Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics?
Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability,...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cremolini, Chiara [verfasserIn] Loupakis, Fotios [verfasserIn] Antoniotti, Carlotta [verfasserIn] Salvatore, Lisa [verfasserIn] Schirripa, Marta [verfasserIn] Fornaro, Lorenzo [verfasserIn] Masi, Gianluca [verfasserIn] Falcone, Alfredo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Current colorectal cancer reports - Heidelberg [u.a.] : Springer, 2005, 8(2012), 3 vom: 24. Juni, Seite 153-160 |
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| Übergeordnetes Werk: |
volume:8 ; year:2012 ; number:3 ; day:24 ; month:06 ; pages:153-160 |
| Links: |
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| DOI / URN: |
10.1007/s11888-012-0128-3 |
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| Katalog-ID: |
SPR022888268 |
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| 520 | |a Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. | ||
| 650 | 4 | |a Chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Bevacizumab |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-EGFR monoclonal antibodies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Secondary resection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a BRAF |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pathologic response |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Loupakis, Fotios |e verfasserin |4 aut | |
| 700 | 1 | |a Antoniotti, Carlotta |e verfasserin |4 aut | |
| 700 | 1 | |a Salvatore, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Schirripa, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Fornaro, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Masi, Gianluca |e verfasserin |4 aut | |
| 700 | 1 | |a Falcone, Alfredo |e verfasserin |4 aut | |
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10.1007/s11888-012-0128-3 doi (DE-627)SPR022888268 (SPR)s11888-012-0128-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Cremolini, Chiara verfasserin aut Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. Chemotherapy (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Anti-EGFR monoclonal antibodies (dpeaa)DE-He213 Secondary resection (dpeaa)DE-He213 BRAF (dpeaa)DE-He213 Pathologic response (dpeaa)DE-He213 Loupakis, Fotios verfasserin aut Antoniotti, Carlotta verfasserin aut Salvatore, Lisa verfasserin aut Schirripa, Marta verfasserin aut Fornaro, Lorenzo verfasserin aut Masi, Gianluca verfasserin aut Falcone, Alfredo verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 3 vom: 24. Juni, Seite 153-160 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:3 day:24 month:06 pages:153-160 https://dx.doi.org/10.1007/s11888-012-0128-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 3 24 06 153-160 |
| spelling |
10.1007/s11888-012-0128-3 doi (DE-627)SPR022888268 (SPR)s11888-012-0128-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Cremolini, Chiara verfasserin aut Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. Chemotherapy (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Anti-EGFR monoclonal antibodies (dpeaa)DE-He213 Secondary resection (dpeaa)DE-He213 BRAF (dpeaa)DE-He213 Pathologic response (dpeaa)DE-He213 Loupakis, Fotios verfasserin aut Antoniotti, Carlotta verfasserin aut Salvatore, Lisa verfasserin aut Schirripa, Marta verfasserin aut Fornaro, Lorenzo verfasserin aut Masi, Gianluca verfasserin aut Falcone, Alfredo verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 3 vom: 24. Juni, Seite 153-160 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:3 day:24 month:06 pages:153-160 https://dx.doi.org/10.1007/s11888-012-0128-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 3 24 06 153-160 |
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10.1007/s11888-012-0128-3 doi (DE-627)SPR022888268 (SPR)s11888-012-0128-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Cremolini, Chiara verfasserin aut Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. Chemotherapy (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Anti-EGFR monoclonal antibodies (dpeaa)DE-He213 Secondary resection (dpeaa)DE-He213 BRAF (dpeaa)DE-He213 Pathologic response (dpeaa)DE-He213 Loupakis, Fotios verfasserin aut Antoniotti, Carlotta verfasserin aut Salvatore, Lisa verfasserin aut Schirripa, Marta verfasserin aut Fornaro, Lorenzo verfasserin aut Masi, Gianluca verfasserin aut Falcone, Alfredo verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 3 vom: 24. Juni, Seite 153-160 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:3 day:24 month:06 pages:153-160 https://dx.doi.org/10.1007/s11888-012-0128-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 3 24 06 153-160 |
