Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection

Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who unde...
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Autor*in:	Zhao, B. [verfasserIn] Huang, X. [verfasserIn] Lu, H. [verfasserIn] Zhang, J. [verfasserIn] Luo, R. [verfasserIn] Xu, H. [verfasserIn] Huang, B. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Gastric cancer Intraoperative blood loss Blood transfusion Postoperative complication Survival

Übergeordnetes Werk:	Enthalten in: Revista de oncología - Barcelona : Doyma, 2000, 21(2019), 9 vom: 28. Jan., Seite 1197-1206
Übergeordnetes Werk:	volume:21 ; year:2019 ; number:9 ; day:28 ; month:01 ; pages:1197-1206

Links:	Volltext

DOI / URN:	10.1007/s12094-019-02046-6

Katalog-ID:	SPR024271217

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520			\|a Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy.
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allfields	10.1007/s12094-019-02046-6 doi (DE-627)SPR024271217 (SPR)s12094-019-02046-6-e DE-627 ger DE-627 rakwb eng 610 ASE Zhao, B. verfasserin aut Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy. Gastric cancer (dpeaa)DE-He213 Intraoperative blood loss (dpeaa)DE-He213 Blood transfusion (dpeaa)DE-He213 Postoperative complication (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Huang, X. verfasserin aut Lu, H. verfasserin aut Zhang, J. verfasserin aut Luo, R. verfasserin aut Xu, H. verfasserin aut Huang, B. verfasserin aut Enthalten in Revista de oncología Barcelona : Doyma, 2000 21(2019), 9 vom: 28. Jan., Seite 1197-1206 (DE-627)385985452 (DE-600)2143451-7 1578-195X nnns volume:21 year:2019 number:9 day:28 month:01 pages:1197-1206 https://dx.doi.org/10.1007/s12094-019-02046-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 21 2019 9 28 01 1197-1206
spelling	10.1007/s12094-019-02046-6 doi (DE-627)SPR024271217 (SPR)s12094-019-02046-6-e DE-627 ger DE-627 rakwb eng 610 ASE Zhao, B. verfasserin aut Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy. Gastric cancer (dpeaa)DE-He213 Intraoperative blood loss (dpeaa)DE-He213 Blood transfusion (dpeaa)DE-He213 Postoperative complication (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Huang, X. verfasserin aut Lu, H. verfasserin aut Zhang, J. verfasserin aut Luo, R. verfasserin aut Xu, H. verfasserin aut Huang, B. verfasserin aut Enthalten in Revista de oncología Barcelona : Doyma, 2000 21(2019), 9 vom: 28. Jan., Seite 1197-1206 (DE-627)385985452 (DE-600)2143451-7 1578-195X nnns volume:21 year:2019 number:9 day:28 month:01 pages:1197-1206 https://dx.doi.org/10.1007/s12094-019-02046-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 21 2019 9 28 01 1197-1206
allfields_unstemmed	10.1007/s12094-019-02046-6 doi (DE-627)SPR024271217 (SPR)s12094-019-02046-6-e DE-627 ger DE-627 rakwb eng 610 ASE Zhao, B. verfasserin aut Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy. Gastric cancer (dpeaa)DE-He213 Intraoperative blood loss (dpeaa)DE-He213 Blood transfusion (dpeaa)DE-He213 Postoperative complication (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Huang, X. verfasserin aut Lu, H. verfasserin aut Zhang, J. verfasserin aut Luo, R. verfasserin aut Xu, H. verfasserin aut Huang, B. verfasserin aut Enthalten in Revista de oncología Barcelona : Doyma, 2000 21(2019), 9 vom: 28. Jan., Seite 1197-1206 (DE-627)385985452 (DE-600)2143451-7 1578-195X nnns volume:21 year:2019 number:9 day:28 month:01 pages:1197-1206 https://dx.doi.org/10.1007/s12094-019-02046-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 21 2019 9 28 01 1197-1206
allfieldsGer	10.1007/s12094-019-02046-6 doi (DE-627)SPR024271217 (SPR)s12094-019-02046-6-e DE-627 ger DE-627 rakwb eng 610 ASE Zhao, B. verfasserin aut Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy. Gastric cancer (dpeaa)DE-He213 Intraoperative blood loss (dpeaa)DE-He213 Blood transfusion (dpeaa)DE-He213 Postoperative complication (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Huang, X. verfasserin aut Lu, H. verfasserin aut Zhang, J. verfasserin aut Luo, R. verfasserin aut Xu, H. verfasserin aut Huang, B. verfasserin aut Enthalten in Revista de oncología Barcelona : Doyma, 2000 21(2019), 9 vom: 28. Jan., Seite 1197-1206 (DE-627)385985452 (DE-600)2143451-7 1578-195X nnns volume:21 year:2019 number:9 day:28 month:01 pages:1197-1206 https://dx.doi.org/10.1007/s12094-019-02046-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 21 2019 9 28 01 1197-1206
