Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants

Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219...
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Autor*in:	Botta-Orfila, Teresa [verfasserIn] Ezquerra, Mario [verfasserIn] Pastor, Pau [verfasserIn] Fernández-Santiago, Rubén [verfasserIn] Pont-Sunyer, Claustre [verfasserIn] Compta, Yaroslau [verfasserIn] Lorenzo-Betancor, Oswaldo [verfasserIn] Samaranch, Lluis [verfasserIn] Martí, Maria José [verfasserIn] Valldeoriola, Francesc [verfasserIn] Calopa, Matilde [verfasserIn] Fernández, Manel [verfasserIn] Aguilar, Miquel [verfasserIn] de Fabregas, Oriol [verfasserIn] Hernández-Vara, Jorge [verfasserIn] Tolosa, Eduard [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Parkinson rs356219 age-at-onset

Übergeordnetes Werk:	Enthalten in: Journal of molecular neuroscience - New York, NY : Springer, 1998, 48(2012), 1 vom: 06. Juni, Seite 245-247
Übergeordnetes Werk:	volume:48 ; year:2012 ; number:1 ; day:06 ; month:06 ; pages:245-247

Links:	Volltext

DOI / URN:	10.1007/s12031-012-9820-7

Katalog-ID:	SPR023845414

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520			\|a Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD.
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Indexfelder

