Negative predictive value of d-dimer for diagnosis of venous thromboembolism
Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was...
Ausführliche Beschreibung
Autor*in: |
Nomura, Hideki [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2008 |
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Schlagwörter: |
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Anmerkung: |
© The Japanese Society of Hematology 2008 |
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Übergeordnetes Werk: |
Enthalten in: International journal of hematology - Tokyo [u.a.] : Springer, 1995, 87(2008), 3 vom: 19. Feb., Seite 250-255 |
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Übergeordnetes Werk: |
volume:87 ; year:2008 ; number:3 ; day:19 ; month:02 ; pages:250-255 |
Links: |
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DOI / URN: |
10.1007/s12185-008-0047-x |
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Katalog-ID: |
SPR025099140 |
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245 | 1 | 0 | |a Negative predictive value of d-dimer for diagnosis of venous thromboembolism |
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520 | |a Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. | ||
650 | 4 | |a Hypercoagulable state |7 (dpeaa)DE-He213 | |
650 | 4 | |a DVT |7 (dpeaa)DE-He213 | |
650 | 4 | |a -dimer |7 (dpeaa)DE-He213 | |
650 | 4 | |a DIC |7 (dpeaa)DE-He213 | |
650 | 4 | |a PE |7 (dpeaa)DE-He213 | |
700 | 1 | |a Wada, Hideo |4 aut | |
700 | 1 | |a Mizuno, Toshiro |4 aut | |
700 | 1 | |a Katayama, Naoyuki |4 aut | |
700 | 1 | |a Abe, Yasunori |4 aut | |
700 | 1 | |a Noda, Maki |4 aut | |
700 | 1 | |a Nakatani, Kaname |4 aut | |
700 | 1 | |a Matsumoto, Takeshi |4 aut | |
700 | 1 | |a Ota, Satoshi |4 aut | |
700 | 1 | |a Yamada, Norikazu |4 aut | |
700 | 1 | |a Sudo, Akihiro |4 aut | |
700 | 1 | |a Uchida, Atsumasa |4 aut | |
700 | 1 | |a Nobori, Tsutomu |4 aut | |
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2008 |
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2008 |
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10.1007/s12185-008-0047-x doi (DE-627)SPR025099140 (SPR)s12185-008-0047-x-e DE-627 ger DE-627 rakwb eng Nomura, Hideki verfasserin aut Negative predictive value of d-dimer for diagnosis of venous thromboembolism 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japanese Society of Hematology 2008 Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. Hypercoagulable state (dpeaa)DE-He213 DVT (dpeaa)DE-He213 -dimer (dpeaa)DE-He213 DIC (dpeaa)DE-He213 PE (dpeaa)DE-He213 Wada, Hideo aut Mizuno, Toshiro aut Katayama, Naoyuki aut Abe, Yasunori aut Noda, Maki aut Nakatani, Kaname aut Matsumoto, Takeshi aut Ota, Satoshi aut Yamada, Norikazu aut Sudo, Akihiro aut Uchida, Atsumasa aut Nobori, Tsutomu aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 87(2008), 3 vom: 19. Feb., Seite 250-255 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:87 year:2008 number:3 day:19 month:02 pages:250-255 https://dx.doi.org/10.1007/s12185-008-0047-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 87 2008 3 19 02 250-255 |
spelling |
10.1007/s12185-008-0047-x doi (DE-627)SPR025099140 (SPR)s12185-008-0047-x-e DE-627 ger DE-627 rakwb eng Nomura, Hideki verfasserin aut Negative predictive value of d-dimer for diagnosis of venous thromboembolism 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japanese Society of Hematology 2008 Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. Hypercoagulable state (dpeaa)DE-He213 DVT (dpeaa)DE-He213 -dimer (dpeaa)DE-He213 DIC (dpeaa)DE-He213 PE (dpeaa)DE-He213 Wada, Hideo aut Mizuno, Toshiro aut Katayama, Naoyuki aut Abe, Yasunori aut Noda, Maki aut Nakatani, Kaname aut Matsumoto, Takeshi aut Ota, Satoshi aut Yamada, Norikazu aut Sudo, Akihiro aut Uchida, Atsumasa aut Nobori, Tsutomu aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 87(2008), 3 vom: 19. Feb., Seite 250-255 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:87 year:2008 number:3 day:19 month:02 pages:250-255 https://dx.doi.org/10.1007/s12185-008-0047-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 87 2008 3 19 02 250-255 |
