Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009
Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similar...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shikov, A. N. [verfasserIn] Sementsova, A. O. [verfasserIn] Demina, O. K. [verfasserIn] Sergeev, A. A. [verfasserIn] Berillo, S. A. [verfasserIn] Sergeeva, E. I. [verfasserIn] Vinokurova, A. V. [verfasserIn] Ishenina, A. V. [verfasserIn] Ternovoi, V. A. [verfasserIn] Agafonov, A. P. [verfasserIn] Drozdov, I. G. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Molecular genetics, microbiology and virology - New York, NY : Allerton Press, Springer, 2007, 26(2011), 4 vom: Dez., Seite 166-173 |
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| Übergeordnetes Werk: |
volume:26 ; year:2011 ; number:4 ; month:12 ; pages:166-173 |
| Links: |
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| DOI / URN: |
10.3103/S0891416811040082 |
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| Katalog-ID: |
SPR023266783 |
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| 245 | 1 | 0 | |a Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 |
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| 520 | |a Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. | ||
| 650 | 4 | |a pandemic influenza virus A (H1N1) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a genotypic variability |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a phylogenetic analysis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a hemagglutinin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a neuraminidase |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Sementsova, A. O. |e verfasserin |4 aut | |
| 700 | 1 | |a Demina, O. K. |e verfasserin |4 aut | |
| 700 | 1 | |a Sergeev, A. A. |e verfasserin |4 aut | |
| 700 | 1 | |a Berillo, S. A. |e verfasserin |4 aut | |
| 700 | 1 | |a Sergeeva, E. I. |e verfasserin |4 aut | |
| 700 | 1 | |a Vinokurova, A. V. |e verfasserin |4 aut | |
| 700 | 1 | |a Ishenina, A. V. |e verfasserin |4 aut | |
| 700 | 1 | |a Ternovoi, V. A. |e verfasserin |4 aut | |
| 700 | 1 | |a Agafonov, A. P. |e verfasserin |4 aut | |
| 700 | 1 | |a Drozdov, I. G. |e verfasserin |4 aut | |
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10.3103/S0891416811040082 doi (DE-627)SPR023266783 (SPR)S0891416811040082-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.30 bkl Shikov, A. N. verfasserin aut Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. pandemic influenza virus A (H1N1) (dpeaa)DE-He213 genotypic variability (dpeaa)DE-He213 phylogenetic analysis (dpeaa)DE-He213 hemagglutinin (dpeaa)DE-He213 neuraminidase (dpeaa)DE-He213 Sementsova, A. O. verfasserin aut Demina, O. K. verfasserin aut Sergeev, A. A. verfasserin aut Berillo, S. A. verfasserin aut Sergeeva, E. I. verfasserin aut Vinokurova, A. V. verfasserin aut Ishenina, A. V. verfasserin aut Ternovoi, V. A. verfasserin aut Agafonov, A. P. verfasserin aut Drozdov, I. G. verfasserin aut Enthalten in Molecular genetics, microbiology and virology New York, NY : Allerton Press, Springer, 2007 26(2011), 4 vom: Dez., Seite 166-173 (DE-627)538221615 (DE-600)2379221-8 1934-841X nnns volume:26 year:2011 number:4 month:12 pages:166-173 https://dx.doi.org/10.3103/S0891416811040082 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.30 ASE AR 26 2011 4 12 166-173 |
| spelling |
10.3103/S0891416811040082 doi (DE-627)SPR023266783 (SPR)S0891416811040082-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.30 bkl Shikov, A. N. verfasserin aut Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. pandemic influenza virus A (H1N1) (dpeaa)DE-He213 genotypic variability (dpeaa)DE-He213 phylogenetic analysis (dpeaa)DE-He213 hemagglutinin (dpeaa)DE-He213 neuraminidase (dpeaa)DE-He213 Sementsova, A. O. verfasserin aut Demina, O. K. verfasserin aut Sergeev, A. A. verfasserin aut Berillo, S. A. verfasserin aut Sergeeva, E. I. verfasserin aut Vinokurova, A. V. verfasserin aut Ishenina, A. V. verfasserin aut Ternovoi, V. A. verfasserin aut Agafonov, A. P. verfasserin aut Drozdov, I. G. verfasserin aut Enthalten in Molecular genetics, microbiology and virology New York, NY : Allerton Press, Springer, 2007 26(2011), 4 vom: Dez., Seite 166-173 (DE-627)538221615 (DE-600)2379221-8 1934-841X nnns volume:26 year:2011 number:4 month:12 pages:166-173 https://dx.doi.org/10.3103/S0891416811040082 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.30 ASE AR 26 2011 4 12 166-173 |
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10.3103/S0891416811040082 doi (DE-627)SPR023266783 (SPR)S0891416811040082-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.30 bkl Shikov, A. N. verfasserin aut Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. pandemic influenza virus A (H1N1) (dpeaa)DE-He213 genotypic variability (dpeaa)DE-He213 phylogenetic analysis (dpeaa)DE-He213 hemagglutinin (dpeaa)DE-He213 neuraminidase (dpeaa)DE-He213 Sementsova, A. O. verfasserin aut Demina, O. K. verfasserin aut Sergeev, A. A. verfasserin aut Berillo, S. A. verfasserin aut Sergeeva, E. I. verfasserin aut Vinokurova, A. V. verfasserin aut Ishenina, A. V. verfasserin aut Ternovoi, V. A. verfasserin aut Agafonov, A. P. verfasserin aut Drozdov, I. G. verfasserin aut Enthalten in Molecular genetics, microbiology and virology New York, NY : Allerton Press, Springer, 2007 26(2011), 4 vom: Dez., Seite 166-173 (DE-627)538221615 (DE-600)2379221-8 1934-841X nnns volume:26 year:2011 number:4 month:12 pages:166-173 https://dx.doi.org/10.3103/S0891416811040082 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.30 ASE AR 26 2011 4 12 166-173 |
