Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia

Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome...
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Autor*in:	Peterson, Jess F. [verfasserIn] Smoley, Stephanie A. Luoma, Ivy M. Pitel, Beth A. Rice, Christopher S. Benevides Demasi, Jonna C. Vasmatzis, George Smadbeck, James B. Yang, Tong Greipp, Patricia T. Ketterling, Rhett P. Baughn, Linda B.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	( ) B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) Next-generation sequencing (NGS) Mate-pair sequencing (MPseq)

Anmerkung:	© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Übergeordnetes Werk:	Enthalten in: Journal of hematopathology - Berlin : Springer, 2008, 12(2019), 2 vom: 03. Mai, Seite 99-104
Übergeordnetes Werk:	volume:12 ; year:2019 ; number:2 ; day:03 ; month:05 ; pages:99-104

Links:	Volltext

DOI / URN:	10.1007/s12308-019-00355-x

Katalog-ID:	SPR024893552

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allfields	10.1007/s12308-019-00355-x doi (DE-627)SPR024893552 (SPR)s12308-019-00355-x-e DE-627 ger DE-627 rakwb eng Peterson, Jess F. verfasserin aut Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) (dpeaa)DE-He213 Next-generation sequencing (NGS) (dpeaa)DE-He213 Mate-pair sequencing (MPseq) (dpeaa)DE-He213 Smoley, Stephanie A. aut Luoma, Ivy M. aut Pitel, Beth A. aut Rice, Christopher S. aut Benevides Demasi, Jonna C. aut Vasmatzis, George aut Smadbeck, James B. aut Yang, Tong aut Greipp, Patricia T. aut Ketterling, Rhett P. aut Baughn, Linda B. aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 12(2019), 2 vom: 03. Mai, Seite 99-104 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:12 year:2019 number:2 day:03 month:05 pages:99-104 https://dx.doi.org/10.1007/s12308-019-00355-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 2 03 05 99-104
spelling	10.1007/s12308-019-00355-x doi (DE-627)SPR024893552 (SPR)s12308-019-00355-x-e DE-627 ger DE-627 rakwb eng Peterson, Jess F. verfasserin aut Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) (dpeaa)DE-He213 Next-generation sequencing (NGS) (dpeaa)DE-He213 Mate-pair sequencing (MPseq) (dpeaa)DE-He213 Smoley, Stephanie A. aut Luoma, Ivy M. aut Pitel, Beth A. aut Rice, Christopher S. aut Benevides Demasi, Jonna C. aut Vasmatzis, George aut Smadbeck, James B. aut Yang, Tong aut Greipp, Patricia T. aut Ketterling, Rhett P. aut Baughn, Linda B. aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 12(2019), 2 vom: 03. Mai, Seite 99-104 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:12 year:2019 number:2 day:03 month:05 pages:99-104 https://dx.doi.org/10.1007/s12308-019-00355-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 2 03 05 99-104
allfields_unstemmed	10.1007/s12308-019-00355-x doi (DE-627)SPR024893552 (SPR)s12308-019-00355-x-e DE-627 ger DE-627 rakwb eng Peterson, Jess F. verfasserin aut Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) (dpeaa)DE-He213 Next-generation sequencing (NGS) (dpeaa)DE-He213 Mate-pair sequencing (MPseq) (dpeaa)DE-He213 Smoley, Stephanie A. aut Luoma, Ivy M. aut Pitel, Beth A. aut Rice, Christopher S. aut Benevides Demasi, Jonna C. aut Vasmatzis, George aut Smadbeck, James B. aut Yang, Tong aut Greipp, Patricia T. aut Ketterling, Rhett P. aut Baughn, Linda B. aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 12(2019), 2 vom: 03. Mai, Seite 99-104 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:12 year:2019 number:2 day:03 month:05 pages:99-104 https://dx.doi.org/10.1007/s12308-019-00355-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 2 03 05 99-104
allfieldsGer	10.1007/s12308-019-00355-x doi (DE-627)SPR024893552 (SPR)s12308-019-00355-x-e DE-627 ger DE-627 rakwb eng Peterson, Jess F. verfasserin aut Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) (dpeaa)DE-He213 Next-generation sequencing (NGS) (dpeaa)DE-He213 Mate-pair sequencing (MPseq) (dpeaa)DE-He213 Smoley, Stephanie A. aut Luoma, Ivy M. aut Pitel, Beth A. aut Rice, Christopher S. aut Benevides Demasi, Jonna C. aut Vasmatzis, George aut Smadbeck, James B. aut Yang, Tong aut Greipp, Patricia T. aut Ketterling, Rhett P. aut Baughn, Linda B. aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 12(2019), 2 vom: 03. Mai, Seite 99-104 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:12 year:2019 number:2 day:03 month:05 pages:99-104 https://dx.doi.org/10.1007/s12308-019-00355-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 2 03 05 99-104
allfieldsSound	10.1007/s12308-019-00355-x doi (DE-627)SPR024893552 (SPR)s12308-019-00355-x-e DE-627 ger DE-627 rakwb eng Peterson, Jess F. verfasserin aut Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) (dpeaa)DE-He213 Next-generation sequencing (NGS) (dpeaa)DE-He213 Mate-pair sequencing (MPseq) (dpeaa)DE-He213 Smoley, Stephanie A. aut Luoma, Ivy M. aut Pitel, Beth A. aut Rice, Christopher S. aut Benevides Demasi, Jonna C. aut Vasmatzis, George aut Smadbeck, James B. aut Yang, Tong aut Greipp, Patricia T. aut Ketterling, Rhett P. aut Baughn, Linda B. aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 12(2019), 2 vom: 03. Mai, Seite 99-104 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:12 year:2019 number:2 day:03 month:05 pages:99-104 https://dx.doi.org/10.1007/s12308-019-00355-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2019 2 03 05 99-104
