Race/Ethnic Disparities in Cardiac Transplantation
Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nayak, Aditi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC, part of Springer Nature 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Current Cardiovascular Risk reports - Philadelphia, Pa. : Current Medicine Group LLC, 2007, 13(2019), 11 vom: 16. Okt. |
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| Übergeordnetes Werk: |
volume:13 ; year:2019 ; number:11 ; day:16 ; month:10 |
| Links: |
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| DOI / URN: |
10.1007/s12170-019-0629-6 |
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| Katalog-ID: |
SPR025394010 |
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| 100 | 1 | |a Nayak, Aditi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Race/Ethnic Disparities in Cardiac Transplantation |
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| 520 | |a Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. | ||
| 650 | 4 | |a Race/ethnic disparities |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Heart transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Transplant outcomes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Transplant disparities |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Cole, Robert T. |4 aut | |
| 700 | 1 | |a Morris, Alanna A. |4 aut | |
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10.1007/s12170-019-0629-6 doi (DE-627)SPR025394010 (SPR)s12170-019-0629-6-e DE-627 ger DE-627 rakwb eng Nayak, Aditi verfasserin aut Race/Ethnic Disparities in Cardiac Transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. Race/ethnic disparities (dpeaa)DE-He213 Heart transplantation (dpeaa)DE-He213 Transplant outcomes (dpeaa)DE-He213 Transplant disparities (dpeaa)DE-He213 Cole, Robert T. aut Morris, Alanna A. aut Enthalten in Current Cardiovascular Risk reports Philadelphia, Pa. : Current Medicine Group LLC, 2007 13(2019), 11 vom: 16. Okt. (DE-627)597544751 (DE-600)2489103-4 1932-9563 nnns volume:13 year:2019 number:11 day:16 month:10 https://dx.doi.org/10.1007/s12170-019-0629-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2019 11 16 10 |
| spelling |
10.1007/s12170-019-0629-6 doi (DE-627)SPR025394010 (SPR)s12170-019-0629-6-e DE-627 ger DE-627 rakwb eng Nayak, Aditi verfasserin aut Race/Ethnic Disparities in Cardiac Transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. Race/ethnic disparities (dpeaa)DE-He213 Heart transplantation (dpeaa)DE-He213 Transplant outcomes (dpeaa)DE-He213 Transplant disparities (dpeaa)DE-He213 Cole, Robert T. aut Morris, Alanna A. aut Enthalten in Current Cardiovascular Risk reports Philadelphia, Pa. : Current Medicine Group LLC, 2007 13(2019), 11 vom: 16. Okt. (DE-627)597544751 (DE-600)2489103-4 1932-9563 nnns volume:13 year:2019 number:11 day:16 month:10 https://dx.doi.org/10.1007/s12170-019-0629-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2019 11 16 10 |
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10.1007/s12170-019-0629-6 doi (DE-627)SPR025394010 (SPR)s12170-019-0629-6-e DE-627 ger DE-627 rakwb eng Nayak, Aditi verfasserin aut Race/Ethnic Disparities in Cardiac Transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. Race/ethnic disparities (dpeaa)DE-He213 Heart transplantation (dpeaa)DE-He213 Transplant outcomes (dpeaa)DE-He213 Transplant disparities (dpeaa)DE-He213 Cole, Robert T. aut Morris, Alanna A. aut Enthalten in Current Cardiovascular Risk reports Philadelphia, Pa. : Current Medicine Group LLC, 2007 13(2019), 11 vom: 16. Okt. (DE-627)597544751 (DE-600)2489103-4 1932-9563 nnns volume:13 year:2019 number:11 day:16 month:10 https://dx.doi.org/10.1007/s12170-019-0629-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2019 11 16 10 |
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10.1007/s12170-019-0629-6 doi (DE-627)SPR025394010 (SPR)s12170-019-0629-6-e DE-627 ger DE-627 rakwb eng Nayak, Aditi verfasserin aut Race/Ethnic Disparities in Cardiac Transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. Race/ethnic disparities (dpeaa)DE-He213 Heart transplantation (dpeaa)DE-He213 Transplant outcomes (dpeaa)DE-He213 Transplant disparities (dpeaa)DE-He213 Cole, Robert T. aut Morris, Alanna A. aut Enthalten in Current Cardiovascular Risk reports Philadelphia, Pa. : Current Medicine Group LLC, 2007 13(2019), 11 vom: 16. Okt. (DE-627)597544751 (DE-600)2489103-4 1932-9563 nnns volume:13 year:2019 number:11 day:16 month:10 https://dx.doi.org/10.1007/s12170-019-0629-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2019 11 16 10 |
