Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus
Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks...
Ausführliche Beschreibung
Autor*in: |
Liu, Chaoqun [verfasserIn] Zhong, Chunrong [verfasserIn] Zhou, Xuezhen [verfasserIn] Chen, Renjuan [verfasserIn] Wu, Jiangyue [verfasserIn] Wang, Weiye [verfasserIn] Li, Xiating [verfasserIn] Ding, Huisi [verfasserIn] Guo, Yanfang [verfasserIn] Gao, Qin [verfasserIn] Hu, Xingwen [verfasserIn] Xiong, Guoping [verfasserIn] Yang, Xuefeng [verfasserIn] Hao, Liping [verfasserIn] Xiao, Mei [verfasserIn] Yang, Nianhong [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2016 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Endocrine - [S.l.] : Springer, 1995, 55(2016), 1 vom: 11. Okt., Seite 165-172 |
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Übergeordnetes Werk: |
volume:55 ; year:2016 ; number:1 ; day:11 ; month:10 ; pages:165-172 |
Links: |
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DOI / URN: |
10.1007/s12020-016-1103-6 |
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Katalog-ID: |
SPR023738111 |
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520 | |a Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. | ||
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650 | 4 | |a Fast blood-glucose |7 (dpeaa)DE-He213 | |
650 | 4 | |a Gestational diabetes mellitus |7 (dpeaa)DE-He213 | |
650 | 4 | |a Pregnant women |7 (dpeaa)DE-He213 | |
700 | 1 | |a Zhong, Chunrong |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Xuezhen |e verfasserin |4 aut | |
700 | 1 | |a Chen, Renjuan |e verfasserin |4 aut | |
700 | 1 | |a Wu, Jiangyue |e verfasserin |4 aut | |
700 | 1 | |a Wang, Weiye |e verfasserin |4 aut | |
700 | 1 | |a Li, Xiating |e verfasserin |4 aut | |
700 | 1 | |a Ding, Huisi |e verfasserin |4 aut | |
700 | 1 | |a Guo, Yanfang |e verfasserin |4 aut | |
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700 | 1 | |a Hu, Xingwen |e verfasserin |4 aut | |
700 | 1 | |a Xiong, Guoping |e verfasserin |4 aut | |
700 | 1 | |a Yang, Xuefeng |e verfasserin |4 aut | |
700 | 1 | |a Hao, Liping |e verfasserin |4 aut | |
700 | 1 | |a Xiao, Mei |e verfasserin |4 aut | |
700 | 1 | |a Yang, Nianhong |e verfasserin |4 aut | |
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10.1007/s12020-016-1103-6 doi (DE-627)SPR023738111 (SPR)s12020-016-1103-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Liu, Chaoqun verfasserin aut Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. Total bilirubin (dpeaa)DE-He213 Direct bilirubin (dpeaa)DE-He213 Fast blood-glucose (dpeaa)DE-He213 Gestational diabetes mellitus (dpeaa)DE-He213 Pregnant women (dpeaa)DE-He213 Zhong, Chunrong verfasserin aut Zhou, Xuezhen verfasserin aut Chen, Renjuan verfasserin aut Wu, Jiangyue verfasserin aut Wang, Weiye verfasserin aut Li, Xiating verfasserin aut Ding, Huisi verfasserin aut Guo, Yanfang verfasserin aut Gao, Qin verfasserin aut Hu, Xingwen verfasserin aut Xiong, Guoping verfasserin aut Yang, Xuefeng verfasserin aut Hao, Liping verfasserin aut Xiao, Mei verfasserin aut Yang, Nianhong verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 55(2016), 1 vom: 11. Okt., Seite 165-172 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:55 year:2016 number:1 day:11 month:10 pages:165-172 https://dx.doi.org/10.1007/s12020-016-1103-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 55 2016 1 11 10 165-172 |
spelling |
10.1007/s12020-016-1103-6 doi (DE-627)SPR023738111 (SPR)s12020-016-1103-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Liu, Chaoqun verfasserin aut Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. Total bilirubin (dpeaa)DE-He213 Direct bilirubin (dpeaa)DE-He213 Fast blood-glucose (dpeaa)DE-He213 Gestational diabetes mellitus (dpeaa)DE-He213 Pregnant women (dpeaa)DE-He213 Zhong, Chunrong verfasserin aut Zhou, Xuezhen verfasserin aut Chen, Renjuan verfasserin aut Wu, Jiangyue verfasserin aut Wang, Weiye verfasserin aut Li, Xiating verfasserin aut Ding, Huisi verfasserin aut Guo, Yanfang verfasserin aut Gao, Qin verfasserin aut Hu, Xingwen verfasserin aut Xiong, Guoping verfasserin aut Yang, Xuefeng verfasserin aut Hao, Liping verfasserin aut Xiao, Mei verfasserin aut Yang, Nianhong verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 55(2016), 1 vom: 11. Okt., Seite 165-172 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:55 year:2016 number:1 day:11 month:10 pages:165-172 https://dx.doi.org/10.1007/s12020-016-1103-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 55 2016 1 11 10 165-172 |
