The Renin–Angiotensin System and Bone

Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Tamargo, Juan [verfasserIn] Caballero, Ricardo [verfasserIn] Delpón, Eva [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Angiotensin-converting enzyme inhibitors Angiotensin II receptor blockers Bone Bone resorption Osteoporosis Renin–angiotensin system

Übergeordnetes Werk:	Enthalten in: Clinical reviews in bone and mineral metabolism - Heidelberg : Springer, 2002, 13(2015), 3 vom: 26. Juli, Seite 125-148
Übergeordnetes Werk:	volume:13 ; year:2015 ; number:3 ; day:26 ; month:07 ; pages:125-148

Links:	Volltext

DOI / URN:	10.1007/s12018-015-9189-6

Katalog-ID:	SPR02371154X

Internformat


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520			\|a Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases.
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Indexfelder

author_variant	j t jt r c rc e d ed
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hierarchy_sort_str	2015
bklnumber	44.77 44.83
publishDate	2015
allfields	10.1007/s12018-015-9189-6 doi (DE-627)SPR02371154X (SPR)s12018-015-9189-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.77 bkl 44.83 bkl Tamargo, Juan verfasserin aut The Renin–Angiotensin System and Bone 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases. Angiotensin-converting enzyme inhibitors (dpeaa)DE-He213 Angiotensin II receptor blockers (dpeaa)DE-He213 Bone (dpeaa)DE-He213 Bone resorption (dpeaa)DE-He213 Osteoporosis (dpeaa)DE-He213 Renin–angiotensin system (dpeaa)DE-He213 Caballero, Ricardo verfasserin aut Delpón, Eva verfasserin aut Enthalten in Clinical reviews in bone and mineral metabolism Heidelberg : Springer, 2002 13(2015), 3 vom: 26. Juli, Seite 125-148 (DE-627)356252744 (DE-600)2091937-2 1559-0119 nnns volume:13 year:2015 number:3 day:26 month:07 pages:125-148 https://dx.doi.org/10.1007/s12018-015-9189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4700 44.77 ASE 44.83 ASE AR 13 2015 3 26 07 125-148
spelling	10.1007/s12018-015-9189-6 doi (DE-627)SPR02371154X (SPR)s12018-015-9189-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.77 bkl 44.83 bkl Tamargo, Juan verfasserin aut The Renin–Angiotensin System and Bone 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases. Angiotensin-converting enzyme inhibitors (dpeaa)DE-He213 Angiotensin II receptor blockers (dpeaa)DE-He213 Bone (dpeaa)DE-He213 Bone resorption (dpeaa)DE-He213 Osteoporosis (dpeaa)DE-He213 Renin–angiotensin system (dpeaa)DE-He213 Caballero, Ricardo verfasserin aut Delpón, Eva verfasserin aut Enthalten in Clinical reviews in bone and mineral metabolism Heidelberg : Springer, 2002 13(2015), 3 vom: 26. Juli, Seite 125-148 (DE-627)356252744 (DE-600)2091937-2 1559-0119 nnns volume:13 year:2015 number:3 day:26 month:07 pages:125-148 https://dx.doi.org/10.1007/s12018-015-9189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4700 44.77 ASE 44.83 ASE AR 13 2015 3 26 07 125-148
allfields_unstemmed	10.1007/s12018-015-9189-6 doi (DE-627)SPR02371154X (SPR)s12018-015-9189-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.77 bkl 44.83 bkl Tamargo, Juan verfasserin aut The Renin–Angiotensin System and Bone 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases. Angiotensin-converting enzyme inhibitors (dpeaa)DE-He213 Angiotensin II receptor blockers (dpeaa)DE-He213 Bone (dpeaa)DE-He213 Bone resorption (dpeaa)DE-He213 Osteoporosis (dpeaa)DE-He213 Renin–angiotensin system (dpeaa)DE-He213 Caballero, Ricardo verfasserin aut Delpón, Eva verfasserin aut Enthalten in Clinical reviews in bone and mineral metabolism Heidelberg : Springer, 2002 13(2015), 3 vom: 26. Juli, Seite 125-148 (DE-627)356252744 (DE-600)2091937-2 1559-0119 nnns volume:13 year:2015 number:3 day:26 month:07 pages:125-148 https://dx.doi.org/10.1007/s12018-015-9189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4700 44.77 ASE 44.83 ASE AR 13 2015 3 26 07 125-148
allfieldsGer	10.1007/s12018-015-9189-6 doi (DE-627)SPR02371154X (SPR)s12018-015-9189-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.77 bkl 44.83 bkl Tamargo, Juan verfasserin aut The Renin–Angiotensin System and Bone 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases. Angiotensin-converting enzyme inhibitors (dpeaa)DE-He213 Angiotensin II receptor blockers (dpeaa)DE-He213 Bone (dpeaa)DE-He213 Bone resorption (dpeaa)DE-He213 Osteoporosis (dpeaa)DE-He213 Renin–angiotensin system (dpeaa)DE-He213 Caballero, Ricardo verfasserin aut Delpón, Eva verfasserin aut Enthalten in Clinical reviews in bone and mineral metabolism Heidelberg : Springer, 2002 13(2015), 3 vom: 26. Juli, Seite 125-148 (DE-627)356252744 (DE-600)2091937-2 1559-0119 nnns volume:13 year:2015 number:3 day:26 month:07 pages:125-148 https://dx.doi.org/10.1007/s12018-015-9189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4700 44.77 ASE 44.83 ASE AR 13 2015 3 26 07 125-148
