Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line

Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Muñoz, María [verfasserIn] Fernández, Ana Isabel Óvilo, Cristina Muñoz, Gloria Rodriguez, Carmen Fernández, Almudena Alves, Estefânia Silió, Luis

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Wild Boar Single Nucleotide Polymorphism Litter Size Paternal Allele Wild Boar Population

Anmerkung:	© Muñoz et al; licensee BioMed Central Ltd. 2010

Übergeordnetes Werk:	Enthalten in: Genetics, selection, evolution - London : BioMed Central, 1989, 42(2010), 1 vom: 25. Juni
Übergeordnetes Werk:	volume:42 ; year:2010 ; number:1 ; day:25 ; month:06

Links:	Volltext

DOI / URN:	10.1186/1297-9686-42-23

Katalog-ID:	SPR026805839

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520			\|a Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes.
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allfields	10.1186/1297-9686-42-23 doi (DE-627)SPR026805839 (SPR)1297-9686-42-23-e DE-627 ger DE-627 rakwb eng Muñoz, María verfasserin aut Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Muñoz et al; licensee BioMed Central Ltd. 2010 Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. Wild Boar (dpeaa)DE-He213 Single Nucleotide Polymorphism (dpeaa)DE-He213 Litter Size (dpeaa)DE-He213 Paternal Allele (dpeaa)DE-He213 Wild Boar Population (dpeaa)DE-He213 Fernández, Ana Isabel aut Óvilo, Cristina aut Muñoz, Gloria aut Rodriguez, Carmen aut Fernández, Almudena aut Alves, Estefânia aut Silió, Luis aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 42(2010), 1 vom: 25. Juni (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:42 year:2010 number:1 day:25 month:06 https://dx.doi.org/10.1186/1297-9686-42-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2010 1 25 06
spelling	10.1186/1297-9686-42-23 doi (DE-627)SPR026805839 (SPR)1297-9686-42-23-e DE-627 ger DE-627 rakwb eng Muñoz, María verfasserin aut Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Muñoz et al; licensee BioMed Central Ltd. 2010 Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. Wild Boar (dpeaa)DE-He213 Single Nucleotide Polymorphism (dpeaa)DE-He213 Litter Size (dpeaa)DE-He213 Paternal Allele (dpeaa)DE-He213 Wild Boar Population (dpeaa)DE-He213 Fernández, Ana Isabel aut Óvilo, Cristina aut Muñoz, Gloria aut Rodriguez, Carmen aut Fernández, Almudena aut Alves, Estefânia aut Silió, Luis aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 42(2010), 1 vom: 25. Juni (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:42 year:2010 number:1 day:25 month:06 https://dx.doi.org/10.1186/1297-9686-42-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2010 1 25 06
allfields_unstemmed	10.1186/1297-9686-42-23 doi (DE-627)SPR026805839 (SPR)1297-9686-42-23-e DE-627 ger DE-627 rakwb eng Muñoz, María verfasserin aut Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Muñoz et al; licensee BioMed Central Ltd. 2010 Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. Wild Boar (dpeaa)DE-He213 Single Nucleotide Polymorphism (dpeaa)DE-He213 Litter Size (dpeaa)DE-He213 Paternal Allele (dpeaa)DE-He213 Wild Boar Population (dpeaa)DE-He213 Fernández, Ana Isabel aut Óvilo, Cristina aut Muñoz, Gloria aut Rodriguez, Carmen aut Fernández, Almudena aut Alves, Estefânia aut Silió, Luis aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 42(2010), 1 vom: 25. Juni (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:42 year:2010 number:1 day:25 month:06 https://dx.doi.org/10.1186/1297-9686-42-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2010 1 25 06
allfieldsGer	10.1186/1297-9686-42-23 doi (DE-627)SPR026805839 (SPR)1297-9686-42-23-e DE-627 ger DE-627 rakwb eng Muñoz, María verfasserin aut Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Muñoz et al; licensee BioMed Central Ltd. 2010 Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. Wild Boar (dpeaa)DE-He213 Single Nucleotide Polymorphism (dpeaa)DE-He213 Litter Size (dpeaa)DE-He213 Paternal Allele (dpeaa)DE-He213 Wild Boar Population (dpeaa)DE-He213 Fernández, Ana Isabel aut Óvilo, Cristina aut Muñoz, Gloria aut Rodriguez, Carmen aut Fernández, Almudena aut Alves, Estefânia aut Silió, Luis aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 42(2010), 1 vom: 25. Juni (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:42 year:2010 number:1 day:25 month:06 https://dx.doi.org/10.1186/1297-9686-42-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2010 1 25 06
allfieldsSound	10.1186/1297-9686-42-23 doi (DE-627)SPR026805839 (SPR)1297-9686-42-23-e DE-627 ger DE-627 rakwb eng Muñoz, María verfasserin aut Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Muñoz et al; licensee BioMed Central Ltd. 2010 Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. Wild Boar (dpeaa)DE-He213 Single Nucleotide Polymorphism (dpeaa)DE-He213 Litter Size (dpeaa)DE-He213 Paternal Allele (dpeaa)DE-He213 Wild Boar Population (dpeaa)DE-He213 Fernández, Ana Isabel aut Óvilo, Cristina aut Muñoz, Gloria aut Rodriguez, Carmen aut Fernández, Almudena aut Alves, Estefânia aut Silió, Luis aut Enthalten in Genetics, selection, evolution London : BioMed Central, 1989 42(2010), 1 vom: 25. Juni (DE-627)312849052 (DE-600)2012369-3 1297-9686 nnns volume:42 year:2010 number:1 day:25 month:06 https://dx.doi.org/10.1186/1297-9686-42-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2010 1 25 06
