The Measurement of Spray Quality for Pan Coating Processes
Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the s...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Wei [verfasserIn] Chang, Shih-Ying [verfasserIn] Kiang, San [verfasserIn] Early, William [verfasserIn] Paruchuri, Srinivasa [verfasserIn] Desai, Divyakant [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of pharmaceutical innovation - New York, NY : Springer, 2006, 3(2008), 1 vom: März, Seite 3-14 |
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| Übergeordnetes Werk: |
volume:3 ; year:2008 ; number:1 ; month:03 ; pages:3-14 |
| Links: |
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| DOI / URN: |
10.1007/s12247-008-9022-6 |
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| Katalog-ID: |
SPR024595349 |
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| 520 | |a Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. | ||
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| 650 | 4 | |a Droplet size distribution |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Spray pattern |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Droplet velocity distribution |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Spray coating |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Process analytical technology (PAT) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Spray quality |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Coating uniformity |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Chang, Shih-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Kiang, San |e verfasserin |4 aut | |
| 700 | 1 | |a Early, William |e verfasserin |4 aut | |
| 700 | 1 | |a Paruchuri, Srinivasa |e verfasserin |4 aut | |
| 700 | 1 | |a Desai, Divyakant |e verfasserin |4 aut | |
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10.1007/s12247-008-9022-6 doi (DE-627)SPR024595349 (SPR)s12247-008-9022-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Chen, Wei verfasserin aut The Measurement of Spray Quality for Pan Coating Processes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. Particle tracking velocimetry (dpeaa)DE-He213 Droplet size distribution (dpeaa)DE-He213 Spray pattern (dpeaa)DE-He213 Droplet velocity distribution (dpeaa)DE-He213 Spray coating (dpeaa)DE-He213 Process analytical technology (PAT) (dpeaa)DE-He213 Spray quality (dpeaa)DE-He213 Coating uniformity (dpeaa)DE-He213 Chang, Shih-Ying verfasserin aut Kiang, San verfasserin aut Early, William verfasserin aut Paruchuri, Srinivasa verfasserin aut Desai, Divyakant verfasserin aut Enthalten in Journal of pharmaceutical innovation New York, NY : Springer, 2006 3(2008), 1 vom: März, Seite 3-14 (DE-627)567146472 (DE-600)2428208-X 1939-8042 nnns volume:3 year:2008 number:1 month:03 pages:3-14 https://dx.doi.org/10.1007/s12247-008-9022-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 3 2008 1 03 3-14 |
| spelling |
10.1007/s12247-008-9022-6 doi (DE-627)SPR024595349 (SPR)s12247-008-9022-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Chen, Wei verfasserin aut The Measurement of Spray Quality for Pan Coating Processes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. Particle tracking velocimetry (dpeaa)DE-He213 Droplet size distribution (dpeaa)DE-He213 Spray pattern (dpeaa)DE-He213 Droplet velocity distribution (dpeaa)DE-He213 Spray coating (dpeaa)DE-He213 Process analytical technology (PAT) (dpeaa)DE-He213 Spray quality (dpeaa)DE-He213 Coating uniformity (dpeaa)DE-He213 Chang, Shih-Ying verfasserin aut Kiang, San verfasserin aut Early, William verfasserin aut Paruchuri, Srinivasa verfasserin aut Desai, Divyakant verfasserin aut Enthalten in Journal of pharmaceutical innovation New York, NY : Springer, 2006 3(2008), 1 vom: März, Seite 3-14 (DE-627)567146472 (DE-600)2428208-X 1939-8042 nnns volume:3 year:2008 number:1 month:03 pages:3-14 https://dx.doi.org/10.1007/s12247-008-9022-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 3 2008 1 03 3-14 |
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10.1007/s12247-008-9022-6 doi (DE-627)SPR024595349 (SPR)s12247-008-9022-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Chen, Wei verfasserin aut The Measurement of Spray Quality for Pan Coating Processes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. Particle tracking velocimetry (dpeaa)DE-He213 Droplet size distribution (dpeaa)DE-He213 Spray pattern (dpeaa)DE-He213 Droplet velocity distribution (dpeaa)DE-He213 Spray coating (dpeaa)DE-He213 Process analytical technology (PAT) (dpeaa)DE-He213 Spray quality (dpeaa)DE-He213 Coating uniformity (dpeaa)DE-He213 Chang, Shih-Ying verfasserin aut Kiang, San verfasserin aut Early, William verfasserin aut Paruchuri, Srinivasa verfasserin aut Desai, Divyakant verfasserin aut Enthalten in Journal of pharmaceutical innovation New York, NY : Springer, 2006 3(2008), 1 vom: März, Seite 3-14 (DE-627)567146472 (DE-600)2428208-X 1939-8042 nnns volume:3 year:2008 number:1 month:03 pages:3-14 https://dx.doi.org/10.1007/s12247-008-9022-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 3 2008 1 03 3-14 |
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10.1007/s12247-008-9022-6 doi (DE-627)SPR024595349 (SPR)s12247-008-9022-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Chen, Wei verfasserin aut The Measurement of Spray Quality for Pan Coating Processes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. Particle tracking velocimetry (dpeaa)DE-He213 Droplet size distribution (dpeaa)DE-He213 Spray pattern (dpeaa)DE-He213 Droplet velocity distribution (dpeaa)DE-He213 Spray coating (dpeaa)DE-He213 Process analytical technology (PAT) (dpeaa)DE-He213 Spray quality (dpeaa)DE-He213 Coating uniformity (dpeaa)DE-He213 Chang, Shih-Ying verfasserin aut Kiang, San verfasserin aut Early, William verfasserin aut Paruchuri, Srinivasa verfasserin aut Desai, Divyakant verfasserin aut Enthalten in Journal of pharmaceutical innovation New York, NY : Springer, 2006 3(2008), 1 vom: März, Seite 3-14 (DE-627)567146472 (DE-600)2428208-X 1939-8042 nnns volume:3 year:2008 number:1 month:03 pages:3-14 https://dx.doi.org/10.1007/s12247-008-9022-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 3 2008 1 03 3-14 |
