The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy
Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide inc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Al Badarin, Firas J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© American Society of Nuclear Cardiology 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of nuclear cardiology - New York, NY : Springer, 1994, 21(2014), 4 vom: 12. Juli, Seite 756-762 |
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| Übergeordnetes Werk: |
volume:21 ; year:2014 ; number:4 ; day:12 ; month:07 ; pages:756-762 |
| Links: |
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| DOI / URN: |
10.1007/s12350-014-9919-z |
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| Katalog-ID: |
SPR024976040 |
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| 100 | 1 | |a Al Badarin, Firas J. |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy |
| 264 | 1 | |c 2014 | |
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| 500 | |a © American Society of Nuclear Cardiology 2014 | ||
| 520 | |a Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. | ||
| 650 | 4 | |a Heart failure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a sudden cardiac death |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a IBG scintigraphy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Wimmer, Alan P. |4 aut | |
| 700 | 1 | |a Kennedy, Kevin F. |4 aut | |
| 700 | 1 | |a Jacobson, Arnold F. |4 aut | |
| 700 | 1 | |a Bateman, Timothy M. |4 aut | |
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10.1007/s12350-014-9919-z doi (DE-627)SPR024976040 (SPR)s12350-014-9919-z-e DE-627 ger DE-627 rakwb eng Al Badarin, Firas J. verfasserin aut The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © American Society of Nuclear Cardiology 2014 Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. Heart failure (dpeaa)DE-He213 sudden cardiac death (dpeaa)DE-He213 IBG scintigraphy (dpeaa)DE-He213 Wimmer, Alan P. aut Kennedy, Kevin F. aut Jacobson, Arnold F. aut Bateman, Timothy M. aut Enthalten in Journal of nuclear cardiology New York, NY : Springer, 1994 21(2014), 4 vom: 12. Juli, Seite 756-762 (DE-627)329395173 (DE-600)2048325-9 1532-6551 nnns volume:21 year:2014 number:4 day:12 month:07 pages:756-762 https://dx.doi.org/10.1007/s12350-014-9919-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 21 2014 4 12 07 756-762 |
| spelling |
10.1007/s12350-014-9919-z doi (DE-627)SPR024976040 (SPR)s12350-014-9919-z-e DE-627 ger DE-627 rakwb eng Al Badarin, Firas J. verfasserin aut The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © American Society of Nuclear Cardiology 2014 Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. Heart failure (dpeaa)DE-He213 sudden cardiac death (dpeaa)DE-He213 IBG scintigraphy (dpeaa)DE-He213 Wimmer, Alan P. aut Kennedy, Kevin F. aut Jacobson, Arnold F. aut Bateman, Timothy M. aut Enthalten in Journal of nuclear cardiology New York, NY : Springer, 1994 21(2014), 4 vom: 12. Juli, Seite 756-762 (DE-627)329395173 (DE-600)2048325-9 1532-6551 nnns volume:21 year:2014 number:4 day:12 month:07 pages:756-762 https://dx.doi.org/10.1007/s12350-014-9919-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 21 2014 4 12 07 756-762 |
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10.1007/s12350-014-9919-z doi (DE-627)SPR024976040 (SPR)s12350-014-9919-z-e DE-627 ger DE-627 rakwb eng Al Badarin, Firas J. verfasserin aut The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © American Society of Nuclear Cardiology 2014 Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. Heart failure (dpeaa)DE-He213 sudden cardiac death (dpeaa)DE-He213 IBG scintigraphy (dpeaa)DE-He213 Wimmer, Alan P. aut Kennedy, Kevin F. aut Jacobson, Arnold F. aut Bateman, Timothy M. aut Enthalten in Journal of nuclear cardiology New York, NY : Springer, 1994 21(2014), 4 vom: 12. Juli, Seite 756-762 (DE-627)329395173 (DE-600)2048325-9 1532-6551 nnns volume:21 year:2014 number:4 day:12 month:07 pages:756-762 https://dx.doi.org/10.1007/s12350-014-9919-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 21 2014 4 12 07 756-762 |
| allfieldsGer |
10.1007/s12350-014-9919-z doi (DE-627)SPR024976040 (SPR)s12350-014-9919-z-e DE-627 ger DE-627 rakwb eng Al Badarin, Firas J. verfasserin aut The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © American Society of Nuclear Cardiology 2014 Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. Heart failure (dpeaa)DE-He213 sudden cardiac death (dpeaa)DE-He213 IBG scintigraphy (dpeaa)DE-He213 Wimmer, Alan P. aut Kennedy, Kevin F. aut Jacobson, Arnold F. aut Bateman, Timothy M. aut Enthalten in Journal of nuclear cardiology New York, NY : Springer, 1994 21(2014), 4 vom: 12. Juli, Seite 756-762 (DE-627)329395173 (DE-600)2048325-9 1532-6551 nnns volume:21 year:2014 number:4 day:12 month:07 pages:756-762 https://dx.doi.org/10.1007/s12350-014-9919-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 21 2014 4 12 07 756-762 |
| allfieldsSound |
10.1007/s12350-014-9919-z doi (DE-627)SPR024976040 (SPR)s12350-014-9919-z-e DE-627 ger DE-627 rakwb eng Al Badarin, Firas J. verfasserin aut The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © American Society of Nuclear Cardiology 2014 Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. Heart failure (dpeaa)DE-He213 sudden cardiac death (dpeaa)DE-He213 IBG scintigraphy (dpeaa)DE-He213 Wimmer, Alan P. aut Kennedy, Kevin F. aut Jacobson, Arnold F. aut Bateman, Timothy M. aut Enthalten in Journal of nuclear cardiology New York, NY : Springer, 1994 21(2014), 4 vom: 12. Juli, Seite 756-762 (DE-627)329395173 (DE-600)2048325-9 1532-6551 nnns volume:21 year:2014 number:4 day:12 month:07 pages:756-762 https://dx.doi.org/10.1007/s12350-014-9919-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 21 2014 4 12 07 756-762 |
