Evaluation of the Protection Provided by Hepatitis B Vaccination in India

Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 chi...
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Autor*in:	Puliyel, Jacob [verfasserIn] Naik, Pathik [verfasserIn] Puliyel, Ashish [verfasserIn] Agarwal, Kishore [verfasserIn] Lal, Vandana [verfasserIn] Kansal, Nimmi [verfasserIn] Nandan, Devki [verfasserIn] Tripathi, Vikas [verfasserIn] Tyagi, Prashant [verfasserIn] Singh, Saroj K. [verfasserIn] Srivastava, Rajeev [verfasserIn] Sharma, Utkarsh [verfasserIn] Sreenivas, V. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Immunization Passive immunity Hepatitis B surface antigen Hepatitis B core antigen Antibody to hepatitis B surface antigen Antibody to hepatitis B core antigen

Übergeordnetes Werk:	Enthalten in: Indian journal of pediatrics - New Delhi : Dept. of Pediatrics, All India of Medical Sciences, 1933, 85(2018), 7 vom: 10. Jan., Seite 510-516
Übergeordnetes Werk:	volume:85 ; year:2018 ; number:7 ; day:10 ; month:01 ; pages:510-516

Links:	Volltext

DOI / URN:	10.1007/s12098-017-2601-0

Katalog-ID:	SPR024313254

Internformat


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082	0	4	\|a 610 \|q ASE
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100	1		\|a Puliyel, Jacob \|e verfasserin \|4 aut
245	1	0	\|a Evaluation of the Protection Provided by Hepatitis B Vaccination in India
264		1	\|c 2018
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk.
650		4	\|a Immunization \|7 (dpeaa)DE-He213
650		4	\|a Passive immunity \|7 (dpeaa)DE-He213
650		4	\|a Hepatitis B surface antigen \|7 (dpeaa)DE-He213
650		4	\|a Hepatitis B core antigen \|7 (dpeaa)DE-He213
650		4	\|a Antibody to hepatitis B surface antigen \|7 (dpeaa)DE-He213
650		4	\|a Antibody to hepatitis B core antigen \|7 (dpeaa)DE-He213
700	1		\|a Naik, Pathik \|e verfasserin \|4 aut
700	1		\|a Puliyel, Ashish \|e verfasserin \|4 aut
700	1		\|a Agarwal, Kishore \|e verfasserin \|4 aut
700	1		\|a Lal, Vandana \|e verfasserin \|4 aut
700	1		\|a Kansal, Nimmi \|e verfasserin \|4 aut
700	1		\|a Nandan, Devki \|e verfasserin \|4 aut
700	1		\|a Tripathi, Vikas \|e verfasserin \|4 aut
700	1		\|a Tyagi, Prashant \|e verfasserin \|4 aut
700	1		\|a Singh, Saroj K. \|e verfasserin \|4 aut
700	1		\|a Srivastava, Rajeev \|e verfasserin \|4 aut
700	1		\|a Sharma, Utkarsh \|e verfasserin \|4 aut
700	1		\|a Sreenivas, V. \|e verfasserin \|4 aut
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912			\|a GBV_ILN_60
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912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
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912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
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952			\|d 85 \|j 2018 \|e 7 \|b 10 \|c 01 \|h 510-516

