Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study
Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and befo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Synetos, Andreas [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC, part of Springer Nature 2018 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of cardiovascular translational research - New York, NY [u.a.] : Springer, 2008, 11(2018), 3 vom: 26. März, Seite 192-200 |
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| Übergeordnetes Werk: |
volume:11 ; year:2018 ; number:3 ; day:26 ; month:03 ; pages:192-200 |
| Links: |
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| DOI / URN: |
10.1007/s12265-018-9802-4 |
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| Katalog-ID: |
SPR024647799 |
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| 520 | |a Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. | ||
| 650 | 4 | |a Bisphosphonates |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Aortic valve |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Calcification |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Toutouzas, Konstantinos |4 aut | |
| 700 | 1 | |a Drakopoulou, Maria |4 aut | |
| 700 | 1 | |a Koutagiar, Iosif |4 aut | |
| 700 | 1 | |a Benetos, George |4 aut | |
| 700 | 1 | |a Kotronias, Rafail |4 aut | |
| 700 | 1 | |a Anousakis-Vlachochristou, Nikolaos |4 aut | |
| 700 | 1 | |a Latsios, George |4 aut | |
| 700 | 1 | |a Karanasos, Antonis |4 aut | |
| 700 | 1 | |a Agrogiannis, George |4 aut | |
| 700 | 1 | |a Metaxas, Marinos |4 aut | |
| 700 | 1 | |a Stathogiannis, Konstantinos |4 aut | |
| 700 | 1 | |a Papanikolaou, Aggelos |4 aut | |
| 700 | 1 | |a Georgakopoulos, Alexandros |4 aut | |
| 700 | 1 | |a Pianou, Nikoleta |4 aut | |
| 700 | 1 | |a Tsiamis, Eleftherios |4 aut | |
| 700 | 1 | |a Patsouris, Efstratios |4 aut | |
| 700 | 1 | |a Papalois, Apostolos |4 aut | |
| 700 | 1 | |a Cokkinos, Dennis |4 aut | |
| 700 | 1 | |a Anagnostopoulos, Constantinos |4 aut | |
| 700 | 1 | |a Tousoulis, Dimitrios |4 aut | |
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10.1007/s12265-018-9802-4 doi (DE-627)SPR024647799 (SPR)s12265-018-9802-4-e DE-627 ger DE-627 rakwb eng Synetos, Andreas verfasserin (orcid)0000-0001-8516-1177 aut Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. Bisphosphonates (dpeaa)DE-He213 Aortic valve (dpeaa)DE-He213 Calcification (dpeaa)DE-He213 Toutouzas, Konstantinos aut Drakopoulou, Maria aut Koutagiar, Iosif aut Benetos, George aut Kotronias, Rafail aut Anousakis-Vlachochristou, Nikolaos aut Latsios, George aut Karanasos, Antonis aut Agrogiannis, George aut Metaxas, Marinos aut Stathogiannis, Konstantinos aut Papanikolaou, Aggelos aut Georgakopoulos, Alexandros aut Pianou, Nikoleta aut Tsiamis, Eleftherios aut Patsouris, Efstratios aut Papalois, Apostolos aut Cokkinos, Dennis aut Anagnostopoulos, Constantinos aut Tousoulis, Dimitrios aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 11(2018), 3 vom: 26. März, Seite 192-200 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:11 year:2018 number:3 day:26 month:03 pages:192-200 https://dx.doi.org/10.1007/s12265-018-9802-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2018 3 26 03 192-200 |
| spelling |
10.1007/s12265-018-9802-4 doi (DE-627)SPR024647799 (SPR)s12265-018-9802-4-e DE-627 ger DE-627 rakwb eng Synetos, Andreas verfasserin (orcid)0000-0001-8516-1177 aut Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. Bisphosphonates (dpeaa)DE-He213 Aortic valve (dpeaa)DE-He213 Calcification (dpeaa)DE-He213 Toutouzas, Konstantinos aut Drakopoulou, Maria aut Koutagiar, Iosif aut Benetos, George aut Kotronias, Rafail aut Anousakis-Vlachochristou, Nikolaos aut Latsios, George aut Karanasos, Antonis aut Agrogiannis, George aut Metaxas, Marinos aut Stathogiannis, Konstantinos aut Papanikolaou, Aggelos aut Georgakopoulos, Alexandros aut Pianou, Nikoleta aut Tsiamis, Eleftherios aut Patsouris, Efstratios aut Papalois, Apostolos aut Cokkinos, Dennis aut Anagnostopoulos, Constantinos aut Tousoulis, Dimitrios aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 11(2018), 3 vom: 26. März, Seite 192-200 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:11 year:2018 number:3 day:26 month:03 pages:192-200 https://dx.doi.org/10.1007/s12265-018-9802-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2018 3 26 03 192-200 |
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10.1007/s12265-018-9802-4 doi (DE-627)SPR024647799 (SPR)s12265-018-9802-4-e DE-627 ger DE-627 rakwb eng Synetos, Andreas verfasserin (orcid)0000-0001-8516-1177 aut Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. Bisphosphonates (dpeaa)DE-He213 Aortic valve (dpeaa)DE-He213 Calcification (dpeaa)DE-He213 Toutouzas, Konstantinos aut Drakopoulou, Maria aut Koutagiar, Iosif aut Benetos, George aut Kotronias, Rafail aut Anousakis-Vlachochristou, Nikolaos aut Latsios, George aut Karanasos, Antonis aut Agrogiannis, George aut Metaxas, Marinos aut Stathogiannis, Konstantinos aut Papanikolaou, Aggelos aut Georgakopoulos, Alexandros aut Pianou, Nikoleta aut Tsiamis, Eleftherios aut Patsouris, Efstratios aut Papalois, Apostolos aut Cokkinos, Dennis aut Anagnostopoulos, Constantinos aut Tousoulis, Dimitrios aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 11(2018), 3 vom: 26. März, Seite 192-200 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:11 year:2018 number:3 day:26 month:03 pages:192-200 https://dx.doi.org/10.1007/s12265-018-9802-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2018 3 26 03 192-200 |