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Enthalten in Journal of nuclear cardiology 21(2014), 4 vom: 12. Juli, Seite 756-762 volume:21 year:2014 number:4 day:12 month:07 pages:756-762 |
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Enthalten in Journal of nuclear cardiology 21(2014), 4 vom: 12. Juli, Seite 756-762 volume:21 year:2014 number:4 day:12 month:07 pages:756-762 |
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Al Badarin, Firas J. @@aut@@ Wimmer, Alan P. @@aut@@ Kennedy, Kevin F. @@aut@@ Jacobson, Arnold F. @@aut@@ Bateman, Timothy M. @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR024976040</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520013150.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12350-014-9919-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR024976040</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12350-014-9919-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Al Badarin, Firas J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© American Society of Nuclear Cardiology 2014</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). 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|
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Al Badarin, Firas J. |
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Al Badarin, Firas J. misc Heart failure misc sudden cardiac death misc IBG scintigraphy The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy |
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1532-6551 |
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The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy Heart failure (dpeaa)DE-He213 sudden cardiac death (dpeaa)DE-He213 IBG scintigraphy (dpeaa)DE-He213 |
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misc Heart failure misc sudden cardiac death misc IBG scintigraphy |
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misc Heart failure misc sudden cardiac death misc IBG scintigraphy |
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misc Heart failure misc sudden cardiac death misc IBG scintigraphy |
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The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy |
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The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy |
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Al Badarin, Firas J. |
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Journal of nuclear cardiology |
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Journal of nuclear cardiology |
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Al Badarin, Firas J. Wimmer, Alan P. Kennedy, Kevin F. Jacobson, Arnold F. Bateman, Timothy M. |
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Al Badarin, Firas J. |
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10.1007/s12350-014-9919-z |
| title_sort |
utility of admire-hf risk score in predicting serious arrhythmic events in heart failure patients: incremental prognostic benefit of cardiac 123i-mibg scintigraphy |
| title_auth |
The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy |
| abstract |
Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. © American Society of Nuclear Cardiology 2014 |
| abstractGer |
Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. © American Society of Nuclear Cardiology 2014 |
| abstract_unstemmed |
Background A minority of heart failure (HF) patients who undergo implantable cardioverter defibrillator (ICD) implantation for primary prevention of sudden cardiac death (SCD) receive device therapy. Whether the addition of mIBG scintigraphy to conventional markers of arrhythmic risk can provide incremental risk stratification in HF patients has not been investigated. Methods We identified 778 patients from the ADMIRE-HF study with LVEF < 35% and class II or III HF symptoms who did not have an ICD at the time of enrollment. Patients were followed up prospectively (median = 17 months) for occurrence of arrhythmic events (ArE). Heart-to-mediastinum ratio (HMR) was determined as a measure of relative myocardial sympathetic nerve activity at baseline using 123I-mIBG. The primary endpoint was the first occurrence of ArE: a composite of SCD, appropriate ICD therapy, resuscitated cardiac arrest or sustained ventricular tachycardia. Multivariate regression was used to determine independent predictors of ArE and to derive a risk score for ArE prediction. The score was used to group patients according to their risk for ArE. Integrated discrimination improvement (IDI) was used to quantify improvement in risk assessment with addition of HMR. Results ArE occurred in 54 patients (6.9%). ArE predictors were: HMR < 1.6 (HR 3.5, 95% CI [1.52-8], P = .02), LVEF < 25% (HR 2.0, 95% CI [1.28-3.05], P = .04) and SBP < 120 (HR 1.2, 95% CI [1.03-1.39], P = .02). Event rates in the low-, intermediate-, and high risk groups were 2, 10 and 16%, respectively (P = .001). The score significantly improved risk prediction (IDI = 45%, P 0.03). Conclusion 123I-mIBG significantly provides incremental risk stratification for ArE in HF patients. © American Society of Nuclear Cardiology 2014 |
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| title_short |
The utility of ADMIRE-HF risk score in predicting serious arrhythmic events in heart failure patients: Incremental prognostic benefit of cardiac 123I-mIBG scintigraphy |
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https://dx.doi.org/10.1007/s12350-014-9919-z |
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Wimmer, Alan P. Kennedy, Kevin F. Jacobson, Arnold F. Bateman, Timothy M. |
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2024-07-04T03:03:03.375Z |
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| score |
7.3997183 |