language	English
source	Enthalten in Journal of hematopathology 12(2019), 2 vom: 03. Mai, Seite 99-104 volume:12 year:2019 number:2 day:03 month:05 pages:99-104
sourceStr	Enthalten in Journal of hematopathology 12(2019), 2 vom: 03. Mai, Seite 99-104 volume:12 year:2019 number:2 day:03 month:05 pages:99-104
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	( ) B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) Next-generation sequencing (NGS) Mate-pair sequencing (MPseq)
isfreeaccess_bool	false
container_title	Journal of hematopathology
authorswithroles_txt_mv	Peterson, Jess F. @@aut@@ Smoley, Stephanie A. @@aut@@ Luoma, Ivy M. @@aut@@ Pitel, Beth A. @@aut@@ Rice, Christopher S. @@aut@@ Benevides Demasi, Jonna C. @@aut@@ Vasmatzis, George @@aut@@ Smadbeck, James B. @@aut@@ Yang, Tong @@aut@@ Greipp, Patricia T. @@aut@@ Ketterling, Rhett P. @@aut@@ Baughn, Linda B. @@aut@@
publishDateDaySort_date	2019-05-03T00:00:00Z
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id	SPR024893552
language_de	englisch
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author	Peterson, Jess F.
spellingShingle	Peterson, Jess F. misc ( misc ) misc B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) misc Next-generation sequencing (NGS) misc Mate-pair sequencing (MPseq) Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia
authorStr	Peterson, Jess F.
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topic_title	Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia ( (dpeaa)DE-He213 ) (dpeaa)DE-He213 B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) (dpeaa)DE-He213 Next-generation sequencing (NGS) (dpeaa)DE-He213 Mate-pair sequencing (MPseq) (dpeaa)DE-He213
topic	misc ( misc ) misc B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) misc Next-generation sequencing (NGS) misc Mate-pair sequencing (MPseq)
topic_unstemmed	misc ( misc ) misc B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) misc Next-generation sequencing (NGS) misc Mate-pair sequencing (MPseq)
topic_browse	misc ( misc ) misc B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) misc Next-generation sequencing (NGS) misc Mate-pair sequencing (MPseq)
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title	Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia
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title_full	Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia
author_sort	Peterson, Jess F.
journal	Journal of hematopathology
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author_browse	Peterson, Jess F. Smoley, Stephanie A. Luoma, Ivy M. Pitel, Beth A. Rice, Christopher S. Benevides Demasi, Jonna C. Vasmatzis, George Smadbeck, James B. Yang, Tong Greipp, Patricia T. Ketterling, Rhett P. Baughn, Linda B.
container_volume	12
format_se	Elektronische Aufsätze
author-letter	Peterson, Jess F.
doi_str_mv	10.1007/s12308-019-00355-x
title_sort	characterization of a cryptic kmt2a/aff1 gene fusion by mate-pair sequencing (mpseq) in a young adult with newly diagnosed b-lymphoblastic leukemia
title_auth	Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia
abstract	Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. © Springer-Verlag GmbH Germany, part of Springer Nature 2019
abstractGer	Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. © Springer-Verlag GmbH Germany, part of Springer Nature 2019
abstract_unstemmed	Abstract The detection of recurrent chromosomal rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is critical for patient management decisions. We present a newly diagnosed case of B-ALL in a young adult with a cryptic KMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH) KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that created KMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. © Springer-Verlag GmbH Germany, part of Springer Nature 2019
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title_short	Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia
url	https://dx.doi.org/10.1007/s12308-019-00355-x
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author2	Smoley, Stephanie A. Luoma, Ivy M. Pitel, Beth A. Rice, Christopher S. Benevides Demasi, Jonna C. Vasmatzis, George Smadbeck, James B. Yang, Tong Greipp, Patricia T. Ketterling, Rhett P. Baughn, Linda B.
author2Str	Smoley, Stephanie A. Luoma, Ivy M. Pitel, Beth A. Rice, Christopher S. Benevides Demasi, Jonna C. Vasmatzis, George Smadbeck, James B. Yang, Tong Greipp, Patricia T. Ketterling, Rhett P. Baughn, Linda B.
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up_date	2024-07-04T02:45:17.486Z
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Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia

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