Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management

Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Da, Ben L. [verfasserIn] Ben-Yakov, Gil [verfasserIn] Kleiner, David [verfasserIn] Koh, Christopher [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Drug-induced liver injury Hepatitis, drug-induced Hepatitis, autoimmune Hepatitis Chemical and drug-induced liver injury Drug-induced abnormalities

Übergeordnetes Werk:	Enthalten in: Current hepatitis reports - Philadelphia, Pa : Current Science Inc., 2002, 17(2018), 3 vom: 18. Juni, Seite 235-244
Übergeordnetes Werk:	volume:17 ; year:2018 ; number:3 ; day:18 ; month:06 ; pages:235-244

Links:	Volltext

DOI / URN:	10.1007/s11901-018-0407-9

Katalog-ID:	SPR02293717X

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520			\|a Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.
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allfields	10.1007/s11901-018-0407-9 doi (DE-627)SPR02293717X (SPR)s11901-018-0407-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Da, Ben L. verfasserin aut Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI. Drug-induced liver injury (dpeaa)DE-He213 Hepatitis, drug-induced (dpeaa)DE-He213 Hepatitis, autoimmune (dpeaa)DE-He213 Hepatitis (dpeaa)DE-He213 Chemical and drug-induced liver injury (dpeaa)DE-He213 Drug-induced abnormalities (dpeaa)DE-He213 Ben-Yakov, Gil verfasserin aut Kleiner, David verfasserin aut Koh, Christopher verfasserin aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 17(2018), 3 vom: 18. Juni, Seite 235-244 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:17 year:2018 number:3 day:18 month:06 pages:235-244 https://dx.doi.org/10.1007/s11901-018-0407-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 44.87 ASE AR 17 2018 3 18 06 235-244
spelling	10.1007/s11901-018-0407-9 doi (DE-627)SPR02293717X (SPR)s11901-018-0407-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Da, Ben L. verfasserin aut Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI. Drug-induced liver injury (dpeaa)DE-He213 Hepatitis, drug-induced (dpeaa)DE-He213 Hepatitis, autoimmune (dpeaa)DE-He213 Hepatitis (dpeaa)DE-He213 Chemical and drug-induced liver injury (dpeaa)DE-He213 Drug-induced abnormalities (dpeaa)DE-He213 Ben-Yakov, Gil verfasserin aut Kleiner, David verfasserin aut Koh, Christopher verfasserin aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 17(2018), 3 vom: 18. Juni, Seite 235-244 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:17 year:2018 number:3 day:18 month:06 pages:235-244 https://dx.doi.org/10.1007/s11901-018-0407-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 44.87 ASE AR 17 2018 3 18 06 235-244
allfields_unstemmed	10.1007/s11901-018-0407-9 doi (DE-627)SPR02293717X (SPR)s11901-018-0407-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Da, Ben L. verfasserin aut Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI. Drug-induced liver injury (dpeaa)DE-He213 Hepatitis, drug-induced (dpeaa)DE-He213 Hepatitis, autoimmune (dpeaa)DE-He213 Hepatitis (dpeaa)DE-He213 Chemical and drug-induced liver injury (dpeaa)DE-He213 Drug-induced abnormalities (dpeaa)DE-He213 Ben-Yakov, Gil verfasserin aut Kleiner, David verfasserin aut Koh, Christopher verfasserin aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 17(2018), 3 vom: 18. Juni, Seite 235-244 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:17 year:2018 number:3 day:18 month:06 pages:235-244 https://dx.doi.org/10.1007/s11901-018-0407-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 44.87 ASE AR 17 2018 3 18 06 235-244
allfieldsGer	10.1007/s11901-018-0407-9 doi (DE-627)SPR02293717X (SPR)s11901-018-0407-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Da, Ben L. verfasserin aut Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI. Drug-induced liver injury (dpeaa)DE-He213 Hepatitis, drug-induced (dpeaa)DE-He213 Hepatitis, autoimmune (dpeaa)DE-He213 Hepatitis (dpeaa)DE-He213 Chemical and drug-induced liver injury (dpeaa)DE-He213 Drug-induced abnormalities (dpeaa)DE-He213 Ben-Yakov, Gil verfasserin aut Kleiner, David verfasserin aut Koh, Christopher verfasserin aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 17(2018), 3 vom: 18. Juni, Seite 235-244 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:17 year:2018 number:3 day:18 month:06 pages:235-244 https://dx.doi.org/10.1007/s11901-018-0407-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 44.87 ASE AR 17 2018 3 18 06 235-244