language	English
source	Enthalten in Genetics, selection, evolution 42(2010), 1 vom: 25. Juni volume:42 year:2010 number:1 day:25 month:06
sourceStr	Enthalten in Genetics, selection, evolution 42(2010), 1 vom: 25. Juni volume:42 year:2010 number:1 day:25 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Wild Boar Single Nucleotide Polymorphism Litter Size Paternal Allele Wild Boar Population
isfreeaccess_bool	true
container_title	Genetics, selection, evolution
authorswithroles_txt_mv	Muñoz, María @@aut@@ Fernández, Ana Isabel @@aut@@ Óvilo, Cristina @@aut@@ Muñoz, Gloria @@aut@@ Rodriguez, Carmen @@aut@@ Fernández, Almudena @@aut@@ Alves, Estefânia @@aut@@ Silió, Luis @@aut@@
publishDateDaySort_date	2010-06-25T00:00:00Z
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Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. 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spellingShingle	Muñoz, María misc Wild Boar misc Single Nucleotide Polymorphism misc Litter Size misc Paternal Allele misc Wild Boar Population Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line
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topic_title	Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line Wild Boar (dpeaa)DE-He213 Single Nucleotide Polymorphism (dpeaa)DE-He213 Litter Size (dpeaa)DE-He213 Paternal Allele (dpeaa)DE-He213 Wild Boar Population (dpeaa)DE-He213
topic	misc Wild Boar misc Single Nucleotide Polymorphism misc Litter Size misc Paternal Allele misc Wild Boar Population
topic_unstemmed	misc Wild Boar misc Single Nucleotide Polymorphism misc Litter Size misc Paternal Allele misc Wild Boar Population
topic_browse	misc Wild Boar misc Single Nucleotide Polymorphism misc Litter Size misc Paternal Allele misc Wild Boar Population
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line
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title_full	Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line
author_sort	Muñoz, María
journal	Genetics, selection, evolution
journalStr	Genetics, selection, evolution
lang_code	eng
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author_browse	Muñoz, María Fernández, Ana Isabel Óvilo, Cristina Muñoz, Gloria Rodriguez, Carmen Fernández, Almudena Alves, Estefânia Silió, Luis
container_volume	42
format_se	Elektronische Aufsätze
author-letter	Muñoz, María
doi_str_mv	10.1186/1297-9686-42-23
title_sort	non-additive effects of rbp4, esr1 and igf2 polymorphisms on litter size at different parities in a chinese-european porcine line
title_auth	Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line
abstract	Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. © Muñoz et al; licensee BioMed Central Ltd. 2010
abstractGer	Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. © Muñoz et al; licensee BioMed Central Ltd. 2010
abstract_unstemmed	Background The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-Pvu II polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early ($ NBA_{12} $) and later parities ($ NBA_{3+} $ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-Pvu II was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Results Four different RBP4 haplotypes were detected (TGAC, GGAG, GAAG and GATG) in different pig breeds and wild boars. A significant interaction effect between RBP4-Msp I and ESR1-Pvu II polymorphisms of 0.61 ± 0.29 piglets was detected on $ NBA_{3+} $. The IGF2 analysis revealed a significant increase on $ NBA_{3+} $ of 0.74 ± 0.37 piglets for the paternally inherited allele A. Conclusions All the analyzed pig and wild boar populations shared one of the four detected RBP4 haplotypes. This suggests an ancestral origin of the quoted haplotype. The joint use of RBP4-Msp I and ESR1-Pvu II polymorphisms could be implemented to select for higher prolificacy in the Tai-Zumu line. In this population, the paternal allele IGF2-intron3-3072A increased litter size from the third parity. The non-additive effects on litter size reported here should be tested before implementation in other pig breeding schemes. © Muñoz et al; licensee BioMed Central Ltd. 2010
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container_issue	1
title_short	Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line
url	https://dx.doi.org/10.1186/1297-9686-42-23
remote_bool	true
author2	Fernández, Ana Isabel Óvilo, Cristina Muñoz, Gloria Rodriguez, Carmen Fernández, Almudena Alves, Estefânia Silió, Luis
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Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line

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