author_variant	t b o tbo m e me p p pp r f s rfs c p s cps y c yc o l b olb l s ls m j m mj mjm f v fv m c mc m f mf m a ma f o d fo fod j h v jhv e t et
matchkey_str	article:15591166:2012----::gaostnrkascaepimdfe
hierarchy_sort_str	2012
bklnumber	44.90
publishDate	2012
allfields	10.1007/s12031-012-9820-7 doi (DE-627)SPR023845414 (SPR)s12031-012-9820-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Botta-Orfila, Teresa verfasserin aut Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD. Parkinson (dpeaa)DE-He213 rs356219 (dpeaa)DE-He213 age-at-onset (dpeaa)DE-He213 Ezquerra, Mario verfasserin aut Pastor, Pau verfasserin aut Fernández-Santiago, Rubén verfasserin aut Pont-Sunyer, Claustre verfasserin aut Compta, Yaroslau verfasserin aut Lorenzo-Betancor, Oswaldo verfasserin aut Samaranch, Lluis verfasserin aut Martí, Maria José verfasserin aut Valldeoriola, Francesc verfasserin aut Calopa, Matilde verfasserin aut Fernández, Manel verfasserin aut Aguilar, Miquel verfasserin aut de Fabregas, Oriol verfasserin aut Hernández-Vara, Jorge verfasserin aut Tolosa, Eduard verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 48(2012), 1 vom: 06. Juni, Seite 245-247 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:48 year:2012 number:1 day:06 month:06 pages:245-247 https://dx.doi.org/10.1007/s12031-012-9820-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 48 2012 1 06 06 245-247
spelling	10.1007/s12031-012-9820-7 doi (DE-627)SPR023845414 (SPR)s12031-012-9820-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Botta-Orfila, Teresa verfasserin aut Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD. Parkinson (dpeaa)DE-He213 rs356219 (dpeaa)DE-He213 age-at-onset (dpeaa)DE-He213 Ezquerra, Mario verfasserin aut Pastor, Pau verfasserin aut Fernández-Santiago, Rubén verfasserin aut Pont-Sunyer, Claustre verfasserin aut Compta, Yaroslau verfasserin aut Lorenzo-Betancor, Oswaldo verfasserin aut Samaranch, Lluis verfasserin aut Martí, Maria José verfasserin aut Valldeoriola, Francesc verfasserin aut Calopa, Matilde verfasserin aut Fernández, Manel verfasserin aut Aguilar, Miquel verfasserin aut de Fabregas, Oriol verfasserin aut Hernández-Vara, Jorge verfasserin aut Tolosa, Eduard verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 48(2012), 1 vom: 06. Juni, Seite 245-247 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:48 year:2012 number:1 day:06 month:06 pages:245-247 https://dx.doi.org/10.1007/s12031-012-9820-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 48 2012 1 06 06 245-247
allfields_unstemmed	10.1007/s12031-012-9820-7 doi (DE-627)SPR023845414 (SPR)s12031-012-9820-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Botta-Orfila, Teresa verfasserin aut Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD. Parkinson (dpeaa)DE-He213 rs356219 (dpeaa)DE-He213 age-at-onset (dpeaa)DE-He213 Ezquerra, Mario verfasserin aut Pastor, Pau verfasserin aut Fernández-Santiago, Rubén verfasserin aut Pont-Sunyer, Claustre verfasserin aut Compta, Yaroslau verfasserin aut Lorenzo-Betancor, Oswaldo verfasserin aut Samaranch, Lluis verfasserin aut Martí, Maria José verfasserin aut Valldeoriola, Francesc verfasserin aut Calopa, Matilde verfasserin aut Fernández, Manel verfasserin aut Aguilar, Miquel verfasserin aut de Fabregas, Oriol verfasserin aut Hernández-Vara, Jorge verfasserin aut Tolosa, Eduard verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 48(2012), 1 vom: 06. Juni, Seite 245-247 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:48 year:2012 number:1 day:06 month:06 pages:245-247 https://dx.doi.org/10.1007/s12031-012-9820-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 48 2012 1 06 06 245-247
allfieldsGer	10.1007/s12031-012-9820-7 doi (DE-627)SPR023845414 (SPR)s12031-012-9820-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Botta-Orfila, Teresa verfasserin aut Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD. Parkinson (dpeaa)DE-He213 rs356219 (dpeaa)DE-He213 age-at-onset (dpeaa)DE-He213 Ezquerra, Mario verfasserin aut Pastor, Pau verfasserin aut Fernández-Santiago, Rubén verfasserin aut Pont-Sunyer, Claustre verfasserin aut Compta, Yaroslau verfasserin aut Lorenzo-Betancor, Oswaldo verfasserin aut Samaranch, Lluis verfasserin aut Martí, Maria José verfasserin aut Valldeoriola, Francesc verfasserin aut Calopa, Matilde verfasserin aut Fernández, Manel verfasserin aut Aguilar, Miquel verfasserin aut de Fabregas, Oriol verfasserin aut Hernández-Vara, Jorge verfasserin aut Tolosa, Eduard verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 48(2012), 1 vom: 06. Juni, Seite 245-247 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:48 year:2012 number:1 day:06 month:06 pages:245-247 https://dx.doi.org/10.1007/s12031-012-9820-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 48 2012 1 06 06 245-247
