The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammali...
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Autor*in:	Bray, Sarah J [verfasserIn] Takada, Shuji Harrison, Emma Shen, Shing-Chuan Ferguson-Smith, Anne C

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Notch Signalling Notch Receptor Notch Ligand Notch Activity Wing Margin

Anmerkung:	© Bray et al; licensee BioMed Central Ltd. 2008

Übergeordnetes Werk:	Enthalten in: BMC developmental biology - London : BioMed Central, 2001, 8(2008), 1 vom: 31. Jan.
Übergeordnetes Werk:	volume:8 ; year:2008 ; number:1 ; day:31 ; month:01

Links:	Volltext

DOI / URN:	10.1186/1471-213X-8-11

Katalog-ID:	SPR02694426X

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520			\|a Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure.
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allfields	10.1186/1471-213X-8-11 doi (DE-627)SPR02694426X (SPR)1471-213X-8-11-e DE-627 ger DE-627 rakwb eng Bray, Sarah J verfasserin aut The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bray et al; licensee BioMed Central Ltd. 2008 Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. Notch Signalling (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Notch Activity (dpeaa)DE-He213 Wing Margin (dpeaa)DE-He213 Takada, Shuji aut Harrison, Emma aut Shen, Shing-Chuan aut Ferguson-Smith, Anne C aut Enthalten in BMC developmental biology London : BioMed Central, 2001 8(2008), 1 vom: 31. Jan. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:8 year:2008 number:1 day:31 month:01 https://dx.doi.org/10.1186/1471-213X-8-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 31 01
spelling	10.1186/1471-213X-8-11 doi (DE-627)SPR02694426X (SPR)1471-213X-8-11-e DE-627 ger DE-627 rakwb eng Bray, Sarah J verfasserin aut The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bray et al; licensee BioMed Central Ltd. 2008 Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. Notch Signalling (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Notch Activity (dpeaa)DE-He213 Wing Margin (dpeaa)DE-He213 Takada, Shuji aut Harrison, Emma aut Shen, Shing-Chuan aut Ferguson-Smith, Anne C aut Enthalten in BMC developmental biology London : BioMed Central, 2001 8(2008), 1 vom: 31. Jan. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:8 year:2008 number:1 day:31 month:01 https://dx.doi.org/10.1186/1471-213X-8-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 31 01
allfields_unstemmed	10.1186/1471-213X-8-11 doi (DE-627)SPR02694426X (SPR)1471-213X-8-11-e DE-627 ger DE-627 rakwb eng Bray, Sarah J verfasserin aut The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bray et al; licensee BioMed Central Ltd. 2008 Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. Notch Signalling (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Notch Activity (dpeaa)DE-He213 Wing Margin (dpeaa)DE-He213 Takada, Shuji aut Harrison, Emma aut Shen, Shing-Chuan aut Ferguson-Smith, Anne C aut Enthalten in BMC developmental biology London : BioMed Central, 2001 8(2008), 1 vom: 31. Jan. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:8 year:2008 number:1 day:31 month:01 https://dx.doi.org/10.1186/1471-213X-8-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 31 01
allfieldsGer	10.1186/1471-213X-8-11 doi (DE-627)SPR02694426X (SPR)1471-213X-8-11-e DE-627 ger DE-627 rakwb eng Bray, Sarah J verfasserin aut The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bray et al; licensee BioMed Central Ltd. 2008 Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. Notch Signalling (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Notch Activity (dpeaa)DE-He213 Wing Margin (dpeaa)DE-He213 Takada, Shuji aut Harrison, Emma aut Shen, Shing-Chuan aut Ferguson-Smith, Anne C aut Enthalten in BMC developmental biology London : BioMed Central, 2001 8(2008), 1 vom: 31. Jan. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:8 year:2008 number:1 day:31 month:01 https://dx.doi.org/10.1186/1471-213X-8-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 31 01
allfieldsSound	10.1186/1471-213X-8-11 doi (DE-627)SPR02694426X (SPR)1471-213X-8-11-e DE-627 ger DE-627 rakwb eng Bray, Sarah J verfasserin aut The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bray et al; licensee BioMed Central Ltd. 2008 Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. Notch Signalling (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Notch Activity (dpeaa)DE-He213 Wing Margin (dpeaa)DE-He213 Takada, Shuji aut Harrison, Emma aut Shen, Shing-Chuan aut Ferguson-Smith, Anne C aut Enthalten in BMC developmental biology London : BioMed Central, 2001 8(2008), 1 vom: 31. Jan. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:8 year:2008 number:1 day:31 month:01 https://dx.doi.org/10.1186/1471-213X-8-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 31 01
language	English
source	Enthalten in BMC developmental biology 8(2008), 1 vom: 31. Jan. volume:8 year:2008 number:1 day:31 month:01
sourceStr	Enthalten in BMC developmental biology 8(2008), 1 vom: 31. Jan. volume:8 year:2008 number:1 day:31 month:01
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institution	findex.gbv.de
topic_facet	Notch Signalling Notch Receptor Notch Ligand Notch Activity Wing Margin
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container_title	BMC developmental biology
authorswithroles_txt_mv	Bray, Sarah J @@aut@@ Takada, Shuji @@aut@@ Harrison, Emma @@aut@@ Shen, Shing-Chuan @@aut@@ Ferguson-Smith, Anne C @@aut@@
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author	Bray, Sarah J
spellingShingle	Bray, Sarah J misc Notch Signalling misc Notch Receptor misc Notch Ligand misc Notch Activity misc Wing Margin The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
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topic_title	The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila Notch Signalling (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Notch Activity (dpeaa)DE-He213 Wing Margin (dpeaa)DE-He213
topic	misc Notch Signalling misc Notch Receptor misc Notch Ligand misc Notch Activity misc Wing Margin
topic_unstemmed	misc Notch Signalling misc Notch Receptor misc Notch Ligand misc Notch Activity misc Wing Margin
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title	The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
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title_full	The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
author_sort	Bray, Sarah J
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author_browse	Bray, Sarah J Takada, Shuji Harrison, Emma Shen, Shing-Chuan Ferguson-Smith, Anne C
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author-letter	Bray, Sarah J
doi_str_mv	10.1186/1471-213X-8-11
title_sort	atypical mammalian ligand delta-like homologue 1 (dlk1) can regulate notch signalling in drosophila
title_auth	The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
abstract	Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. © Bray et al; licensee BioMed Central Ltd. 2008
abstractGer	Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. © Bray et al; licensee BioMed Central Ltd. 2008
abstract_unstemmed	Background Mammalian Delta-like 1 (Dlk-1) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. Conclusion Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure. © Bray et al; licensee BioMed Central Ltd. 2008
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title_short	The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
url	https://dx.doi.org/10.1186/1471-213X-8-11
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author2	Takada, Shuji Harrison, Emma Shen, Shing-Chuan Ferguson-Smith, Anne C
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up_date	2024-07-03T23:35:00.835Z
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Thus it is unclear whether it is able to interact with Notch in vivo. Unlike mammals, Drosophila have a single Notch receptor allowing a simple in vivo assay for mammalian Dlk1 function. Results Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by Notch mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative Dlk1 isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target. 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The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

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