Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia
Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the uri...
Ausführliche Beschreibung
Autor*in: |
Bao, Pei-Zhong [verfasserIn] Ye, Jun [verfasserIn] Han, Lian-Shu [verfasserIn] Qiu, Wen-Juan [verfasserIn] Zhang, Hui-Wen [verfasserIn] Yu, Yong-Guo [verfasserIn] Wang, Jian-Guo [verfasserIn] Gu, Xue-Fan [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2018 |
---|
Schlagwörter: |
---|
Übergeordnetes Werk: |
Enthalten in: World Journal of Pediatrics - Springer-Verlag, 2008, 15(2018), 1 vom: 15. Nov., Seite 66-71 |
---|---|
Übergeordnetes Werk: |
volume:15 ; year:2018 ; number:1 ; day:15 ; month:11 ; pages:66-71 |
Links: |
---|
DOI / URN: |
10.1007/s12519-018-0202-2 |
---|
Katalog-ID: |
SPR025997548 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | SPR025997548 | ||
003 | DE-627 | ||
005 | 20201125083914.0 | ||
007 | cr uuu---uuuuu | ||
008 | 201007s2018 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s12519-018-0202-2 |2 doi | |
035 | |a (DE-627)SPR025997548 | ||
035 | |a (SPR)s12519-018-0202-2-e | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Bao, Pei-Zhong |e verfasserin |4 aut | |
245 | 1 | 0 | |a Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia |
264 | 1 | |c 2018 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. | ||
650 | 4 | |a 6-Pyruvoyltetrahydropterin synthase |7 (dpeaa)DE-He213 | |
650 | 4 | |a Hyperphenylalaninemia |7 (dpeaa)DE-He213 | |
650 | 4 | |a Isoxanthopterin |7 (dpeaa)DE-He213 | |
650 | 4 | |a Phenylalanine hydroxylase |7 (dpeaa)DE-He213 | |
650 | 4 | |a Pterin |7 (dpeaa)DE-He213 | |
700 | 1 | |a Ye, Jun |e verfasserin |4 aut | |
700 | 1 | |a Han, Lian-Shu |e verfasserin |4 aut | |
700 | 1 | |a Qiu, Wen-Juan |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Hui-Wen |e verfasserin |4 aut | |
700 | 1 | |a Yu, Yong-Guo |e verfasserin |4 aut | |
700 | 1 | |a Wang, Jian-Guo |e verfasserin |4 aut | |
700 | 1 | |a Gu, Xue-Fan |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t World Journal of Pediatrics |d Springer-Verlag, 2008 |g 15(2018), 1 vom: 15. Nov., Seite 66-71 |w (DE-627)SPR02598876X |7 nnns |
773 | 1 | 8 | |g volume:15 |g year:2018 |g number:1 |g day:15 |g month:11 |g pages:66-71 |
856 | 4 | 0 | |u https://dx.doi.org/10.1007/s12519-018-0202-2 |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_SPRINGER | ||
912 | |a GBV_ILN_21 | ||
912 | |a GBV_ILN_31 | ||
912 | |a GBV_ILN_40 | ||
912 | |a GBV_ILN_61 | ||
912 | |a GBV_ILN_62 | ||
912 | |a GBV_ILN_63 | ||
912 | |a GBV_ILN_65 | ||
912 | |a GBV_ILN_66 | ||
912 | |a GBV_ILN_69 | ||
912 | |a GBV_ILN_92 | ||
912 | |a GBV_ILN_135 | ||
912 | |a GBV_ILN_181 | ||
912 | |a GBV_ILN_192 | ||
912 | |a GBV_ILN_211 | ||
912 | |a GBV_ILN_252 | ||
951 | |a AR | ||
952 | |d 15 |j 2018 |e 1 |b 15 |c 11 |h 66-71 |
author_variant |
p z b pzb j y jy l s h lsh w j q wjq h w z hwz y g y ygy j g w jgw x f g xfg |
---|---|
matchkey_str |
baopeizhongyejunhanlianshuqiuwenjuanzhan:2018----:plctooioatotrnsnwtrnakrnhdfeetadan |
hierarchy_sort_str |
2018 |
publishDate |
2018 |
allfields |
10.1007/s12519-018-0202-2 doi (DE-627)SPR025997548 (SPR)s12519-018-0202-2-e DE-627 ger DE-627 rakwb eng Bao, Pei-Zhong verfasserin aut Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. 6-Pyruvoyltetrahydropterin synthase (dpeaa)DE-He213 Hyperphenylalaninemia (dpeaa)DE-He213 Isoxanthopterin (dpeaa)DE-He213 Phenylalanine hydroxylase (dpeaa)DE-He213 Pterin (dpeaa)DE-He213 Ye, Jun verfasserin aut Han, Lian-Shu verfasserin aut Qiu, Wen-Juan verfasserin aut Zhang, Hui-Wen verfasserin aut Yu, Yong-Guo verfasserin aut Wang, Jian-Guo verfasserin aut Gu, Xue-Fan verfasserin aut Enthalten in World Journal of Pediatrics Springer-Verlag, 2008 15(2018), 1 vom: 15. Nov., Seite 66-71 (DE-627)SPR02598876X nnns volume:15 year:2018 number:1 day:15 month:11 pages:66-71 https://dx.doi.org/10.1007/s12519-018-0202-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_66 GBV_ILN_69 GBV_ILN_92 GBV_ILN_135 GBV_ILN_181 GBV_ILN_192 GBV_ILN_211 GBV_ILN_252 AR 15 2018 1 15 11 66-71 |
spelling |
10.1007/s12519-018-0202-2 doi (DE-627)SPR025997548 (SPR)s12519-018-0202-2-e DE-627 ger DE-627 rakwb eng Bao, Pei-Zhong verfasserin aut Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. 6-Pyruvoyltetrahydropterin synthase (dpeaa)DE-He213 Hyperphenylalaninemia (dpeaa)DE-He213 Isoxanthopterin (dpeaa)DE-He213 Phenylalanine hydroxylase (dpeaa)DE-He213 Pterin (dpeaa)DE-He213 Ye, Jun verfasserin aut Han, Lian-Shu verfasserin aut Qiu, Wen-Juan verfasserin aut Zhang, Hui-Wen verfasserin aut Yu, Yong-Guo verfasserin aut Wang, Jian-Guo verfasserin aut Gu, Xue-Fan verfasserin aut Enthalten in World Journal of Pediatrics Springer-Verlag, 2008 15(2018), 1 vom: 15. Nov., Seite 66-71 (DE-627)SPR02598876X nnns volume:15 year:2018 number:1 day:15 month:11 pages:66-71 https://dx.doi.org/10.1007/s12519-018-0202-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_66 GBV_ILN_69 GBV_ILN_92 GBV_ILN_135 GBV_ILN_181 GBV_ILN_192 GBV_ILN_211 GBV_ILN_252 AR 15 2018 1 15 11 66-71 |
