RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis
Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender,...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lv, Shunzeng [verfasserIn] Dai, Congxin [verfasserIn] Liu, Yuting [verfasserIn] Shi, Ranran [verfasserIn] Tang, Zhenyu [verfasserIn] Han, Mingzhi [verfasserIn] Bian, Ruixiang [verfasserIn] Sun, Bowen [verfasserIn] Wang, Renzhi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Molecular neurobiology - Totowa, NJ : Humana Press, 1987, 51(2014), 3 vom: 27. Juli, Seite 1462-1467 |
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| Übergeordnetes Werk: |
volume:51 ; year:2014 ; number:3 ; day:27 ; month:07 ; pages:1462-1467 |
| Links: |
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| DOI / URN: |
10.1007/s12035-014-8823-5 |
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| Katalog-ID: |
SPR023957603 |
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| 520 | |a Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. | ||
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| 650 | 4 | |a Gliomas |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Clinicopathology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Meta-analysis |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Liu, Yuting |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Ranran |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Zhenyu |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Mingzhi |e verfasserin |4 aut | |
| 700 | 1 | |a Bian, Ruixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Bowen |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Renzhi |e verfasserin |4 aut | |
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10.1007/s12035-014-8823-5 doi (DE-627)SPR023957603 (SPR)s12035-014-8823-5-e DE-627 ger DE-627 rakwb eng 610 570 ASE 44.90 bkl Lv, Shunzeng verfasserin aut RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. Survivin (dpeaa)DE-He213 Gliomas (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Dai, Congxin verfasserin aut Liu, Yuting verfasserin aut Shi, Ranran verfasserin aut Tang, Zhenyu verfasserin aut Han, Mingzhi verfasserin aut Bian, Ruixiang verfasserin aut Sun, Bowen verfasserin aut Wang, Renzhi verfasserin aut Enthalten in Molecular neurobiology Totowa, NJ : Humana Press, 1987 51(2014), 3 vom: 27. Juli, Seite 1462-1467 (DE-627)34858444X (DE-600)2079384-4 1559-1182 nnns volume:51 year:2014 number:3 day:27 month:07 pages:1462-1467 https://dx.doi.org/10.1007/s12035-014-8823-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2014 3 27 07 1462-1467 |
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10.1007/s12035-014-8823-5 doi (DE-627)SPR023957603 (SPR)s12035-014-8823-5-e DE-627 ger DE-627 rakwb eng 610 570 ASE 44.90 bkl Lv, Shunzeng verfasserin aut RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. Survivin (dpeaa)DE-He213 Gliomas (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Dai, Congxin verfasserin aut Liu, Yuting verfasserin aut Shi, Ranran verfasserin aut Tang, Zhenyu verfasserin aut Han, Mingzhi verfasserin aut Bian, Ruixiang verfasserin aut Sun, Bowen verfasserin aut Wang, Renzhi verfasserin aut Enthalten in Molecular neurobiology Totowa, NJ : Humana Press, 1987 51(2014), 3 vom: 27. Juli, Seite 1462-1467 (DE-627)34858444X (DE-600)2079384-4 1559-1182 nnns volume:51 year:2014 number:3 day:27 month:07 pages:1462-1467 https://dx.doi.org/10.1007/s12035-014-8823-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2014 3 27 07 1462-1467 |
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10.1007/s12035-014-8823-5 doi (DE-627)SPR023957603 (SPR)s12035-014-8823-5-e DE-627 ger DE-627 rakwb eng 610 570 ASE 44.90 bkl Lv, Shunzeng verfasserin aut RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. Survivin (dpeaa)DE-He213 Gliomas (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Dai, Congxin verfasserin aut Liu, Yuting verfasserin aut Shi, Ranran verfasserin aut Tang, Zhenyu verfasserin aut Han, Mingzhi verfasserin aut Bian, Ruixiang verfasserin aut Sun, Bowen verfasserin aut Wang, Renzhi verfasserin aut Enthalten in Molecular neurobiology Totowa, NJ : Humana Press, 1987 51(2014), 3 vom: 27. Juli, Seite 1462-1467 (DE-627)34858444X (DE-600)2079384-4 1559-1182 nnns volume:51 year:2014 number:3 day:27 month:07 pages:1462-1467 https://dx.doi.org/10.1007/s12035-014-8823-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2014 3 27 07 1462-1467 |
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10.1007/s12035-014-8823-5 doi (DE-627)SPR023957603 (SPR)s12035-014-8823-5-e DE-627 ger DE-627 rakwb eng 610 570 ASE 44.90 bkl Lv, Shunzeng verfasserin aut RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. Survivin (dpeaa)DE-He213 Gliomas (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Dai, Congxin verfasserin aut Liu, Yuting verfasserin aut Shi, Ranran verfasserin aut Tang, Zhenyu verfasserin aut Han, Mingzhi verfasserin aut Bian, Ruixiang verfasserin aut Sun, Bowen verfasserin aut Wang, Renzhi verfasserin aut Enthalten in Molecular neurobiology Totowa, NJ : Humana Press, 1987 51(2014), 3 vom: 27. Juli, Seite 1462-1467 (DE-627)34858444X (DE-600)2079384-4 1559-1182 nnns volume:51 year:2014 number:3 day:27 month:07 pages:1462-1467 https://dx.doi.org/10.1007/s12035-014-8823-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2014 3 27 07 1462-1467 |
