Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study
Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Delvecchio, Maurizio [verfasserIn] Salerno, Mariacarolina [verfasserIn] Vigone, Maria Cristina [verfasserIn] Wasniewska, Malgorzata [verfasserIn] Popolo, Pietro Pio [verfasserIn] Lapolla, Rosa [verfasserIn] Mussa, Alessandro [verfasserIn] Tronconi, Giulia Maria [verfasserIn] D’Acunzo, Ida [verfasserIn] Di Mase, Raffaella [verfasserIn] Falcone, Rosa Maria [verfasserIn] Corrias, Andrea [verfasserIn] De Luca, Filippo [verfasserIn] Weber, Giovanna [verfasserIn] Cavallo, Luciano [verfasserIn] Faienza, Maria Felicia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Endocrine - [S.l.] : Springer, 1995, 50(2015), 3 vom: 12. März, Seite 674-680 |
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| Übergeordnetes Werk: |
volume:50 ; year:2015 ; number:3 ; day:12 ; month:03 ; pages:674-680 |
| Links: |
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| DOI / URN: |
10.1007/s12020-015-0574-1 |
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| Katalog-ID: |
SPR023733500 |
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| 100 | 1 | |a Delvecchio, Maurizio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study |
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| 520 | |a Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. | ||
| 650 | 4 | |a Congenital hypothyroidism |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Thyroxine requirement |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Replacement therapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Congenital hypothyroidism etiology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Congenital hypothyroidism severity |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Salerno, Mariacarolina |e verfasserin |4 aut | |
| 700 | 1 | |a Vigone, Maria Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Wasniewska, Malgorzata |e verfasserin |4 aut | |
| 700 | 1 | |a Popolo, Pietro Pio |e verfasserin |4 aut | |
| 700 | 1 | |a Lapolla, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Mussa, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Tronconi, Giulia Maria |e verfasserin |4 aut | |
| 700 | 1 | |a D’Acunzo, Ida |e verfasserin |4 aut | |
| 700 | 1 | |a Di Mase, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Falcone, Rosa Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Corrias, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a De Luca, Filippo |e verfasserin |4 aut | |
| 700 | 1 | |a Weber, Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Cavallo, Luciano |e verfasserin |4 aut | |
| 700 | 1 | |a Faienza, Maria Felicia |e verfasserin |4 aut | |
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10.1007/s12020-015-0574-1 doi (DE-627)SPR023733500 (SPR)s12020-015-0574-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Delvecchio, Maurizio verfasserin aut Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. Congenital hypothyroidism (dpeaa)DE-He213 Thyroxine requirement (dpeaa)DE-He213 Replacement therapy (dpeaa)DE-He213 Congenital hypothyroidism etiology (dpeaa)DE-He213 Congenital hypothyroidism severity (dpeaa)DE-He213 Salerno, Mariacarolina verfasserin aut Vigone, Maria Cristina verfasserin aut Wasniewska, Malgorzata verfasserin aut Popolo, Pietro Pio verfasserin aut Lapolla, Rosa verfasserin aut Mussa, Alessandro verfasserin aut Tronconi, Giulia Maria verfasserin aut D’Acunzo, Ida verfasserin aut Di Mase, Raffaella verfasserin aut Falcone, Rosa Maria verfasserin aut Corrias, Andrea verfasserin aut De Luca, Filippo verfasserin aut Weber, Giovanna verfasserin aut Cavallo, Luciano verfasserin aut Faienza, Maria Felicia verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 50(2015), 3 vom: 12. März, Seite 674-680 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:50 year:2015 number:3 day:12 month:03 pages:674-680 https://dx.doi.org/10.1007/s12020-015-0574-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 50 2015 3 12 03 674-680 |
| spelling |
10.1007/s12020-015-0574-1 doi (DE-627)SPR023733500 (SPR)s12020-015-0574-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Delvecchio, Maurizio verfasserin aut Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. Congenital hypothyroidism (dpeaa)DE-He213 Thyroxine requirement (dpeaa)DE-He213 Replacement therapy (dpeaa)DE-He213 Congenital hypothyroidism etiology (dpeaa)DE-He213 Congenital hypothyroidism severity (dpeaa)DE-He213 Salerno, Mariacarolina verfasserin aut Vigone, Maria Cristina verfasserin aut Wasniewska, Malgorzata verfasserin aut Popolo, Pietro Pio verfasserin aut Lapolla, Rosa verfasserin aut Mussa, Alessandro verfasserin aut Tronconi, Giulia Maria verfasserin aut D’Acunzo, Ida verfasserin aut Di Mase, Raffaella verfasserin aut Falcone, Rosa Maria verfasserin aut Corrias, Andrea verfasserin aut De Luca, Filippo verfasserin aut Weber, Giovanna verfasserin aut Cavallo, Luciano verfasserin aut Faienza, Maria Felicia verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 50(2015), 3 vom: 12. März, Seite 674-680 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:50 year:2015 number:3 day:12 month:03 pages:674-680 https://dx.doi.org/10.1007/s12020-015-0574-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 50 2015 3 12 03 674-680 |