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10.1007/s12265-018-9802-4 doi (DE-627)SPR024647799 (SPR)s12265-018-9802-4-e DE-627 ger DE-627 rakwb eng Synetos, Andreas verfasserin (orcid)0000-0001-8516-1177 aut Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. Bisphosphonates (dpeaa)DE-He213 Aortic valve (dpeaa)DE-He213 Calcification (dpeaa)DE-He213 Toutouzas, Konstantinos aut Drakopoulou, Maria aut Koutagiar, Iosif aut Benetos, George aut Kotronias, Rafail aut Anousakis-Vlachochristou, Nikolaos aut Latsios, George aut Karanasos, Antonis aut Agrogiannis, George aut Metaxas, Marinos aut Stathogiannis, Konstantinos aut Papanikolaou, Aggelos aut Georgakopoulos, Alexandros aut Pianou, Nikoleta aut Tsiamis, Eleftherios aut Patsouris, Efstratios aut Papalois, Apostolos aut Cokkinos, Dennis aut Anagnostopoulos, Constantinos aut Tousoulis, Dimitrios aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 11(2018), 3 vom: 26. März, Seite 192-200 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:11 year:2018 number:3 day:26 month:03 pages:192-200 https://dx.doi.org/10.1007/s12265-018-9802-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2018 3 26 03 192-200 |
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10.1007/s12265-018-9802-4 doi (DE-627)SPR024647799 (SPR)s12265-018-9802-4-e DE-627 ger DE-627 rakwb eng Synetos, Andreas verfasserin (orcid)0000-0001-8516-1177 aut Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. Bisphosphonates (dpeaa)DE-He213 Aortic valve (dpeaa)DE-He213 Calcification (dpeaa)DE-He213 Toutouzas, Konstantinos aut Drakopoulou, Maria aut Koutagiar, Iosif aut Benetos, George aut Kotronias, Rafail aut Anousakis-Vlachochristou, Nikolaos aut Latsios, George aut Karanasos, Antonis aut Agrogiannis, George aut Metaxas, Marinos aut Stathogiannis, Konstantinos aut Papanikolaou, Aggelos aut Georgakopoulos, Alexandros aut Pianou, Nikoleta aut Tsiamis, Eleftherios aut Patsouris, Efstratios aut Papalois, Apostolos aut Cokkinos, Dennis aut Anagnostopoulos, Constantinos aut Tousoulis, Dimitrios aut Enthalten in Journal of cardiovascular translational research New York, NY [u.a.] : Springer, 2008 11(2018), 3 vom: 26. März, Seite 192-200 (DE-627)564751529 (DE-600)2422411-X 1937-5395 nnns volume:11 year:2018 number:3 day:26 month:03 pages:192-200 https://dx.doi.org/10.1007/s12265-018-9802-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2018 3 26 03 192-200 |
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Enthalten in Journal of cardiovascular translational research 11(2018), 3 vom: 26. März, Seite 192-200 volume:11 year:2018 number:3 day:26 month:03 pages:192-200 |
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Enthalten in Journal of cardiovascular translational research 11(2018), 3 vom: 26. März, Seite 192-200 volume:11 year:2018 number:3 day:26 month:03 pages:192-200 |
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Synetos, Andreas @@aut@@ Toutouzas, Konstantinos @@aut@@ Drakopoulou, Maria @@aut@@ Koutagiar, Iosif @@aut@@ Benetos, George @@aut@@ Kotronias, Rafail @@aut@@ Anousakis-Vlachochristou, Nikolaos @@aut@@ Latsios, George @@aut@@ Karanasos, Antonis @@aut@@ Agrogiannis, George @@aut@@ Metaxas, Marinos @@aut@@ Stathogiannis, Konstantinos @@aut@@ Papanikolaou, Aggelos @@aut@@ Georgakopoulos, Alexandros @@aut@@ Pianou, Nikoleta @@aut@@ Tsiamis, Eleftherios @@aut@@ Patsouris, Efstratios @@aut@@ Papalois, Apostolos @@aut@@ Cokkinos, Dennis @@aut@@ Anagnostopoulos, Constantinos @@aut@@ Tousoulis, Dimitrios @@aut@@ |
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Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. 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Synetos, Andreas |
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Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study Bisphosphonates (dpeaa)DE-He213 Aortic valve (dpeaa)DE-He213 Calcification (dpeaa)DE-He213 |
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Synetos, Andreas Toutouzas, Konstantinos Drakopoulou, Maria Koutagiar, Iosif Benetos, George Kotronias, Rafail Anousakis-Vlachochristou, Nikolaos Latsios, George Karanasos, Antonis Agrogiannis, George Metaxas, Marinos Stathogiannis, Konstantinos Papanikolaou, Aggelos Georgakopoulos, Alexandros Pianou, Nikoleta Tsiamis, Eleftherios Patsouris, Efstratios Papalois, Apostolos Cokkinos, Dennis Anagnostopoulos, Constantinos Tousoulis, Dimitrios |
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inhibition of aortic valve calcification by local delivery of zoledronic acid—an experimental study |
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Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study |
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Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. © Springer Science+Business Media, LLC, part of Springer Nature 2018 |
| abstractGer |
Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. © Springer Science+Business Media, LLC, part of Springer Nature 2018 |
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Abstract The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. © Springer Science+Business Media, LLC, part of Springer Nature 2018 |
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| score |
7.4001484 |