Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation
Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pontikoglou, Charalampos [verfasserIn] Deschaseaux, Frédéric [verfasserIn] Sensebé, Luc [verfasserIn] Papadaki, Helen A. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
Myelodysplastic syndromes (MDS) |
|---|
| Übergeordnetes Werk: |
Enthalten in: Stem cell reviews - New York, NY : Springer, 2005, 7(2011), 3 vom: 20. Jan., Seite 569-589 |
|---|---|
| Übergeordnetes Werk: |
volume:7 ; year:2011 ; number:3 ; day:20 ; month:01 ; pages:569-589 |
| Links: |
|---|
| DOI / URN: |
10.1007/s12015-011-9228-8 |
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SPR023685255 |
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| 520 | |a Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. | ||
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10.1007/s12015-011-9228-8 doi (DE-627)SPR023685255 (SPR)s12015-011-9228-8-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Pontikoglou, Charalampos verfasserin aut Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. Hematopoiesis (dpeaa)DE-He213 Bone marrow (BM) (dpeaa)DE-He213 Mesenchymal stem cells (MSCs) (dpeaa)DE-He213 Niche (dpeaa)DE-He213 Pericytes (dpeaa)DE-He213 Immunosuppression (dpeaa)DE-He213 Osteoblasts (dpeaa)DE-He213 Myelodysplastic syndromes (MDS) (dpeaa)DE-He213 Graft versus host disease (GVHD) (dpeaa)DE-He213 Hematopoiestic stem cell transplantation (HSCT) (dpeaa)DE-He213 Deschaseaux, Frédéric verfasserin aut Sensebé, Luc verfasserin aut Papadaki, Helen A. verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 7(2011), 3 vom: 20. Jan., Seite 569-589 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:7 year:2011 number:3 day:20 month:01 pages:569-589 https://dx.doi.org/10.1007/s12015-011-9228-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 7 2011 3 20 01 569-589 |
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10.1007/s12015-011-9228-8 doi (DE-627)SPR023685255 (SPR)s12015-011-9228-8-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Pontikoglou, Charalampos verfasserin aut Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. Hematopoiesis (dpeaa)DE-He213 Bone marrow (BM) (dpeaa)DE-He213 Mesenchymal stem cells (MSCs) (dpeaa)DE-He213 Niche (dpeaa)DE-He213 Pericytes (dpeaa)DE-He213 Immunosuppression (dpeaa)DE-He213 Osteoblasts (dpeaa)DE-He213 Myelodysplastic syndromes (MDS) (dpeaa)DE-He213 Graft versus host disease (GVHD) (dpeaa)DE-He213 Hematopoiestic stem cell transplantation (HSCT) (dpeaa)DE-He213 Deschaseaux, Frédéric verfasserin aut Sensebé, Luc verfasserin aut Papadaki, Helen A. verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 7(2011), 3 vom: 20. Jan., Seite 569-589 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:7 year:2011 number:3 day:20 month:01 pages:569-589 https://dx.doi.org/10.1007/s12015-011-9228-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 7 2011 3 20 01 569-589 |
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10.1007/s12015-011-9228-8 doi (DE-627)SPR023685255 (SPR)s12015-011-9228-8-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Pontikoglou, Charalampos verfasserin aut Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. Hematopoiesis (dpeaa)DE-He213 Bone marrow (BM) (dpeaa)DE-He213 Mesenchymal stem cells (MSCs) (dpeaa)DE-He213 Niche (dpeaa)DE-He213 Pericytes (dpeaa)DE-He213 Immunosuppression (dpeaa)DE-He213 Osteoblasts (dpeaa)DE-He213 Myelodysplastic syndromes (MDS) (dpeaa)DE-He213 Graft versus host disease (GVHD) (dpeaa)DE-He213 Hematopoiestic stem cell transplantation (HSCT) (dpeaa)DE-He213 Deschaseaux, Frédéric verfasserin aut Sensebé, Luc verfasserin aut Papadaki, Helen A. verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 7(2011), 3 vom: 20. Jan., Seite 569-589 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:7 year:2011 number:3 day:20 month:01 pages:569-589 https://dx.doi.org/10.1007/s12015-011-9228-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 7 2011 3 20 01 569-589 |
