Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice

Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscl...
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Autor*in:	Kawamura, Naoya [verfasserIn] Ohnuki, Yoshiki Matsuo, Ichiro Suita, Kenji Ishikawa, Misao Mototani, Yasumasa Shiozawa, Kouichi Ito, Aiko Yagisawa, Yuka Hayakawa, Yoshio Nariyama, Megumi Umeki, Daisuke Ujiie, Yuko Gomi, Kazuhiro Okumura, Satoshi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Lipopolysaccharide Periodontitis Sarcopenia Apoptosis Fibrosis Signal transduction

Anmerkung:	© The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019

Übergeordnetes Werk:	Enthalten in: The journal of physiological sciences - [Tokyo] : Springer, 2006, 69(2019), 3 vom: 08. März, Seite 503-511
Übergeordnetes Werk:	volume:69 ; year:2019 ; number:3 ; day:08 ; month:03 ; pages:503-511

Links:	Volltext

DOI / URN:	10.1007/s12576-019-00670-z

Katalog-ID:	SPR02617264X

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520			\|a Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia.
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allfields	10.1007/s12576-019-00670-z doi (DE-627)SPR02617264X (SPR)s12576-019-00670-z-e DE-627 ger DE-627 rakwb eng Kawamura, Naoya verfasserin aut Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019 Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. Lipopolysaccharide (dpeaa)DE-He213 Periodontitis (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Ohnuki, Yoshiki aut Matsuo, Ichiro aut Suita, Kenji aut Ishikawa, Misao aut Mototani, Yasumasa aut Shiozawa, Kouichi aut Ito, Aiko aut Yagisawa, Yuka aut Hayakawa, Yoshio aut Nariyama, Megumi aut Umeki, Daisuke aut Ujiie, Yuko aut Gomi, Kazuhiro aut Okumura, Satoshi (orcid)0000-0001-8747-7941 aut Enthalten in The journal of physiological sciences [Tokyo] : Springer, 2006 69(2019), 3 vom: 08. März, Seite 503-511 (DE-627)572081235 (DE-600)2437104-X 1880-6562 nnns volume:69 year:2019 number:3 day:08 month:03 pages:503-511 https://dx.doi.org/10.1007/s12576-019-00670-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 3 08 03 503-511
spelling	10.1007/s12576-019-00670-z doi (DE-627)SPR02617264X (SPR)s12576-019-00670-z-e DE-627 ger DE-627 rakwb eng Kawamura, Naoya verfasserin aut Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019 Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. Lipopolysaccharide (dpeaa)DE-He213 Periodontitis (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Ohnuki, Yoshiki aut Matsuo, Ichiro aut Suita, Kenji aut Ishikawa, Misao aut Mototani, Yasumasa aut Shiozawa, Kouichi aut Ito, Aiko aut Yagisawa, Yuka aut Hayakawa, Yoshio aut Nariyama, Megumi aut Umeki, Daisuke aut Ujiie, Yuko aut Gomi, Kazuhiro aut Okumura, Satoshi (orcid)0000-0001-8747-7941 aut Enthalten in The journal of physiological sciences [Tokyo] : Springer, 2006 69(2019), 3 vom: 08. März, Seite 503-511 (DE-627)572081235 (DE-600)2437104-X 1880-6562 nnns volume:69 year:2019 number:3 day:08 month:03 pages:503-511 https://dx.doi.org/10.1007/s12576-019-00670-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 3 08 03 503-511
allfields_unstemmed	10.1007/s12576-019-00670-z doi (DE-627)SPR02617264X (SPR)s12576-019-00670-z-e DE-627 ger DE-627 rakwb eng Kawamura, Naoya verfasserin aut Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019 Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. Lipopolysaccharide (dpeaa)DE-He213 Periodontitis (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Ohnuki, Yoshiki aut Matsuo, Ichiro aut Suita, Kenji aut Ishikawa, Misao aut Mototani, Yasumasa aut Shiozawa, Kouichi aut Ito, Aiko aut Yagisawa, Yuka aut Hayakawa, Yoshio aut Nariyama, Megumi aut Umeki, Daisuke aut Ujiie, Yuko aut Gomi, Kazuhiro aut Okumura, Satoshi (orcid)0000-0001-8747-7941 aut Enthalten in The journal of physiological sciences [Tokyo] : Springer, 2006 69(2019), 3 vom: 08. März, Seite 503-511 (DE-627)572081235 (DE-600)2437104-X 1880-6562 nnns volume:69 year:2019 number:3 day:08 month:03 pages:503-511 https://dx.doi.org/10.1007/s12576-019-00670-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 3 08 03 503-511
allfieldsGer	10.1007/s12576-019-00670-z doi (DE-627)SPR02617264X (SPR)s12576-019-00670-z-e DE-627 ger DE-627 rakwb eng Kawamura, Naoya verfasserin aut Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019 Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. Lipopolysaccharide (dpeaa)DE-He213 Periodontitis (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Ohnuki, Yoshiki aut Matsuo, Ichiro aut Suita, Kenji aut Ishikawa, Misao aut Mototani, Yasumasa aut Shiozawa, Kouichi aut Ito, Aiko aut Yagisawa, Yuka aut Hayakawa, Yoshio aut Nariyama, Megumi aut Umeki, Daisuke aut Ujiie, Yuko aut Gomi, Kazuhiro aut Okumura, Satoshi (orcid)0000-0001-8747-7941 aut Enthalten in The journal of physiological sciences [Tokyo] : Springer, 2006 69(2019), 3 vom: 08. März, Seite 503-511 (DE-627)572081235 (DE-600)2437104-X 1880-6562 nnns volume:69 year:2019 number:3 day:08 month:03 pages:503-511 https://dx.doi.org/10.1007/s12576-019-00670-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 3 08 03 503-511