Indexfelder

author_variant	j p jp p n pn a p ap k a ka v l vl n k nk d n dn v t vt p t pt s k s sk sks r s rs u s us v s vs
matchkey_str	article:09737693:2018----::vlainfhpoetopoiebhptts
hierarchy_sort_str	2018
bklnumber	44.67
publishDate	2018
allfields	10.1007/s12098-017-2601-0 doi (DE-627)SPR024313254 (SPR)s12098-017-2601-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Puliyel, Jacob verfasserin aut Evaluation of the Protection Provided by Hepatitis B Vaccination in India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk. Immunization (dpeaa)DE-He213 Passive immunity (dpeaa)DE-He213 Hepatitis B surface antigen (dpeaa)DE-He213 Hepatitis B core antigen (dpeaa)DE-He213 Antibody to hepatitis B surface antigen (dpeaa)DE-He213 Antibody to hepatitis B core antigen (dpeaa)DE-He213 Naik, Pathik verfasserin aut Puliyel, Ashish verfasserin aut Agarwal, Kishore verfasserin aut Lal, Vandana verfasserin aut Kansal, Nimmi verfasserin aut Nandan, Devki verfasserin aut Tripathi, Vikas verfasserin aut Tyagi, Prashant verfasserin aut Singh, Saroj K. verfasserin aut Srivastava, Rajeev verfasserin aut Sharma, Utkarsh verfasserin aut Sreenivas, V. verfasserin aut Enthalten in Indian journal of pediatrics New Delhi : Dept. of Pediatrics, All India of Medical Sciences, 1933 85(2018), 7 vom: 10. Jan., Seite 510-516 (DE-627)340077271 (DE-600)2065273-2 0973-7693 nnns volume:85 year:2018 number:7 day:10 month:01 pages:510-516 https://dx.doi.org/10.1007/s12098-017-2601-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 85 2018 7 10 01 510-516
spelling	10.1007/s12098-017-2601-0 doi (DE-627)SPR024313254 (SPR)s12098-017-2601-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Puliyel, Jacob verfasserin aut Evaluation of the Protection Provided by Hepatitis B Vaccination in India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk. Immunization (dpeaa)DE-He213 Passive immunity (dpeaa)DE-He213 Hepatitis B surface antigen (dpeaa)DE-He213 Hepatitis B core antigen (dpeaa)DE-He213 Antibody to hepatitis B surface antigen (dpeaa)DE-He213 Antibody to hepatitis B core antigen (dpeaa)DE-He213 Naik, Pathik verfasserin aut Puliyel, Ashish verfasserin aut Agarwal, Kishore verfasserin aut Lal, Vandana verfasserin aut Kansal, Nimmi verfasserin aut Nandan, Devki verfasserin aut Tripathi, Vikas verfasserin aut Tyagi, Prashant verfasserin aut Singh, Saroj K. verfasserin aut Srivastava, Rajeev verfasserin aut Sharma, Utkarsh verfasserin aut Sreenivas, V. verfasserin aut Enthalten in Indian journal of pediatrics New Delhi : Dept. of Pediatrics, All India of Medical Sciences, 1933 85(2018), 7 vom: 10. Jan., Seite 510-516 (DE-627)340077271 (DE-600)2065273-2 0973-7693 nnns volume:85 year:2018 number:7 day:10 month:01 pages:510-516 https://dx.doi.org/10.1007/s12098-017-2601-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 85 2018 7 10 01 510-516
allfields_unstemmed	10.1007/s12098-017-2601-0 doi (DE-627)SPR024313254 (SPR)s12098-017-2601-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Puliyel, Jacob verfasserin aut Evaluation of the Protection Provided by Hepatitis B Vaccination in India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk. Immunization (dpeaa)DE-He213 Passive immunity (dpeaa)DE-He213 Hepatitis B surface antigen (dpeaa)DE-He213 Hepatitis B core antigen (dpeaa)DE-He213 Antibody to hepatitis B surface antigen (dpeaa)DE-He213 Antibody to hepatitis B core antigen (dpeaa)DE-He213 Naik, Pathik verfasserin aut Puliyel, Ashish verfasserin aut Agarwal, Kishore verfasserin aut Lal, Vandana verfasserin aut Kansal, Nimmi verfasserin aut Nandan, Devki verfasserin aut Tripathi, Vikas verfasserin aut Tyagi, Prashant verfasserin aut Singh, Saroj K. verfasserin aut Srivastava, Rajeev verfasserin aut Sharma, Utkarsh verfasserin aut Sreenivas, V. verfasserin aut Enthalten in Indian journal of pediatrics New Delhi : Dept. of Pediatrics, All India of Medical Sciences, 1933 85(2018), 7 vom: 10. Jan., Seite 510-516 (DE-627)340077271 (DE-600)2065273-2 0973-7693 nnns volume:85 year:2018 number:7 day:10 month:01 pages:510-516 https://dx.doi.org/10.1007/s12098-017-2601-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 85 2018 7 10 01 510-516
