Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method
Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. T...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tamura, Mikoto [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 |
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| Übergeordnetes Werk: |
Enthalten in: Radiological physics and technology - Tokyo : Springer, 2008, 6(2013), 2 vom: 25. Apr., Seite 415-422 |
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| Übergeordnetes Werk: |
volume:6 ; year:2013 ; number:2 ; day:25 ; month:04 ; pages:415-422 |
| Links: |
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| DOI / URN: |
10.1007/s12194-013-0214-5 |
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| Katalog-ID: |
SPR02517763X |
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| 100 | 1 | |a Tamura, Mikoto |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method |
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| 520 | |a Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. | ||
| 650 | 4 | |a Biological dose |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Microdosimetry |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Microdosimetric kinetic model |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Carbon-ion radiotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Passive method |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Monte Carlo simulation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Komori, Masataka |4 aut | |
| 700 | 1 | |a Oguchi, Hiroshi |4 aut | |
| 700 | 1 | |a Iwamoto, Yasushi |4 aut | |
| 700 | 1 | |a Rachi, Toshiya |4 aut | |
| 700 | 1 | |a Ota, Kenji |4 aut | |
| 700 | 1 | |a Hemmi, Atsushi |4 aut | |
| 700 | 1 | |a Shimozato, Tomohiro |4 aut | |
| 700 | 1 | |a Obata, Yasunori |4 aut | |
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10.1007/s12194-013-0214-5 doi (DE-627)SPR02517763X (SPR)s12194-013-0214-5-e DE-627 ger DE-627 rakwb eng Tamura, Mikoto verfasserin aut Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. Biological dose (dpeaa)DE-He213 Microdosimetry (dpeaa)DE-He213 Microdosimetric kinetic model (dpeaa)DE-He213 Carbon-ion radiotherapy (dpeaa)DE-He213 Passive method (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Komori, Masataka aut Oguchi, Hiroshi aut Iwamoto, Yasushi aut Rachi, Toshiya aut Ota, Kenji aut Hemmi, Atsushi aut Shimozato, Tomohiro aut Obata, Yasunori aut Enthalten in Radiological physics and technology Tokyo : Springer, 2008 6(2013), 2 vom: 25. Apr., Seite 415-422 (DE-627)571166032 (DE-600)2433581-2 1865-0341 nnns volume:6 year:2013 number:2 day:25 month:04 pages:415-422 https://dx.doi.org/10.1007/s12194-013-0214-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2013 2 25 04 415-422 |
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10.1007/s12194-013-0214-5 doi (DE-627)SPR02517763X (SPR)s12194-013-0214-5-e DE-627 ger DE-627 rakwb eng Tamura, Mikoto verfasserin aut Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. Biological dose (dpeaa)DE-He213 Microdosimetry (dpeaa)DE-He213 Microdosimetric kinetic model (dpeaa)DE-He213 Carbon-ion radiotherapy (dpeaa)DE-He213 Passive method (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Komori, Masataka aut Oguchi, Hiroshi aut Iwamoto, Yasushi aut Rachi, Toshiya aut Ota, Kenji aut Hemmi, Atsushi aut Shimozato, Tomohiro aut Obata, Yasunori aut Enthalten in Radiological physics and technology Tokyo : Springer, 2008 6(2013), 2 vom: 25. Apr., Seite 415-422 (DE-627)571166032 (DE-600)2433581-2 1865-0341 nnns volume:6 year:2013 number:2 day:25 month:04 pages:415-422 https://dx.doi.org/10.1007/s12194-013-0214-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2013 2 25 04 415-422 |
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10.1007/s12194-013-0214-5 doi (DE-627)SPR02517763X (SPR)s12194-013-0214-5-e DE-627 ger DE-627 rakwb eng Tamura, Mikoto verfasserin aut Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. Biological dose (dpeaa)DE-He213 Microdosimetry (dpeaa)DE-He213 Microdosimetric kinetic model (dpeaa)DE-He213 Carbon-ion radiotherapy (dpeaa)DE-He213 Passive method (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Komori, Masataka aut Oguchi, Hiroshi aut Iwamoto, Yasushi aut Rachi, Toshiya aut Ota, Kenji aut Hemmi, Atsushi aut Shimozato, Tomohiro aut Obata, Yasunori aut Enthalten in Radiological physics and technology Tokyo : Springer, 2008 6(2013), 2 vom: 25. Apr., Seite 415-422 (DE-627)571166032 (DE-600)2433581-2 1865-0341 nnns volume:6 year:2013 number:2 day:25 month:04 pages:415-422 https://dx.doi.org/10.1007/s12194-013-0214-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2013 2 25 04 415-422 |
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10.1007/s12194-013-0214-5 doi (DE-627)SPR02517763X (SPR)s12194-013-0214-5-e DE-627 ger DE-627 rakwb eng Tamura, Mikoto verfasserin aut Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. Biological dose (dpeaa)DE-He213 Microdosimetry (dpeaa)DE-He213 Microdosimetric kinetic model (dpeaa)DE-He213 Carbon-ion radiotherapy (dpeaa)DE-He213 Passive method (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Komori, Masataka aut Oguchi, Hiroshi aut Iwamoto, Yasushi aut Rachi, Toshiya aut Ota, Kenji aut Hemmi, Atsushi aut Shimozato, Tomohiro aut Obata, Yasunori aut Enthalten in Radiological physics and technology Tokyo : Springer, 2008 6(2013), 2 vom: 25. Apr., Seite 415-422 (DE-627)571166032 (DE-600)2433581-2 1865-0341 nnns volume:6 year:2013 number:2 day:25 month:04 pages:415-422 https://dx.doi.org/10.1007/s12194-013-0214-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2013 2 25 04 415-422 |