allfieldsSound	10.1007/s11901-018-0407-9 doi (DE-627)SPR02293717X (SPR)s11901-018-0407-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.87 bkl Da, Ben L. verfasserin aut Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI. Drug-induced liver injury (dpeaa)DE-He213 Hepatitis, drug-induced (dpeaa)DE-He213 Hepatitis, autoimmune (dpeaa)DE-He213 Hepatitis (dpeaa)DE-He213 Chemical and drug-induced liver injury (dpeaa)DE-He213 Drug-induced abnormalities (dpeaa)DE-He213 Ben-Yakov, Gil verfasserin aut Kleiner, David verfasserin aut Koh, Christopher verfasserin aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 17(2018), 3 vom: 18. Juni, Seite 235-244 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:17 year:2018 number:3 day:18 month:06 pages:235-244 https://dx.doi.org/10.1007/s11901-018-0407-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 44.87 ASE AR 17 2018 3 18 06 235-244
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source	Enthalten in Current hepatitis reports 17(2018), 3 vom: 18. Juni, Seite 235-244 volume:17 year:2018 number:3 day:18 month:06 pages:235-244
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author	Da, Ben L.
spellingShingle	Da, Ben L. ddc 610 bkl 44.87 misc Drug-induced liver injury misc Hepatitis, drug-induced misc Hepatitis, autoimmune misc Hepatitis misc Chemical and drug-induced liver injury misc Drug-induced abnormalities Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management
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topic_title	610 ASE 44.87 bkl Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management Drug-induced liver injury (dpeaa)DE-He213 Hepatitis, drug-induced (dpeaa)DE-He213 Hepatitis, autoimmune (dpeaa)DE-He213 Hepatitis (dpeaa)DE-He213 Chemical and drug-induced liver injury (dpeaa)DE-He213 Drug-induced abnormalities (dpeaa)DE-He213
topic	ddc 610 bkl 44.87 misc Drug-induced liver injury misc Hepatitis, drug-induced misc Hepatitis, autoimmune misc Hepatitis misc Chemical and drug-induced liver injury misc Drug-induced abnormalities
topic_unstemmed	ddc 610 bkl 44.87 misc Drug-induced liver injury misc Hepatitis, drug-induced misc Hepatitis, autoimmune misc Hepatitis misc Chemical and drug-induced liver injury misc Drug-induced abnormalities
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title	Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management
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title_full	Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management
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title_sort	drug-induced liver injury: understanding the different immune-mediated phenotypes and clinical management
title_auth	Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management
abstract	Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.
abstractGer	Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.
abstract_unstemmed	Purpose of Review The aim of this manuscript is to review two immune-mediated drug-induced liver injury (DILI) phenotypes, immune-allergic DILI (IA-DILI) and DILI with autoimmune hepatitis features (DILI-AIH), which are poorly defined and can lead to significant morbidity and mortality. Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. Further studies are needed to improve our understanding of immune-mediated DILI.
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title_short	Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management
url	https://dx.doi.org/10.1007/s11901-018-0407-9
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up_date	2024-07-03T15:49:50.830Z
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Recent Findings Recent information on this topic improves the understanding of IA-DILI and DILI-AIH regarding risk factors, associated medications, clinical presentations, histopathologic findings, and management strategies. Summary Although the pathogenesis and specific mechanisms remain elusive, clinical and pathological advancements in our understanding of IA-DILI and DILI-AIH have provided clinicians with added tools for the diagnosis and management of these diseases. 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Drug-Induced Liver Injury: Understanding the Different Immune-Mediated Phenotypes and Clinical Management

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