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10.1007/s12020-016-1103-6 doi (DE-627)SPR023738111 (SPR)s12020-016-1103-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Liu, Chaoqun verfasserin aut Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. Total bilirubin (dpeaa)DE-He213 Direct bilirubin (dpeaa)DE-He213 Fast blood-glucose (dpeaa)DE-He213 Gestational diabetes mellitus (dpeaa)DE-He213 Pregnant women (dpeaa)DE-He213 Zhong, Chunrong verfasserin aut Zhou, Xuezhen verfasserin aut Chen, Renjuan verfasserin aut Wu, Jiangyue verfasserin aut Wang, Weiye verfasserin aut Li, Xiating verfasserin aut Ding, Huisi verfasserin aut Guo, Yanfang verfasserin aut Gao, Qin verfasserin aut Hu, Xingwen verfasserin aut Xiong, Guoping verfasserin aut Yang, Xuefeng verfasserin aut Hao, Liping verfasserin aut Xiao, Mei verfasserin aut Yang, Nianhong verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 55(2016), 1 vom: 11. Okt., Seite 165-172 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:55 year:2016 number:1 day:11 month:10 pages:165-172 https://dx.doi.org/10.1007/s12020-016-1103-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 55 2016 1 11 10 165-172 |
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10.1007/s12020-016-1103-6 doi (DE-627)SPR023738111 (SPR)s12020-016-1103-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Liu, Chaoqun verfasserin aut Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. Total bilirubin (dpeaa)DE-He213 Direct bilirubin (dpeaa)DE-He213 Fast blood-glucose (dpeaa)DE-He213 Gestational diabetes mellitus (dpeaa)DE-He213 Pregnant women (dpeaa)DE-He213 Zhong, Chunrong verfasserin aut Zhou, Xuezhen verfasserin aut Chen, Renjuan verfasserin aut Wu, Jiangyue verfasserin aut Wang, Weiye verfasserin aut Li, Xiating verfasserin aut Ding, Huisi verfasserin aut Guo, Yanfang verfasserin aut Gao, Qin verfasserin aut Hu, Xingwen verfasserin aut Xiong, Guoping verfasserin aut Yang, Xuefeng verfasserin aut Hao, Liping verfasserin aut Xiao, Mei verfasserin aut Yang, Nianhong verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 55(2016), 1 vom: 11. Okt., Seite 165-172 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:55 year:2016 number:1 day:11 month:10 pages:165-172 https://dx.doi.org/10.1007/s12020-016-1103-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 55 2016 1 11 10 165-172 |
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10.1007/s12020-016-1103-6 doi (DE-627)SPR023738111 (SPR)s12020-016-1103-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.89 bkl Liu, Chaoqun verfasserin aut Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. Total bilirubin (dpeaa)DE-He213 Direct bilirubin (dpeaa)DE-He213 Fast blood-glucose (dpeaa)DE-He213 Gestational diabetes mellitus (dpeaa)DE-He213 Pregnant women (dpeaa)DE-He213 Zhong, Chunrong verfasserin aut Zhou, Xuezhen verfasserin aut Chen, Renjuan verfasserin aut Wu, Jiangyue verfasserin aut Wang, Weiye verfasserin aut Li, Xiating verfasserin aut Ding, Huisi verfasserin aut Guo, Yanfang verfasserin aut Gao, Qin verfasserin aut Hu, Xingwen verfasserin aut Xiong, Guoping verfasserin aut Yang, Xuefeng verfasserin aut Hao, Liping verfasserin aut Xiao, Mei verfasserin aut Yang, Nianhong verfasserin aut Enthalten in Endocrine [S.l.] : Springer, 1995 55(2016), 1 vom: 11. Okt., Seite 165-172 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:55 year:2016 number:1 day:11 month:10 pages:165-172 https://dx.doi.org/10.1007/s12020-016-1103-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 ASE AR 55 2016 1 11 10 165-172 |
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Enthalten in Endocrine 55(2016), 1 vom: 11. Okt., Seite 165-172 volume:55 year:2016 number:1 day:11 month:10 pages:165-172 |
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Liu, Chaoqun @@aut@@ Zhong, Chunrong @@aut@@ Zhou, Xuezhen @@aut@@ Chen, Renjuan @@aut@@ Wu, Jiangyue @@aut@@ Wang, Weiye @@aut@@ Li, Xiating @@aut@@ Ding, Huisi @@aut@@ Guo, Yanfang @@aut@@ Gao, Qin @@aut@@ Hu, Xingwen @@aut@@ Xiong, Guoping @@aut@@ Yang, Xuefeng @@aut@@ Hao, Liping @@aut@@ Xiao, Mei @@aut@@ Yang, Nianhong @@aut@@ |
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2016-10-11T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR023738111</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520001700.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12020-016-1103-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR023738111</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12020-016-1103-6-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.89</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Liu, Chaoqun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). 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|