allfieldsGer	10.1007/s12098-017-2601-0 doi (DE-627)SPR024313254 (SPR)s12098-017-2601-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Puliyel, Jacob verfasserin aut Evaluation of the Protection Provided by Hepatitis B Vaccination in India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk. Immunization (dpeaa)DE-He213 Passive immunity (dpeaa)DE-He213 Hepatitis B surface antigen (dpeaa)DE-He213 Hepatitis B core antigen (dpeaa)DE-He213 Antibody to hepatitis B surface antigen (dpeaa)DE-He213 Antibody to hepatitis B core antigen (dpeaa)DE-He213 Naik, Pathik verfasserin aut Puliyel, Ashish verfasserin aut Agarwal, Kishore verfasserin aut Lal, Vandana verfasserin aut Kansal, Nimmi verfasserin aut Nandan, Devki verfasserin aut Tripathi, Vikas verfasserin aut Tyagi, Prashant verfasserin aut Singh, Saroj K. verfasserin aut Srivastava, Rajeev verfasserin aut Sharma, Utkarsh verfasserin aut Sreenivas, V. verfasserin aut Enthalten in Indian journal of pediatrics New Delhi : Dept. of Pediatrics, All India of Medical Sciences, 1933 85(2018), 7 vom: 10. Jan., Seite 510-516 (DE-627)340077271 (DE-600)2065273-2 0973-7693 nnns volume:85 year:2018 number:7 day:10 month:01 pages:510-516 https://dx.doi.org/10.1007/s12098-017-2601-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 85 2018 7 10 01 510-516
allfieldsSound	10.1007/s12098-017-2601-0 doi (DE-627)SPR024313254 (SPR)s12098-017-2601-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Puliyel, Jacob verfasserin aut Evaluation of the Protection Provided by Hepatitis B Vaccination in India 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk. Immunization (dpeaa)DE-He213 Passive immunity (dpeaa)DE-He213 Hepatitis B surface antigen (dpeaa)DE-He213 Hepatitis B core antigen (dpeaa)DE-He213 Antibody to hepatitis B surface antigen (dpeaa)DE-He213 Antibody to hepatitis B core antigen (dpeaa)DE-He213 Naik, Pathik verfasserin aut Puliyel, Ashish verfasserin aut Agarwal, Kishore verfasserin aut Lal, Vandana verfasserin aut Kansal, Nimmi verfasserin aut Nandan, Devki verfasserin aut Tripathi, Vikas verfasserin aut Tyagi, Prashant verfasserin aut Singh, Saroj K. verfasserin aut Srivastava, Rajeev verfasserin aut Sharma, Utkarsh verfasserin aut Sreenivas, V. verfasserin aut Enthalten in Indian journal of pediatrics New Delhi : Dept. of Pediatrics, All India of Medical Sciences, 1933 85(2018), 7 vom: 10. Jan., Seite 510-516 (DE-627)340077271 (DE-600)2065273-2 0973-7693 nnns volume:85 year:2018 number:7 day:10 month:01 pages:510-516 https://dx.doi.org/10.1007/s12098-017-2601-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 85 2018 7 10 01 510-516
language	English
source	Enthalten in Indian journal of pediatrics 85(2018), 7 vom: 10. Jan., Seite 510-516 volume:85 year:2018 number:7 day:10 month:01 pages:510-516
sourceStr	Enthalten in Indian journal of pediatrics 85(2018), 7 vom: 10. Jan., Seite 510-516 volume:85 year:2018 number:7 day:10 month:01 pages:510-516
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Immunization Passive immunity Hepatitis B surface antigen Hepatitis B core antigen Antibody to hepatitis B surface antigen Antibody to hepatitis B core antigen
dewey-raw	610
isfreeaccess_bool	false
container_title	Indian journal of pediatrics
authorswithroles_txt_mv	Puliyel, Jacob @@aut@@ Naik, Pathik @@aut@@ Puliyel, Ashish @@aut@@ Agarwal, Kishore @@aut@@ Lal, Vandana @@aut@@ Kansal, Nimmi @@aut@@ Nandan, Devki @@aut@@ Tripathi, Vikas @@aut@@ Tyagi, Prashant @@aut@@ Singh, Saroj K. @@aut@@ Srivastava, Rajeev @@aut@@ Sharma, Utkarsh @@aut@@ Sreenivas, V. @@aut@@
publishDateDaySort_date	2018-01-10T00:00:00Z
hierarchy_top_id	340077271
dewey-sort	3610
id	SPR024313254
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR024313254</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520000210.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201006s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12098-017-2601-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR024313254</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12098-017-2601-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.67</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Puliyel, Jacob</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evaluation of the Protection Provided by Hepatitis B Vaccination in India</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. 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author	Puliyel, Jacob
