Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy
Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergis...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Xu, Keqiang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Anmerkung: |
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Nano research - [S.l.] : Tsinghua Press, 2008, 12(2019), 12 vom: 23. Okt., Seite 2947-2953 |
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| Übergeordnetes Werk: |
volume:12 ; year:2019 ; number:12 ; day:23 ; month:10 ; pages:2947-2953 |
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| DOI / URN: |
10.1007/s12274-019-2532-3 |
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| Katalog-ID: |
SPR024731358 |
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| 100 | 1 | |a Xu, Keqiang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy |
| 264 | 1 | |c 2019 | |
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| 500 | |a © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 | ||
| 520 | |a Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. | ||
| 650 | 4 | |a photothermal therapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a chemodynamic therapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a polydopamine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a cerium oxide |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Cheng, Yan |4 aut | |
| 700 | 1 | |a Yan, Jiao |4 aut | |
| 700 | 1 | |a Feng, Yanlin |4 aut | |
| 700 | 1 | |a Zheng, Runxiao |4 aut | |
| 700 | 1 | |a Wu, Xiaqing |4 aut | |
| 700 | 1 | |a Wang, Yanjing |4 aut | |
| 700 | 1 | |a Song, Panpan |4 aut | |
| 700 | 1 | |a Zhang, Haiyuan |4 aut | |
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10.1007/s12274-019-2532-3 doi (DE-627)SPR024731358 (SPR)s12274-019-2532-3-e DE-627 ger DE-627 rakwb eng Xu, Keqiang verfasserin aut Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. photothermal therapy (dpeaa)DE-He213 chemotherapy (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 polydopamine (dpeaa)DE-He213 cerium oxide (dpeaa)DE-He213 Cheng, Yan aut Yan, Jiao aut Feng, Yanlin aut Zheng, Runxiao aut Wu, Xiaqing aut Wang, Yanjing aut Song, Panpan aut Zhang, Haiyuan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 12(2019), 12 vom: 23. Okt., Seite 2947-2953 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:12 year:2019 number:12 day:23 month:10 pages:2947-2953 https://dx.doi.org/10.1007/s12274-019-2532-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 12 23 10 2947-2953 |
| spelling |
10.1007/s12274-019-2532-3 doi (DE-627)SPR024731358 (SPR)s12274-019-2532-3-e DE-627 ger DE-627 rakwb eng Xu, Keqiang verfasserin aut Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. photothermal therapy (dpeaa)DE-He213 chemotherapy (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 polydopamine (dpeaa)DE-He213 cerium oxide (dpeaa)DE-He213 Cheng, Yan aut Yan, Jiao aut Feng, Yanlin aut Zheng, Runxiao aut Wu, Xiaqing aut Wang, Yanjing aut Song, Panpan aut Zhang, Haiyuan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 12(2019), 12 vom: 23. Okt., Seite 2947-2953 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:12 year:2019 number:12 day:23 month:10 pages:2947-2953 https://dx.doi.org/10.1007/s12274-019-2532-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 12 23 10 2947-2953 |
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10.1007/s12274-019-2532-3 doi (DE-627)SPR024731358 (SPR)s12274-019-2532-3-e DE-627 ger DE-627 rakwb eng Xu, Keqiang verfasserin aut Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. photothermal therapy (dpeaa)DE-He213 chemotherapy (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 polydopamine (dpeaa)DE-He213 cerium oxide (dpeaa)DE-He213 Cheng, Yan aut Yan, Jiao aut Feng, Yanlin aut Zheng, Runxiao aut Wu, Xiaqing aut Wang, Yanjing aut Song, Panpan aut Zhang, Haiyuan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 12(2019), 12 vom: 23. Okt., Seite 2947-2953 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:12 year:2019 number:12 day:23 month:10 pages:2947-2953 https://dx.doi.org/10.1007/s12274-019-2532-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 12 23 10 2947-2953 |