allfieldsSound	10.1007/s12031-012-9820-7 doi (DE-627)SPR023845414 (SPR)s12031-012-9820-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Botta-Orfila, Teresa verfasserin aut Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD. Parkinson (dpeaa)DE-He213 rs356219 (dpeaa)DE-He213 age-at-onset (dpeaa)DE-He213 Ezquerra, Mario verfasserin aut Pastor, Pau verfasserin aut Fernández-Santiago, Rubén verfasserin aut Pont-Sunyer, Claustre verfasserin aut Compta, Yaroslau verfasserin aut Lorenzo-Betancor, Oswaldo verfasserin aut Samaranch, Lluis verfasserin aut Martí, Maria José verfasserin aut Valldeoriola, Francesc verfasserin aut Calopa, Matilde verfasserin aut Fernández, Manel verfasserin aut Aguilar, Miquel verfasserin aut de Fabregas, Oriol verfasserin aut Hernández-Vara, Jorge verfasserin aut Tolosa, Eduard verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 48(2012), 1 vom: 06. Juni, Seite 245-247 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:48 year:2012 number:1 day:06 month:06 pages:245-247 https://dx.doi.org/10.1007/s12031-012-9820-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 48 2012 1 06 06 245-247
language	English
source	Enthalten in Journal of molecular neuroscience 48(2012), 1 vom: 06. Juni, Seite 245-247 volume:48 year:2012 number:1 day:06 month:06 pages:245-247
sourceStr	Enthalten in Journal of molecular neuroscience 48(2012), 1 vom: 06. Juni, Seite 245-247 volume:48 year:2012 number:1 day:06 month:06 pages:245-247
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Parkinson rs356219 age-at-onset
dewey-raw	610
isfreeaccess_bool	false
container_title	Journal of molecular neuroscience
authorswithroles_txt_mv	Botta-Orfila, Teresa @@aut@@ Ezquerra, Mario @@aut@@ Pastor, Pau @@aut@@ Fernández-Santiago, Rubén @@aut@@ Pont-Sunyer, Claustre @@aut@@ Compta, Yaroslau @@aut@@ Lorenzo-Betancor, Oswaldo @@aut@@ Samaranch, Lluis @@aut@@ Martí, Maria José @@aut@@ Valldeoriola, Francesc @@aut@@ Calopa, Matilde @@aut@@ Fernández, Manel @@aut@@ Aguilar, Miquel @@aut@@ de Fabregas, Oriol @@aut@@ Hernández-Vara, Jorge @@aut@@ Tolosa, Eduard @@aut@@
publishDateDaySort_date	2012-06-06T00:00:00Z
hierarchy_top_id	342319477
dewey-sort	3610
id	SPR023845414
language_de	englisch
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author	Botta-Orfila, Teresa
spellingShingle	Botta-Orfila, Teresa ddc 610 bkl 44.90 misc Parkinson misc rs356219 misc age-at-onset Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
authorStr	Botta-Orfila, Teresa
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topic_title	610 ASE 44.90 bkl Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants Parkinson (dpeaa)DE-He213 rs356219 (dpeaa)DE-He213 age-at-onset (dpeaa)DE-He213
topic	ddc 610 bkl 44.90 misc Parkinson misc rs356219 misc age-at-onset
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title	Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
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title_full	Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
author_sort	Botta-Orfila, Teresa
journal	Journal of molecular neuroscience
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author_browse	Botta-Orfila, Teresa Ezquerra, Mario Pastor, Pau Fernández-Santiago, Rubén Pont-Sunyer, Claustre Compta, Yaroslau Lorenzo-Betancor, Oswaldo Samaranch, Lluis Martí, Maria José Valldeoriola, Francesc Calopa, Matilde Fernández, Manel Aguilar, Miquel de Fabregas, Oriol Hernández-Vara, Jorge Tolosa, Eduard
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author-letter	Botta-Orfila, Teresa
doi_str_mv	10.1007/s12031-012-9820-7
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author2-role	verfasserin
title_sort	age at onset in lrrk2-associated pd is modified by snca variants
title_auth	Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
abstract	Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD.
abstractGer	Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD.
abstract_unstemmed	Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an earlier age at onset in LRRK2-associated PD. Our results support the notion that SNCA variants can modify the pathogenic effect of LRRK2 mutations as described previously for IPD.
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container_issue	1
title_short	Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
url	https://dx.doi.org/10.1007/s12031-012-9820-7
remote_bool	true
author2	Ezquerra, Mario Pastor, Pau Fernández-Santiago, Rubén Pont-Sunyer, Claustre Compta, Yaroslau Lorenzo-Betancor, Oswaldo Samaranch, Lluis Martí, Maria José Valldeoriola, Francesc Calopa, Matilde Fernández, Manel Aguilar, Miquel de Fabregas, Oriol Hernández-Vara, Jorge Tolosa, Eduard
author2Str	Ezquerra, Mario Pastor, Pau Fernández-Santiago, Rubén Pont-Sunyer, Claustre Compta, Yaroslau Lorenzo-Betancor, Oswaldo Samaranch, Lluis Martí, Maria José Valldeoriola, Francesc Calopa, Matilde Fernández, Manel Aguilar, Miquel de Fabregas, Oriol Hernández-Vara, Jorge Tolosa, Eduard
ppnlink	342319477
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s12031-012-9820-7
up_date	2024-07-03T21:46:10.268Z
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score	7.4031916

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Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants

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