Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor

Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resect...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Idrees, Kamran [verfasserIn] Safar, Bashar [verfasserIn] Hawkins, William G. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Colorectal cancer Synchronous disease Prophylactic resection Primary tumor Metastatic disease Unresectable

Übergeordnetes Werk:	Enthalten in: Current colorectal cancer reports - Heidelberg [u.a.] : Springer, 2005, 8(2012), 2 vom: 19. Apr., Seite 118-122
Übergeordnetes Werk:	volume:8 ; year:2012 ; number:2 ; day:19 ; month:04 ; pages:118-122

Links:	Volltext

DOI / URN:	10.1007/s11888-012-0125-6

Katalog-ID:	SPR022888217

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520			\|a Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature.
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matchkey_str	article:15563804:2012----::neetbeooetlacrycrnumtsaehwo
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allfields	10.1007/s11888-012-0125-6 doi (DE-627)SPR022888217 (SPR)s11888-012-0125-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Idrees, Kamran verfasserin aut Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature. Colorectal cancer (dpeaa)DE-He213 Synchronous disease (dpeaa)DE-He213 Prophylactic resection (dpeaa)DE-He213 Primary tumor (dpeaa)DE-He213 Metastatic disease (dpeaa)DE-He213 Unresectable (dpeaa)DE-He213 Safar, Bashar verfasserin aut Hawkins, William G. verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 2 vom: 19. Apr., Seite 118-122 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:2 day:19 month:04 pages:118-122 https://dx.doi.org/10.1007/s11888-012-0125-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 2 19 04 118-122
spelling	10.1007/s11888-012-0125-6 doi (DE-627)SPR022888217 (SPR)s11888-012-0125-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Idrees, Kamran verfasserin aut Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature. Colorectal cancer (dpeaa)DE-He213 Synchronous disease (dpeaa)DE-He213 Prophylactic resection (dpeaa)DE-He213 Primary tumor (dpeaa)DE-He213 Metastatic disease (dpeaa)DE-He213 Unresectable (dpeaa)DE-He213 Safar, Bashar verfasserin aut Hawkins, William G. verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 2 vom: 19. Apr., Seite 118-122 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:2 day:19 month:04 pages:118-122 https://dx.doi.org/10.1007/s11888-012-0125-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 2 19 04 118-122
allfields_unstemmed	10.1007/s11888-012-0125-6 doi (DE-627)SPR022888217 (SPR)s11888-012-0125-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Idrees, Kamran verfasserin aut Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature. Colorectal cancer (dpeaa)DE-He213 Synchronous disease (dpeaa)DE-He213 Prophylactic resection (dpeaa)DE-He213 Primary tumor (dpeaa)DE-He213 Metastatic disease (dpeaa)DE-He213 Unresectable (dpeaa)DE-He213 Safar, Bashar verfasserin aut Hawkins, William G. verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 2 vom: 19. Apr., Seite 118-122 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:2 day:19 month:04 pages:118-122 https://dx.doi.org/10.1007/s11888-012-0125-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 2 19 04 118-122
allfieldsGer	10.1007/s11888-012-0125-6 doi (DE-627)SPR022888217 (SPR)s11888-012-0125-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Idrees, Kamran verfasserin aut Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature. Colorectal cancer (dpeaa)DE-He213 Synchronous disease (dpeaa)DE-He213 Prophylactic resection (dpeaa)DE-He213 Primary tumor (dpeaa)DE-He213 Metastatic disease (dpeaa)DE-He213 Unresectable (dpeaa)DE-He213 Safar, Bashar verfasserin aut Hawkins, William G. verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 2 vom: 19. Apr., Seite 118-122 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:2 day:19 month:04 pages:118-122 https://dx.doi.org/10.1007/s11888-012-0125-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 2 19 04 118-122