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10.1007/s12185-008-0047-x doi (DE-627)SPR025099140 (SPR)s12185-008-0047-x-e DE-627 ger DE-627 rakwb eng Nomura, Hideki verfasserin aut Negative predictive value of d-dimer for diagnosis of venous thromboembolism 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japanese Society of Hematology 2008 Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. Hypercoagulable state (dpeaa)DE-He213 DVT (dpeaa)DE-He213 -dimer (dpeaa)DE-He213 DIC (dpeaa)DE-He213 PE (dpeaa)DE-He213 Wada, Hideo aut Mizuno, Toshiro aut Katayama, Naoyuki aut Abe, Yasunori aut Noda, Maki aut Nakatani, Kaname aut Matsumoto, Takeshi aut Ota, Satoshi aut Yamada, Norikazu aut Sudo, Akihiro aut Uchida, Atsumasa aut Nobori, Tsutomu aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 87(2008), 3 vom: 19. Feb., Seite 250-255 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:87 year:2008 number:3 day:19 month:02 pages:250-255 https://dx.doi.org/10.1007/s12185-008-0047-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 87 2008 3 19 02 250-255 |
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10.1007/s12185-008-0047-x doi (DE-627)SPR025099140 (SPR)s12185-008-0047-x-e DE-627 ger DE-627 rakwb eng Nomura, Hideki verfasserin aut Negative predictive value of d-dimer for diagnosis of venous thromboembolism 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japanese Society of Hematology 2008 Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. Hypercoagulable state (dpeaa)DE-He213 DVT (dpeaa)DE-He213 -dimer (dpeaa)DE-He213 DIC (dpeaa)DE-He213 PE (dpeaa)DE-He213 Wada, Hideo aut Mizuno, Toshiro aut Katayama, Naoyuki aut Abe, Yasunori aut Noda, Maki aut Nakatani, Kaname aut Matsumoto, Takeshi aut Ota, Satoshi aut Yamada, Norikazu aut Sudo, Akihiro aut Uchida, Atsumasa aut Nobori, Tsutomu aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 87(2008), 3 vom: 19. Feb., Seite 250-255 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:87 year:2008 number:3 day:19 month:02 pages:250-255 https://dx.doi.org/10.1007/s12185-008-0047-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 87 2008 3 19 02 250-255 |
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10.1007/s12185-008-0047-x doi (DE-627)SPR025099140 (SPR)s12185-008-0047-x-e DE-627 ger DE-627 rakwb eng Nomura, Hideki verfasserin aut Negative predictive value of d-dimer for diagnosis of venous thromboembolism 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japanese Society of Hematology 2008 Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. Hypercoagulable state (dpeaa)DE-He213 DVT (dpeaa)DE-He213 -dimer (dpeaa)DE-He213 DIC (dpeaa)DE-He213 PE (dpeaa)DE-He213 Wada, Hideo aut Mizuno, Toshiro aut Katayama, Naoyuki aut Abe, Yasunori aut Noda, Maki aut Nakatani, Kaname aut Matsumoto, Takeshi aut Ota, Satoshi aut Yamada, Norikazu aut Sudo, Akihiro aut Uchida, Atsumasa aut Nobori, Tsutomu aut Enthalten in International journal of hematology Tokyo [u.a.] : Springer, 1995 87(2008), 3 vom: 19. Feb., Seite 250-255 (DE-627)324615485 (DE-600)2028991-1 1865-3774 nnns volume:87 year:2008 number:3 day:19 month:02 pages:250-255 https://dx.doi.org/10.1007/s12185-008-0047-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 87 2008 3 19 02 250-255 |
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Enthalten in International journal of hematology 87(2008), 3 vom: 19. Feb., Seite 250-255 volume:87 year:2008 number:3 day:19 month:02 pages:250-255 |
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Enthalten in International journal of hematology 87(2008), 3 vom: 19. Feb., Seite 250-255 volume:87 year:2008 number:3 day:19 month:02 pages:250-255 |
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International journal of hematology |
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Nomura, Hideki @@aut@@ Wada, Hideo @@aut@@ Mizuno, Toshiro @@aut@@ Katayama, Naoyuki @@aut@@ Abe, Yasunori @@aut@@ Noda, Maki @@aut@@ Nakatani, Kaname @@aut@@ Matsumoto, Takeshi @@aut@@ Ota, Satoshi @@aut@@ Yamada, Norikazu @@aut@@ Sudo, Akihiro @@aut@@ Uchida, Atsumasa @@aut@@ Nobori, Tsutomu @@aut@@ |
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2008-02-19T00:00:00Z |
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However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. 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|
author |
Nomura, Hideki |
spellingShingle |
Nomura, Hideki misc Hypercoagulable state misc DVT misc -dimer misc DIC misc PE Negative predictive value of d-dimer for diagnosis of venous thromboembolism |
