volume:178 ; year:2009 ; number:3 ; day:02 ; month:04 ; pages:333-336

Links:	Volltext

DOI / URN:	10.1007/s11845-009-0327-3

Katalog-ID:	SPR022772480

Internformat


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245	1	0	\|a Late-onset CMV disease following CMV prophylaxis
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520			\|a Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage.
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912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
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912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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matchkey_str	article:00211265:2009----::aenecviesfloigm
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publishDate	2009
allfields	10.1007/s11845-009-0327-3 doi (DE-627)SPR022772480 (SPR)s11845-009-0327-3-e DE-627 ger DE-627 rakwb eng Donnelly, C. verfasserin aut Late-onset CMV disease following CMV prophylaxis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2009 Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. Cytomegalovirus (dpeaa)DE-He213 Liver transplant (dpeaa)DE-He213 Valganciclovir (dpeaa)DE-He213 Ganciclovir (dpeaa)DE-He213 Cytomegalovirus prophylaxis (dpeaa)DE-He213 Late-onset cytomegalovirus (dpeaa)DE-He213 Kennedy, F. aut Keane, C. aut Schaffer, K. aut McCormick, P. A. aut Enthalten in Irish journal of medical science London : Springer, 1922 178(2009), 3 vom: 02. Apr., Seite 333-336 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:178 year:2009 number:3 day:02 month:04 pages:333-336 https://dx.doi.org/10.1007/s11845-009-0327-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 178 2009 3 02 04 333-336
spelling	10.1007/s11845-009-0327-3 doi (DE-627)SPR022772480 (SPR)s11845-009-0327-3-e DE-627 ger DE-627 rakwb eng Donnelly, C. verfasserin aut Late-onset CMV disease following CMV prophylaxis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2009 Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. Cytomegalovirus (dpeaa)DE-He213 Liver transplant (dpeaa)DE-He213 Valganciclovir (dpeaa)DE-He213 Ganciclovir (dpeaa)DE-He213 Cytomegalovirus prophylaxis (dpeaa)DE-He213 Late-onset cytomegalovirus (dpeaa)DE-He213 Kennedy, F. aut Keane, C. aut Schaffer, K. aut McCormick, P. A. aut Enthalten in Irish journal of medical science London : Springer, 1922 178(2009), 3 vom: 02. Apr., Seite 333-336 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:178 year:2009 number:3 day:02 month:04 pages:333-336 https://dx.doi.org/10.1007/s11845-009-0327-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 178 2009 3 02 04 333-336
allfields_unstemmed	10.1007/s11845-009-0327-3 doi (DE-627)SPR022772480 (SPR)s11845-009-0327-3-e DE-627 ger DE-627 rakwb eng Donnelly, C. verfasserin aut Late-onset CMV disease following CMV prophylaxis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2009 Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. Cytomegalovirus (dpeaa)DE-He213 Liver transplant (dpeaa)DE-He213 Valganciclovir (dpeaa)DE-He213 Ganciclovir (dpeaa)DE-He213 Cytomegalovirus prophylaxis (dpeaa)DE-He213 Late-onset cytomegalovirus (dpeaa)DE-He213 Kennedy, F. aut Keane, C. aut Schaffer, K. aut McCormick, P. A. aut Enthalten in Irish journal of medical science London : Springer, 1922 178(2009), 3 vom: 02. Apr., Seite 333-336 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:178 year:2009 number:3 day:02 month:04 pages:333-336 https://dx.doi.org/10.1007/s11845-009-0327-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 178 2009 3 02 04 333-336
allfieldsGer	10.1007/s11845-009-0327-3 doi (DE-627)SPR022772480 (SPR)s11845-009-0327-3-e DE-627 ger DE-627 rakwb eng Donnelly, C. verfasserin aut Late-onset CMV disease following CMV prophylaxis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2009 Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. Cytomegalovirus (dpeaa)DE-He213 Liver transplant (dpeaa)DE-He213 Valganciclovir (dpeaa)DE-He213 Ganciclovir (dpeaa)DE-He213 Cytomegalovirus prophylaxis (dpeaa)DE-He213 Late-onset cytomegalovirus (dpeaa)DE-He213 Kennedy, F. aut Keane, C. aut Schaffer, K. aut McCormick, P. A. aut Enthalten in Irish journal of medical science London : Springer, 1922 178(2009), 3 vom: 02. Apr., Seite 333-336 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:178 year:2009 number:3 day:02 month:04 pages:333-336 https://dx.doi.org/10.1007/s11845-009-0327-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 178 2009 3 02 04 333-336