allfieldsSound	10.1007/s12094-019-02046-6 doi (DE-627)SPR024271217 (SPR)s12094-019-02046-6-e DE-627 ger DE-627 rakwb eng 610 ASE Zhao, B. verfasserin aut Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy. Gastric cancer (dpeaa)DE-He213 Intraoperative blood loss (dpeaa)DE-He213 Blood transfusion (dpeaa)DE-He213 Postoperative complication (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Huang, X. verfasserin aut Lu, H. verfasserin aut Zhang, J. verfasserin aut Luo, R. verfasserin aut Xu, H. verfasserin aut Huang, B. verfasserin aut Enthalten in Revista de oncología Barcelona : Doyma, 2000 21(2019), 9 vom: 28. Jan., Seite 1197-1206 (DE-627)385985452 (DE-600)2143451-7 1578-195X nnns volume:21 year:2019 number:9 day:28 month:01 pages:1197-1206 https://dx.doi.org/10.1007/s12094-019-02046-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 21 2019 9 28 01 1197-1206
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topic_facet	Gastric cancer Intraoperative blood loss Blood transfusion Postoperative complication Survival
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In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. 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author	Zhao, B.
spellingShingle	Zhao, B. ddc 610 misc Gastric cancer misc Intraoperative blood loss misc Blood transfusion misc Postoperative complication misc Survival Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection
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topic_title	610 ASE Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection Gastric cancer (dpeaa)DE-He213 Intraoperative blood loss (dpeaa)DE-He213 Blood transfusion (dpeaa)DE-He213 Postoperative complication (dpeaa)DE-He213 Survival (dpeaa)DE-He213
topic	ddc 610 misc Gastric cancer misc Intraoperative blood loss misc Blood transfusion misc Postoperative complication misc Survival
topic_unstemmed	ddc 610 misc Gastric cancer misc Intraoperative blood loss misc Blood transfusion misc Postoperative complication misc Survival
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title	Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection
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title_full	Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection
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title_sort	intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection
title_auth	Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection
abstract	Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy.
abstractGer	Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy.
abstract_unstemmed	Background Whether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. Intraoperative blood loss itself could not independently affect survival outcome of GC patients after curative gastrectomy.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702
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title_short	Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection
url	https://dx.doi.org/10.1007/s12094-019-02046-6
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author2	Huang, X. Lu, H. Zhang, J. Luo, R. Xu, H. Huang, B.
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In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients. Methods A total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL < 400 mL and IBL ≥ 400 mL group according to the amount of IBL. The prognostic difference between two patient groups was compared and clinicopathologic factors associated with the prognosis of GC patients were analyzed. Results The 5-year DFS rate of the patients with IBL < 400 mL and those with IBL ≥ 400 mL was 52.1% and 41.5%, respectively (P < 0.001). The 5-year DFS rate of the patients who did and did not receive intraoperative blood transfusion was 36.9% and 53.2%, respectively (P < 0.001). However, the similar survival outcomes were not observed in the subgroup analysis based on the TNM stage. The multivariate analysis indicated that IBL (HR 1.021, 95% CI 0.875–1.191, P > 0.05) and intraoperative blood transfusion (HR 1.111, 95% CI 0.943–1.309, P > 0.05) were not independent prognostic factors for GC patients. In addition, the patients with IBL ≥ 400 mL had a higher risk of postoperative complications than those with IBL < 400 mL, especially for intraabdominal infection and wound infection. The tumor located in upper 1/3 stomach, total gastrectomy, combined organ resection and advanced tumor stage (stage III) were independent risk factors for intraoperative massive hemorrhage. Conclusion Intraoperative blood loss was significantly associated with tumor-related and surgery-related factors. 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Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection

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