Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival
Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusio...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Citro, Antonio [verfasserIn] Cantarelli, Elisa [verfasserIn] Piemonti, Lorenzo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Current diabetes reports - Heidelberg [u.a.] : Springer, 2001, 13(2013), 5 vom: 04. Aug., Seite 733-744 |
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| Übergeordnetes Werk: |
volume:13 ; year:2013 ; number:5 ; day:04 ; month:08 ; pages:733-744 |
| Links: |
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| DOI / URN: |
10.1007/s11892-013-0401-0 |
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| Katalog-ID: |
SPR022897771 |
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| 520 | |a Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). | ||
| 650 | 4 | |a Islet transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Early innate immune events |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chemokines |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Danger signals |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Polymorphonuclear cells |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Instant blood mediated inflammatory reaction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-inflammatory strategies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Islet engraftment |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Survival |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Cantarelli, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Piemonti, Lorenzo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current diabetes reports |d Heidelberg [u.a.] : Springer, 2001 |g 13(2013), 5 vom: 04. Aug., Seite 733-744 |w (DE-627)357168216 |w (DE-600)2094158-4 |x 1539-0829 |7 nnns |
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| 912 | |a GBV_ILN_2037 | ||
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| 912 | |a GBV_ILN_2044 | ||
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| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
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| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
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| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
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10.1007/s11892-013-0401-0 doi (DE-627)SPR022897771 (SPR)s11892-013-0401-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Citro, Antonio verfasserin aut Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). Islet transplantation (dpeaa)DE-He213 Early innate immune events (dpeaa)DE-He213 Chemokines (dpeaa)DE-He213 Danger signals (dpeaa)DE-He213 Polymorphonuclear cells (dpeaa)DE-He213 Instant blood mediated inflammatory reaction (dpeaa)DE-He213 Anti-inflammatory strategies (dpeaa)DE-He213 Islet engraftment (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Cantarelli, Elisa verfasserin aut Piemonti, Lorenzo verfasserin aut Enthalten in Current diabetes reports Heidelberg [u.a.] : Springer, 2001 13(2013), 5 vom: 04. Aug., Seite 733-744 (DE-627)357168216 (DE-600)2094158-4 1539-0829 nnns volume:13 year:2013 number:5 day:04 month:08 pages:733-744 https://dx.doi.org/10.1007/s11892-013-0401-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 13 2013 5 04 08 733-744 |
| spelling |
10.1007/s11892-013-0401-0 doi (DE-627)SPR022897771 (SPR)s11892-013-0401-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Citro, Antonio verfasserin aut Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). Islet transplantation (dpeaa)DE-He213 Early innate immune events (dpeaa)DE-He213 Chemokines (dpeaa)DE-He213 Danger signals (dpeaa)DE-He213 Polymorphonuclear cells (dpeaa)DE-He213 Instant blood mediated inflammatory reaction (dpeaa)DE-He213 Anti-inflammatory strategies (dpeaa)DE-He213 Islet engraftment (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Cantarelli, Elisa verfasserin aut Piemonti, Lorenzo verfasserin aut Enthalten in Current diabetes reports Heidelberg [u.a.] : Springer, 2001 13(2013), 5 vom: 04. Aug., Seite 733-744 (DE-627)357168216 (DE-600)2094158-4 1539-0829 nnns volume:13 year:2013 number:5 day:04 month:08 pages:733-744 https://dx.doi.org/10.1007/s11892-013-0401-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 13 2013 5 04 08 733-744 |
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10.1007/s11892-013-0401-0 doi (DE-627)SPR022897771 (SPR)s11892-013-0401-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Citro, Antonio verfasserin aut Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). Islet transplantation (dpeaa)DE-He213 Early innate immune events (dpeaa)DE-He213 Chemokines (dpeaa)DE-He213 Danger signals (dpeaa)DE-He213 Polymorphonuclear cells (dpeaa)DE-He213 Instant blood mediated inflammatory reaction (dpeaa)DE-He213 Anti-inflammatory strategies (dpeaa)DE-He213 Islet engraftment (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Cantarelli, Elisa verfasserin aut Piemonti, Lorenzo verfasserin aut Enthalten in Current diabetes reports Heidelberg [u.a.] : Springer, 2001 13(2013), 5 vom: 04. Aug., Seite 733-744 (DE-627)357168216 (DE-600)2094158-4 1539-0829 nnns volume:13 year:2013 number:5 day:04 month:08 pages:733-744 https://dx.doi.org/10.1007/s11892-013-0401-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 13 2013 5 04 08 733-744 |