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Nomura, Hideki |
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1865-3774 |
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Negative predictive value of d-dimer for diagnosis of venous thromboembolism Hypercoagulable state (dpeaa)DE-He213 DVT (dpeaa)DE-He213 -dimer (dpeaa)DE-He213 DIC (dpeaa)DE-He213 PE (dpeaa)DE-He213 |
topic |
misc Hypercoagulable state misc DVT misc -dimer misc DIC misc PE |
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misc Hypercoagulable state misc DVT misc -dimer misc DIC misc PE |
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misc Hypercoagulable state misc DVT misc -dimer misc DIC misc PE |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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International journal of hematology |
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International journal of hematology |
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Negative predictive value of d-dimer for diagnosis of venous thromboembolism |
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Negative predictive value of d-dimer for diagnosis of venous thromboembolism |
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Nomura, Hideki |
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International journal of hematology |
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International journal of hematology |
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2008 |
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Nomura, Hideki Wada, Hideo Mizuno, Toshiro Katayama, Naoyuki Abe, Yasunori Noda, Maki Nakatani, Kaname Matsumoto, Takeshi Ota, Satoshi Yamada, Norikazu Sudo, Akihiro Uchida, Atsumasa Nobori, Tsutomu |
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Elektronische Aufsätze |
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Nomura, Hideki |
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10.1007/s12185-008-0047-x |
title_sort |
negative predictive value of d-dimer for diagnosis of venous thromboembolism |
title_auth |
Negative predictive value of d-dimer for diagnosis of venous thromboembolism |
abstract |
Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. © The Japanese Society of Hematology 2008 |
abstractGer |
Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. © The Japanese Society of Hematology 2008 |
abstract_unstemmed |
Abstract The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the d-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of d-dimer levels as a negative predictor for thrombosis. The plasma concentrations of d-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis. In healthy volunteers, the median value of VIDAS-d-dimer was 0.12 μg/ml, and the 95% confidence interval was from 0.05 to 0.38 μg/ml. However, the plasma d-dimer levels were significantly higher in patients with thrombosis than in those without thrombosis; there was no significant difference in d-dimer levels among various thromboses such as pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). The NPV for venous thromboembolism was 100% in patients with 0.5 μg/ml VIDAS-d-dimer and 1.2 μg/ml LPIA-d-dimer levels. Elevated d-dimer levels might indicate a high risk of thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for thrombosis. © The Japanese Society of Hematology 2008 |
collection_details |
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container_issue |
3 |
title_short |
Negative predictive value of d-dimer for diagnosis of venous thromboembolism |
url |
https://dx.doi.org/10.1007/s12185-008-0047-x |
remote_bool |
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author2 |
Wada, Hideo Mizuno, Toshiro Katayama, Naoyuki Abe, Yasunori Noda, Maki Nakatani, Kaname Matsumoto, Takeshi Ota, Satoshi Yamada, Norikazu Sudo, Akihiro Uchida, Atsumasa Nobori, Tsutomu |
author2Str |
Wada, Hideo Mizuno, Toshiro Katayama, Naoyuki Abe, Yasunori Noda, Maki Nakatani, Kaname Matsumoto, Takeshi Ota, Satoshi Yamada, Norikazu Sudo, Akihiro Uchida, Atsumasa Nobori, Tsutomu |
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doi_str |
10.1007/s12185-008-0047-x |
up_date |
2024-07-03T13:50:40.363Z |
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|
score |
7.400317 |