Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection
Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hiyoshi, Masahide [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
Dye-dilution cardiac output flowmeter |
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| Anmerkung: |
© Indian Society of Gastroenterology 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Indian Journal of Gastroenterology - Springer-Verlag, 2009, 38(2019), 5 vom: Okt., Seite 441-449 |
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| Übergeordnetes Werk: |
volume:38 ; year:2019 ; number:5 ; month:10 ; pages:441-449 |
| Links: |
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| DOI / URN: |
10.1007/s12664-019-00994-z |
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| Katalog-ID: |
SPR026663279 |
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| 100 | 1 | |a Hiyoshi, Masahide |e verfasserin |0 (orcid)0000-0002-2392-7787 |4 aut | |
| 245 | 1 | 0 | |a Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection |
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| 520 | |a Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. | ||
| 650 | 4 | |a Clearance value |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dye-dilution cardiac output flowmeter |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Indocyanine green retention rate at 15 min (ICGR15) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Liver resection |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Yano, Koichi |4 aut | |
| 700 | 1 | |a Nanashima, Atsushi |4 aut | |
| 700 | 1 | |a Imamura, Naoya |4 aut | |
| 700 | 1 | |a Hamada, Takeomi |4 aut | |
| 700 | 1 | |a Wada, Takashi |4 aut | |
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10.1007/s12664-019-00994-z doi (DE-627)SPR026663279 (SPR)s12664-019-00994-z-e DE-627 ger DE-627 rakwb eng Hiyoshi, Masahide verfasserin (orcid)0000-0002-2392-7787 aut Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2019 Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. Clearance value (dpeaa)DE-He213 Dye-dilution cardiac output flowmeter (dpeaa)DE-He213 Indocyanine green retention rate at 15 min (ICGR15) (dpeaa)DE-He213 Liver resection (dpeaa)DE-He213 Yano, Koichi aut Nanashima, Atsushi aut Imamura, Naoya aut Hamada, Takeomi aut Wada, Takashi aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 38(2019), 5 vom: Okt., Seite 441-449 (DE-627)SPR02665167X nnns volume:38 year:2019 number:5 month:10 pages:441-449 https://dx.doi.org/10.1007/s12664-019-00994-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 38 2019 5 10 441-449 |
| spelling |
10.1007/s12664-019-00994-z doi (DE-627)SPR026663279 (SPR)s12664-019-00994-z-e DE-627 ger DE-627 rakwb eng Hiyoshi, Masahide verfasserin (orcid)0000-0002-2392-7787 aut Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2019 Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. Clearance value (dpeaa)DE-He213 Dye-dilution cardiac output flowmeter (dpeaa)DE-He213 Indocyanine green retention rate at 15 min (ICGR15) (dpeaa)DE-He213 Liver resection (dpeaa)DE-He213 Yano, Koichi aut Nanashima, Atsushi aut Imamura, Naoya aut Hamada, Takeomi aut Wada, Takashi aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 38(2019), 5 vom: Okt., Seite 441-449 (DE-627)SPR02665167X nnns volume:38 year:2019 number:5 month:10 pages:441-449 https://dx.doi.org/10.1007/s12664-019-00994-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 38 2019 5 10 441-449 |
| allfields_unstemmed |
10.1007/s12664-019-00994-z doi (DE-627)SPR026663279 (SPR)s12664-019-00994-z-e DE-627 ger DE-627 rakwb eng Hiyoshi, Masahide verfasserin (orcid)0000-0002-2392-7787 aut Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2019 Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. Clearance value (dpeaa)DE-He213 Dye-dilution cardiac output flowmeter (dpeaa)DE-He213 Indocyanine green retention rate at 15 min (ICGR15) (dpeaa)DE-He213 Liver resection (dpeaa)DE-He213 Yano, Koichi aut Nanashima, Atsushi aut Imamura, Naoya aut Hamada, Takeomi aut Wada, Takashi aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 38(2019), 5 vom: Okt., Seite 441-449 (DE-627)SPR02665167X nnns volume:38 year:2019 number:5 month:10 pages:441-449 https://dx.doi.org/10.1007/s12664-019-00994-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 38 2019 5 10 441-449 |
| allfieldsGer |