allfieldsSound	10.1007/s11845-009-0327-3 doi (DE-627)SPR022772480 (SPR)s11845-009-0327-3-e DE-627 ger DE-627 rakwb eng Donnelly, C. verfasserin aut Late-onset CMV disease following CMV prophylaxis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2009 Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. Cytomegalovirus (dpeaa)DE-He213 Liver transplant (dpeaa)DE-He213 Valganciclovir (dpeaa)DE-He213 Ganciclovir (dpeaa)DE-He213 Cytomegalovirus prophylaxis (dpeaa)DE-He213 Late-onset cytomegalovirus (dpeaa)DE-He213 Kennedy, F. aut Keane, C. aut Schaffer, K. aut McCormick, P. A. aut Enthalten in Irish journal of medical science London : Springer, 1922 178(2009), 3 vom: 02. Apr., Seite 333-336 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:178 year:2009 number:3 day:02 month:04 pages:333-336 https://dx.doi.org/10.1007/s11845-009-0327-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 178 2009 3 02 04 333-336
language	English
source	Enthalten in Irish journal of medical science 178(2009), 3 vom: 02. Apr., Seite 333-336 volume:178 year:2009 number:3 day:02 month:04 pages:333-336
sourceStr	Enthalten in Irish journal of medical science 178(2009), 3 vom: 02. Apr., Seite 333-336 volume:178 year:2009 number:3 day:02 month:04 pages:333-336
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cytomegalovirus Liver transplant Valganciclovir Ganciclovir Cytomegalovirus prophylaxis Late-onset cytomegalovirus
isfreeaccess_bool	false
container_title	Irish journal of medical science
authorswithroles_txt_mv	Donnelly, C. @@aut@@ Kennedy, F. @@aut@@ Keane, C. @@aut@@ Schaffer, K. @@aut@@ McCormick, P. A. @@aut@@
publishDateDaySort_date	2009-04-02T00:00:00Z
hierarchy_top_id	527569887
id	SPR022772480
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR022772480</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231006061348.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2009 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s11845-009-0327-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR022772480</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s11845-009-0327-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Donnelly, C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Late-onset CMV disease following CMV prophylaxis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2009</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Royal Academy of Medicine in Ireland 2009</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. 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author	Donnelly, C.
spellingShingle	Donnelly, C. misc Cytomegalovirus misc Liver transplant misc Valganciclovir misc Ganciclovir misc Cytomegalovirus prophylaxis misc Late-onset cytomegalovirus Late-onset CMV disease following CMV prophylaxis
authorStr	Donnelly, C.
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topic_title	Late-onset CMV disease following CMV prophylaxis Cytomegalovirus (dpeaa)DE-He213 Liver transplant (dpeaa)DE-He213 Valganciclovir (dpeaa)DE-He213 Ganciclovir (dpeaa)DE-He213 Cytomegalovirus prophylaxis (dpeaa)DE-He213 Late-onset cytomegalovirus (dpeaa)DE-He213
topic	misc Cytomegalovirus misc Liver transplant misc Valganciclovir misc Ganciclovir misc Cytomegalovirus prophylaxis misc Late-onset cytomegalovirus
topic_unstemmed	misc Cytomegalovirus misc Liver transplant misc Valganciclovir misc Ganciclovir misc Cytomegalovirus prophylaxis misc Late-onset cytomegalovirus
topic_browse	misc Cytomegalovirus misc Liver transplant misc Valganciclovir misc Ganciclovir misc Cytomegalovirus prophylaxis misc Late-onset cytomegalovirus
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title	Late-onset CMV disease following CMV prophylaxis
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title_full	Late-onset CMV disease following CMV prophylaxis
author_sort	Donnelly, C.
journal	Irish journal of medical science
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author_browse	Donnelly, C. Kennedy, F. Keane, C. Schaffer, K. McCormick, P. A.
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doi_str_mv	10.1007/s11845-009-0327-3
title_sort	late-onset cmv disease following cmv prophylaxis
title_auth	Late-onset CMV disease following CMV prophylaxis
abstract	Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. © Royal Academy of Medicine in Ireland 2009
abstractGer	Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. © Royal Academy of Medicine in Ireland 2009
abstract_unstemmed	Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage. © Royal Academy of Medicine in Ireland 2009
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container_issue	3
title_short	Late-onset CMV disease following CMV prophylaxis
url	https://dx.doi.org/10.1007/s11845-009-0327-3
remote_bool	true
author2	Kennedy, F. Keane, C. Schaffer, K. McCormick, P. A.
author2Str	Kennedy, F. Keane, C. Schaffer, K. McCormick, P. A.
ppnlink	527569887
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s11845-009-0327-3
up_date	2024-07-03T14:45:52.632Z
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Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. Aims To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. Methods Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. Results The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. 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