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10.1007/s12194-013-0214-5 doi (DE-627)SPR02517763X (SPR)s12194-013-0214-5-e DE-627 ger DE-627 rakwb eng Tamura, Mikoto verfasserin aut Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. Biological dose (dpeaa)DE-He213 Microdosimetry (dpeaa)DE-He213 Microdosimetric kinetic model (dpeaa)DE-He213 Carbon-ion radiotherapy (dpeaa)DE-He213 Passive method (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Komori, Masataka aut Oguchi, Hiroshi aut Iwamoto, Yasushi aut Rachi, Toshiya aut Ota, Kenji aut Hemmi, Atsushi aut Shimozato, Tomohiro aut Obata, Yasunori aut Enthalten in Radiological physics and technology Tokyo : Springer, 2008 6(2013), 2 vom: 25. Apr., Seite 415-422 (DE-627)571166032 (DE-600)2433581-2 1865-0341 nnns volume:6 year:2013 number:2 day:25 month:04 pages:415-422 https://dx.doi.org/10.1007/s12194-013-0214-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2013 2 25 04 415-422 |
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Enthalten in Radiological physics and technology 6(2013), 2 vom: 25. Apr., Seite 415-422 volume:6 year:2013 number:2 day:25 month:04 pages:415-422 |
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Enthalten in Radiological physics and technology 6(2013), 2 vom: 25. Apr., Seite 415-422 volume:6 year:2013 number:2 day:25 month:04 pages:415-422 |
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Tamura, Mikoto @@aut@@ Komori, Masataka @@aut@@ Oguchi, Hiroshi @@aut@@ Iwamoto, Yasushi @@aut@@ Rachi, Toshiya @@aut@@ Ota, Kenji @@aut@@ Hemmi, Atsushi @@aut@@ Shimozato, Tomohiro @@aut@@ Obata, Yasunori @@aut@@ |
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The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. 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Tamura, Mikoto |
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Tamura, Mikoto misc Biological dose misc Microdosimetry misc Microdosimetric kinetic model misc Carbon-ion radiotherapy misc Passive method misc Monte Carlo simulation Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method |
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Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method Biological dose (dpeaa)DE-He213 Microdosimetry (dpeaa)DE-He213 Microdosimetric kinetic model (dpeaa)DE-He213 Carbon-ion radiotherapy (dpeaa)DE-He213 Passive method (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 |
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misc Biological dose misc Microdosimetry misc Microdosimetric kinetic model misc Carbon-ion radiotherapy misc Passive method misc Monte Carlo simulation |
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Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method |
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Tamura, Mikoto Komori, Masataka Oguchi, Hiroshi Iwamoto, Yasushi Rachi, Toshiya Ota, Kenji Hemmi, Atsushi Shimozato, Tomohiro Obata, Yasunori |
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10.1007/s12194-013-0214-5 |
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microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with monte carlo method |
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Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method |
| abstract |
Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 |
| abstractGer |
Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 |
| abstract_unstemmed |
Abstract In carbon-ion radiotherapy, it is important to evaluate the biological dose because the relative biological effectiveness values vary greatly in a patient’s body. The microdosimetric kinetic model (MKM) is a method of estimating the biological effect of radiation by use of microdosimetry. The lateral biological dose distributions were estimated with a modified MKM, in which we considered the overkilling effect in the high linear-energy-transfer region. In this study, we used the Monte Carlo calculation of the Geant4 code to simulate a horizontal port at the Heavy Ion Medical Accelerator in Chiba of the National Institute of Radiological Sciences. The lateral biological dose distributions calculated by Geant4 were almost flat as the lateral absorbed dose in the flattened area. However, in the penumbra region, the lateral biological dose distributions were sharper than the lateral absorbed dose distributions. Furthermore, the differences between the lateral absorbed dose and biological dose distributions were dependent on the depth for each multi-leaf collimator opening size. We expect that the lateral biological dose distribution presented here will enable high-precision calculations for a treatment-planning system. © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013 |
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| title_short |
Microdosimetric calculation of penumbra for biological dose in wobbled carbon-ion beams with Monte Carlo Method |
| url |
https://dx.doi.org/10.1007/s12194-013-0214-5 |
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| author2 |
Komori, Masataka Oguchi, Hiroshi Iwamoto, Yasushi Rachi, Toshiya Ota, Kenji Hemmi, Atsushi Shimozato, Tomohiro Obata, Yasunori |
| author2Str |
Komori, Masataka Oguchi, Hiroshi Iwamoto, Yasushi Rachi, Toshiya Ota, Kenji Hemmi, Atsushi Shimozato, Tomohiro Obata, Yasunori |
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| score |
7.4017324 |