Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep
Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vitezica, Zulma G. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Anmerkung: |
© INRA, EDP Sciences 2007 |
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| Übergeordnetes Werk: |
Enthalten in: Genetics, selection, evolution - London : BioMed Central, 1989, 39(2007), 4 vom: 06. Juli |
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| Übergeordnetes Werk: |
volume:39 ; year:2007 ; number:4 ; day:06 ; month:07 |
| Links: |
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| DOI / URN: |
10.1186/1297-9686-39-4-421 |
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| Katalog-ID: |
SPR026804271 |
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| 520 | |a Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. | ||
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| 700 | 1 | |a Elsen, Jean-Michel |4 aut | |
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10.1186/1297-9686-39-4-421 doi (DE-627)SPR026804271 (SPR)1297-9686-39-4-421-e DE-627 ger DE-627 rakwb eng Vitezica, Zulma G. verfasserin aut Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © INRA, EDP Sciences 2007 Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. association analysis (dpeaa)DE-He213 production trait (dpeaa)DE-He213 health trait (dpeaa)DE-He213 gene (dpeaa)DE-He213 sheep (dpeaa)DE-He213 Moreno, Carole R. aut Lantier, Frederic aut Lantier, Isabelle aut Schibler, Laurent aut Roig, Anne aut François, Dominique aut Bouix, Jacques aut Allain, Daniel aut Brunel, Jean-Claude aut Barillet, Francis aut Elsen, Jean-Michel aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 39(2007), 4 vom: 06. Juli (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:39 year:2007 number:4 day:06 month:07 https://dx.doi.org/10.1186/1297-9686-39-4-421 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2007 4 06 07 |
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10.1186/1297-9686-39-4-421 doi (DE-627)SPR026804271 (SPR)1297-9686-39-4-421-e DE-627 ger DE-627 rakwb eng Vitezica, Zulma G. verfasserin aut Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © INRA, EDP Sciences 2007 Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. association analysis (dpeaa)DE-He213 production trait (dpeaa)DE-He213 health trait (dpeaa)DE-He213 gene (dpeaa)DE-He213 sheep (dpeaa)DE-He213 Moreno, Carole R. aut Lantier, Frederic aut Lantier, Isabelle aut Schibler, Laurent aut Roig, Anne aut François, Dominique aut Bouix, Jacques aut Allain, Daniel aut Brunel, Jean-Claude aut Barillet, Francis aut Elsen, Jean-Michel aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 39(2007), 4 vom: 06. Juli (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:39 year:2007 number:4 day:06 month:07 https://dx.doi.org/10.1186/1297-9686-39-4-421 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2007 4 06 07 |
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10.1186/1297-9686-39-4-421 doi (DE-627)SPR026804271 (SPR)1297-9686-39-4-421-e DE-627 ger DE-627 rakwb eng Vitezica, Zulma G. verfasserin aut Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © INRA, EDP Sciences 2007 Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. association analysis (dpeaa)DE-He213 production trait (dpeaa)DE-He213 health trait (dpeaa)DE-He213 gene (dpeaa)DE-He213 sheep (dpeaa)DE-He213 Moreno, Carole R. aut Lantier, Frederic aut Lantier, Isabelle aut Schibler, Laurent aut Roig, Anne aut François, Dominique aut Bouix, Jacques aut Allain, Daniel aut Brunel, Jean-Claude aut Barillet, Francis aut Elsen, Jean-Michel aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 39(2007), 4 vom: 06. Juli (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:39 year:2007 number:4 day:06 month:07 https://dx.doi.org/10.1186/1297-9686-39-4-421 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2007 4 06 07 |
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10.1186/1297-9686-39-4-421 doi (DE-627)SPR026804271 (SPR)1297-9686-39-4-421-e DE-627 ger DE-627 rakwb eng Vitezica, Zulma G. verfasserin aut Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © INRA, EDP Sciences 2007 Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. association analysis (dpeaa)DE-He213 production trait (dpeaa)DE-He213 health trait (dpeaa)DE-He213 gene (dpeaa)DE-He213 sheep (dpeaa)DE-He213 Moreno, Carole R. aut Lantier, Frederic aut Lantier, Isabelle aut Schibler, Laurent aut Roig, Anne aut François, Dominique aut Bouix, Jacques aut Allain, Daniel aut Brunel, Jean-Claude aut Barillet, Francis aut Elsen, Jean-Michel aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 39(2007), 4 vom: 06. Juli (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:39 year:2007 number:4 day:06 month:07 https://dx.doi.org/10.1186/1297-9686-39-4-421 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2007 4 06 07 |
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10.1186/1297-9686-39-4-421 doi (DE-627)SPR026804271 (SPR)1297-9686-39-4-421-e DE-627 ger DE-627 rakwb eng Vitezica, Zulma G. verfasserin aut Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © INRA, EDP Sciences 2007 Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. association analysis (dpeaa)DE-He213 production trait (dpeaa)DE-He213 health trait (dpeaa)DE-He213 gene (dpeaa)DE-He213 sheep (dpeaa)DE-He213 Moreno, Carole R. aut Lantier, Frederic aut Lantier, Isabelle aut Schibler, Laurent aut Roig, Anne aut François, Dominique aut Bouix, Jacques aut Allain, Daniel aut Brunel, Jean-Claude aut Barillet, Francis aut Elsen, Jean-Michel aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 39(2007), 4 vom: 06. Juli (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:39 year:2007 number:4 day:06 month:07 https://dx.doi.org/10.1186/1297-9686-39-4-421 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 39 2007 4 06 07 |
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Vitezica, Zulma G. |
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Vitezica, Zulma G. misc association analysis misc production trait misc health trait misc gene misc sheep Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep |
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Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep association analysis (dpeaa)DE-He213 production trait (dpeaa)DE-He213 health trait (dpeaa)DE-He213 gene (dpeaa)DE-He213 sheep (dpeaa)DE-He213 |
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Vitezica, Zulma G. Moreno, Carole R. Lantier, Frederic Lantier, Isabelle Schibler, Laurent Roig, Anne François, Dominique Bouix, Jacques Allain, Daniel Brunel, Jean-Claude Barillet, Francis Elsen, Jean-Michel |
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quantitative trait loci linked to prnp gene controlling health and production traits in inra 401 sheep |
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Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep |
| abstract |
Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. © INRA, EDP Sciences 2007 |
| abstractGer |
Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. © INRA, EDP Sciences 2007 |
| abstract_unstemmed |
Abstract In this study, the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. However, a linkage between PRNP and this QTL does not imply unfavorable linkage disequilibrium for PRNP selection purposes. © INRA, EDP Sciences 2007 |
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Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes, which produced 1310 lambs. The animals were categorized into three PrP genotype classes: ARR homozygous, ARR heterozygous, and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly, the potential association of the PrP genotype with disease (Salmonella resistance) and production (wool and carcass) traits was studied. The data used included 1042, 1043 and 1013 genotyped animals for the Salmonella resistance, wool and carcass traits, respectively. The different traits were analyzed using an animal model, where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly, a quantitative trait loci (QTL) detection approach using the PRNP gene as a marker was applied on ovine chromosome 13. Interval mapping was used. Evidence for one QTL affecting mean fiber diameter was found at 25 cM from the PRNP gene. 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