Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma

Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinic...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ma, Xiang-Rui [verfasserIn] Cheng, Hui [verfasserIn] Wang, Xiao-Yi [verfasserIn] Liu, Hao [verfasserIn] Zhao, Dan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Single-nucleotide polymorphisms Oral squamous cell carcinoma Susceptibility Lymph node metastasis

Übergeordnetes Werk:	Enthalten in: Medical oncology - New York, NY : Springer, 1984, 29(2012), 4 vom: 21. Jan., Seite 2492-2498
Übergeordnetes Werk:	volume:29 ; year:2012 ; number:4 ; day:21 ; month:01 ; pages:2492-2498

Links:	Volltext

DOI / URN:	10.1007/s12032-012-0167-2

Katalog-ID:	SPR023878479

Internformat


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245	1	0	\|a Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma
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520			\|a Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target.
650		4	\|a Single-nucleotide polymorphisms \|7 (dpeaa)DE-He213
650		4	\|a Oral squamous cell carcinoma \|7 (dpeaa)DE-He213
650		4	\|a Susceptibility \|7 (dpeaa)DE-He213
650		4	\|a Lymph node metastasis \|7 (dpeaa)DE-He213
700	1		\|a Cheng, Hui \|e verfasserin \|4 aut
700	1		\|a Wang, Xiao-Yi \|e verfasserin \|4 aut
700	1		\|a Liu, Hao \|e verfasserin \|4 aut
700	1		\|a Zhao, Dan \|e verfasserin \|4 aut
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912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
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912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
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912			\|a GBV_ILN_2005
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912			\|a GBV_ILN_2009
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912			\|a GBV_ILN_2015
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912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
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912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
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912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
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Indexfelder