author |
Liu, Chaoqun |
spellingShingle |
Liu, Chaoqun ddc 610 bkl 44.89 misc Total bilirubin misc Direct bilirubin misc Fast blood-glucose misc Gestational diabetes mellitus misc Pregnant women Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus |
authorStr |
Liu, Chaoqun |
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electronic Article |
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610 - Medicine & health |
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Not Illustrated |
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1559-0100 |
topic_title |
610 ASE 44.89 bkl Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus Total bilirubin (dpeaa)DE-He213 Direct bilirubin (dpeaa)DE-He213 Fast blood-glucose (dpeaa)DE-He213 Gestational diabetes mellitus (dpeaa)DE-He213 Pregnant women (dpeaa)DE-He213 |
topic |
ddc 610 bkl 44.89 misc Total bilirubin misc Direct bilirubin misc Fast blood-glucose misc Gestational diabetes mellitus misc Pregnant women |
topic_unstemmed |
ddc 610 bkl 44.89 misc Total bilirubin misc Direct bilirubin misc Fast blood-glucose misc Gestational diabetes mellitus misc Pregnant women |
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ddc 610 bkl 44.89 misc Total bilirubin misc Direct bilirubin misc Fast blood-glucose misc Gestational diabetes mellitus misc Pregnant women |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus |
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Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus |
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Endocrine |
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Liu, Chaoqun Zhong, Chunrong Zhou, Xuezhen Chen, Renjuan Wu, Jiangyue Wang, Weiye Li, Xiating Ding, Huisi Guo, Yanfang Gao, Qin Hu, Xingwen Xiong, Guoping Yang, Xuefeng Hao, Liping Xiao, Mei Yang, Nianhong |
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higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus |
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Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus |
abstract |
Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. |
abstractGer |
Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. |
abstract_unstemmed |
Abstract Bilirubin concentrations have been recently reported to be negatively associated with type 2 diabetes mellitus. We examined the association between bilirubin concentrations and gestational diabetes mellitus. In a prospective cohort study, 2969 pregnant women were recruited prior to 16 weeks of gestation and were followed up until delivery. The value of bilirubin was tested and oral glucose tolerance test was conducted to screen gestational diabetes mellitus. The relationship between serum bilirubin concentration and gestational weeks was studied by two-piecewise linear regression. A subsample of 1135 participants with serum bilirubin test during 16–18 weeks gestation was conducted to research the association between serum bilirubin levels and risk of gestational diabetes mellitus by logistic regression. Gestational diabetes mellitus developed in 8.5 % of the participants (223 of 2969). Two-piecewise linear regression analyses demonstrated that the levels of bilirubin decreased with gestational week up to the turning point 23 and after that point, levels of bilirubin were increased slightly. In multiple logistic regression analysis, the relative risk of developing gestational diabetes mellitus was lower in the highest tertile of direct bilirubin than that in the lowest tertile (RR 0.60; 95 % CI, 0.35–0.89). The results suggested that women with higher serum direct bilirubin levels during the second trimester of pregnancy have lower risk for development of gestational diabetes mellitus. |
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Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus |
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https://dx.doi.org/10.1007/s12020-016-1103-6 |
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Zhong, Chunrong Zhou, Xuezhen Chen, Renjuan Wu, Jiangyue Wang, Weiye Li, Xiating Ding, Huisi Guo, Yanfang Gao, Qin Hu, Xingwen Xiong, Guoping Yang, Xuefeng Hao, Liping Xiao, Mei Yang, Nianhong |
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Zhong, Chunrong Zhou, Xuezhen Chen, Renjuan Wu, Jiangyue Wang, Weiye Li, Xiating Ding, Huisi Guo, Yanfang Gao, Qin Hu, Xingwen Xiong, Guoping Yang, Xuefeng Hao, Liping Xiao, Mei Yang, Nianhong |
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|
score |
7.402895 |