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10.1007/s12170-019-0629-6 doi (DE-627)SPR025394010 (SPR)s12170-019-0629-6-e DE-627 ger DE-627 rakwb eng Nayak, Aditi verfasserin aut Race/Ethnic Disparities in Cardiac Transplantation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2019 Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. Race/ethnic disparities (dpeaa)DE-He213 Heart transplantation (dpeaa)DE-He213 Transplant outcomes (dpeaa)DE-He213 Transplant disparities (dpeaa)DE-He213 Cole, Robert T. aut Morris, Alanna A. aut Enthalten in Current Cardiovascular Risk reports Philadelphia, Pa. : Current Medicine Group LLC, 2007 13(2019), 11 vom: 16. Okt. (DE-627)597544751 (DE-600)2489103-4 1932-9563 nnns volume:13 year:2019 number:11 day:16 month:10 https://dx.doi.org/10.1007/s12170-019-0629-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2019 11 16 10 |
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However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. 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Race/Ethnic Disparities in Cardiac Transplantation Race/ethnic disparities (dpeaa)DE-He213 Heart transplantation (dpeaa)DE-He213 Transplant outcomes (dpeaa)DE-He213 Transplant disparities (dpeaa)DE-He213 |
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Race/Ethnic Disparities in Cardiac Transplantation |
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race/ethnic disparities in cardiac transplantation |
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Race/Ethnic Disparities in Cardiac Transplantation |
| abstract |
Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. © Springer Science+Business Media, LLC, part of Springer Nature 2019 |
| abstractGer |
Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. © Springer Science+Business Media, LLC, part of Springer Nature 2019 |
| abstract_unstemmed |
Purpose of Review Heart transplant (HT) is the therapy of choice for patients with end-stage heart failure (HF), leading to substantial improvements in quality of life, functional status, and longevity compared to optimal medical therapy for end-stage HF. However, race/ethnic disparities in post-HT survival persist and remain a major concern. The purpose of this review is to describe differences in post-transplant outcomes based on race/ethnicity and to highlight evolving knowledge of the reasons for these persistent disparate outcomes. Recent Findings Black HT recipients have the highest risk for allograft failure and the worst survival post-HT compared to other race/ethnic groups. Although differences in socioeconomic status, access to medical care, and medical compliance have been cited in the past as reasons for these disparate outcomes, recent research highlights the importance of heightened immune reactivity in black HT recipients as a major cause of allograft loss and death. Novel techniques such as gene expression profiling, detection of donor specific antibodies, and detection of genotypes associated with increased metabolism of immunosuppressive medications highlight the role of immune and inflammatory dysregulation and reduced immunosuppressive drug efficacy as significant contributors to post-HT outcomes. Summary Race/ethnic disparities in post-HT outcomes are due to a complex interplay of immunologic, clinical, and socioeconomic factors. However, multiple reports that demonstrate that black race confers a survival disadvantage post-HT that is independent of differences in access to care or socioeconomic status highlight the need for more research to understand racial differences in biological and genetic responses to immunosuppressive therapy. © Springer Science+Business Media, LLC, part of Springer Nature 2019 |
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| title_short |
Race/Ethnic Disparities in Cardiac Transplantation |
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https://dx.doi.org/10.1007/s12170-019-0629-6 |
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Cole, Robert T. Morris, Alanna A. |
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10.1007/s12170-019-0629-6 |
| up_date |
2024-07-03T15:44:20.067Z |
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|
| score |
7.400321 |