Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury
Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD me...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sekhon, Mypinder S. [verfasserIn] McBeth, Paul [verfasserIn] Zou, Jie [verfasserIn] Qiao, Lu [verfasserIn] Kolmodin, Leif [verfasserIn] Henderson, William R. [verfasserIn] Reynolds, Steve [verfasserIn] Griesdale, Donald E. G. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Neurocritical care - New York, NY : Springer, 2004, 21(2014), 2 vom: 27. Juni, Seite 245-252 |
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| Übergeordnetes Werk: |
volume:21 ; year:2014 ; number:2 ; day:27 ; month:06 ; pages:245-252 |
| Links: |
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| DOI / URN: |
10.1007/s12028-014-0003-y |
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| Katalog-ID: |
SPR023810041 |
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| 245 | 1 | 0 | |a Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury |
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| 520 | |a Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. | ||
| 650 | 4 | |a Optic nerve sheath diameter |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Computed tomography |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Traumatic brain injury |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Intracranial pressure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cerebral spinal fluid |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a McBeth, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Kolmodin, Leif |e verfasserin |4 aut | |
| 700 | 1 | |a Henderson, William R. |e verfasserin |4 aut | |
| 700 | 1 | |a Reynolds, Steve |e verfasserin |4 aut | |
| 700 | 1 | |a Griesdale, Donald E. G. |e verfasserin |4 aut | |
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10.1007/s12028-014-0003-y doi (DE-627)SPR023810041 (SPR)s12028-014-0003-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Sekhon, Mypinder S. verfasserin aut Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. Optic nerve sheath diameter (dpeaa)DE-He213 Computed tomography (dpeaa)DE-He213 Traumatic brain injury (dpeaa)DE-He213 Intracranial pressure (dpeaa)DE-He213 Cerebral spinal fluid (dpeaa)DE-He213 McBeth, Paul verfasserin aut Zou, Jie verfasserin aut Qiao, Lu verfasserin aut Kolmodin, Leif verfasserin aut Henderson, William R. verfasserin aut Reynolds, Steve verfasserin aut Griesdale, Donald E. G. verfasserin aut Enthalten in Neurocritical care New York, NY : Springer, 2004 21(2014), 2 vom: 27. Juni, Seite 245-252 (DE-627)478509855 (DE-600)2176033-0 1556-0961 nnns volume:21 year:2014 number:2 day:27 month:06 pages:245-252 https://dx.doi.org/10.1007/s12028-014-0003-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 21 2014 2 27 06 245-252 |
| spelling |
10.1007/s12028-014-0003-y doi (DE-627)SPR023810041 (SPR)s12028-014-0003-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Sekhon, Mypinder S. verfasserin aut Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. Optic nerve sheath diameter (dpeaa)DE-He213 Computed tomography (dpeaa)DE-He213 Traumatic brain injury (dpeaa)DE-He213 Intracranial pressure (dpeaa)DE-He213 Cerebral spinal fluid (dpeaa)DE-He213 McBeth, Paul verfasserin aut Zou, Jie verfasserin aut Qiao, Lu verfasserin aut Kolmodin, Leif verfasserin aut Henderson, William R. verfasserin aut Reynolds, Steve verfasserin aut Griesdale, Donald E. G. verfasserin aut Enthalten in Neurocritical care New York, NY : Springer, 2004 21(2014), 2 vom: 27. Juni, Seite 245-252 (DE-627)478509855 (DE-600)2176033-0 1556-0961 nnns volume:21 year:2014 number:2 day:27 month:06 pages:245-252 https://dx.doi.org/10.1007/s12028-014-0003-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 21 2014 2 27 06 245-252 |
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10.1007/s12028-014-0003-y doi (DE-627)SPR023810041 (SPR)s12028-014-0003-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Sekhon, Mypinder S. verfasserin aut Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. Optic nerve sheath diameter (dpeaa)DE-He213 Computed tomography (dpeaa)DE-He213 Traumatic brain injury (dpeaa)DE-He213 Intracranial pressure (dpeaa)DE-He213 Cerebral spinal fluid (dpeaa)DE-He213 McBeth, Paul verfasserin aut Zou, Jie verfasserin aut Qiao, Lu verfasserin aut Kolmodin, Leif verfasserin aut Henderson, William R. verfasserin aut Reynolds, Steve verfasserin aut Griesdale, Donald E. G. verfasserin aut Enthalten in Neurocritical care New York, NY : Springer, 2004 21(2014), 2 vom: 27. Juni, Seite 245-252 (DE-627)478509855 (DE-600)2176033-0 1556-0961 nnns volume:21 year:2014 number:2 day:27 month:06 pages:245-252 https://dx.doi.org/10.1007/s12028-014-0003-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 21 2014 2 27 06 245-252 |
| allfieldsGer |
10.1007/s12028-014-0003-y doi (DE-627)SPR023810041 (SPR)s12028-014-0003-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Sekhon, Mypinder S. verfasserin aut Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. Optic nerve sheath diameter (dpeaa)DE-He213 Computed tomography (dpeaa)DE-He213 Traumatic brain injury (dpeaa)DE-He213 Intracranial pressure (dpeaa)DE-He213 Cerebral spinal fluid (dpeaa)DE-He213 McBeth, Paul verfasserin aut Zou, Jie verfasserin aut Qiao, Lu verfasserin aut Kolmodin, Leif verfasserin aut Henderson, William R. verfasserin aut Reynolds, Steve verfasserin aut Griesdale, Donald E. G. verfasserin aut Enthalten in Neurocritical care New York, NY : Springer, 2004 21(2014), 2 vom: 27. Juni, Seite 245-252 (DE-627)478509855 (DE-600)2176033-0 1556-0961 nnns volume:21 year:2014 number:2 day:27 month:06 pages:245-252 https://dx.doi.org/10.1007/s12028-014-0003-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 21 2014 2 27 06 245-252 |
