Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain
Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that N...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Sheng [verfasserIn] Luo, Guang Rui [verfasserIn] Li, Ting [verfasserIn] Liu, Ting Xi [verfasserIn] Le, Weidong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of molecular neuroscience - New York, NY : Springer, 1998, 51(2013), 3 vom: 11. Juli, Seite 719-723 |
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| Übergeordnetes Werk: |
volume:51 ; year:2013 ; number:3 ; day:11 ; month:07 ; pages:719-723 |
| Links: |
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| DOI / URN: |
10.1007/s12031-013-0054-0 |
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| Katalog-ID: |
SPR023848669 |
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| 245 | 1 | 0 | |a Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain |
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| 520 | |a Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. | ||
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| 700 | 1 | |a Liu, Ting Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Le, Weidong |e verfasserin |4 aut | |
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10.1007/s12031-013-0054-0 doi (DE-627)SPR023848669 (SPR)s12031-013-0054-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Chen, Sheng verfasserin aut Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. Tyrosine hydroxylase (dpeaa)DE-He213 Nestin (dpeaa)DE-He213 Adult zebrafish brain (dpeaa)DE-He213 Luo, Guang Rui verfasserin aut Li, Ting verfasserin aut Liu, Ting Xi verfasserin aut Le, Weidong verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 51(2013), 3 vom: 11. Juli, Seite 719-723 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:51 year:2013 number:3 day:11 month:07 pages:719-723 https://dx.doi.org/10.1007/s12031-013-0054-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2013 3 11 07 719-723 |
| spelling |
10.1007/s12031-013-0054-0 doi (DE-627)SPR023848669 (SPR)s12031-013-0054-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Chen, Sheng verfasserin aut Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. Tyrosine hydroxylase (dpeaa)DE-He213 Nestin (dpeaa)DE-He213 Adult zebrafish brain (dpeaa)DE-He213 Luo, Guang Rui verfasserin aut Li, Ting verfasserin aut Liu, Ting Xi verfasserin aut Le, Weidong verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 51(2013), 3 vom: 11. Juli, Seite 719-723 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:51 year:2013 number:3 day:11 month:07 pages:719-723 https://dx.doi.org/10.1007/s12031-013-0054-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2013 3 11 07 719-723 |
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10.1007/s12031-013-0054-0 doi (DE-627)SPR023848669 (SPR)s12031-013-0054-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Chen, Sheng verfasserin aut Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. Tyrosine hydroxylase (dpeaa)DE-He213 Nestin (dpeaa)DE-He213 Adult zebrafish brain (dpeaa)DE-He213 Luo, Guang Rui verfasserin aut Li, Ting verfasserin aut Liu, Ting Xi verfasserin aut Le, Weidong verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 51(2013), 3 vom: 11. Juli, Seite 719-723 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:51 year:2013 number:3 day:11 month:07 pages:719-723 https://dx.doi.org/10.1007/s12031-013-0054-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2013 3 11 07 719-723 |
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10.1007/s12031-013-0054-0 doi (DE-627)SPR023848669 (SPR)s12031-013-0054-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Chen, Sheng verfasserin aut Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. Tyrosine hydroxylase (dpeaa)DE-He213 Nestin (dpeaa)DE-He213 Adult zebrafish brain (dpeaa)DE-He213 Luo, Guang Rui verfasserin aut Li, Ting verfasserin aut Liu, Ting Xi verfasserin aut Le, Weidong verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 51(2013), 3 vom: 11. Juli, Seite 719-723 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:51 year:2013 number:3 day:11 month:07 pages:719-723 https://dx.doi.org/10.1007/s12031-013-0054-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2013 3 11 07 719-723 |
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10.1007/s12031-013-0054-0 doi (DE-627)SPR023848669 (SPR)s12031-013-0054-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Chen, Sheng verfasserin aut Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. Tyrosine hydroxylase (dpeaa)DE-He213 Nestin (dpeaa)DE-He213 Adult zebrafish brain (dpeaa)DE-He213 Luo, Guang Rui verfasserin aut Li, Ting verfasserin aut Liu, Ting Xi verfasserin aut Le, Weidong verfasserin aut Enthalten in Journal of molecular neuroscience New York, NY : Springer, 1998 51(2013), 3 vom: 11. Juli, Seite 719-723 (DE-627)342319477 (DE-600)2071508-0 1559-1166 nnns volume:51 year:2013 number:3 day:11 month:07 pages:719-723 https://dx.doi.org/10.1007/s12031-013-0054-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2013 3 11 07 719-723 |