author_variant	x r m xrm h c hc x y w xyw h l hl d z dz
matchkey_str	article:1559131X:2012----::igeuloieoyopimoitgisrascaewtteiknlmhoeeats
hierarchy_sort_str	2012
bklnumber	44.81
publishDate	2012
allfields	10.1007/s12032-012-0167-2 doi (DE-627)SPR023878479 (SPR)s12032-012-0167-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ma, Xiang-Rui verfasserin aut Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target. Single-nucleotide polymorphisms (dpeaa)DE-He213 Oral squamous cell carcinoma (dpeaa)DE-He213 Susceptibility (dpeaa)DE-He213 Lymph node metastasis (dpeaa)DE-He213 Cheng, Hui verfasserin aut Wang, Xiao-Yi verfasserin aut Liu, Hao verfasserin aut Zhao, Dan verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 29(2012), 4 vom: 21. Jan., Seite 2492-2498 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:29 year:2012 number:4 day:21 month:01 pages:2492-2498 https://dx.doi.org/10.1007/s12032-012-0167-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 29 2012 4 21 01 2492-2498
spelling	10.1007/s12032-012-0167-2 doi (DE-627)SPR023878479 (SPR)s12032-012-0167-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ma, Xiang-Rui verfasserin aut Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target. Single-nucleotide polymorphisms (dpeaa)DE-He213 Oral squamous cell carcinoma (dpeaa)DE-He213 Susceptibility (dpeaa)DE-He213 Lymph node metastasis (dpeaa)DE-He213 Cheng, Hui verfasserin aut Wang, Xiao-Yi verfasserin aut Liu, Hao verfasserin aut Zhao, Dan verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 29(2012), 4 vom: 21. Jan., Seite 2492-2498 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:29 year:2012 number:4 day:21 month:01 pages:2492-2498 https://dx.doi.org/10.1007/s12032-012-0167-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 29 2012 4 21 01 2492-2498
allfields_unstemmed	10.1007/s12032-012-0167-2 doi (DE-627)SPR023878479 (SPR)s12032-012-0167-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ma, Xiang-Rui verfasserin aut Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target. Single-nucleotide polymorphisms (dpeaa)DE-He213 Oral squamous cell carcinoma (dpeaa)DE-He213 Susceptibility (dpeaa)DE-He213 Lymph node metastasis (dpeaa)DE-He213 Cheng, Hui verfasserin aut Wang, Xiao-Yi verfasserin aut Liu, Hao verfasserin aut Zhao, Dan verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 29(2012), 4 vom: 21. Jan., Seite 2492-2498 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:29 year:2012 number:4 day:21 month:01 pages:2492-2498 https://dx.doi.org/10.1007/s12032-012-0167-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 29 2012 4 21 01 2492-2498
allfieldsGer	10.1007/s12032-012-0167-2 doi (DE-627)SPR023878479 (SPR)s12032-012-0167-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ma, Xiang-Rui verfasserin aut Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target. Single-nucleotide polymorphisms (dpeaa)DE-He213 Oral squamous cell carcinoma (dpeaa)DE-He213 Susceptibility (dpeaa)DE-He213 Lymph node metastasis (dpeaa)DE-He213 Cheng, Hui verfasserin aut Wang, Xiao-Yi verfasserin aut Liu, Hao verfasserin aut Zhao, Dan verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 29(2012), 4 vom: 21. Jan., Seite 2492-2498 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:29 year:2012 number:4 day:21 month:01 pages:2492-2498 https://dx.doi.org/10.1007/s12032-012-0167-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 29 2012 4 21 01 2492-2498
allfieldsSound	10.1007/s12032-012-0167-2 doi (DE-627)SPR023878479 (SPR)s12032-012-0167-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Ma, Xiang-Rui verfasserin aut Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target. Single-nucleotide polymorphisms (dpeaa)DE-He213 Oral squamous cell carcinoma (dpeaa)DE-He213 Susceptibility (dpeaa)DE-He213 Lymph node metastasis (dpeaa)DE-He213 Cheng, Hui verfasserin aut Wang, Xiao-Yi verfasserin aut Liu, Hao verfasserin aut Zhao, Dan verfasserin aut Enthalten in Medical oncology New York, NY : Springer, 1984 29(2012), 4 vom: 21. Jan., Seite 2492-2498 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:29 year:2012 number:4 day:21 month:01 pages:2492-2498 https://dx.doi.org/10.1007/s12032-012-0167-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 29 2012 4 21 01 2492-2498
language	English
source	Enthalten in Medical oncology 29(2012), 4 vom: 21. Jan., Seite 2492-2498 volume:29 year:2012 number:4 day:21 month:01 pages:2492-2498
sourceStr	Enthalten in Medical oncology 29(2012), 4 vom: 21. Jan., Seite 2492-2498 volume:29 year:2012 number:4 day:21 month:01 pages:2492-2498
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Single-nucleotide polymorphisms Oral squamous cell carcinoma Susceptibility Lymph node metastasis
dewey-raw	610
isfreeaccess_bool	false
container_title	Medical oncology
authorswithroles_txt_mv	Ma, Xiang-Rui @@aut@@ Cheng, Hui @@aut@@ Wang, Xiao-Yi @@aut@@ Liu, Hao @@aut@@ Zhao, Dan @@aut@@
publishDateDaySort_date	2012-01-21T00:00:00Z
hierarchy_top_id	320468240
dewey-sort	3610
id	SPR023878479
language_de	englisch
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author	Ma, Xiang-Rui
spellingShingle	Ma, Xiang-Rui ddc 610 bkl 44.81 misc Single-nucleotide polymorphisms misc Oral squamous cell carcinoma misc Susceptibility misc Lymph node metastasis Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma
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topic_title	610 ASE 44.81 bkl Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma Single-nucleotide polymorphisms (dpeaa)DE-He213 Oral squamous cell carcinoma (dpeaa)DE-He213 Susceptibility (dpeaa)DE-He213 Lymph node metastasis (dpeaa)DE-He213
topic	ddc 610 bkl 44.81 misc Single-nucleotide polymorphisms misc Oral squamous cell carcinoma misc Susceptibility misc Lymph node metastasis
topic_unstemmed	ddc 610 bkl 44.81 misc Single-nucleotide polymorphisms misc Oral squamous cell carcinoma misc Susceptibility misc Lymph node metastasis
topic_browse	ddc 610 bkl 44.81 misc Single-nucleotide polymorphisms misc Oral squamous cell carcinoma misc Susceptibility misc Lymph node metastasis
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title	Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma
ctrlnum	(DE-627)SPR023878479 (SPR)s12032-012-0167-2-e
title_full	Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma
author_sort	Ma, Xiang-Rui
journal	Medical oncology
journalStr	Medical oncology
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author_browse	Ma, Xiang-Rui Cheng, Hui Wang, Xiao-Yi Liu, Hao Zhao, Dan
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class	610 ASE 44.81 bkl
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title_sort	single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma
title_auth	Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma
abstract	Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target.
abstractGer	Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target.
abstract_unstemmed	Abstract Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323–3.829, P = 0.004) and 2.85-fold (95% confidence interval 1.583–5.138, P < 0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P < 0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target.
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title_short	Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma
url	https://dx.doi.org/10.1007/s12032-012-0167-2
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author2	Cheng, Hui Wang, Xiao-Yi Liu, Hao Zhao, Dan
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doi_str	10.1007/s12032-012-0167-2
up_date	2024-07-03T22:01:55.757Z
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Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma

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