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10.1007/s11888-012-0128-3 doi (DE-627)SPR022888268 (SPR)s11888-012-0128-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Cremolini, Chiara verfasserin aut Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. Chemotherapy (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Anti-EGFR monoclonal antibodies (dpeaa)DE-He213 Secondary resection (dpeaa)DE-He213 BRAF (dpeaa)DE-He213 Pathologic response (dpeaa)DE-He213 Loupakis, Fotios verfasserin aut Antoniotti, Carlotta verfasserin aut Salvatore, Lisa verfasserin aut Schirripa, Marta verfasserin aut Fornaro, Lorenzo verfasserin aut Masi, Gianluca verfasserin aut Falcone, Alfredo verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 3 vom: 24. Juni, Seite 153-160 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:3 day:24 month:06 pages:153-160 https://dx.doi.org/10.1007/s11888-012-0128-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 3 24 06 153-160 |
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10.1007/s11888-012-0128-3 doi (DE-627)SPR022888268 (SPR)s11888-012-0128-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Cremolini, Chiara verfasserin aut Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. Chemotherapy (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Anti-EGFR monoclonal antibodies (dpeaa)DE-He213 Secondary resection (dpeaa)DE-He213 BRAF (dpeaa)DE-He213 Pathologic response (dpeaa)DE-He213 Loupakis, Fotios verfasserin aut Antoniotti, Carlotta verfasserin aut Salvatore, Lisa verfasserin aut Schirripa, Marta verfasserin aut Fornaro, Lorenzo verfasserin aut Masi, Gianluca verfasserin aut Falcone, Alfredo verfasserin aut Enthalten in Current colorectal cancer reports Heidelberg [u.a.] : Springer, 2005 8(2012), 3 vom: 24. Juni, Seite 153-160 (DE-627)511638213 (DE-600)2233562-6 1556-3804 nnns volume:8 year:2012 number:3 day:24 month:06 pages:153-160 https://dx.doi.org/10.1007/s11888-012-0128-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 8 2012 3 24 06 153-160 |
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Enthalten in Current colorectal cancer reports 8(2012), 3 vom: 24. Juni, Seite 153-160 volume:8 year:2012 number:3 day:24 month:06 pages:153-160 |
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Enthalten in Current colorectal cancer reports 8(2012), 3 vom: 24. Juni, Seite 153-160 volume:8 year:2012 number:3 day:24 month:06 pages:153-160 |
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Chemotherapy Bevacizumab Anti-EGFR monoclonal antibodies Secondary resection BRAF Pathologic response |
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Current colorectal cancer reports |
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Cremolini, Chiara @@aut@@ Loupakis, Fotios @@aut@@ Antoniotti, Carlotta @@aut@@ Salvatore, Lisa @@aut@@ Schirripa, Marta @@aut@@ Fornaro, Lorenzo @@aut@@ Masi, Gianluca @@aut@@ Falcone, Alfredo @@aut@@ |
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2012-06-24T00:00:00Z |
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Cremolini, Chiara |
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Cremolini, Chiara ddc 610 bkl 44.87 misc Chemotherapy misc Bevacizumab misc Anti-EGFR monoclonal antibodies misc Secondary resection misc BRAF misc Pathologic response Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? |
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610 ASE 44.87 bkl Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? Chemotherapy (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Anti-EGFR monoclonal antibodies (dpeaa)DE-He213 Secondary resection (dpeaa)DE-He213 BRAF (dpeaa)DE-He213 Pathologic response (dpeaa)DE-He213 |
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upfront chemotherapy regimens in unresectable disease: one, two, or three cytotoxics? |
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Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? |
| abstract |
Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. |
| abstractGer |
Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. |
| abstract_unstemmed |
Abstract Today, the upfront treatment of unresectable metastatic colorectal cancer (mCRC) may span from single-agent fluoropyrimidines to three and even four-drug regimens, currently under investigation in several trials. While clinical factors, including the crucial item of secondary resectability, certainly contribute to formulate the most appropriate strategy for each patient, also molecular markers are gaining increasing prominence in the decision-making process. This review aims at collecting our group’s point of view about the role of upfront combination regimens, both in patients pursuing a radical resection and in those unlikely to undergo a secondary surgery. |
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| container_issue |
3 |
| title_short |
Upfront Chemotherapy Regimens in Unresectable Disease: One, Two, or Three Cytotoxics? |
| url |
https://dx.doi.org/10.1007/s11888-012-0128-3 |
| remote_bool |
true |
| author2 |
Loupakis, Fotios Antoniotti, Carlotta Salvatore, Lisa Schirripa, Marta Fornaro, Lorenzo Masi, Gianluca Falcone, Alfredo |
| author2Str |
Loupakis, Fotios Antoniotti, Carlotta Salvatore, Lisa Schirripa, Marta Fornaro, Lorenzo Masi, Gianluca Falcone, Alfredo |
| ppnlink |
511638213 |
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c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s11888-012-0128-3 |
| up_date |
2024-07-03T15:30:38.852Z |
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| score |
7.4003572 |