Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus
Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Singh, Namrata [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© Indian Society of Gastroenterology 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Indian Journal of Gastroenterology - Springer-Verlag, 2009, 31(2012), 5 vom: 25. Aug., Seite 226-231 |
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| Übergeordnetes Werk: |
volume:31 ; year:2012 ; number:5 ; day:25 ; month:08 ; pages:226-231 |
| Links: |
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| DOI / URN: |
10.1007/s12664-012-0236-7 |
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| Katalog-ID: |
SPR026654970 |
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| 520 | |a Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. | ||
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| 650 | 4 | |a Nutrient deficiency |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxidative stress |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pancreatic calcification |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pancreatic diabetes |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Pandey, Ravinder M |4 aut | |
| 700 | 1 | |a Saraya, Anoop |4 aut | |
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10.1007/s12664-012-0236-7 doi (DE-627)SPR026654970 (SPR)s12664-012-0236-7-e DE-627 ger DE-627 rakwb eng Singh, Namrata verfasserin aut Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2012 Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. Chronic pancreatitis (dpeaa)DE-He213 Nutrient deficiency (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Pancreatic calcification (dpeaa)DE-He213 Pancreatic diabetes (dpeaa)DE-He213 Total antioxidant capacity (dpeaa)DE-He213 Tropical pancreatitis (dpeaa)DE-He213 Bhardwaj, Payal aut Pandey, Ravinder M aut Saraya, Anoop aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 31(2012), 5 vom: 25. Aug., Seite 226-231 (DE-627)SPR02665167X nnns volume:31 year:2012 number:5 day:25 month:08 pages:226-231 https://dx.doi.org/10.1007/s12664-012-0236-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2012 5 25 08 226-231 |
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10.1007/s12664-012-0236-7 doi (DE-627)SPR026654970 (SPR)s12664-012-0236-7-e DE-627 ger DE-627 rakwb eng Singh, Namrata verfasserin aut Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2012 Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. Chronic pancreatitis (dpeaa)DE-He213 Nutrient deficiency (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Pancreatic calcification (dpeaa)DE-He213 Pancreatic diabetes (dpeaa)DE-He213 Total antioxidant capacity (dpeaa)DE-He213 Tropical pancreatitis (dpeaa)DE-He213 Bhardwaj, Payal aut Pandey, Ravinder M aut Saraya, Anoop aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 31(2012), 5 vom: 25. Aug., Seite 226-231 (DE-627)SPR02665167X nnns volume:31 year:2012 number:5 day:25 month:08 pages:226-231 https://dx.doi.org/10.1007/s12664-012-0236-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2012 5 25 08 226-231 |
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10.1007/s12664-012-0236-7 doi (DE-627)SPR026654970 (SPR)s12664-012-0236-7-e DE-627 ger DE-627 rakwb eng Singh, Namrata verfasserin aut Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2012 Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. Chronic pancreatitis (dpeaa)DE-He213 Nutrient deficiency (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Pancreatic calcification (dpeaa)DE-He213 Pancreatic diabetes (dpeaa)DE-He213 Total antioxidant capacity (dpeaa)DE-He213 Tropical pancreatitis (dpeaa)DE-He213 Bhardwaj, Payal aut Pandey, Ravinder M aut Saraya, Anoop aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 31(2012), 5 vom: 25. Aug., Seite 226-231 (DE-627)SPR02665167X nnns volume:31 year:2012 number:5 day:25 month:08 pages:226-231 https://dx.doi.org/10.1007/s12664-012-0236-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2012 5 25 08 226-231 |
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10.1007/s12664-012-0236-7 doi (DE-627)SPR026654970 (SPR)s12664-012-0236-7-e DE-627 ger DE-627 rakwb eng Singh, Namrata verfasserin aut Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2012 Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. Chronic pancreatitis (dpeaa)DE-He213 Nutrient deficiency (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Pancreatic calcification (dpeaa)DE-He213 Pancreatic diabetes (dpeaa)DE-He213 Total antioxidant capacity (dpeaa)DE-He213 Tropical pancreatitis (dpeaa)DE-He213 Bhardwaj, Payal aut Pandey, Ravinder M aut Saraya, Anoop aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 31(2012), 5 vom: 25. Aug., Seite 226-231 (DE-627)SPR02665167X nnns volume:31 year:2012 number:5 day:25 month:08 pages:226-231 https://dx.doi.org/10.1007/s12664-012-0236-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2012 5 25 08 226-231 |
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10.1007/s12664-012-0236-7 doi (DE-627)SPR026654970 (SPR)s12664-012-0236-7-e DE-627 ger DE-627 rakwb eng Singh, Namrata verfasserin aut Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2012 Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. Chronic pancreatitis (dpeaa)DE-He213 Nutrient deficiency (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Pancreatic calcification (dpeaa)DE-He213 Pancreatic diabetes (dpeaa)DE-He213 Total antioxidant capacity (dpeaa)DE-He213 Tropical pancreatitis (dpeaa)DE-He213 Bhardwaj, Payal aut Pandey, Ravinder M aut Saraya, Anoop aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 31(2012), 5 vom: 25. Aug., Seite 226-231 (DE-627)SPR02665167X nnns volume:31 year:2012 number:5 day:25 month:08 pages:226-231 https://dx.doi.org/10.1007/s12664-012-0236-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 31 2012 5 25 08 226-231 |
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Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus Chronic pancreatitis (dpeaa)DE-He213 Nutrient deficiency (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Pancreatic calcification (dpeaa)DE-He213 Pancreatic diabetes (dpeaa)DE-He213 Total antioxidant capacity (dpeaa)DE-He213 Tropical pancreatitis (dpeaa)DE-He213 |
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Indian Journal of Gastroenterology |
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Indian Journal of Gastroenterology |
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Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus |
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Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus |
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Singh, Namrata |
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Indian Journal of Gastroenterology |
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Indian Journal of Gastroenterology |
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eng |
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2012 |
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226 |
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Singh, Namrata Bhardwaj, Payal Pandey, Ravinder M Saraya, Anoop |
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31 |
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Singh, Namrata |
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10.1007/s12664-012-0236-7 |
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oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus |
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Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus |
| abstract |
Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. © Indian Society of Gastroenterology 2012 |
| abstractGer |
Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. © Indian Society of Gastroenterology 2012 |
| abstract_unstemmed |
Aim To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. Methods This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). Results Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3–21) vs. 3 (0.3–24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles $ Fe^{+2} $ liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles $ Fe^{+2} $ liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. Conclusions Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. © Indian Society of Gastroenterology 2012 |
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Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus |
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https://dx.doi.org/10.1007/s12664-012-0236-7 |
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Bhardwaj, Payal Pandey, Ravinder M Saraya, Anoop |
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