Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis
Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tian, G. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Royal Academy of Medicine in Ireland 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Irish journal of medical science - London : Springer, 1922, 183(2014), 4 vom: 09. Feb., Seite 659-666 |
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| Übergeordnetes Werk: |
volume:183 ; year:2014 ; number:4 ; day:09 ; month:02 ; pages:659-666 |
| Links: |
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| DOI / URN: |
10.1007/s11845-014-1072-9 |
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| Katalog-ID: |
SPR022781412 |
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| 100 | 1 | |a Tian, G. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis |
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| 500 | |a © Royal Academy of Medicine in Ireland 2014 | ||
| 520 | |a Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. | ||
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| 650 | 4 | |a Leptin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Rheumatoid arthritis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Meta-analysis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Liang, J.-N. |4 aut | |
| 700 | 1 | |a Pan, H.-F. |4 aut | |
| 700 | 1 | |a Zhou, D. |4 aut | |
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10.1007/s11845-014-1072-9 doi (DE-627)SPR022781412 (SPR)s11845-014-1072-9-e DE-627 ger DE-627 rakwb eng Tian, G. verfasserin aut Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2014 Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. Adipocytokines (dpeaa)DE-He213 Leptin (dpeaa)DE-He213 Rheumatoid arthritis (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Liang, J.-N. aut Pan, H.-F. aut Zhou, D. aut Enthalten in Irish journal of medical science London : Springer, 1922 183(2014), 4 vom: 09. Feb., Seite 659-666 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:183 year:2014 number:4 day:09 month:02 pages:659-666 https://dx.doi.org/10.1007/s11845-014-1072-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 183 2014 4 09 02 659-666 |
| spelling |
10.1007/s11845-014-1072-9 doi (DE-627)SPR022781412 (SPR)s11845-014-1072-9-e DE-627 ger DE-627 rakwb eng Tian, G. verfasserin aut Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2014 Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. Adipocytokines (dpeaa)DE-He213 Leptin (dpeaa)DE-He213 Rheumatoid arthritis (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Liang, J.-N. aut Pan, H.-F. aut Zhou, D. aut Enthalten in Irish journal of medical science London : Springer, 1922 183(2014), 4 vom: 09. Feb., Seite 659-666 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:183 year:2014 number:4 day:09 month:02 pages:659-666 https://dx.doi.org/10.1007/s11845-014-1072-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 183 2014 4 09 02 659-666 |
| allfields_unstemmed |
10.1007/s11845-014-1072-9 doi (DE-627)SPR022781412 (SPR)s11845-014-1072-9-e DE-627 ger DE-627 rakwb eng Tian, G. verfasserin aut Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2014 Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. Adipocytokines (dpeaa)DE-He213 Leptin (dpeaa)DE-He213 Rheumatoid arthritis (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Liang, J.-N. aut Pan, H.-F. aut Zhou, D. aut Enthalten in Irish journal of medical science London : Springer, 1922 183(2014), 4 vom: 09. Feb., Seite 659-666 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:183 year:2014 number:4 day:09 month:02 pages:659-666 https://dx.doi.org/10.1007/s11845-014-1072-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 183 2014 4 09 02 659-666 |
| allfieldsGer |
10.1007/s11845-014-1072-9 doi (DE-627)SPR022781412 (SPR)s11845-014-1072-9-e DE-627 ger DE-627 rakwb eng Tian, G. verfasserin aut Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2014 Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. Adipocytokines (dpeaa)DE-He213 Leptin (dpeaa)DE-He213 Rheumatoid arthritis (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Liang, J.-N. aut Pan, H.-F. aut Zhou, D. aut Enthalten in Irish journal of medical science London : Springer, 1922 183(2014), 4 vom: 09. Feb., Seite 659-666 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:183 year:2014 number:4 day:09 month:02 pages:659-666 https://dx.doi.org/10.1007/s11845-014-1072-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 183 2014 4 09 02 659-666 |
| allfieldsSound |
10.1007/s11845-014-1072-9 doi (DE-627)SPR022781412 (SPR)s11845-014-1072-9-e DE-627 ger DE-627 rakwb eng Tian, G. verfasserin aut Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Royal Academy of Medicine in Ireland 2014 Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. Adipocytokines (dpeaa)DE-He213 Leptin (dpeaa)DE-He213 Rheumatoid arthritis (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Liang, J.-N. aut Pan, H.-F. aut Zhou, D. aut Enthalten in Irish journal of medical science London : Springer, 1922 183(2014), 4 vom: 09. Feb., Seite 659-666 (DE-627)527569887 (DE-600)2275855-0 0021-1265 nnns volume:183 year:2014 number:4 day:09 month:02 pages:659-666 https://dx.doi.org/10.1007/s11845-014-1072-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 183 2014 4 09 02 659-666 |
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To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. 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Tian, G. |
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Tian, G. misc Adipocytokines misc Leptin misc Rheumatoid arthritis misc Meta-analysis Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis |
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Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis Adipocytokines (dpeaa)DE-He213 Leptin (dpeaa)DE-He213 Rheumatoid arthritis (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 |
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misc Adipocytokines misc Leptin misc Rheumatoid arthritis misc Meta-analysis |
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misc Adipocytokines misc Leptin misc Rheumatoid arthritis misc Meta-analysis |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis |
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Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis |
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Tian, G. Liang, J.-N. Pan, H.-F. Zhou, D. |
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Tian, G. |
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10.1007/s11845-014-1072-9 |
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increased leptin levels in patients with rheumatoid arthritis: a meta-analysis |
| title_auth |
Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis |
| abstract |
Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. © Royal Academy of Medicine in Ireland 2014 |
| abstractGer |
Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. © Royal Academy of Medicine in Ireland 2014 |
| abstract_unstemmed |
Aim Published data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed. Methods Published literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I2 statistics. The study quality was assessed by the Newcastle–Ottawa scale. Results A total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59–1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected. Conclusions The present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity. © Royal Academy of Medicine in Ireland 2014 |
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Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis |
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https://dx.doi.org/10.1007/s11845-014-1072-9 |
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Liang, J.-N. Pan, H.-F. Zhou, D. |
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10.1007/s11845-014-1072-9 |
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2024-07-03T14:49:25.430Z |
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| score |
7.3975677 |