allfieldsSound	10.1007/s12576-019-00670-z doi (DE-627)SPR02617264X (SPR)s12576-019-00670-z-e DE-627 ger DE-627 rakwb eng Kawamura, Naoya verfasserin aut Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019 Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. Lipopolysaccharide (dpeaa)DE-He213 Periodontitis (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Ohnuki, Yoshiki aut Matsuo, Ichiro aut Suita, Kenji aut Ishikawa, Misao aut Mototani, Yasumasa aut Shiozawa, Kouichi aut Ito, Aiko aut Yagisawa, Yuka aut Hayakawa, Yoshio aut Nariyama, Megumi aut Umeki, Daisuke aut Ujiie, Yuko aut Gomi, Kazuhiro aut Okumura, Satoshi (orcid)0000-0001-8747-7941 aut Enthalten in The journal of physiological sciences [Tokyo] : Springer, 2006 69(2019), 3 vom: 08. März, Seite 503-511 (DE-627)572081235 (DE-600)2437104-X 1880-6562 nnns volume:69 year:2019 number:3 day:08 month:03 pages:503-511 https://dx.doi.org/10.1007/s12576-019-00670-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 69 2019 3 08 03 503-511
language	English
source	Enthalten in The journal of physiological sciences 69(2019), 3 vom: 08. März, Seite 503-511 volume:69 year:2019 number:3 day:08 month:03 pages:503-511
sourceStr	Enthalten in The journal of physiological sciences 69(2019), 3 vom: 08. März, Seite 503-511 volume:69 year:2019 number:3 day:08 month:03 pages:503-511
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lipopolysaccharide Periodontitis Sarcopenia Apoptosis Fibrosis Signal transduction
isfreeaccess_bool	false
container_title	The journal of physiological sciences
authorswithroles_txt_mv	Kawamura, Naoya @@aut@@ Ohnuki, Yoshiki @@aut@@ Matsuo, Ichiro @@aut@@ Suita, Kenji @@aut@@ Ishikawa, Misao @@aut@@ Mototani, Yasumasa @@aut@@ Shiozawa, Kouichi @@aut@@ Ito, Aiko @@aut@@ Yagisawa, Yuka @@aut@@ Hayakawa, Yoshio @@aut@@ Nariyama, Megumi @@aut@@ Umeki, Daisuke @@aut@@ Ujiie, Yuko @@aut@@ Gomi, Kazuhiro @@aut@@ Okumura, Satoshi @@aut@@
publishDateDaySort_date	2019-03-08T00:00:00Z
hierarchy_top_id	572081235
id	SPR02617264X
language_de	englisch
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However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. 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author	Kawamura, Naoya
spellingShingle	Kawamura, Naoya misc Lipopolysaccharide misc Periodontitis misc Sarcopenia misc Apoptosis misc Fibrosis misc Signal transduction Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice
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topic_title	Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice Lipopolysaccharide (dpeaa)DE-He213 Periodontitis (dpeaa)DE-He213 Sarcopenia (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213
topic	misc Lipopolysaccharide misc Periodontitis misc Sarcopenia misc Apoptosis misc Fibrosis misc Signal transduction
topic_unstemmed	misc Lipopolysaccharide misc Periodontitis misc Sarcopenia misc Apoptosis misc Fibrosis misc Signal transduction
topic_browse	misc Lipopolysaccharide misc Periodontitis misc Sarcopenia misc Apoptosis misc Fibrosis misc Signal transduction
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title	Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice
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title_full	Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice
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author_browse	Kawamura, Naoya Ohnuki, Yoshiki Matsuo, Ichiro Suita, Kenji Ishikawa, Misao Mototani, Yasumasa Shiozawa, Kouichi Ito, Aiko Yagisawa, Yuka Hayakawa, Yoshio Nariyama, Megumi Umeki, Daisuke Ujiie, Yuko Gomi, Kazuhiro Okumura, Satoshi
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title_sort	effects of chronic porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice
title_auth	Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice
abstract	Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019
abstractGer	Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019
abstract_unstemmed	Abstract Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia. © The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2019
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title_short	Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice
url	https://dx.doi.org/10.1007/s12576-019-00670-z
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up_date	2024-07-03T19:18:06.215Z
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However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. 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Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice

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