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10.1007/s12020-015-0574-1 doi (DE-627)SPR023733500 (SPR)s12020-015-0574-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Delvecchio, Maurizio verfasserin aut Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. Congenital hypothyroidism (dpeaa)DE-He213 Thyroxine requirement (dpeaa)DE-He213 Replacement therapy (dpeaa)DE-He213 Congenital hypothyroidism etiology (dpeaa)DE-He213 Congenital hypothyroidism severity (dpeaa)DE-He213 Salerno, Mariacarolina verfasserin aut Vigone, Maria Cristina verfasserin aut Wasniewska, Malgorzata verfasserin aut Popolo, Pietro Pio verfasserin aut Lapolla, Rosa verfasserin aut Mussa, Alessandro verfasserin aut Tronconi, Giulia Maria verfasserin aut D’Acunzo, Ida verfasserin aut Di Mase, Raffaella verfasserin aut Falcone, Rosa Maria verfasserin aut Corrias, Andrea verfasserin aut De Luca, Filippo verfasserin aut Weber, Giovanna verfasserin aut Cavallo, Luciano verfasserin aut Faienza, Maria Felicia verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 50(2015), 3 vom: 12. März, Seite 674-680 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:50 year:2015 number:3 day:12 month:03 pages:674-680 https://dx.doi.org/10.1007/s12020-015-0574-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 50 2015 3 12 03 674-680 |
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10.1007/s12020-015-0574-1 doi (DE-627)SPR023733500 (SPR)s12020-015-0574-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Delvecchio, Maurizio verfasserin aut Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. Congenital hypothyroidism (dpeaa)DE-He213 Thyroxine requirement (dpeaa)DE-He213 Replacement therapy (dpeaa)DE-He213 Congenital hypothyroidism etiology (dpeaa)DE-He213 Congenital hypothyroidism severity (dpeaa)DE-He213 Salerno, Mariacarolina verfasserin aut Vigone, Maria Cristina verfasserin aut Wasniewska, Malgorzata verfasserin aut Popolo, Pietro Pio verfasserin aut Lapolla, Rosa verfasserin aut Mussa, Alessandro verfasserin aut Tronconi, Giulia Maria verfasserin aut D’Acunzo, Ida verfasserin aut Di Mase, Raffaella verfasserin aut Falcone, Rosa Maria verfasserin aut Corrias, Andrea verfasserin aut De Luca, Filippo verfasserin aut Weber, Giovanna verfasserin aut Cavallo, Luciano verfasserin aut Faienza, Maria Felicia verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 50(2015), 3 vom: 12. März, Seite 674-680 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:50 year:2015 number:3 day:12 month:03 pages:674-680 https://dx.doi.org/10.1007/s12020-015-0574-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 50 2015 3 12 03 674-680 |
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10.1007/s12020-015-0574-1 doi (DE-627)SPR023733500 (SPR)s12020-015-0574-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Delvecchio, Maurizio verfasserin aut Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. Congenital hypothyroidism (dpeaa)DE-He213 Thyroxine requirement (dpeaa)DE-He213 Replacement therapy (dpeaa)DE-He213 Congenital hypothyroidism etiology (dpeaa)DE-He213 Congenital hypothyroidism severity (dpeaa)DE-He213 Salerno, Mariacarolina verfasserin aut Vigone, Maria Cristina verfasserin aut Wasniewska, Malgorzata verfasserin aut Popolo, Pietro Pio verfasserin aut Lapolla, Rosa verfasserin aut Mussa, Alessandro verfasserin aut Tronconi, Giulia Maria verfasserin aut D’Acunzo, Ida verfasserin aut Di Mase, Raffaella verfasserin aut Falcone, Rosa Maria verfasserin aut Corrias, Andrea verfasserin aut De Luca, Filippo verfasserin aut Weber, Giovanna verfasserin aut Cavallo, Luciano verfasserin aut Faienza, Maria Felicia verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 50(2015), 3 vom: 12. März, Seite 674-680 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:50 year:2015 number:3 day:12 month:03 pages:674-680 https://dx.doi.org/10.1007/s12020-015-0574-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 50 2015 3 12 03 674-680 |
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Enthalten in Endocrine 50(2015), 3 vom: 12. März, Seite 674-680 volume:50 year:2015 number:3 day:12 month:03 pages:674-680 |
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Enthalten in Endocrine 50(2015), 3 vom: 12. März, Seite 674-680 volume:50 year:2015 number:3 day:12 month:03 pages:674-680 |
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Congenital hypothyroidism Thyroxine requirement Replacement therapy Congenital hypothyroidism etiology Congenital hypothyroidism severity |
