First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis
Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-N...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Freesmeyer, Martin [verfasserIn] Stecker, Franz F. [verfasserIn] Schierz, Jan-Henning [verfasserIn] Hofmann, Gunther O. [verfasserIn] Winkens, Thomas [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
Positron emission tomography/computed tomography |
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| Übergeordnetes Werk: |
Enthalten in: Annals of nuclear medicine - [S.l.] : Springer Japan, 1987, 28(2014), 4 vom: 29. Jan., Seite 314-321 |
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| Übergeordnetes Werk: |
volume:28 ; year:2014 ; number:4 ; day:29 ; month:01 ; pages:314-321 |
| Links: |
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| DOI / URN: |
10.1007/s12149-014-0810-4 |
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| Katalog-ID: |
SPR024503851 |
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| 520 | |a Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. | ||
| 650 | 4 | |a Positron emission tomography/computed tomography |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Early dynamic positron emission tomography |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a F-sodium fluoride |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a F-NaF |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chronic osteomyelitis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a List mode |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Stecker, Franz F. |e verfasserin |4 aut | |
| 700 | 1 | |a Schierz, Jan-Henning |e verfasserin |4 aut | |
| 700 | 1 | |a Hofmann, Gunther O. |e verfasserin |4 aut | |
| 700 | 1 | |a Winkens, Thomas |e verfasserin |4 aut | |
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10.1007/s12149-014-0810-4 doi (DE-627)SPR024503851 (SPR)s12149-014-0810-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Freesmeyer, Martin verfasserin aut First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. Positron emission tomography/computed tomography (dpeaa)DE-He213 Early dynamic positron emission tomography (dpeaa)DE-He213 F-sodium fluoride (dpeaa)DE-He213 F-NaF (dpeaa)DE-He213 Chronic osteomyelitis (dpeaa)DE-He213 List mode (dpeaa)DE-He213 Stecker, Franz F. verfasserin aut Schierz, Jan-Henning verfasserin aut Hofmann, Gunther O. verfasserin aut Winkens, Thomas verfasserin aut Enthalten in Annals of nuclear medicine [S.l.] : Springer Japan, 1987 28(2014), 4 vom: 29. Jan., Seite 314-321 (DE-627)325789339 (DE-600)2039738-0 1864-6433 nnns volume:28 year:2014 number:4 day:29 month:01 pages:314-321 https://dx.doi.org/10.1007/s12149-014-0810-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 28 2014 4 29 01 314-321 |
| spelling |
10.1007/s12149-014-0810-4 doi (DE-627)SPR024503851 (SPR)s12149-014-0810-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Freesmeyer, Martin verfasserin aut First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. Positron emission tomography/computed tomography (dpeaa)DE-He213 Early dynamic positron emission tomography (dpeaa)DE-He213 F-sodium fluoride (dpeaa)DE-He213 F-NaF (dpeaa)DE-He213 Chronic osteomyelitis (dpeaa)DE-He213 List mode (dpeaa)DE-He213 Stecker, Franz F. verfasserin aut Schierz, Jan-Henning verfasserin aut Hofmann, Gunther O. verfasserin aut Winkens, Thomas verfasserin aut Enthalten in Annals of nuclear medicine [S.l.] : Springer Japan, 1987 28(2014), 4 vom: 29. Jan., Seite 314-321 (DE-627)325789339 (DE-600)2039738-0 1864-6433 nnns volume:28 year:2014 number:4 day:29 month:01 pages:314-321 https://dx.doi.org/10.1007/s12149-014-0810-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 28 2014 4 29 01 314-321 |
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10.1007/s12149-014-0810-4 doi (DE-627)SPR024503851 (SPR)s12149-014-0810-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Freesmeyer, Martin verfasserin aut First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. Positron emission tomography/computed tomography (dpeaa)DE-He213 Early dynamic positron emission tomography (dpeaa)DE-He213 F-sodium fluoride (dpeaa)DE-He213 F-NaF (dpeaa)DE-He213 Chronic osteomyelitis (dpeaa)DE-He213 List mode (dpeaa)DE-He213 Stecker, Franz F. verfasserin aut Schierz, Jan-Henning verfasserin aut Hofmann, Gunther O. verfasserin aut Winkens, Thomas verfasserin aut Enthalten in Annals of nuclear medicine [S.l.] : Springer Japan, 1987 28(2014), 4 vom: 29. Jan., Seite 314-321 (DE-627)325789339 (DE-600)2039738-0 1864-6433 nnns volume:28 year:2014 number:4 day:29 month:01 pages:314-321 https://dx.doi.org/10.1007/s12149-014-0810-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 28 2014 4 29 01 314-321 |
| allfieldsGer |
