Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia
Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Noneth...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Taylor, Brittany [verfasserIn] Cheema, Adnan [verfasserIn] Soslowsky, Louis [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Übergeordnetes Werk: |
Enthalten in: Current rheumatology reports - Philadelphia, Pa. : Current Science Inc., 1999, 19(2017), 12 vom: 04. Nov. |
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| Übergeordnetes Werk: |
volume:19 ; year:2017 ; number:12 ; day:04 ; month:11 |
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| DOI / URN: |
10.1007/s11926-017-0704-2 |
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SPR023037024 |
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| 520 | |a Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. | ||
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| 700 | 1 | |a Soslowsky, Louis |e verfasserin |4 aut | |
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10.1007/s11926-017-0704-2 doi (DE-627)SPR023037024 (SPR)s11926-017-0704-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.83 bkl Taylor, Brittany verfasserin aut Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. Hypercholesterolemia (dpeaa)DE-He213 Familial hypercholesterolemia (dpeaa)DE-He213 Tendon pathology (dpeaa)DE-He213 Statins (dpeaa)DE-He213 xanthomas (dpeaa)DE-He213 Cheema, Adnan verfasserin aut Soslowsky, Louis verfasserin aut Enthalten in Current rheumatology reports Philadelphia, Pa. : Current Science Inc., 1999 19(2017), 12 vom: 04. Nov. (DE-627)357168445 (DE-600)2094184-5 1534-6307 nnns volume:19 year:2017 number:12 day:04 month:11 https://dx.doi.org/10.1007/s11926-017-0704-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.83 ASE AR 19 2017 12 04 11 |
| spelling |
10.1007/s11926-017-0704-2 doi (DE-627)SPR023037024 (SPR)s11926-017-0704-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.83 bkl Taylor, Brittany verfasserin aut Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. Hypercholesterolemia (dpeaa)DE-He213 Familial hypercholesterolemia (dpeaa)DE-He213 Tendon pathology (dpeaa)DE-He213 Statins (dpeaa)DE-He213 xanthomas (dpeaa)DE-He213 Cheema, Adnan verfasserin aut Soslowsky, Louis verfasserin aut Enthalten in Current rheumatology reports Philadelphia, Pa. : Current Science Inc., 1999 19(2017), 12 vom: 04. Nov. (DE-627)357168445 (DE-600)2094184-5 1534-6307 nnns volume:19 year:2017 number:12 day:04 month:11 https://dx.doi.org/10.1007/s11926-017-0704-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.83 ASE AR 19 2017 12 04 11 |
| allfields_unstemmed |
10.1007/s11926-017-0704-2 doi (DE-627)SPR023037024 (SPR)s11926-017-0704-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.83 bkl Taylor, Brittany verfasserin aut Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. Hypercholesterolemia (dpeaa)DE-He213 Familial hypercholesterolemia (dpeaa)DE-He213 Tendon pathology (dpeaa)DE-He213 Statins (dpeaa)DE-He213 xanthomas (dpeaa)DE-He213 Cheema, Adnan verfasserin aut Soslowsky, Louis verfasserin aut Enthalten in Current rheumatology reports Philadelphia, Pa. : Current Science Inc., 1999 19(2017), 12 vom: 04. Nov. (DE-627)357168445 (DE-600)2094184-5 1534-6307 nnns volume:19 year:2017 number:12 day:04 month:11 https://dx.doi.org/10.1007/s11926-017-0704-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.83 ASE AR 19 2017 12 04 11 |
| allfieldsGer |
10.1007/s11926-017-0704-2 doi (DE-627)SPR023037024 (SPR)s11926-017-0704-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.83 bkl Taylor, Brittany verfasserin aut Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. Hypercholesterolemia (dpeaa)DE-He213 Familial hypercholesterolemia (dpeaa)DE-He213 Tendon pathology (dpeaa)DE-He213 Statins (dpeaa)DE-He213 xanthomas (dpeaa)DE-He213 Cheema, Adnan verfasserin aut Soslowsky, Louis verfasserin aut Enthalten in Current rheumatology reports Philadelphia, Pa. : Current Science Inc., 1999 19(2017), 12 vom: 04. Nov. (DE-627)357168445 (DE-600)2094184-5 1534-6307 nnns volume:19 year:2017 number:12 day:04 month:11 https://dx.doi.org/10.1007/s11926-017-0704-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.83 ASE AR 19 2017 12 04 11 |
| allfieldsSound |