allfieldsSound	10.1007/s11888-012-0125-6 doi (DE-627)SPR022888217 (SPR)s11888-012-0125-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Idrees, Kamran verfasserin aut Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature. Colorectal cancer (dpeaa)DE-He213 Synchronous disease (dpeaa)DE-He213 Prophylactic resection (dpeaa)DE-He213 Primary tumor (dpeaa)DE-He213 Metastatic disease (dpeaa)DE-He213 Unresectable (dpeaa)DE-He213 Safar, Bashar verfasserin aut Hawkins, William G. verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 2 vom: 19. Apr., Seite 118-122 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:2 day:19 month:04 pages:118-122 https://dx.doi.org/10.1007/s11888-012-0125-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 2 19 04 118-122
language	English
source	Enthalten in Current colorectal cancer reports 8(2012), 2 vom: 19. Apr., Seite 118-122 volume:8 year:2012 number:2 day:19 month:04 pages:118-122
sourceStr	Enthalten in Current colorectal cancer reports 8(2012), 2 vom: 19. Apr., Seite 118-122 volume:8 year:2012 number:2 day:19 month:04 pages:118-122
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Colorectal cancer Synchronous disease Prophylactic resection Primary tumor Metastatic disease Unresectable
dewey-raw	610
isfreeaccess_bool	false
container_title	Current colorectal cancer reports
authorswithroles_txt_mv	Idrees, Kamran @@aut@@ Safar, Bashar @@aut@@ Hawkins, William G. @@aut@@
publishDateDaySort_date	2012-04-19T00:00:00Z
hierarchy_top_id	511638213
dewey-sort	3610
id	SPR022888217
language_de	englisch
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author	Idrees, Kamran
spellingShingle	Idrees, Kamran ddc 610 bkl 44.87 misc Colorectal cancer misc Synchronous disease misc Prophylactic resection misc Primary tumor misc Metastatic disease misc Unresectable Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor
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topic_title	610 ASE 44.87 bkl Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor Colorectal cancer (dpeaa)DE-He213 Synchronous disease (dpeaa)DE-He213 Prophylactic resection (dpeaa)DE-He213 Primary tumor (dpeaa)DE-He213 Metastatic disease (dpeaa)DE-He213 Unresectable (dpeaa)DE-He213
topic	ddc 610 bkl 44.87 misc Colorectal cancer misc Synchronous disease misc Prophylactic resection misc Primary tumor misc Metastatic disease misc Unresectable
topic_unstemmed	ddc 610 bkl 44.87 misc Colorectal cancer misc Synchronous disease misc Prophylactic resection misc Primary tumor misc Metastatic disease misc Unresectable
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title	Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor
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title_full	Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor
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title_sort	unresectable colorectal cancer synchronous metastases: how to manage the primary tumor
title_auth	Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor
abstract	Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature.
abstractGer	Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature.
abstract_unstemmed	Abstract In patients with newly diagnosed colorectal cancer, a significant proportion of patients will present with disseminated disease. In the presence of a symptomatic primary tumor, resection may be required to alleviate the symptoms of obstruction, bleeding, or perforation. Historically, resection of the primary asymptomatic tumor was advocated because a large portion of patients eventually developed symptoms or complications related to their primary tumors. Resection was followed by adjuvant chemotherapy with 5FU and survival was modest. However, with the improved response rates to the newer cytotoxic systemic therapies the role of prophylactic resection of the primary tumor in unresectable stage IV colorectal cancer has been questioned. Newer data suggest that routine palliative resection of the synchronous primary lesion should not be performed in the absence of symptoms. Several questions remain and ongoing prospective randomized trials will likely address many of the limitations of currently available literature.
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container_issue	2
title_short	Unresectable Colorectal Cancer Synchronous Metastases: How to Manage the Primary Tumor
url	https://dx.doi.org/10.1007/s11888-012-0125-6
remote_bool	true
author2	Safar, Bashar Hawkins, William G.
author2Str	Safar, Bashar Hawkins, William G.
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doi_str	10.1007/s11888-012-0125-6
up_date	2024-07-03T15:30:38.058Z
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