Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis

Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Prev...
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Autor*in:	Li, Qi [verfasserIn] Shen, Ling Xin, Tianchi Xiang, Wenjuan Chen, Wenlian Gao, Yin Zhu, Mingwei Yu, Lingzhu Li, Mingfa

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Notch Signaling Notch Pathway Mutant Clone Follicular Epithelium Notch Signaling Activity

Anmerkung:	© Li et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: BMC developmental biology - London : BioMed Central, 2001, 9(2009), 1 vom: 01. Dez.
Übergeordnetes Werk:	volume:9 ; year:2009 ; number:1 ; day:01 ; month:12

Links:	Volltext

DOI / URN:	10.1186/1471-213X-9-60

Katalog-ID:	SPR026946130

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245	1	0	\|a Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis
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520			\|a Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development.
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700	1		\|a Li, Mingfa \|4 aut
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publishDate	2009
allfields	10.1186/1471-213X-9-60 doi (DE-627)SPR026946130 (SPR)1471-213X-9-60-e DE-627 ger DE-627 rakwb eng Li, Qi verfasserin aut Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Li et al; licensee BioMed Central Ltd. 2009 Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Mutant Clone (dpeaa)DE-He213 Follicular Epithelium (dpeaa)DE-He213 Notch Signaling Activity (dpeaa)DE-He213 Shen, Ling aut Xin, Tianchi aut Xiang, Wenjuan aut Chen, Wenlian aut Gao, Yin aut Zhu, Mingwei aut Yu, Lingzhu aut Li, Mingfa aut Enthalten in BMC developmental biology London : BioMed Central, 2001 9(2009), 1 vom: 01. Dez. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:9 year:2009 number:1 day:01 month:12 https://dx.doi.org/10.1186/1471-213X-9-60 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 01 12
spelling	10.1186/1471-213X-9-60 doi (DE-627)SPR026946130 (SPR)1471-213X-9-60-e DE-627 ger DE-627 rakwb eng Li, Qi verfasserin aut Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Li et al; licensee BioMed Central Ltd. 2009 Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Mutant Clone (dpeaa)DE-He213 Follicular Epithelium (dpeaa)DE-He213 Notch Signaling Activity (dpeaa)DE-He213 Shen, Ling aut Xin, Tianchi aut Xiang, Wenjuan aut Chen, Wenlian aut Gao, Yin aut Zhu, Mingwei aut Yu, Lingzhu aut Li, Mingfa aut Enthalten in BMC developmental biology London : BioMed Central, 2001 9(2009), 1 vom: 01. Dez. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:9 year:2009 number:1 day:01 month:12 https://dx.doi.org/10.1186/1471-213X-9-60 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 01 12
allfields_unstemmed	10.1186/1471-213X-9-60 doi (DE-627)SPR026946130 (SPR)1471-213X-9-60-e DE-627 ger DE-627 rakwb eng Li, Qi verfasserin aut Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Li et al; licensee BioMed Central Ltd. 2009 Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Mutant Clone (dpeaa)DE-He213 Follicular Epithelium (dpeaa)DE-He213 Notch Signaling Activity (dpeaa)DE-He213 Shen, Ling aut Xin, Tianchi aut Xiang, Wenjuan aut Chen, Wenlian aut Gao, Yin aut Zhu, Mingwei aut Yu, Lingzhu aut Li, Mingfa aut Enthalten in BMC developmental biology London : BioMed Central, 2001 9(2009), 1 vom: 01. Dez. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:9 year:2009 number:1 day:01 month:12 https://dx.doi.org/10.1186/1471-213X-9-60 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 01 12
allfieldsGer	10.1186/1471-213X-9-60 doi (DE-627)SPR026946130 (SPR)1471-213X-9-60-e DE-627 ger DE-627 rakwb eng Li, Qi verfasserin aut Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Li et al; licensee BioMed Central Ltd. 2009 Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Mutant Clone (dpeaa)DE-He213 Follicular Epithelium (dpeaa)DE-He213 Notch Signaling Activity (dpeaa)DE-He213 Shen, Ling aut Xin, Tianchi aut Xiang, Wenjuan aut Chen, Wenlian aut Gao, Yin aut Zhu, Mingwei aut Yu, Lingzhu aut Li, Mingfa aut Enthalten in BMC developmental biology London : BioMed Central, 2001 9(2009), 1 vom: 01. Dez. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:9 year:2009 number:1 day:01 month:12 https://dx.doi.org/10.1186/1471-213X-9-60 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 01 12
