MicroRNAs Challenge the Status Quo of Therapeutic Targeting
Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were...
Ausführliche Beschreibung
Autor*in: |
Sayed, Danish [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2008 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2008 |
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Übergeordnetes Werk: |
Enthalten in: Journal of cardiovascular translational research - New York, NY [u.a.] : Springer, 2008, 2(2008), 1 vom: 09. Sept., Seite 100-107 |
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Übergeordnetes Werk: |
volume:2 ; year:2008 ; number:1 ; day:09 ; month:09 ; pages:100-107 |
Links: |
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DOI / URN: |
10.1007/s12265-008-9052-y |
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Katalog-ID: |
SPR024639818 |
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245 | 1 | 0 | |a MicroRNAs Challenge the Status Quo of Therapeutic Targeting |
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520 | |a Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. | ||
650 | 4 | |a MicroRNA |7 (dpeaa)DE-He213 | |
650 | 4 | |a Posttranscriptional Regulation |7 (dpeaa)DE-He213 | |
650 | 4 | |a miRNA Eraser |7 (dpeaa)DE-He213 | |
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650 | 4 | |a miR-133a |7 (dpeaa)DE-He213 | |
650 | 4 | |a miR-21 |7 (dpeaa)DE-He213 | |
650 | 4 | |a Therapeutic Targeting |7 (dpeaa)DE-He213 | |
700 | 1 | |a Rane, Shweta |4 aut | |
700 | 1 | |a Abdellatif, Maha |4 aut | |
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912 | |a SYSFLAG_A | ||
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912 | |a GBV_ILN_90 | ||
912 | |a GBV_ILN_95 | ||
912 | |a GBV_ILN_100 | ||
912 | |a GBV_ILN_101 | ||
912 | |a GBV_ILN_105 | ||
912 | |a GBV_ILN_110 | ||
912 | |a GBV_ILN_120 | ||
912 | |a GBV_ILN_138 | ||
912 | |a GBV_ILN_150 | ||
912 | |a GBV_ILN_151 | ||
912 | |a GBV_ILN_161 | ||
912 | |a GBV_ILN_170 | ||
912 | |a GBV_ILN_171 | ||
912 | |a GBV_ILN_187 | ||
912 | |a GBV_ILN_213 | ||
912 | |a GBV_ILN_224 | ||
912 | |a GBV_ILN_230 | ||
912 | |a GBV_ILN_250 | ||
912 | |a GBV_ILN_281 | ||
912 | |a GBV_ILN_285 | ||
912 | |a GBV_ILN_293 | ||
912 | |a GBV_ILN_370 | ||
912 | |a GBV_ILN_602 | ||
912 | |a GBV_ILN_636 | ||
912 | |a GBV_ILN_702 | ||
912 | |a GBV_ILN_2001 | ||
912 | |a GBV_ILN_2003 | ||
912 | |a GBV_ILN_2004 | ||
912 | |a GBV_ILN_2005 | ||
912 | |a GBV_ILN_2006 | ||
912 | |a GBV_ILN_2007 | ||
912 | |a GBV_ILN_2008 | ||
912 | |a GBV_ILN_2009 | ||
912 | |a GBV_ILN_2010 | ||
912 | |a GBV_ILN_2011 | ||
912 | |a GBV_ILN_2014 | ||
912 | |a GBV_ILN_2015 | ||
912 | |a GBV_ILN_2020 | ||
912 | |a GBV_ILN_2021 | ||
912 | |a GBV_ILN_2025 | ||
912 | |a GBV_ILN_2026 | ||
912 | |a GBV_ILN_2027 | ||
912 | |a GBV_ILN_2031 | ||
912 | |a GBV_ILN_2034 | ||
912 | |a GBV_ILN_2037 | ||
912 | |a GBV_ILN_2038 | ||
912 | |a GBV_ILN_2039 | ||
912 | |a GBV_ILN_2044 | ||
912 | |a GBV_ILN_2048 | ||
912 | |a GBV_ILN_2049 | ||
912 | |a GBV_ILN_2050 | ||
912 | |a GBV_ILN_2055 | ||
912 | |a GBV_ILN_2057 | ||
912 | |a GBV_ILN_2059 | ||
912 | |a GBV_ILN_2061 | ||
912 | |a GBV_ILN_2064 | ||
912 | |a GBV_ILN_2065 | ||
912 | |a GBV_ILN_2068 | ||
912 | |a GBV_ILN_2070 | ||
912 | |a GBV_ILN_2086 | ||
912 | |a GBV_ILN_2088 | ||
912 | |a GBV_ILN_2093 | ||
912 | |a GBV_ILN_2106 | ||
912 | |a GBV_ILN_2107 | ||
912 | |a GBV_ILN_2108 | ||
912 | |a GBV_ILN_2110 | ||
912 | |a GBV_ILN_2111 | ||
912 | |a GBV_ILN_2112 | ||
912 | |a GBV_ILN_2113 | ||
912 | |a GBV_ILN_2116 | ||
912 | |a GBV_ILN_2118 | ||
912 | |a GBV_ILN_2119 | ||
912 | |a GBV_ILN_2122 | ||
912 | |a GBV_ILN_2129 | ||
912 | |a GBV_ILN_2143 | ||
912 | |a GBV_ILN_2144 | ||
912 | |a GBV_ILN_2147 | ||