10.1007/s12149-014-0810-4 doi (DE-627)SPR024503851 (SPR)s12149-014-0810-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Freesmeyer, Martin verfasserin aut First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. Positron emission tomography/computed tomography (dpeaa)DE-He213 Early dynamic positron emission tomography (dpeaa)DE-He213 F-sodium fluoride (dpeaa)DE-He213 F-NaF (dpeaa)DE-He213 Chronic osteomyelitis (dpeaa)DE-He213 List mode (dpeaa)DE-He213 Stecker, Franz F. verfasserin aut Schierz, Jan-Henning verfasserin aut Hofmann, Gunther O. verfasserin aut Winkens, Thomas verfasserin aut Enthalten in Annals of nuclear medicine [S.l.] : Springer Japan, 1987 28(2014), 4 vom: 29. Jan., Seite 314-321 (DE-627)325789339 (DE-600)2039738-0 1864-6433 nnns volume:28 year:2014 number:4 day:29 month:01 pages:314-321 https://dx.doi.org/10.1007/s12149-014-0810-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 28 2014 4 29 01 314-321 |
| allfieldsSound |
10.1007/s12149-014-0810-4 doi (DE-627)SPR024503851 (SPR)s12149-014-0810-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Freesmeyer, Martin verfasserin aut First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. Positron emission tomography/computed tomography (dpeaa)DE-He213 Early dynamic positron emission tomography (dpeaa)DE-He213 F-sodium fluoride (dpeaa)DE-He213 F-NaF (dpeaa)DE-He213 Chronic osteomyelitis (dpeaa)DE-He213 List mode (dpeaa)DE-He213 Stecker, Franz F. verfasserin aut Schierz, Jan-Henning verfasserin aut Hofmann, Gunther O. verfasserin aut Winkens, Thomas verfasserin aut Enthalten in Annals of nuclear medicine [S.l.] : Springer Japan, 1987 28(2014), 4 vom: 29. Jan., Seite 314-321 (DE-627)325789339 (DE-600)2039738-0 1864-6433 nnns volume:28 year:2014 number:4 day:29 month:01 pages:314-321 https://dx.doi.org/10.1007/s12149-014-0810-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 28 2014 4 29 01 314-321 |
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English |
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Enthalten in Annals of nuclear medicine 28(2014), 4 vom: 29. Jan., Seite 314-321 volume:28 year:2014 number:4 day:29 month:01 pages:314-321 |
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Enthalten in Annals of nuclear medicine 28(2014), 4 vom: 29. Jan., Seite 314-321 volume:28 year:2014 number:4 day:29 month:01 pages:314-321 |
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Positron emission tomography/computed tomography Early dynamic positron emission tomography F-sodium fluoride F-NaF Chronic osteomyelitis List mode |
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Freesmeyer, Martin @@aut@@ Stecker, Franz F. @@aut@@ Schierz, Jan-Henning @@aut@@ Hofmann, Gunther O. @@aut@@ Winkens, Thomas @@aut@@ |
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2014-01-29T00:00:00Z |
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Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. 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Freesmeyer, Martin |
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first experience with early dynamic 18f-naf-pet/ct in patients with chronic osteomyelitis |
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First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis |
| abstract |
Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. |
| abstractGer |
Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. |
| abstract_unstemmed |
Objective This study investigates whether early dynamic positron emission tomography/computed tomography (edPET/CT) using 18F-sodium fluoride-(18F-NaF) is feasible in depicting early phases of radiotracer distribution in patients with chronic osteomyelitis (COM). Methods A total of 12 $ ed^{18} $F-NaF-PET/CT examinations were performed on 11 consecutive patients (2 female, 9 male; age 53 ± 12 years) in list mode over 5 min starting with radiopharmaceutical injection before standard late 18F-NaF-PET/CT. Eight consecutive time intervals (frames) were reconstructed for each patient: four 15 s, then four 60 s. Several volumes of interest (VOI) were selected, representing the affected area as well as different reference areas within the bone and soft tissue. Maximum and mean ed standardized uptake values ($ edSUV_{max} $, $ edSUV_{mean,} $ respectively) were calculated in each VOI during each frame to measure early fluoride influx and accumulation. Results were compared between affected and non-affected (contralateral) bones. Results Starting in the 31–45 s frame, the affected bone area showed significantly higher $ edSUV_{max} $ and $ edSUV_{mean} $ compared to the healthy contralateral region. The affected bone areas also significantly differed from non-affected contralateral regions in conventional late 18F-NaF-PET/CT. Conclusions This pilot study suggests that, in patients with COM, $ ed^{18} $F-NaF -PET offers additional information about early radiotracer distribution to standard 18F-NaF -PET/CT, similar to a three-phase bone scan. The results should be validated in larger trials which directly compare $ ed^{18} $F-NaF-PET to a three-phase bone scan. |
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First experience with early dynamic 18F-NaF-PET/CT in patients with chronic osteomyelitis |
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Stecker, Franz F. Schierz, Jan-Henning Hofmann, Gunther O. Winkens, Thomas |
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| score |
7.4011145 |