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Enthalten in Journal of molecular neuroscience 51(2013), 3 vom: 11. Juli, Seite 719-723 volume:51 year:2013 number:3 day:11 month:07 pages:719-723 |
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Enthalten in Journal of molecular neuroscience 51(2013), 3 vom: 11. Juli, Seite 719-723 volume:51 year:2013 number:3 day:11 month:07 pages:719-723 |
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Tyrosine hydroxylase Nestin Adult zebrafish brain |
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Journal of molecular neuroscience |
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Chen, Sheng @@aut@@ Luo, Guang Rui @@aut@@ Li, Ting @@aut@@ Liu, Ting Xi @@aut@@ Le, Weidong @@aut@@ |
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2013-07-11T00:00:00Z |
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It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tyrosine hydroxylase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nestin</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Adult zebrafish brain</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Luo, Guang Rui</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Ting</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liu, Ting Xi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Le, Weidong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of molecular neuroscience</subfield><subfield code="d">New York, NY : Springer, 1998</subfield><subfield code="g">51(2013), 3 vom: 11. 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Chen, Sheng |
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Chen, Sheng ddc 610 bkl 44.90 misc Tyrosine hydroxylase misc Nestin misc Adult zebrafish brain Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain |
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610 ASE 44.90 bkl Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain Tyrosine hydroxylase (dpeaa)DE-He213 Nestin (dpeaa)DE-He213 Adult zebrafish brain (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Tyrosine hydroxylase misc Nestin misc Adult zebrafish brain |
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ddc 610 bkl 44.90 misc Tyrosine hydroxylase misc Nestin misc Adult zebrafish brain |
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Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain |
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Chen, Sheng Luo, Guang Rui Li, Ting Liu, Ting Xi Le, Weidong |
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correlation of nr4a2 expression with the neuron progenitors in adult zebrafish brain |
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Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain |
| abstract |
Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. |
| abstractGer |
Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. |
| abstract_unstemmed |
Abstract Our previous study showed that although Nr4a2b transcripts have little co-localization with tyrosine hydroxylase (TH) in the posterior tuberculum area, knockdown of Nr4a2 caused a decrease in the number of TH-positive ($ TH^{+} $) neurons in the posterior tuberculum area. It suggests that Nr4a2 expression in the progenitors may play an important role in regulating differentiation rather than survival of $ TH^{+} $ progenitors in the posterior tuberculum area during early zebrafish embryogenesis. In this study, we determined the correlation between TH and Nr4a2 in adult zebrafish brain and found that Nr4a2b was co-localized with the spindle-shaped $ TH^{+} $ cells in the posterior tuberculum area and some small round $ TH^{+} $ cells in the pretectum area, but not with large pear-shaped $ TH^{+} $ cells in adult zebrafish diencephalon. In the pretectum area, Nr4a$ 2^{+} $ cells were localized next to the dorsal side of $ TH^{+} $ cells. Furthermore, we demonstrated that Nr4a2 was co-expressed with nestin in the progenitors of pretectum area and caudal periventricular hypothalamic zones with a lateral symmetry pattern beside the diencephalic ventricle. Co-expression of Nr4a2 and nestin in these areas was remarkably declined with aging. These findings indicate that Nr4a2 is expressed in the neuronal progenitors and plays a crucial role in the differentiation process of dopamine neuron from the stem cell. The change in Nr4a2 expression with aging suggests its possible association with neurodegenerative diseases. |
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| title_short |
Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain |
| url |
https://dx.doi.org/10.1007/s12031-013-0054-0 |
| remote_bool |
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| author2 |
Luo, Guang Rui Li, Ting Liu, Ting Xi Le, Weidong |
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Luo, Guang Rui Li, Ting Liu, Ting Xi Le, Weidong |
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| doi_str |
10.1007/s12031-013-0054-0 |
| up_date |
2024-07-03T21:47:44.718Z |
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| score |
7.3989124 |