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10.1007/s11892-013-0401-0 doi (DE-627)SPR022897771 (SPR)s11892-013-0401-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Citro, Antonio verfasserin aut Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). Islet transplantation (dpeaa)DE-He213 Early innate immune events (dpeaa)DE-He213 Chemokines (dpeaa)DE-He213 Danger signals (dpeaa)DE-He213 Polymorphonuclear cells (dpeaa)DE-He213 Instant blood mediated inflammatory reaction (dpeaa)DE-He213 Anti-inflammatory strategies (dpeaa)DE-He213 Islet engraftment (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Cantarelli, Elisa verfasserin aut Piemonti, Lorenzo verfasserin aut Enthalten in Current diabetes reports Heidelberg [u.a.] : Springer, 2001 13(2013), 5 vom: 04. Aug., Seite 733-744 (DE-627)357168216 (DE-600)2094158-4 1539-0829 nnns volume:13 year:2013 number:5 day:04 month:08 pages:733-744 https://dx.doi.org/10.1007/s11892-013-0401-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 13 2013 5 04 08 733-744 |
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10.1007/s11892-013-0401-0 doi (DE-627)SPR022897771 (SPR)s11892-013-0401-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Citro, Antonio verfasserin aut Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). Islet transplantation (dpeaa)DE-He213 Early innate immune events (dpeaa)DE-He213 Chemokines (dpeaa)DE-He213 Danger signals (dpeaa)DE-He213 Polymorphonuclear cells (dpeaa)DE-He213 Instant blood mediated inflammatory reaction (dpeaa)DE-He213 Anti-inflammatory strategies (dpeaa)DE-He213 Islet engraftment (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Cantarelli, Elisa verfasserin aut Piemonti, Lorenzo verfasserin aut Enthalten in Current diabetes reports Heidelberg [u.a.] : Springer, 2001 13(2013), 5 vom: 04. Aug., Seite 733-744 (DE-627)357168216 (DE-600)2094158-4 1539-0829 nnns volume:13 year:2013 number:5 day:04 month:08 pages:733-744 https://dx.doi.org/10.1007/s11892-013-0401-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 13 2013 5 04 08 733-744 |
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Enthalten in Current diabetes reports 13(2013), 5 vom: 04. Aug., Seite 733-744 volume:13 year:2013 number:5 day:04 month:08 pages:733-744 |
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Islet transplantation Early innate immune events Chemokines Danger signals Polymorphonuclear cells Instant blood mediated inflammatory reaction Anti-inflammatory strategies Islet engraftment Survival |
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Current diabetes reports |
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Citro, Antonio @@aut@@ Cantarelli, Elisa @@aut@@ Piemonti, Lorenzo @@aut@@ |
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2013-08-04T00:00:00Z |
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Citro, Antonio |
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Citro, Antonio ddc 610 bkl 44.89 misc Islet transplantation misc Early innate immune events misc Chemokines misc Danger signals misc Polymorphonuclear cells misc Instant blood mediated inflammatory reaction misc Anti-inflammatory strategies misc Islet engraftment misc Survival Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival |
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610 ASE 44.89 bkl Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival Islet transplantation (dpeaa)DE-He213 Early innate immune events (dpeaa)DE-He213 Chemokines (dpeaa)DE-He213 Danger signals (dpeaa)DE-He213 Polymorphonuclear cells (dpeaa)DE-He213 Instant blood mediated inflammatory reaction (dpeaa)DE-He213 Anti-inflammatory strategies (dpeaa)DE-He213 Islet engraftment (dpeaa)DE-He213 Survival (dpeaa)DE-He213 |
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ddc 610 bkl 44.89 misc Islet transplantation misc Early innate immune events misc Chemokines misc Danger signals misc Polymorphonuclear cells misc Instant blood mediated inflammatory reaction misc Anti-inflammatory strategies misc Islet engraftment misc Survival |
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ddc 610 bkl 44.89 misc Islet transplantation misc Early innate immune events misc Chemokines misc Danger signals misc Polymorphonuclear cells misc Instant blood mediated inflammatory reaction misc Anti-inflammatory strategies misc Islet engraftment misc Survival |
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anti-inflammatory strategies to enhance islet engraftment and survival |
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Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival |
| abstract |
Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). |
| abstractGer |
Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). |
| abstract_unstemmed |
Abstract Early innate inflammatory reaction strongly affects islet engraftment and survival after intrahepatic transplantation. This early immune response is triggered by ischemia-reperfusion injury and instant blood mediated inflammatory reaction (IBMIR) occurring hours and days after islet infusion. Evidence in both mouse model and in human counterpart suggest the involvement of coagulation, complement system, and proinflammatory chemokines/cytokines. Identification and targeting of pathway(s), playing a role as “master regulator(s)” in post-transplant detrimental inflammatory events, is now mandatory to improve islet transplantation success. This review will focus on inflammatory pathway(s) differentially modulated by islet isolation and mainly associated with the early post-transplant events. Moreover, we will take into account anti-inflammatory strategies that have been tested at 2 levels: on the graft, ex vivo, during islet culture (i.e., donor) and/or on the graft site, in vivo, early after islet infusion (i.e., recipient). |
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| container_issue |
5 |
| title_short |
Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival |
| url |
https://dx.doi.org/10.1007/s11892-013-0401-0 |
| remote_bool |
true |
| author2 |
Cantarelli, Elisa Piemonti, Lorenzo |
| author2Str |
Cantarelli, Elisa Piemonti, Lorenzo |
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| doi_str |
10.1007/s11892-013-0401-0 |
| up_date |
2024-07-03T15:34:19.689Z |
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| score |
7.4003115 |