spellingShingle	Puliyel, Jacob ddc 610 bkl 44.67 misc Immunization misc Passive immunity misc Hepatitis B surface antigen misc Hepatitis B core antigen misc Antibody to hepatitis B surface antigen misc Antibody to hepatitis B core antigen Evaluation of the Protection Provided by Hepatitis B Vaccination in India
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topic_title	610 ASE 44.67 bkl Evaluation of the Protection Provided by Hepatitis B Vaccination in India Immunization (dpeaa)DE-He213 Passive immunity (dpeaa)DE-He213 Hepatitis B surface antigen (dpeaa)DE-He213 Hepatitis B core antigen (dpeaa)DE-He213 Antibody to hepatitis B surface antigen (dpeaa)DE-He213 Antibody to hepatitis B core antigen (dpeaa)DE-He213
topic	ddc 610 bkl 44.67 misc Immunization misc Passive immunity misc Hepatitis B surface antigen misc Hepatitis B core antigen misc Antibody to hepatitis B surface antigen misc Antibody to hepatitis B core antigen
topic_unstemmed	ddc 610 bkl 44.67 misc Immunization misc Passive immunity misc Hepatitis B surface antigen misc Hepatitis B core antigen misc Antibody to hepatitis B surface antigen misc Antibody to hepatitis B core antigen
topic_browse	ddc 610 bkl 44.67 misc Immunization misc Passive immunity misc Hepatitis B surface antigen misc Hepatitis B core antigen misc Antibody to hepatitis B surface antigen misc Antibody to hepatitis B core antigen
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title	Evaluation of the Protection Provided by Hepatitis B Vaccination in India
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title_full	Evaluation of the Protection Provided by Hepatitis B Vaccination in India
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author_browse	Puliyel, Jacob Naik, Pathik Puliyel, Ashish Agarwal, Kishore Lal, Vandana Kansal, Nimmi Nandan, Devki Tripathi, Vikas Tyagi, Prashant Singh, Saroj K. Srivastava, Rajeev Sharma, Utkarsh Sreenivas, V.
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title_sort	evaluation of the protection provided by hepatitis b vaccination in india
title_auth	Evaluation of the Protection Provided by Hepatitis B Vaccination in India
abstract	Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk.
abstractGer	Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk.
abstract_unstemmed	Objective In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). The odds of getting HBV infection was 0.42 (CI 0.25–0.68) with birth dose and 0.49 (CI 0.30–0.82) without the birth dose compared to the unvaccinated. Protective antibody (HBsAb) was present in about 70% of the vaccinated. In the unimmunised, in the first 2 y HBsAb protection was present in 40%. The odds ratio (OR) for HBsAb in the fully vaccinated between 4 and 5 y was 1.4 (95%CI 0.9–2.18) compared to the unvaccinated. Conclusions The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk.
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container_issue	7
title_short	Evaluation of the Protection Provided by Hepatitis B Vaccination in India
url	https://dx.doi.org/10.1007/s12098-017-2601-0
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author2	Naik, Pathik Puliyel, Ashish Agarwal, Kishore Lal, Vandana Kansal, Nimmi Nandan, Devki Tripathi, Vikas Tyagi, Prashant Singh, Saroj K. Srivastava, Rajeev Sharma, Utkarsh Sreenivas, V.
author2Str	Naik, Pathik Puliyel, Ashish Agarwal, Kishore Lal, Vandana Kansal, Nimmi Nandan, Devki Tripathi, Vikas Tyagi, Prashant Singh, Saroj K. Srivastava, Rajeev Sharma, Utkarsh Sreenivas, V.
ppnlink	340077271
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s12098-017-2601-0
up_date	2024-07-04T00:26:14.737Z
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The authors examined protection afforded by the birth dose. Methods A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases. Exposed were the unvaccinated. In another analysis, exposed were those vaccinated without the birth dose. Results The odds ratio (OR) for HBsAg positivity with birth vaccination was 0.35 (95% CI 0.19–0.66); while with vaccination at 6 wk was 0.29 (95%CI 0.14–0.61), both compared to unvaccinated. Birth vaccination has no added protection when compared to the unvaccinated. Unvaccinated children in index study had HBsAg positivity of 4.38%. The number needed to treat (NNT) to prevent one case of HBsAg positivity was 32.6 (95% CI, 20.9 to 73.6). 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