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10.1007/s12247-008-9022-6 doi (DE-627)SPR024595349 (SPR)s12247-008-9022-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Chen, Wei verfasserin aut The Measurement of Spray Quality for Pan Coating Processes 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. Particle tracking velocimetry (dpeaa)DE-He213 Droplet size distribution (dpeaa)DE-He213 Spray pattern (dpeaa)DE-He213 Droplet velocity distribution (dpeaa)DE-He213 Spray coating (dpeaa)DE-He213 Process analytical technology (PAT) (dpeaa)DE-He213 Spray quality (dpeaa)DE-He213 Coating uniformity (dpeaa)DE-He213 Chang, Shih-Ying verfasserin aut Kiang, San verfasserin aut Early, William verfasserin aut Paruchuri, Srinivasa verfasserin aut Desai, Divyakant verfasserin aut Enthalten in Journal of pharmaceutical innovation New York, NY : Springer, 2006 3(2008), 1 vom: März, Seite 3-14 (DE-627)567146472 (DE-600)2428208-X 1939-8042 nnns volume:3 year:2008 number:1 month:03 pages:3-14 https://dx.doi.org/10.1007/s12247-008-9022-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 3 2008 1 03 3-14 |
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Enthalten in Journal of pharmaceutical innovation 3(2008), 1 vom: März, Seite 3-14 volume:3 year:2008 number:1 month:03 pages:3-14 |
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Particle tracking velocimetry Droplet size distribution Spray pattern Droplet velocity distribution Spray coating Process analytical technology (PAT) Spray quality Coating uniformity |
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Chen, Wei @@aut@@ Chang, Shih-Ying @@aut@@ Kiang, San @@aut@@ Early, William @@aut@@ Paruchuri, Srinivasa @@aut@@ Desai, Divyakant @@aut@@ |
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2008-03-01T00:00:00Z |
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These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Particle tracking velocimetry</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Droplet size distribution</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Spray pattern</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Droplet velocity distribution</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Spray coating</subfield><subfield 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Chen, Wei |
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Chen, Wei ddc 610 bkl 44.40 misc Particle tracking velocimetry misc Droplet size distribution misc Spray pattern misc Droplet velocity distribution misc Spray coating misc Process analytical technology (PAT) misc Spray quality misc Coating uniformity The Measurement of Spray Quality for Pan Coating Processes |
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610 ASE 44.40 bkl The Measurement of Spray Quality for Pan Coating Processes Particle tracking velocimetry (dpeaa)DE-He213 Droplet size distribution (dpeaa)DE-He213 Spray pattern (dpeaa)DE-He213 Droplet velocity distribution (dpeaa)DE-He213 Spray coating (dpeaa)DE-He213 Process analytical technology (PAT) (dpeaa)DE-He213 Spray quality (dpeaa)DE-He213 Coating uniformity (dpeaa)DE-He213 |
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Chen, Wei Chang, Shih-Ying Kiang, San Early, William Paruchuri, Srinivasa Desai, Divyakant |
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measurement of spray quality for pan coating processes |
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The Measurement of Spray Quality for Pan Coating Processes |
| abstract |
Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. |
| abstractGer |
Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. |
| abstract_unstemmed |
Abstract In this study, we describe the use of an innovative imaging system to measure and control the effect of nozzle operating parameters on the characteristics of a spray. These characteristics, including spray pattern, droplet size distribution, and droplet velocity, define the quality of the spray. They can have significant impact on the efficiency of the pan coating process and the quality of the coat. Suspensions of different composition were used in this study, and the authors demonstrated that the spray characteristics can be controlled with this approach. The main conclusions from this study were:The AA/Spray (atomization air/spray rate) and AA/PA (atomization air/pattern air) mass flow ratios were the key parameters that affect spray characteristics. Although viscosity can impact the spray, there was minimal impact within the viscosity range tested in this study.With proper selection of the AA/Spray and AA/PA mass flow ratios, it was possible to generate sprays with consistent spatial distributions of volume flux with minimal variations of mean droplet size over the range of coating suspensions and spray rates studied. Spray characterization can be a powerful tool for exploring and establishing the design space of nozzles operation in the pan coating process. When scaling or transferring a spray coating process, the focus should be on maintaining consistent spray qualities rather than limiting nozzle operating parameters to a range. This approach embraces the FDA concept of process analytical technology (PAT) and design space (FDA, Guidance for industry PAT—A framework for innovative pharmaceutical development, manufacturing, and quality assurance, 2004) for science-based operation flexibility. |
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The Measurement of Spray Quality for Pan Coating Processes |
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| score |
7.4028063 |