912 | |a GBV_ILN_2148 | ||
912 | |a GBV_ILN_2152 | ||
912 | |a GBV_ILN_2153 | ||
912 | |a GBV_ILN_2188 | ||
912 | |a GBV_ILN_2190 | ||
912 | |a GBV_ILN_2232 | ||
912 | |a GBV_ILN_2336 | ||
912 | |a GBV_ILN_2446 | ||
912 | |a GBV_ILN_2470 | ||
912 | |a GBV_ILN_2472 | ||
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allfields |
10.1007/s12265-008-9052-y doi (DE-627)SPR024639818 (SPR)s12265-008-9052-y-e DE-627 ger DE-627 rakwb eng Sayed, Danish verfasserin aut MicroRNAs Challenge the Status Quo of Therapeutic Targeting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2008 Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. MicroRNA (dpeaa)DE-He213 Posttranscriptional Regulation (dpeaa)DE-He213 miRNA Eraser (dpeaa)DE-He213 miR-1 (dpeaa)DE-He213 miR-133a (dpeaa)DE-He213 miR-21 (dpeaa)DE-He213 Therapeutic Targeting (dpeaa)DE-He213 Rane, Shweta aut Abdellatif, Maha aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 2(2008), 1 vom: 09. Sept., Seite 100-107 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:2 year:2008 number:1 day:09 month:09 pages:100-107 https://dx.doi.org/10.1007/s12265-008-9052-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 1 09 09 100-107 |
spelling |
10.1007/s12265-008-9052-y doi (DE-627)SPR024639818 (SPR)s12265-008-9052-y-e DE-627 ger DE-627 rakwb eng Sayed, Danish verfasserin aut MicroRNAs Challenge the Status Quo of Therapeutic Targeting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2008 Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. MicroRNA (dpeaa)DE-He213 Posttranscriptional Regulation (dpeaa)DE-He213 miRNA Eraser (dpeaa)DE-He213 miR-1 (dpeaa)DE-He213 miR-133a (dpeaa)DE-He213 miR-21 (dpeaa)DE-He213 Therapeutic Targeting (dpeaa)DE-He213 Rane, Shweta aut Abdellatif, Maha aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 2(2008), 1 vom: 09. Sept., Seite 100-107 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:2 year:2008 number:1 day:09 month:09 pages:100-107 https://dx.doi.org/10.1007/s12265-008-9052-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 1 09 09 100-107 |
allfields_unstemmed |
10.1007/s12265-008-9052-y doi (DE-627)SPR024639818 (SPR)s12265-008-9052-y-e DE-627 ger DE-627 rakwb eng Sayed, Danish verfasserin aut MicroRNAs Challenge the Status Quo of Therapeutic Targeting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2008 Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. MicroRNA (dpeaa)DE-He213 Posttranscriptional Regulation (dpeaa)DE-He213 miRNA Eraser (dpeaa)DE-He213 miR-1 (dpeaa)DE-He213 miR-133a (dpeaa)DE-He213 miR-21 (dpeaa)DE-He213 Therapeutic Targeting (dpeaa)DE-He213 Rane, Shweta aut Abdellatif, Maha aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 2(2008), 1 vom: 09. Sept., Seite 100-107 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:2 year:2008 number:1 day:09 month:09 pages:100-107 https://dx.doi.org/10.1007/s12265-008-9052-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 1 09 09 100-107 |
allfieldsGer |
10.1007/s12265-008-9052-y doi (DE-627)SPR024639818 (SPR)s12265-008-9052-y-e DE-627 ger DE-627 rakwb eng Sayed, Danish verfasserin aut MicroRNAs Challenge the Status Quo of Therapeutic Targeting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2008 Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. MicroRNA (dpeaa)DE-He213 Posttranscriptional Regulation (dpeaa)DE-He213 miRNA Eraser (dpeaa)DE-He213 miR-1 (dpeaa)DE-He213 miR-133a (dpeaa)DE-He213 miR-21 (dpeaa)DE-He213 Therapeutic Targeting (dpeaa)DE-He213 Rane, Shweta aut Abdellatif, Maha aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 2(2008), 1 vom: 09. Sept., Seite 100-107 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:2 year:2008 number:1 day:09 month:09 pages:100-107 https://dx.doi.org/10.1007/s12265-008-9052-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 1 09 09 100-107 |