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10.1007/s12274-019-2532-3 doi (DE-627)SPR024731358 (SPR)s12274-019-2532-3-e DE-627 ger DE-627 rakwb eng Xu, Keqiang verfasserin aut Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. photothermal therapy (dpeaa)DE-He213 chemotherapy (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 polydopamine (dpeaa)DE-He213 cerium oxide (dpeaa)DE-He213 Cheng, Yan aut Yan, Jiao aut Feng, Yanlin aut Zheng, Runxiao aut Wu, Xiaqing aut Wang, Yanjing aut Song, Panpan aut Zhang, Haiyuan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 12(2019), 12 vom: 23. Okt., Seite 2947-2953 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:12 year:2019 number:12 day:23 month:10 pages:2947-2953 https://dx.doi.org/10.1007/s12274-019-2532-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 12 23 10 2947-2953 |
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10.1007/s12274-019-2532-3 doi (DE-627)SPR024731358 (SPR)s12274-019-2532-3-e DE-627 ger DE-627 rakwb eng Xu, Keqiang verfasserin aut Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. photothermal therapy (dpeaa)DE-He213 chemotherapy (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 polydopamine (dpeaa)DE-He213 cerium oxide (dpeaa)DE-He213 Cheng, Yan aut Yan, Jiao aut Feng, Yanlin aut Zheng, Runxiao aut Wu, Xiaqing aut Wang, Yanjing aut Song, Panpan aut Zhang, Haiyuan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 12(2019), 12 vom: 23. Okt., Seite 2947-2953 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:12 year:2019 number:12 day:23 month:10 pages:2947-2953 https://dx.doi.org/10.1007/s12274-019-2532-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 12 23 10 2947-2953 |
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Enthalten in Nano research 12(2019), 12 vom: 23. Okt., Seite 2947-2953 volume:12 year:2019 number:12 day:23 month:10 pages:2947-2953 |
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Enthalten in Nano research 12(2019), 12 vom: 23. Okt., Seite 2947-2953 volume:12 year:2019 number:12 day:23 month:10 pages:2947-2953 |
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Xu, Keqiang @@aut@@ Cheng, Yan @@aut@@ Yan, Jiao @@aut@@ Feng, Yanlin @@aut@@ Zheng, Runxiao @@aut@@ Wu, Xiaqing @@aut@@ Wang, Yanjing @@aut@@ Song, Panpan @@aut@@ Zhang, Haiyuan @@aut@@ |
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Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. 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Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy photothermal therapy (dpeaa)DE-He213 chemotherapy (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 polydopamine (dpeaa)DE-He213 cerium oxide (dpeaa)DE-He213 |
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Xu, Keqiang Cheng, Yan Yan, Jiao Feng, Yanlin Zheng, Runxiao Wu, Xiaqing Wang, Yanjing Song, Panpan Zhang, Haiyuan |
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polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy |
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Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy |
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Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 |
| abstractGer |
Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 |
| abstract_unstemmed |
Abstract The development of effective nanoplatforms is extremely necessary for cancer therapy. Herein, we prepared polydopamine (PDA) and ammonium bicarbonate ($ NH_{4} %$ HCO_{3} $) coated and doxorubicin (Dox) loaded hollow cerium oxide ($ CeO_{2} $) NPs (PDAC NPs), which showed excellent synergistic effect for photothermal therapy, chemotherapy and chemodynamic therapy. Under near infrared laser irradiation, PDA shell could absorb the incident light and convert it into heat, which could not only kill tumor cells with hyperthermia, but also trigger the decomposition of $ NH_{4} %$ HCO_{3} $ into gaseous carbon dioxide and ammonia, leading to the destroy of PDA shell. The leakage of PDA further accelerated Dox release and exposed $ CeO_{2} $ surface, in which Dox could enter into cell nucleus to induce chemotherapy, and $ CeO_{2} $ could catalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy. In fact, PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo. This design provides a new strategy for synergistic tumor therapy. © Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019 |
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Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy |
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Cheng, Yan Yan, Jiao Feng, Yanlin Zheng, Runxiao Wu, Xiaqing Wang, Yanjing Song, Panpan Zhang, Haiyuan |
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Cheng, Yan Yan, Jiao Feng, Yanlin Zheng, Runxiao Wu, Xiaqing Wang, Yanjing Song, Panpan Zhang, Haiyuan |
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| score |
7.400199 |