allfields_unstemmed |
10.1007/s12519-018-0202-2 doi (DE-627)SPR025997548 (SPR)s12519-018-0202-2-e DE-627 ger DE-627 rakwb eng Bao, Pei-Zhong verfasserin aut Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. 6-Pyruvoyltetrahydropterin synthase (dpeaa)DE-He213 Hyperphenylalaninemia (dpeaa)DE-He213 Isoxanthopterin (dpeaa)DE-He213 Phenylalanine hydroxylase (dpeaa)DE-He213 Pterin (dpeaa)DE-He213 Ye, Jun verfasserin aut Han, Lian-Shu verfasserin aut Qiu, Wen-Juan verfasserin aut Zhang, Hui-Wen verfasserin aut Yu, Yong-Guo verfasserin aut Wang, Jian-Guo verfasserin aut Gu, Xue-Fan verfasserin aut Enthalten in World Journal of Pediatrics Springer-Verlag, 2008 15(2018), 1 vom: 15. Nov., Seite 66-71 (DE-627)SPR02598876X nnns volume:15 year:2018 number:1 day:15 month:11 pages:66-71 https://dx.doi.org/10.1007/s12519-018-0202-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_66 GBV_ILN_69 GBV_ILN_92 GBV_ILN_135 GBV_ILN_181 GBV_ILN_192 GBV_ILN_211 GBV_ILN_252 AR 15 2018 1 15 11 66-71 |
allfieldsGer |
10.1007/s12519-018-0202-2 doi (DE-627)SPR025997548 (SPR)s12519-018-0202-2-e DE-627 ger DE-627 rakwb eng Bao, Pei-Zhong verfasserin aut Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. 6-Pyruvoyltetrahydropterin synthase (dpeaa)DE-He213 Hyperphenylalaninemia (dpeaa)DE-He213 Isoxanthopterin (dpeaa)DE-He213 Phenylalanine hydroxylase (dpeaa)DE-He213 Pterin (dpeaa)DE-He213 Ye, Jun verfasserin aut Han, Lian-Shu verfasserin aut Qiu, Wen-Juan verfasserin aut Zhang, Hui-Wen verfasserin aut Yu, Yong-Guo verfasserin aut Wang, Jian-Guo verfasserin aut Gu, Xue-Fan verfasserin aut Enthalten in World Journal of Pediatrics Springer-Verlag, 2008 15(2018), 1 vom: 15. Nov., Seite 66-71 (DE-627)SPR02598876X nnns volume:15 year:2018 number:1 day:15 month:11 pages:66-71 https://dx.doi.org/10.1007/s12519-018-0202-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_66 GBV_ILN_69 GBV_ILN_92 GBV_ILN_135 GBV_ILN_181 GBV_ILN_192 GBV_ILN_211 GBV_ILN_252 AR 15 2018 1 15 11 66-71 |
allfieldsSound |
10.1007/s12519-018-0202-2 doi (DE-627)SPR025997548 (SPR)s12519-018-0202-2-e DE-627 ger DE-627 rakwb eng Bao, Pei-Zhong verfasserin aut Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. 6-Pyruvoyltetrahydropterin synthase (dpeaa)DE-He213 Hyperphenylalaninemia (dpeaa)DE-He213 Isoxanthopterin (dpeaa)DE-He213 Phenylalanine hydroxylase (dpeaa)DE-He213 Pterin (dpeaa)DE-He213 Ye, Jun verfasserin aut Han, Lian-Shu verfasserin aut Qiu, Wen-Juan verfasserin aut Zhang, Hui-Wen verfasserin aut Yu, Yong-Guo verfasserin aut Wang, Jian-Guo verfasserin aut Gu, Xue-Fan verfasserin aut Enthalten in World Journal of Pediatrics Springer-Verlag, 2008 15(2018), 1 vom: 15. Nov., Seite 66-71 (DE-627)SPR02598876X nnns volume:15 year:2018 number:1 day:15 month:11 pages:66-71 https://dx.doi.org/10.1007/s12519-018-0202-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_66 GBV_ILN_69 GBV_ILN_92 GBV_ILN_135 GBV_ILN_181 GBV_ILN_192 GBV_ILN_211 GBV_ILN_252 AR 15 2018 1 15 11 66-71 |
language |
English |
source |
Enthalten in World Journal of Pediatrics 15(2018), 1 vom: 15. Nov., Seite 66-71 volume:15 year:2018 number:1 day:15 month:11 pages:66-71 |
sourceStr |
Enthalten in World Journal of Pediatrics 15(2018), 1 vom: 15. Nov., Seite 66-71 volume:15 year:2018 number:1 day:15 month:11 pages:66-71 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
6-Pyruvoyltetrahydropterin synthase Hyperphenylalaninemia Isoxanthopterin Phenylalanine hydroxylase Pterin |
isfreeaccess_bool |
false |
container_title |
World Journal of Pediatrics |
authorswithroles_txt_mv |
Bao, Pei-Zhong @@aut@@ Ye, Jun @@aut@@ Han, Lian-Shu @@aut@@ Qiu, Wen-Juan @@aut@@ Zhang, Hui-Wen @@aut@@ Yu, Yong-Guo @@aut@@ Wang, Jian-Guo @@aut@@ Gu, Xue-Fan @@aut@@ |
publishDateDaySort_date |
2018-11-15T00:00:00Z |
hierarchy_top_id |
SPR02598876X |
id |