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10.1007/s12265-008-9052-y doi (DE-627)SPR024639818 (SPR)s12265-008-9052-y-e DE-627 ger DE-627 rakwb eng Sayed, Danish verfasserin aut MicroRNAs Challenge the Status Quo of Therapeutic Targeting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2008 Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. MicroRNA (dpeaa)DE-He213 Posttranscriptional Regulation (dpeaa)DE-He213 miRNA Eraser (dpeaa)DE-He213 miR-1 (dpeaa)DE-He213 miR-133a (dpeaa)DE-He213 miR-21 (dpeaa)DE-He213 Therapeutic Targeting (dpeaa)DE-He213 Rane, Shweta aut Abdellatif, Maha aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 2(2008), 1 vom: 09. Sept., Seite 100-107 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:2 year:2008 number:1 day:09 month:09 pages:100-107 https://dx.doi.org/10.1007/s12265-008-9052-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2008 1 09 09 100-107 |
language |
English |
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Enthalten in Journal of cardiovascular translational research 2(2008), 1 vom: 09. Sept., Seite 100-107 volume:2 year:2008 number:1 day:09 month:09 pages:100-107 |
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Enthalten in Journal of cardiovascular translational research 2(2008), 1 vom: 09. Sept., Seite 100-107 volume:2 year:2008 number:1 day:09 month:09 pages:100-107 |
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MicroRNA Posttranscriptional Regulation miRNA Eraser miR-1 miR-133a miR-21 Therapeutic Targeting |
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Journal of cardiovascular translational research |
authorswithroles_txt_mv |
Sayed, Danish @@aut@@ Rane, Shweta @@aut@@ Abdellatif, Maha @@aut@@ |
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2008-09-09T00:00:00Z |
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MicroRNAs Challenge the Status Quo of Therapeutic Targeting MicroRNA (dpeaa)DE-He213 Posttranscriptional Regulation (dpeaa)DE-He213 miRNA Eraser (dpeaa)DE-He213 miR-1 (dpeaa)DE-He213 miR-133a (dpeaa)DE-He213 miR-21 (dpeaa)DE-He213 Therapeutic Targeting (dpeaa)DE-He213 |
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MicroRNAs Challenge the Status Quo of Therapeutic Targeting |
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micrornas challenge the status quo of therapeutic targeting |
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MicroRNAs Challenge the Status Quo of Therapeutic Targeting |
abstract |
Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. © The Author(s) 2008 |
abstractGer |
Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. © The Author(s) 2008 |
abstract_unstemmed |
Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting. © The Author(s) 2008 |
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MicroRNAs Challenge the Status Quo of Therapeutic Targeting |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR024639818</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519101014.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2008 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12265-008-9052-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR024639818</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12265-008-9052-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sayed, Danish</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">MicroRNAs Challenge the Status Quo of Therapeutic Targeting</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2008</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. 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