10.1007/s11926-017-0704-2 doi (DE-627)SPR023037024 (SPR)s11926-017-0704-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.83 bkl Taylor, Brittany verfasserin aut Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. Hypercholesterolemia (dpeaa)DE-He213 Familial hypercholesterolemia (dpeaa)DE-He213 Tendon pathology (dpeaa)DE-He213 Statins (dpeaa)DE-He213 xanthomas (dpeaa)DE-He213 Cheema, Adnan verfasserin aut Soslowsky, Louis verfasserin aut Enthalten in Current rheumatology reports Philadelphia, Pa. : Current Science Inc., 1999 19(2017), 12 vom: 04. Nov. (DE-627)357168445 (DE-600)2094184-5 1534-6307 nnns volume:19 year:2017 number:12 day:04 month:11 https://dx.doi.org/10.1007/s11926-017-0704-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.83 ASE AR 19 2017 12 04 11 |
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English |
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Enthalten in Current rheumatology reports 19(2017), 12 vom: 04. Nov. volume:19 year:2017 number:12 day:04 month:11 |
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Enthalten in Current rheumatology reports 19(2017), 12 vom: 04. Nov. volume:19 year:2017 number:12 day:04 month:11 |
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findex.gbv.de |
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Hypercholesterolemia Familial hypercholesterolemia Tendon pathology Statins xanthomas |
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610 |
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Current rheumatology reports |
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Taylor, Brittany @@aut@@ Cheema, Adnan @@aut@@ Soslowsky, Louis @@aut@@ |
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2017-11-04T00:00:00Z |
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357168445 |
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3610 |
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englisch |
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|
| author |
Taylor, Brittany |
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Taylor, Brittany ddc 610 bkl 44.83 misc Hypercholesterolemia misc Familial hypercholesterolemia misc Tendon pathology misc Statins misc xanthomas Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia |
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610 ASE 44.83 bkl Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia Hypercholesterolemia (dpeaa)DE-He213 Familial hypercholesterolemia (dpeaa)DE-He213 Tendon pathology (dpeaa)DE-He213 Statins (dpeaa)DE-He213 xanthomas (dpeaa)DE-He213 |
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ddc 610 bkl 44.83 misc Hypercholesterolemia misc Familial hypercholesterolemia misc Tendon pathology misc Statins misc xanthomas |
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ddc 610 bkl 44.83 misc Hypercholesterolemia misc Familial hypercholesterolemia misc Tendon pathology misc Statins misc xanthomas |
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ddc 610 bkl 44.83 misc Hypercholesterolemia misc Familial hypercholesterolemia misc Tendon pathology misc Statins misc xanthomas |
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Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia |
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Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia |
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Taylor, Brittany |
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tendon pathology in hypercholesterolemia and familial hypercholesterolemia |
| title_auth |
Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia |
| abstract |
Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. |
| abstractGer |
Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. |
| abstract_unstemmed |
Purpose of Review Hypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. Recent Findings The release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. Summary More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients. |
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12 |
| title_short |
Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia |
| url |
https://dx.doi.org/10.1007/s11926-017-0704-2 |
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true |
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Cheema, Adnan Soslowsky, Louis |
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Cheema, Adnan Soslowsky, Louis |
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c |
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| doi_str |
10.1007/s11926-017-0704-2 |
| up_date |
2024-07-03T16:27:10.494Z |
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1803575917800325120 |
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| score |
7.398053 |