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Delvecchio, Maurizio @@aut@@ Salerno, Mariacarolina @@aut@@ Vigone, Maria Cristina @@aut@@ Wasniewska, Malgorzata @@aut@@ Popolo, Pietro Pio @@aut@@ Lapolla, Rosa @@aut@@ Mussa, Alessandro @@aut@@ Tronconi, Giulia Maria @@aut@@ D’Acunzo, Ida @@aut@@ Di Mase, Raffaella @@aut@@ Falcone, Rosa Maria @@aut@@ Corrias, Andrea @@aut@@ De Luca, Filippo @@aut@@ Weber, Giovanna @@aut@@ Cavallo, Luciano @@aut@@ Faienza, Maria Felicia @@aut@@ |
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2015-03-12T00:00:00Z |
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3610 |
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Delvecchio, Maurizio |
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Delvecchio, Maurizio ddc 610 bkl 44.89 misc Congenital hypothyroidism misc Thyroxine requirement misc Replacement therapy misc Congenital hypothyroidism etiology misc Congenital hypothyroidism severity Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study |
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610 ASE 44.89 bkl Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study Congenital hypothyroidism (dpeaa)DE-He213 Thyroxine requirement (dpeaa)DE-He213 Replacement therapy (dpeaa)DE-He213 Congenital hypothyroidism etiology (dpeaa)DE-He213 Congenital hypothyroidism severity (dpeaa)DE-He213 |
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ddc 610 bkl 44.89 misc Congenital hypothyroidism misc Thyroxine requirement misc Replacement therapy misc Congenital hypothyroidism etiology misc Congenital hypothyroidism severity |
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Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study |
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Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study |
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Delvecchio, Maurizio Salerno, Mariacarolina Vigone, Maria Cristina Wasniewska, Malgorzata Popolo, Pietro Pio Lapolla, Rosa Mussa, Alessandro Tronconi, Giulia Maria D’Acunzo, Ida Di Mase, Raffaella Falcone, Rosa Maria Corrias, Andrea De Luca, Filippo Weber, Giovanna Cavallo, Luciano Faienza, Maria Felicia |
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levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study |
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Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study |
| abstract |
Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. |
| abstractGer |
Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. |
| abstract_unstemmed |
Abstract The aim of the replacement therapy with levothyroxine in congenital hypothyroidism (CH) is to correct hypothyroidism and ensure normal growth and neuropsychological development. Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. Euthyroidism may be achieved in pre-school and in-school patients by 3–4 and 2–3 µg/kg/day (70–90 and 60–80 µg/$ m^{2} $/day) of levothyroxine, respectively. |
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Levothyroxine requirement in congenital hypothyroidism: a 12-year longitudinal study |
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Salerno, Mariacarolina Vigone, Maria Cristina Wasniewska, Malgorzata Popolo, Pietro Pio Lapolla, Rosa Mussa, Alessandro Tronconi, Giulia Maria D’Acunzo, Ida Di Mase, Raffaella Falcone, Rosa Maria Corrias, Andrea De Luca, Filippo Weber, Giovanna Cavallo, Luciano Faienza, Maria Felicia |
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Few data are available about the appropriate dose during childhood and early adolescence; therefore, we performed a multicenter observational study in a large population of patients with CH to assess the required levothyroxine dose to obtain euthyroidism. We recruited 216 patients with permanent CH classified into three groups (agenesia, ectopia, and in situ gland) on the basis of the thyroid imaging. The levothyroxine dose was recorded at 6 and 12 months and then yearly until 12 years of age. The daily levothyroxine requirement progressively decreased during the follow-up, irrespective of etiology. It was significantly lower in patients with in situ gland than in patients with athyreosis during the entire study period and with ectopic gland from the age of 1 year. The levothyroxine requirement at 6 months of age was correlated with the requirement at each later time-point. The daily dose was modified less frequently in patients with in situ thyroid (36 %) than in patients with ectopic gland (41.4 %) or with athyreosis (43.6 %). Patients with in situ gland required a lower dose than the other two subgroups. The dose at 6 months seems predictive of the requirement until 12 years of age. 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