Biosensor approaches for the detection of autoantibodies in human serum
Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Schlichtiger, Alice [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2012 |
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Enthalten in: Bioanalytical reviews - Wien [u.a.] : Springer, 2009, 4(2012), 2-4 vom: 14. März, Seite 75-86 |
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volume:4 ; year:2012 ; number:2-4 ; day:14 ; month:03 ; pages:75-86 |
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10.1007/s12566-012-0028-7 |
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| 520 | |a Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. | ||
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10.1007/s12566-012-0028-7 doi (DE-627)SPR026137305 (SPR)s12566-012-0028-7-e DE-627 ger DE-627 rakwb eng Schlichtiger, Alice verfasserin aut Biosensor approaches for the detection of autoantibodies in human serum 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. Biosensor (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Autoantibodies (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Luppa, Peter B. aut Neumeier, Dieter aut Thaler, Markus aut Enthalten in Bioanalytical reviews Wien [u.a.] : Springer, 2009 4(2012), 2-4 vom: 14. März, Seite 75-86 (DE-627)605216738 (DE-600)2505915-4 1867-2094 nnns volume:4 year:2012 number:2-4 day:14 month:03 pages:75-86 https://dx.doi.org/10.1007/s12566-012-0028-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_702 GBV_ILN_2190 AR 4 2012 2-4 14 03 75-86 |
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10.1007/s12566-012-0028-7 doi (DE-627)SPR026137305 (SPR)s12566-012-0028-7-e DE-627 ger DE-627 rakwb eng Schlichtiger, Alice verfasserin aut Biosensor approaches for the detection of autoantibodies in human serum 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. Biosensor (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Autoantibodies (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Luppa, Peter B. aut Neumeier, Dieter aut Thaler, Markus aut Enthalten in Bioanalytical reviews Wien [u.a.] : Springer, 2009 4(2012), 2-4 vom: 14. März, Seite 75-86 (DE-627)605216738 (DE-600)2505915-4 1867-2094 nnns volume:4 year:2012 number:2-4 day:14 month:03 pages:75-86 https://dx.doi.org/10.1007/s12566-012-0028-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_702 GBV_ILN_2190 AR 4 2012 2-4 14 03 75-86 |
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10.1007/s12566-012-0028-7 doi (DE-627)SPR026137305 (SPR)s12566-012-0028-7-e DE-627 ger DE-627 rakwb eng Schlichtiger, Alice verfasserin aut Biosensor approaches for the detection of autoantibodies in human serum 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. Biosensor (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Autoantibodies (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Luppa, Peter B. aut Neumeier, Dieter aut Thaler, Markus aut Enthalten in Bioanalytical reviews Wien [u.a.] : Springer, 2009 4(2012), 2-4 vom: 14. März, Seite 75-86 (DE-627)605216738 (DE-600)2505915-4 1867-2094 nnns volume:4 year:2012 number:2-4 day:14 month:03 pages:75-86 https://dx.doi.org/10.1007/s12566-012-0028-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_702 GBV_ILN_2190 AR 4 2012 2-4 14 03 75-86 |
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10.1007/s12566-012-0028-7 doi (DE-627)SPR026137305 (SPR)s12566-012-0028-7-e DE-627 ger DE-627 rakwb eng Schlichtiger, Alice verfasserin aut Biosensor approaches for the detection of autoantibodies in human serum 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. Biosensor (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Autoantibodies (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Luppa, Peter B. aut Neumeier, Dieter aut Thaler, Markus aut Enthalten in Bioanalytical reviews Wien [u.a.] : Springer, 2009 4(2012), 2-4 vom: 14. März, Seite 75-86 (DE-627)605216738 (DE-600)2505915-4 1867-2094 nnns volume:4 year:2012 number:2-4 day:14 month:03 pages:75-86 https://dx.doi.org/10.1007/s12566-012-0028-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_702 GBV_ILN_2190 AR 4 2012 2-4 14 03 75-86 |
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10.1007/s12566-012-0028-7 doi (DE-627)SPR026137305 (SPR)s12566-012-0028-7-e DE-627 ger DE-627 rakwb eng Schlichtiger, Alice verfasserin aut Biosensor approaches for the detection of autoantibodies in human serum 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag 2012 Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. Biosensor (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Autoantibodies (dpeaa)DE-He213 Autoimmune disease (dpeaa)DE-He213 Luppa, Peter B. aut Neumeier, Dieter aut Thaler, Markus aut Enthalten in Bioanalytical reviews Wien [u.a.] : Springer, 2009 4(2012), 2-4 vom: 14. März, Seite 75-86 (DE-627)605216738 (DE-600)2505915-4 1867-2094 nnns volume:4 year:2012 number:2-4 day:14 month:03 pages:75-86 https://dx.doi.org/10.1007/s12566-012-0028-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_702 GBV_ILN_2190 AR 4 2012 2-4 14 03 75-86 |
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Biosensor approaches for the detection of autoantibodies in human serum |
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Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. © Springer-Verlag 2012 |
| abstractGer |
Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. © Springer-Verlag 2012 |
| abstract_unstemmed |
Abstract The analysis of autoantibodies in human serum plays a crucial role in the diagnosis and follow-up of autoimmune diseases. The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. This promising bioanalytical technique is also particularly important for the structural identification of novel antigens. © Springer-Verlag 2012 |
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| title_short |
Biosensor approaches for the detection of autoantibodies in human serum |
| url |
https://dx.doi.org/10.1007/s12566-012-0028-7 |
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Luppa, Peter B. Neumeier, Dieter Thaler, Markus |
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| doi_str |
10.1007/s12566-012-0028-7 |
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2024-07-03T19:04:51.666Z |
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The analytical tools available for the determination of these analytes, however, are still far from mature, lack standardization, and give low negative predictive values. Approaches using biosensor technology for analysis are an attractive alternative to classical techniques. In special applications, biosensors already have been proven to be effective for clinical diagnostics. This is due to the fact that real-time monitoring of the antigen/antibody interaction gives valuable information on autoantibody affinity to the respective antigenic structure. The potentials of biosensors for the serological analysis of autoantibodies are evident from the increasing number of publications on the subject. Thus, this review focuses on underlying biosensor techniques and published clinical trials. The advantages of multiplexed analyses of autoantibodies by use of microarrays are also emphasized. 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