| allfieldsSound |
10.1007/s12028-014-0003-y doi (DE-627)SPR023810041 (SPR)s12028-014-0003-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Sekhon, Mypinder S. verfasserin aut Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. Optic nerve sheath diameter (dpeaa)DE-He213 Computed tomography (dpeaa)DE-He213 Traumatic brain injury (dpeaa)DE-He213 Intracranial pressure (dpeaa)DE-He213 Cerebral spinal fluid (dpeaa)DE-He213 McBeth, Paul verfasserin aut Zou, Jie verfasserin aut Qiao, Lu verfasserin aut Kolmodin, Leif verfasserin aut Henderson, William R. verfasserin aut Reynolds, Steve verfasserin aut Griesdale, Donald E. G. verfasserin aut Enthalten in Neurocritical care New York, NY : Springer, 2004 21(2014), 2 vom: 27. Juni, Seite 245-252 (DE-627)478509855 (DE-600)2176033-0 1556-0961 nnns volume:21 year:2014 number:2 day:27 month:06 pages:245-252 https://dx.doi.org/10.1007/s12028-014-0003-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 21 2014 2 27 06 245-252 |
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English |
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Enthalten in Neurocritical care 21(2014), 2 vom: 27. Juni, Seite 245-252 volume:21 year:2014 number:2 day:27 month:06 pages:245-252 |
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Enthalten in Neurocritical care 21(2014), 2 vom: 27. Juni, Seite 245-252 volume:21 year:2014 number:2 day:27 month:06 pages:245-252 |
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Optic nerve sheath diameter Computed tomography Traumatic brain injury Intracranial pressure Cerebral spinal fluid |
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Sekhon, Mypinder S. @@aut@@ McBeth, Paul @@aut@@ Zou, Jie @@aut@@ Qiao, Lu @@aut@@ Kolmodin, Leif @@aut@@ Henderson, William R. @@aut@@ Reynolds, Steve @@aut@@ Griesdale, Donald E. G. @@aut@@ |
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2014-06-27T00:00:00Z |
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Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). 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|
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Sekhon, Mypinder S. |
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Sekhon, Mypinder S. ddc 610 bkl 44.90 misc Optic nerve sheath diameter misc Computed tomography misc Traumatic brain injury misc Intracranial pressure misc Cerebral spinal fluid Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury |
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610 ASE 44.90 bkl Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury Optic nerve sheath diameter (dpeaa)DE-He213 Computed tomography (dpeaa)DE-He213 Traumatic brain injury (dpeaa)DE-He213 Intracranial pressure (dpeaa)DE-He213 Cerebral spinal fluid (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Optic nerve sheath diameter misc Computed tomography misc Traumatic brain injury misc Intracranial pressure misc Cerebral spinal fluid |
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Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury |
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Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury |
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Sekhon, Mypinder S. McBeth, Paul Zou, Jie Qiao, Lu Kolmodin, Leif Henderson, William R. Reynolds, Steve Griesdale, Donald E. G. |
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Sekhon, Mypinder S. |
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10.1007/s12028-014-0003-y |
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| title_sort |
association between optic nerve sheath diameter and mortality in patients with severe traumatic brain injury |
| title_auth |
Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury |
| abstract |
Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. |
| abstractGer |
Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. |
| abstract_unstemmed |
Purpose Increased intracranial pressure (ICP) is associated with worse outcomes following traumatic brain injury (TBI). Studies have confirmed that ICP is correlated with optic nerve sheath diameter (ONSD) on ultrasound. The aim of our study was to assess the independent relationship between ONSD measured using CT and mortality in a population of patients admitted with severe TBI. Methods We conducted a retrospective cohort study of patients with a TBI requiring ICP monitoring admitted to the ICU between April 2006 and May 2012 to two neurotrauma centers. ONSD was independently measured by two physicians blinded to patient outcomes. Multivariable logistic regression modeling was used to assess an association between ONSD and hospital mortality. Results A total of 220 patients were included in the analysis. Overall, the cohort had a mean age of 35 (SD 17) years and 171 of 220 (79 %) were male. The median admission GCS was 6 (IQR 3–8). Intra-class correlation coefficient between raters for ONSD measurements was 0.92 (95 % CI 0.90–0.94, P < 0.0001). On multivariable analysis, each 1 mm increase in ONSD was associated with a twofold increase in hospital mortality (OR 2.0, 95 % CI 1.2–3.2, P = 0.007). Using linear regression, ONSD was independently associated with increased ICP in the first 48 h after admission (β = 4.4, 95 % CI 2.5–6.3, P < 0.0001). Conclusions In patients with TBI, ONSD measured on CT scanning was independently associated with ICP and mortality. |
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Association Between Optic Nerve Sheath Diameter and Mortality in Patients with Severe Traumatic Brain Injury |
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McBeth, Paul Zou, Jie Qiao, Lu Kolmodin, Leif Henderson, William R. Reynolds, Steve Griesdale, Donald E. G. |
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| score |
7.3995953 |