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10.1007/s12015-011-9228-8 doi (DE-627)SPR023685255 (SPR)s12015-011-9228-8-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Pontikoglou, Charalampos verfasserin aut Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. Hematopoiesis (dpeaa)DE-He213 Bone marrow (BM) (dpeaa)DE-He213 Mesenchymal stem cells (MSCs) (dpeaa)DE-He213 Niche (dpeaa)DE-He213 Pericytes (dpeaa)DE-He213 Immunosuppression (dpeaa)DE-He213 Osteoblasts (dpeaa)DE-He213 Myelodysplastic syndromes (MDS) (dpeaa)DE-He213 Graft versus host disease (GVHD) (dpeaa)DE-He213 Hematopoiestic stem cell transplantation (HSCT) (dpeaa)DE-He213 Deschaseaux, Frédéric verfasserin aut Sensebé, Luc verfasserin aut Papadaki, Helen A. verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 7(2011), 3 vom: 20. Jan., Seite 569-589 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:7 year:2011 number:3 day:20 month:01 pages:569-589 https://dx.doi.org/10.1007/s12015-011-9228-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 7 2011 3 20 01 569-589 |
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10.1007/s12015-011-9228-8 doi (DE-627)SPR023685255 (SPR)s12015-011-9228-8-e DE-627 ger DE-627 rakwb eng 570 610 ASE 42.15 bkl Pontikoglou, Charalampos verfasserin aut Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. Hematopoiesis (dpeaa)DE-He213 Bone marrow (BM) (dpeaa)DE-He213 Mesenchymal stem cells (MSCs) (dpeaa)DE-He213 Niche (dpeaa)DE-He213 Pericytes (dpeaa)DE-He213 Immunosuppression (dpeaa)DE-He213 Osteoblasts (dpeaa)DE-He213 Myelodysplastic syndromes (MDS) (dpeaa)DE-He213 Graft versus host disease (GVHD) (dpeaa)DE-He213 Hematopoiestic stem cell transplantation (HSCT) (dpeaa)DE-He213 Deschaseaux, Frédéric verfasserin aut Sensebé, Luc verfasserin aut Papadaki, Helen A. verfasserin aut Enthalten in Stem cell reviews New York, NY : Springer, 2005 7(2011), 3 vom: 20. Jan., Seite 569-589 (DE-627)494833777 (DE-600)2197218-7 1558-6804 nnns volume:7 year:2011 number:3 day:20 month:01 pages:569-589 https://dx.doi.org/10.1007/s12015-011-9228-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2005 42.15 ASE AR 7 2011 3 20 01 569-589 |
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Pontikoglou, Charalampos |
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Pontikoglou, Charalampos ddc 570 bkl 42.15 misc Hematopoiesis misc Bone marrow (BM) misc Mesenchymal stem cells (MSCs) misc Niche misc Pericytes misc Immunosuppression misc Osteoblasts misc Myelodysplastic syndromes (MDS) misc Graft versus host disease (GVHD) misc Hematopoiestic stem cell transplantation (HSCT) Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation |
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Bone Marrow Mesenchymal Stem Cells: Biological Properties and Their Role in Hematopoiesis and Hematopoietic Stem Cell Transplantation |
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Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. |
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Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. |
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Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined. |
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Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist’s point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hematopoiesis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bone marrow (BM)</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mesenchymal stem cells (MSCs)</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Niche</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pericytes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunosuppression</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Osteoblasts</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Myelodysplastic syndromes (MDS)</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Graft versus host disease (GVHD)</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hematopoiestic stem cell transplantation (HSCT)</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Deschaseaux, Frédéric</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sensebé, Luc</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Papadaki, Helen A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Stem cell reviews</subfield><subfield code="d">New York, NY : Springer, 2005</subfield><subfield code="g">7(2011), 3 vom: 20. 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