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10.1007/s12035-014-8823-5 doi (DE-627)SPR023957603 (SPR)s12035-014-8823-5-e DE-627 ger DE-627 rakwb eng 610 570 ASE 44.90 bkl Lv, Shunzeng verfasserin aut RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. Survivin (dpeaa)DE-He213 Gliomas (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Dai, Congxin verfasserin aut Liu, Yuting verfasserin aut Shi, Ranran verfasserin aut Tang, Zhenyu verfasserin aut Han, Mingzhi verfasserin aut Bian, Ruixiang verfasserin aut Sun, Bowen verfasserin aut Wang, Renzhi verfasserin aut Enthalten in Molecular neurobiology Totowa, NJ : Humana Press, 1987 51(2014), 3 vom: 27. Juli, Seite 1462-1467 (DE-627)34858444X (DE-600)2079384-4 1559-1182 nnns volume:51 year:2014 number:3 day:27 month:07 pages:1462-1467 https://dx.doi.org/10.1007/s12035-014-8823-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 51 2014 3 27 07 1462-1467 |
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Enthalten in Molecular neurobiology 51(2014), 3 vom: 27. Juli, Seite 1462-1467 volume:51 year:2014 number:3 day:27 month:07 pages:1462-1467 |
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Enthalten in Molecular neurobiology 51(2014), 3 vom: 27. Juli, Seite 1462-1467 volume:51 year:2014 number:3 day:27 month:07 pages:1462-1467 |
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Survivin Gliomas Prognosis Clinicopathology Meta-analysis |
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Molecular neurobiology |
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Lv, Shunzeng @@aut@@ Dai, Congxin @@aut@@ Liu, Yuting @@aut@@ Shi, Ranran @@aut@@ Tang, Zhenyu @@aut@@ Han, Mingzhi @@aut@@ Bian, Ruixiang @@aut@@ Sun, Bowen @@aut@@ Wang, Renzhi @@aut@@ |
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2014-07-27T00:00:00Z |
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However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. 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|
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Lv, Shunzeng |
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Lv, Shunzeng ddc 610 bkl 44.90 misc Survivin misc Gliomas misc Prognosis misc Clinicopathology misc Meta-analysis RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis |
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610 570 ASE 44.90 bkl RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis Survivin (dpeaa)DE-He213 Gliomas (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Clinicopathology (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Survivin misc Gliomas misc Prognosis misc Clinicopathology misc Meta-analysis |
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ddc 610 bkl 44.90 misc Survivin misc Gliomas misc Prognosis misc Clinicopathology misc Meta-analysis |
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ddc 610 bkl 44.90 misc Survivin misc Gliomas misc Prognosis misc Clinicopathology misc Meta-analysis |
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RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis |
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RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis |
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Lv, Shunzeng |
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Molecular neurobiology |
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retracted article: the impact of survivin on prognosis and clinicopathology of glioma patients: a systematic meta-analysis |
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RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis |
| abstract |
Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. |
| abstractGer |
Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. |
| abstract_unstemmed |
Abstract Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible studies were available through careful assessment, and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were estimated. Funnel plots were introduced to evaluate the publication bias. Additionally, heterogeneity and sensitivity were also evaluated. In the present meta-analysis, 15 eligible studies with a total of 1,089 patients were incorporated. Survivin expression in gliomas correlated with 2-year OS (n = 8; HR 0.17, 95 % CI 0.11–0.26) and 5-year OS (n = 7; HR 0.12, 95 % CI 0.07–0.22) in patients. In addition, a fixed-effect model revealed a significant association between survivin and age (male/+; OR 2.10, 95 % CI 1.44–3.05) and survivin and WHO grade (I+II/+; OR 0.27, 95 % CI 0.19–0.38). No heterogeneity was observed across all studies. According to Begg’s and Egger’s test and funnel plot, no publication bias was reported. Taken together, our meta-analysis suggests that survivin expression is associated with poor survival, older age, and higher WHO grade and could be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target. |
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RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis |
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| score |
7.4000845 |