SPR025997548 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR025997548</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20201125083914.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12519-018-0202-2</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR025997548</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12519-018-0202-2-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bao, Pei-Zhong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">6-Pyruvoyltetrahydropterin synthase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hyperphenylalaninemia</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Isoxanthopterin</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phenylalanine hydroxylase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pterin</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ye, Jun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Lian-Shu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Qiu, Wen-Juan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Hui-Wen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yu, Yong-Guo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Jian-Guo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gu, Xue-Fan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">World Journal of Pediatrics</subfield><subfield code="d">Springer-Verlag, 2008</subfield><subfield code="g">15(2018), 1 vom: 15. Nov., Seite 66-71</subfield><subfield code="w">(DE-627)SPR02598876X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:15</subfield><subfield code="g">year:2018</subfield><subfield code="g">number:1</subfield><subfield code="g">day:15</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:66-71</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s12519-018-0202-2</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_61</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_66</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_92</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_135</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_181</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_192</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_211</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_252</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">15</subfield><subfield code="j">2018</subfield><subfield code="e">1</subfield><subfield code="b">15</subfield><subfield code="c">11</subfield><subfield code="h">66-71</subfield></datafield></record></collection>
|
author |
Bao, Pei-Zhong |
spellingShingle |
Bao, Pei-Zhong misc 6-Pyruvoyltetrahydropterin synthase misc Hyperphenylalaninemia misc Isoxanthopterin misc Phenylalanine hydroxylase misc Pterin Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia |
authorStr |
Bao, Pei-Zhong |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)SPR02598876X |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut aut aut aut aut aut |
collection |
springer |
remote_str |
true |
illustrated |
Not Illustrated |
topic_title |
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia 6-Pyruvoyltetrahydropterin synthase (dpeaa)DE-He213 Hyperphenylalaninemia (dpeaa)DE-He213 Isoxanthopterin (dpeaa)DE-He213 Phenylalanine hydroxylase (dpeaa)DE-He213 Pterin (dpeaa)DE-He213 |
topic |
misc 6-Pyruvoyltetrahydropterin synthase misc Hyperphenylalaninemia misc Isoxanthopterin misc Phenylalanine hydroxylase misc Pterin |
topic_unstemmed |
misc 6-Pyruvoyltetrahydropterin synthase misc Hyperphenylalaninemia misc Isoxanthopterin misc Phenylalanine hydroxylase misc Pterin |
topic_browse |
misc 6-Pyruvoyltetrahydropterin synthase misc Hyperphenylalaninemia misc Isoxanthopterin misc Phenylalanine hydroxylase misc Pterin |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
World Journal of Pediatrics |
hierarchy_parent_id |
SPR02598876X |
hierarchy_top_title |
World Journal of Pediatrics |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)SPR02598876X |
title |
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia |
ctrlnum |
(DE-627)SPR025997548 (SPR)s12519-018-0202-2-e |
title_full |
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia |
author_sort |
Bao, Pei-Zhong |
journal |
World Journal of Pediatrics |
journalStr |
World Journal of Pediatrics |
lang_code |
eng |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
2018 |
contenttype_str_mv |
txt |
container_start_page |
66 |
author_browse |
Bao, Pei-Zhong Ye, Jun Han, Lian-Shu Qiu, Wen-Juan Zhang, Hui-Wen Yu, Yong-Guo Wang, Jian-Guo Gu, Xue-Fan |
container_volume |
15 |
format_se |
Elektronische Aufsätze |
author-letter |
Bao, Pei-Zhong |
doi_str_mv |
10.1007/s12519-018-0202-2 |
author2-role |
verfasserin |
title_sort |
application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia |
title_auth |
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia |
abstract |
Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. |
abstractGer |
Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. |
abstract_unstemmed |
Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization. |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_66 GBV_ILN_69 GBV_ILN_92 GBV_ILN_135 GBV_ILN_181 GBV_ILN_192 GBV_ILN_211 GBV_ILN_252 |
container_issue |
1 |
title_short |
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia |
url |
https://dx.doi.org/10.1007/s12519-018-0202-2 |
remote_bool |
true |
author2 |
Ye, Jun Han, Lian-Shu Qiu, Wen-Juan Zhang, Hui-Wen Yu, Yong-Guo Wang, Jian-Guo Gu, Xue-Fan |
author2Str |
Ye, Jun Han, Lian-Shu Qiu, Wen-Juan Zhang, Hui-Wen Yu, Yong-Guo Wang, Jian-Guo Gu, Xue-Fan |
ppnlink |
SPR02598876X |
mediatype_str_mv |
c |
isOA_txt |
false |
hochschulschrift_bool |
false |
doi_str |
10.1007/s12519-018-0202-2 |
up_date |
2024-07-03T18:14:28.539Z |
_version_ |
1803582668592381952 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR025997548</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20201125083914.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12519-018-0202-2</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR025997548</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12519-018-0202-2-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bao, Pei-Zhong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of diagnosis. Methods We compared the urine neopterin (N), biopterin (B), isoxanthopterin (Iso), B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD, and found the most specific pterin biomarkers by ROC analysis. A positive cut-off value of urine pterins was determined. The effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated, and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were compared. The concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was determined. Results (1) Urinary B, B%, Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01); (2) Iso%, B%, and B were the most specific markers; (3) The positive cut-off values of B, B%, Iso% for PTPSD were < 0.17 mmoL/moLCr, < 5.0%, and < 9.5%, respectively; (4) urinary B + B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional ones. The Iso% levels in FPTPSD group were higher than the ones in PTPSD group; (5) an accuracy of diagnosis for PTPSD was increased by 9–19% when Iso% was introduced to urinary pterin scheme. Conclusions Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of diagnosis. This approach is worthy of further development and increased utilization.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">6-Pyruvoyltetrahydropterin synthase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hyperphenylalaninemia</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Isoxanthopterin</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phenylalanine hydroxylase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pterin</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ye, Jun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Lian-Shu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Qiu, Wen-Juan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Hui-Wen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yu, Yong-Guo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Jian-Guo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gu, Xue-Fan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">World Journal of Pediatrics</subfield><subfield code="d">Springer-Verlag, 2008</subfield><subfield code="g">15(2018), 1 vom: 15. Nov., Seite 66-71</subfield><subfield code="w">(DE-627)SPR02598876X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:15</subfield><subfield code="g">year:2018</subfield><subfield code="g">number:1</subfield><subfield code="g">day:15</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:66-71</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s12519-018-0202-2</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_61</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_66</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_92</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_135</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_181</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_192</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_211</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_252</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">15</subfield><subfield code="j">2018</subfield><subfield code="e">1</subfield><subfield code="b">15</subfield><subfield code="c">11</subfield><subfield code="h">66-71</subfield></datafield></record></collection>
|
score |
7.4008036 |