allfieldsSound	10.1186/1471-213X-9-60 doi (DE-627)SPR026946130 (SPR)1471-213X-9-60-e DE-627 ger DE-627 rakwb eng Li, Qi verfasserin aut Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Li et al; licensee BioMed Central Ltd. 2009 Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Mutant Clone (dpeaa)DE-He213 Follicular Epithelium (dpeaa)DE-He213 Notch Signaling Activity (dpeaa)DE-He213 Shen, Ling aut Xin, Tianchi aut Xiang, Wenjuan aut Chen, Wenlian aut Gao, Yin aut Zhu, Mingwei aut Yu, Lingzhu aut Li, Mingfa aut Enthalten in BMC developmental biology London : BioMed Central, 2001 9(2009), 1 vom: 01. Dez. (DE-627)326644881 (DE-600)2041492-4 1471-213X nnns volume:9 year:2009 number:1 day:01 month:12 https://dx.doi.org/10.1186/1471-213X-9-60 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 01 12
language	English
source	Enthalten in BMC developmental biology 9(2009), 1 vom: 01. Dez. volume:9 year:2009 number:1 day:01 month:12
sourceStr	Enthalten in BMC developmental biology 9(2009), 1 vom: 01. Dez. volume:9 year:2009 number:1 day:01 month:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Notch Signaling Notch Pathway Mutant Clone Follicular Epithelium Notch Signaling Activity
isfreeaccess_bool	true
container_title	BMC developmental biology
authorswithroles_txt_mv	Li, Qi @@aut@@ Shen, Ling @@aut@@ Xin, Tianchi @@aut@@ Xiang, Wenjuan @@aut@@ Chen, Wenlian @@aut@@ Gao, Yin @@aut@@ Zhu, Mingwei @@aut@@ Yu, Lingzhu @@aut@@ Li, Mingfa @@aut@@
publishDateDaySort_date	2009-12-01T00:00:00Z
hierarchy_top_id	326644881
id	SPR026946130
language_de	englisch
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author	Li, Qi
spellingShingle	Li, Qi misc Notch Signaling misc Notch Pathway misc Mutant Clone misc Follicular Epithelium misc Notch Signaling Activity Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis
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topic_title	Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Mutant Clone (dpeaa)DE-He213 Follicular Epithelium (dpeaa)DE-He213 Notch Signaling Activity (dpeaa)DE-He213
topic	misc Notch Signaling misc Notch Pathway misc Mutant Clone misc Follicular Epithelium misc Notch Signaling Activity
topic_unstemmed	misc Notch Signaling misc Notch Pathway misc Mutant Clone misc Follicular Epithelium misc Notch Signaling Activity
topic_browse	misc Notch Signaling misc Notch Pathway misc Mutant Clone misc Follicular Epithelium misc Notch Signaling Activity
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title	Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis
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title_full	Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis
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author_browse	Li, Qi Shen, Ling Xin, Tianchi Xiang, Wenjuan Chen, Wenlian Gao, Yin Zhu, Mingwei Yu, Lingzhu Li, Mingfa
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doi_str_mv	10.1186/1471-213X-9-60
title_sort	role of scrib and dlg in anterior-posterior patterning of the follicular epithelium during drosophila oogenesis
title_auth	Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis
abstract	Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. © Li et al; licensee BioMed Central Ltd. 2009
abstractGer	Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. © Li et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. Results We found that removal of scrib or dlg function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in scrib/dlg at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that scrib genetically interacts with dlg in regulating posterior patterning of the epithelium. Conclusion In this study we provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of scrib/dlg in controlling epithelial polarity and cell proliferation during development. © Li et al; licensee BioMed Central Ltd. 2009
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container_issue	1
title_short	Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis
url	https://dx.doi.org/10.1186/1471-213X-9-60
remote_bool	true
author2	Shen, Ling Xin, Tianchi Xiang, Wenjuan Chen, Wenlian Gao, Yin Zhu, Mingwei Yu, Lingzhu Li, Mingfa
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up_date	2024-07-03T23:35:34.339Z
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Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis

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