10.1007/s12664-019-00994-z doi (DE-627)SPR026663279 (SPR)s12664-019-00994-z-e DE-627 ger DE-627 rakwb eng Hiyoshi, Masahide verfasserin (orcid)0000-0002-2392-7787 aut Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2019 Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. Clearance value (dpeaa)DE-He213 Dye-dilution cardiac output flowmeter (dpeaa)DE-He213 Indocyanine green retention rate at 15 min (ICGR15) (dpeaa)DE-He213 Liver resection (dpeaa)DE-He213 Yano, Koichi aut Nanashima, Atsushi aut Imamura, Naoya aut Hamada, Takeomi aut Wada, Takashi aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 38(2019), 5 vom: Okt., Seite 441-449 (DE-627)SPR02665167X nnns volume:38 year:2019 number:5 month:10 pages:441-449 https://dx.doi.org/10.1007/s12664-019-00994-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 38 2019 5 10 441-449 |
| allfieldsSound |
10.1007/s12664-019-00994-z doi (DE-627)SPR026663279 (SPR)s12664-019-00994-z-e DE-627 ger DE-627 rakwb eng Hiyoshi, Masahide verfasserin (orcid)0000-0002-2392-7787 aut Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Society of Gastroenterology 2019 Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. Clearance value (dpeaa)DE-He213 Dye-dilution cardiac output flowmeter (dpeaa)DE-He213 Indocyanine green retention rate at 15 min (ICGR15) (dpeaa)DE-He213 Liver resection (dpeaa)DE-He213 Yano, Koichi aut Nanashima, Atsushi aut Imamura, Naoya aut Hamada, Takeomi aut Wada, Takashi aut Enthalten in Indian Journal of Gastroenterology Springer-Verlag, 2009 38(2019), 5 vom: Okt., Seite 441-449 (DE-627)SPR02665167X nnns volume:38 year:2019 number:5 month:10 pages:441-449 https://dx.doi.org/10.1007/s12664-019-00994-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 38 2019 5 10 441-449 |
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Hiyoshi, Masahide @@aut@@ Yano, Koichi @@aut@@ Nanashima, Atsushi @@aut@@ Imamura, Naoya @@aut@@ Hamada, Takeomi @@aut@@ Wada, Takashi @@aut@@ |
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To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). 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Hiyoshi, Masahide |
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Hiyoshi, Masahide misc Clearance value misc Dye-dilution cardiac output flowmeter misc Indocyanine green retention rate at 15 min (ICGR15) misc Liver resection Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection |
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Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection Clearance value (dpeaa)DE-He213 Dye-dilution cardiac output flowmeter (dpeaa)DE-He213 Indocyanine green retention rate at 15 min (ICGR15) (dpeaa)DE-He213 Liver resection (dpeaa)DE-He213 |
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Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection |
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reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection |
| title_auth |
Reliability of indocyanine green retention and clearance rates at 15 minutes calculated by dye-dilution cardiac output flowmetry in comparison to blood sampling in patients undergoing hepatic resection |
| abstract |
Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. © Indian Society of Gastroenterology 2019 |
| abstractGer |
Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. © Indian Society of Gastroenterology 2019 |
| abstract_unstemmed |
Background The indocyanine green retention rate at 15 min (ICGR15) is a marker of the liver function and is useful for planning hepatectomy. To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. Significant differences were observed between R15-BS and R15-DCOF (1.1 ± 4.8%; p = 0.002) and R15m-DCOF (4.0 ± 5.9%; p < 0.001). The difference between R15-BS and R15m-DCOF was greater than that between R15-BS and R15-DCOF. Correlation between R15-BS and R15-DCOF was significant r = 0.839 (p < 0.001). Conclusions The ICGR15 measured by DCOF shows comparable reliability and stability to the BS method, which is useful for planning hepatectomy. © Indian Society of Gastroenterology 2019 |
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To clarify the ICGR15 and the related clearance value (ICGK) calculated by a dye-dilution cardiac output flowmetry (DCOF), we examined the correlation and clinical significance of the ICGR15 values determined by DCOF and those determined with the conventional blood sampling (BS) procedure. Methods We extracted liver function parameters, including the ICGR15 modified value and ICGK, and the extent of hepatectomy from the clinical and surgical records of 63 patients with various liver diseases in whom the ICGR15 (actual value), R15m (mean), and K (clearance rate per minute) were measured by DCOF. Results All the patients were classified as Child-Pugh grade A. Hepatic complications were observed in 10 (16%) patients, but there was no mortality. The mean values of ICGR15 determined by BS (R15-BS) and DCOF (R15-DCOF) were 12.2 ± 8.1% and 11.2 ± 8.7%, respectively. The mean R15m determined by DCOF (R15m-DCOF) was 15.7 ± 10.2%. 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