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10.3103/S0891416811040082 doi (DE-627)SPR023266783 (SPR)S0891416811040082-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.30 bkl Shikov, A. N. verfasserin aut Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. pandemic influenza virus A (H1N1) (dpeaa)DE-He213 genotypic variability (dpeaa)DE-He213 phylogenetic analysis (dpeaa)DE-He213 hemagglutinin (dpeaa)DE-He213 neuraminidase (dpeaa)DE-He213 Sementsova, A. O. verfasserin aut Demina, O. K. verfasserin aut Sergeev, A. A. verfasserin aut Berillo, S. A. verfasserin aut Sergeeva, E. I. verfasserin aut Vinokurova, A. V. verfasserin aut Ishenina, A. V. verfasserin aut Ternovoi, V. A. verfasserin aut Agafonov, A. P. verfasserin aut Drozdov, I. G. verfasserin aut Enthalten in Molecular genetics, microbiology and virology New York, NY : Allerton Press, Springer, 2007 26(2011), 4 vom: Dez., Seite 166-173 (DE-627)538221615 (DE-600)2379221-8 1934-841X nnns volume:26 year:2011 number:4 month:12 pages:166-173 https://dx.doi.org/10.3103/S0891416811040082 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.30 ASE AR 26 2011 4 12 166-173 |
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Enthalten in Molecular genetics, microbiology and virology 26(2011), 4 vom: Dez., Seite 166-173 volume:26 year:2011 number:4 month:12 pages:166-173 |
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Enthalten in Molecular genetics, microbiology and virology 26(2011), 4 vom: Dez., Seite 166-173 volume:26 year:2011 number:4 month:12 pages:166-173 |
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Shikov, A. N. @@aut@@ Sementsova, A. O. @@aut@@ Demina, O. K. @@aut@@ Sergeev, A. A. @@aut@@ Berillo, S. A. @@aut@@ Sergeeva, E. I. @@aut@@ Vinokurova, A. V. @@aut@@ Ishenina, A. V. @@aut@@ Ternovoi, V. A. @@aut@@ Agafonov, A. P. @@aut@@ Drozdov, I. G. @@aut@@ |
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Shikov, A. N. |
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Shikov, A. N. ddc 570 bkl 42.30 misc pandemic influenza virus A (H1N1) misc genotypic variability misc phylogenetic analysis misc hemagglutinin misc neuraminidase Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 |
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570 610 ASE 42.30 bkl Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 pandemic influenza virus A (H1N1) (dpeaa)DE-He213 genotypic variability (dpeaa)DE-He213 phylogenetic analysis (dpeaa)DE-He213 hemagglutinin (dpeaa)DE-He213 neuraminidase (dpeaa)DE-He213 |
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Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 |
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Shikov, A. N. Sementsova, A. O. Demina, O. K. Sergeev, A. A. Berillo, S. A. Sergeeva, E. I. Vinokurova, A. V. Ishenina, A. V. Ternovoi, V. A. Agafonov, A. P. Drozdov, I. G. |
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genetic variability of isolates of pandemic influenza virus a h1n1 isolated in russia in 2009 |
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Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 |
| abstract |
Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. |
| abstractGer |
Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. |
| abstract_unstemmed |
Abstract In 14 isolates of pandemic influenza virus A H1N1 extracted from patients with influenza in 2009, complete nucleotide sequences of genome segments encoding surface proteins hemagglutinin and neuraminidase were determined. Phylogenetic analysis of these sequences showed their genetic similarity with the corresponding genes of other isolates of pandemic influenza virus A (H1N1) 2009 extracted in other countries, and the degree of homology for each gene was over 99%. Neuraminidase mutations known in the literature that lead to the stability of the virus to oseltamivir and other drugs of neuraminidase inhibitors were not recorded in the studied isolates. In four isolates from autopsy material, G155E mutation was found in hemagglutinin of the isolate A/Salekhard/01/2009 (H1N1). This mutation leads to increased viral replication in developing chick embryos. The frequency and nature of the nucleotide substitutions in the hemagglutinin and neuraminidase genes are determined. |
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Genetic variability of isolates of pandemic influenza virus A H1N1 isolated in Russia in 2009 |
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https://dx.doi.org/10.3103/S0891416811040082 |
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Sementsova, A. O. Demina, O. K. Sergeev, A. A. Berillo, S. A. Sergeeva, E. I. Vinokurova, A. V. Ishenina, A. V. Ternovoi, V. A. Agafonov, A. P. Drozdov, I. G. |
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Sementsova, A. O. Demina, O. K. Sergeev, A. A. Berillo, S. A. Sergeeva, E. I. Vinokurova, A. V. Ishenina, A. V. Ternovoi, V. A. Agafonov, A. P. Drozdov, I. G. |
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10.3103/S0891416811040082 |
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2024-07-03T17:53:47.384Z |
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| score |
7.401662 |