allfieldsSound	10.1007/s12018-015-9189-6 doi (DE-627)SPR02371154X (SPR)s12018-015-9189-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.77 bkl 44.83 bkl Tamargo, Juan verfasserin aut The Renin–Angiotensin System and Bone 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases. Angiotensin-converting enzyme inhibitors (dpeaa)DE-He213 Angiotensin II receptor blockers (dpeaa)DE-He213 Bone (dpeaa)DE-He213 Bone resorption (dpeaa)DE-He213 Osteoporosis (dpeaa)DE-He213 Renin–angiotensin system (dpeaa)DE-He213 Caballero, Ricardo verfasserin aut Delpón, Eva verfasserin aut Enthalten in Clinical reviews in bone and mineral metabolism Heidelberg : Springer, 2002 13(2015), 3 vom: 26. Juli, Seite 125-148 (DE-627)356252744 (DE-600)2091937-2 1559-0119 nnns volume:13 year:2015 number:3 day:26 month:07 pages:125-148 https://dx.doi.org/10.1007/s12018-015-9189-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4700 44.77 ASE 44.83 ASE AR 13 2015 3 26 07 125-148
language	English
source	Enthalten in Clinical reviews in bone and mineral metabolism 13(2015), 3 vom: 26. Juli, Seite 125-148 volume:13 year:2015 number:3 day:26 month:07 pages:125-148
sourceStr	Enthalten in Clinical reviews in bone and mineral metabolism 13(2015), 3 vom: 26. Juli, Seite 125-148 volume:13 year:2015 number:3 day:26 month:07 pages:125-148
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Angiotensin-converting enzyme inhibitors Angiotensin II receptor blockers Bone Bone resorption Osteoporosis Renin–angiotensin system
dewey-raw	610
isfreeaccess_bool	false
container_title	Clinical reviews in bone and mineral metabolism
authorswithroles_txt_mv	Tamargo, Juan @@aut@@ Caballero, Ricardo @@aut@@ Delpón, Eva @@aut@@
publishDateDaySort_date	2015-07-26T00:00:00Z
hierarchy_top_id	356252744
dewey-sort	3610
id	SPR02371154X
language_de	englisch
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author	Tamargo, Juan
spellingShingle	Tamargo, Juan ddc 610 bkl 44.77 bkl 44.83 misc Angiotensin-converting enzyme inhibitors misc Angiotensin II receptor blockers misc Bone misc Bone resorption misc Osteoporosis misc Renin–angiotensin system The Renin–Angiotensin System and Bone
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topic_title	610 ASE 44.77 bkl 44.83 bkl The Renin–Angiotensin System and Bone Angiotensin-converting enzyme inhibitors (dpeaa)DE-He213 Angiotensin II receptor blockers (dpeaa)DE-He213 Bone (dpeaa)DE-He213 Bone resorption (dpeaa)DE-He213 Osteoporosis (dpeaa)DE-He213 Renin–angiotensin system (dpeaa)DE-He213
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title	The Renin–Angiotensin System and Bone
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title_sort	renin–angiotensin system and bone
title_auth	The Renin–Angiotensin System and Bone
abstract	Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases.
abstractGer	Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases.
abstract_unstemmed	Abstract The RAS (renin–angiotensin system) plays a key role in the regulation of blood pressure, fluid and electrolyte homeostasis and cardiovascular and renal structure and function. There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. Thus, in the next future a better understanding on how the components of the local RAS influence bone metabolism and remodeling will allow us to select the best therapeutic strategy for patients with osteoporosis and cardiovascular diseases.
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title_short	The Renin–Angiotensin System and Bone
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There is evidence that in addition to the systemic RAS the components of the RAS are expressed in the local milieu of bone, where angiotensin II increases the osteoclastogenesis while inhibit the osteoblastic activity leading to a decrease in bone mineral density. Hypertension and osteoporosis are two common diseases that frequently coexist in the elderly population, and it has been hypothesized that the activation of the local RAS might be involved in the occurrence of both diseases often seen with advancing age. Epidemiological studies have found that RAS inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may exert a beneficial effect on bone mineral density, increasing the bone mass and decreasing the risk of bone fractures in patients with osteoporosis and cardiovascular diseases, and might accelerate the fracture healing process. However, both experimental and clinical studies with these RAS inhibitors led to sparse and contradictory results. 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