A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies
Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shi, Xing [verfasserIn] Liu, Li [verfasserIn] Din, Qian [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Medical oncology - New York, NY : Springer, 1984, 26(2009), 4 vom: 07. Jan. |
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| Übergeordnetes Werk: |
volume:26 ; year:2009 ; number:4 ; day:07 ; month:01 |
| Links: |
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| DOI / URN: |
10.1007/s12032-008-9151-2 |
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| Katalog-ID: |
SPR023867256 |
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| 100 | 1 | |a Shi, Xing |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies |
| 264 | 1 | |c 2009 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 520 | |a Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. | ||
| 650 | 4 | |a Gastrointestinal malignancies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a CD4 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a CD25 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Regulatory T cells |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Liu, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Din, Qian |e verfasserin |4 aut | |
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| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_370 | ||
| 912 | |a GBV_ILN_602 | ||
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| 912 | |a GBV_ILN_2010 | ||
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| 912 | |a GBV_ILN_2018 | ||
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| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2031 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2039 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2113 | ||
| 912 | |a GBV_ILN_2116 | ||
| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2119 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2144 | ||
| 912 | |a GBV_ILN_2147 | ||
| 912 | |a GBV_ILN_2148 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2188 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2232 | ||
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| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4246 | ||
| 912 | |a GBV_ILN_4249 | ||
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| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
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| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
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10.1007/s12032-008-9151-2 doi (DE-627)SPR023867256 (SPR)s12032-008-9151-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Shi, Xing verfasserin aut A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. Gastrointestinal malignancies (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD25 (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 Liu, Li verfasserin aut Din, Qian verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 26(2009), 4 vom: 07. Jan. (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:26 year:2009 number:4 day:07 month:01 https://dx.doi.org/10.1007/s12032-008-9151-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2009 4 07 01 |
| spelling |
10.1007/s12032-008-9151-2 doi (DE-627)SPR023867256 (SPR)s12032-008-9151-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Shi, Xing verfasserin aut A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. Gastrointestinal malignancies (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD25 (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 Liu, Li verfasserin aut Din, Qian verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 26(2009), 4 vom: 07. Jan. (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:26 year:2009 number:4 day:07 month:01 https://dx.doi.org/10.1007/s12032-008-9151-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2009 4 07 01 |
| allfields_unstemmed |
10.1007/s12032-008-9151-2 doi (DE-627)SPR023867256 (SPR)s12032-008-9151-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Shi, Xing verfasserin aut A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. Gastrointestinal malignancies (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD25 (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 Liu, Li verfasserin aut Din, Qian verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 26(2009), 4 vom: 07. Jan. (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:26 year:2009 number:4 day:07 month:01 https://dx.doi.org/10.1007/s12032-008-9151-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2009 4 07 01 |
| allfieldsGer |
10.1007/s12032-008-9151-2 doi (DE-627)SPR023867256 (SPR)s12032-008-9151-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Shi, Xing verfasserin aut A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. Gastrointestinal malignancies (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD25 (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 Liu, Li verfasserin aut Din, Qian verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 26(2009), 4 vom: 07. Jan. (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:26 year:2009 number:4 day:07 month:01 https://dx.doi.org/10.1007/s12032-008-9151-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2009 4 07 01 |
| allfieldsSound |
10.1007/s12032-008-9151-2 doi (DE-627)SPR023867256 (SPR)s12032-008-9151-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Shi, Xing verfasserin aut A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. Gastrointestinal malignancies (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD25 (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 Liu, Li verfasserin aut Din, Qian verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 26(2009), 4 vom: 07. Jan. (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:26 year:2009 number:4 day:07 month:01 https://dx.doi.org/10.1007/s12032-008-9151-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 26 2009 4 07 01 |
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English |
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Enthalten in Medical oncology 26(2009), 4 vom: 07. Jan. volume:26 year:2009 number:4 day:07 month:01 |
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Enthalten in Medical oncology 26(2009), 4 vom: 07. Jan. volume:26 year:2009 number:4 day:07 month:01 |
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Gastrointestinal malignancies CD4 CD25 Regulatory T cells |
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Medical oncology |
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Shi, Xing @@aut@@ Liu, Li @@aut@@ Din, Qian @@aut@@ |
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2009-01-07T00:00:00Z |
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Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. 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Shi, Xing |
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Shi, Xing ddc 610 bkl 44.81 misc Gastrointestinal malignancies misc CD4 misc CD25 misc Regulatory T cells A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies |
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610 ASE 44.81 bkl A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies Gastrointestinal malignancies (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD25 (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Gastrointestinal malignancies misc CD4 misc CD25 misc Regulatory T cells |
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A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies |
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study on the $ cd_{4} $+ $ cd_{25} $+ regulatory t cells in patients with gastrointestinal malignancies |
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A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies |
| abstract |
Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. |
| abstractGer |
Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. |
| abstract_unstemmed |
Abstract Objectives Regulatory T cells play an active role in the maintenance of the immune system’s tolerance of both foreign and self antigens. Particularly, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells participate in tumor immunity. The study provided further evidence on the involvement of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in immune system impairment in patients with gastrointestinal malignancies. Methods Using flow cytometry, $ CD_{4} $+ $ CD_{25} $+ regulatory T cells were analyzed in peripheral blood from 114 patients with gastrointestinal malignancies and 15 healthy controls. Results The prevalence of the $ CD_{25} $+ subset in $ CD_{4} $+ T cells was increased in patients with colorectal carcinoma compared with healthy controls. The phenotic characteristics of the $ CD_{4} $+ $ CD_{25} $+ T cells in patient with malignancies were low expression of $ CD_{45} $ RA and no expression of $ CD_{69} $. Our results indicated that when compared with healthy control, the proportions of $ CD_{4} $+ $ CD_{25} $+ T cells in the peripheral blood of patients with colorectal, gastric, and esophageal carcinoma were significantly higher (P < 0.05) in colorectal carcinoma (22.11 ± 9.65%), gastric carcinoma (17.74 ± 4.24%), and esophageal carcinoma (24.37 ± 4.82)%, respectively. Further analysis on the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells revealed that those patients with gastrointestinal malignancies in stages IV were higher than those of in stage I–III, though no significant difference was observed (P > 0.05). However, the proportion of $ CD_{4} $+ $ CD_{25} $+ T cells in the patients with relapse gastric carcinoma (23.32 ± 4.98%) was significantly higher than that of patients with primary gastric carcinoma (P < 0.01). Conclusions The increased $ CD_{4} $+ $ CD_{25} $+ T cells in patients with gastrointestinal malignancies may be related to immunosuppression and tumor progression. This suggests that elimination or reduction of $ CD_{4} $+ $ CD_{25} $+ regulatory T cells can improve effective tumor immunity for immunotherapy. |
| collection_details |
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| title_short |
A study on the $ CD_{4} $+ $ CD_{25} $+ regulatory T cells in patients with gastrointestinal malignancies |
| url |
https://dx.doi.org/10.1007/s12032-008-9151-2 |
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Liu, Li Din, Qian |
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| doi_str |
10.1007/s12032-008-9151-2 |
| up_date |
2024-07-03T21:56:46.815Z |
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| score |
7.4019337 |