Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales

Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rick...
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Autor*in:	Kang, Yan-Jun [verfasserIn] Diao, Xiu-Nian Zhao, Gao-Yu Chen, Ming-Hui Xiong, Yanwen Shi, Mang Fu, Wei-Ming Guo, Yu-Jiang Pan, Bao Chen, Xiao-Ping Holmes, Edward C Gillespie, Joseph J Dumler, Stephen J Zhang, Yong-Zhen

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Co-divergence Evolution Phylogeny Rickettsiales bacteria Ticks Vectors

Anmerkung:	© Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC evolutionary biology - London : BioMed Central, 2001, 14(2014), 1 vom: 30. Juli
Übergeordnetes Werk:	volume:14 ; year:2014 ; number:1 ; day:30 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s12862-014-0167-2

Katalog-ID:	SPR026979810

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100	1		\|a Kang, Yan-Jun \|e verfasserin \|4 aut
245	1	0	\|a Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales
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520			\|a Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution.
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650		4	\|a Vectors \|7 (dpeaa)DE-He213
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700	1		\|a Chen, Xiao-Ping \|4 aut
700	1		\|a Holmes, Edward C \|4 aut
700	1		\|a Gillespie, Joseph J \|4 aut
700	1		\|a Dumler, Stephen J \|4 aut
700	1		\|a Zhang, Yong-Zhen \|4 aut
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allfields	10.1186/s12862-014-0167-2 doi (DE-627)SPR026979810 (SPR)s12862-014-0167-2-e DE-627 ger DE-627 rakwb eng Kang, Yan-Jun verfasserin aut Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. Co-divergence (dpeaa)DE-He213 Evolution (dpeaa)DE-He213 Phylogeny (dpeaa)DE-He213 Rickettsiales bacteria (dpeaa)DE-He213 Ticks (dpeaa)DE-He213 Vectors (dpeaa)DE-He213 Diao, Xiu-Nian aut Zhao, Gao-Yu aut Chen, Ming-Hui aut Xiong, Yanwen aut Shi, Mang aut Fu, Wei-Ming aut Guo, Yu-Jiang aut Pan, Bao aut Chen, Xiao-Ping aut Holmes, Edward C aut Gillespie, Joseph J aut Dumler, Stephen J aut Zhang, Yong-Zhen aut Enthalten in BMC evolutionary biology London : BioMed Central, 2001 14(2014), 1 vom: 30. Juli (DE-627)32664489X (DE-600)2041493-6 1471-2148 nnns volume:14 year:2014 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12862-014-0167-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 30 07
spelling	10.1186/s12862-014-0167-2 doi (DE-627)SPR026979810 (SPR)s12862-014-0167-2-e DE-627 ger DE-627 rakwb eng Kang, Yan-Jun verfasserin aut Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. Co-divergence (dpeaa)DE-He213 Evolution (dpeaa)DE-He213 Phylogeny (dpeaa)DE-He213 Rickettsiales bacteria (dpeaa)DE-He213 Ticks (dpeaa)DE-He213 Vectors (dpeaa)DE-He213 Diao, Xiu-Nian aut Zhao, Gao-Yu aut Chen, Ming-Hui aut Xiong, Yanwen aut Shi, Mang aut Fu, Wei-Ming aut Guo, Yu-Jiang aut Pan, Bao aut Chen, Xiao-Ping aut Holmes, Edward C aut Gillespie, Joseph J aut Dumler, Stephen J aut Zhang, Yong-Zhen aut Enthalten in BMC evolutionary biology London : BioMed Central, 2001 14(2014), 1 vom: 30. Juli (DE-627)32664489X (DE-600)2041493-6 1471-2148 nnns volume:14 year:2014 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12862-014-0167-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 30 07
allfields_unstemmed	10.1186/s12862-014-0167-2 doi (DE-627)SPR026979810 (SPR)s12862-014-0167-2-e DE-627 ger DE-627 rakwb eng Kang, Yan-Jun verfasserin aut Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. Co-divergence (dpeaa)DE-He213 Evolution (dpeaa)DE-He213 Phylogeny (dpeaa)DE-He213 Rickettsiales bacteria (dpeaa)DE-He213 Ticks (dpeaa)DE-He213 Vectors (dpeaa)DE-He213 Diao, Xiu-Nian aut Zhao, Gao-Yu aut Chen, Ming-Hui aut Xiong, Yanwen aut Shi, Mang aut Fu, Wei-Ming aut Guo, Yu-Jiang aut Pan, Bao aut Chen, Xiao-Ping aut Holmes, Edward C aut Gillespie, Joseph J aut Dumler, Stephen J aut Zhang, Yong-Zhen aut Enthalten in BMC evolutionary biology London : BioMed Central, 2001 14(2014), 1 vom: 30. Juli (DE-627)32664489X (DE-600)2041493-6 1471-2148 nnns volume:14 year:2014 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12862-014-0167-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 30 07
allfieldsGer	10.1186/s12862-014-0167-2 doi (DE-627)SPR026979810 (SPR)s12862-014-0167-2-e DE-627 ger DE-627 rakwb eng Kang, Yan-Jun verfasserin aut Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. Co-divergence (dpeaa)DE-He213 Evolution (dpeaa)DE-He213 Phylogeny (dpeaa)DE-He213 Rickettsiales bacteria (dpeaa)DE-He213 Ticks (dpeaa)DE-He213 Vectors (dpeaa)DE-He213 Diao, Xiu-Nian aut Zhao, Gao-Yu aut Chen, Ming-Hui aut Xiong, Yanwen aut Shi, Mang aut Fu, Wei-Ming aut Guo, Yu-Jiang aut Pan, Bao aut Chen, Xiao-Ping aut Holmes, Edward C aut Gillespie, Joseph J aut Dumler, Stephen J aut Zhang, Yong-Zhen aut Enthalten in BMC evolutionary biology London : BioMed Central, 2001 14(2014), 1 vom: 30. Juli (DE-627)32664489X (DE-600)2041493-6 1471-2148 nnns volume:14 year:2014 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12862-014-0167-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 30 07
allfieldsSound	10.1186/s12862-014-0167-2 doi (DE-627)SPR026979810 (SPR)s12862-014-0167-2-e DE-627 ger DE-627 rakwb eng Kang, Yan-Jun verfasserin aut Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. Co-divergence (dpeaa)DE-He213 Evolution (dpeaa)DE-He213 Phylogeny (dpeaa)DE-He213 Rickettsiales bacteria (dpeaa)DE-He213 Ticks (dpeaa)DE-He213 Vectors (dpeaa)DE-He213 Diao, Xiu-Nian aut Zhao, Gao-Yu aut Chen, Ming-Hui aut Xiong, Yanwen aut Shi, Mang aut Fu, Wei-Ming aut Guo, Yu-Jiang aut Pan, Bao aut Chen, Xiao-Ping aut Holmes, Edward C aut Gillespie, Joseph J aut Dumler, Stephen J aut Zhang, Yong-Zhen aut Enthalten in BMC evolutionary biology London : BioMed Central, 2001 14(2014), 1 vom: 30. Juli (DE-627)32664489X (DE-600)2041493-6 1471-2148 nnns volume:14 year:2014 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12862-014-0167-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 30 07
language	English
source	Enthalten in BMC evolutionary biology 14(2014), 1 vom: 30. Juli volume:14 year:2014 number:1 day:30 month:07
sourceStr	Enthalten in BMC evolutionary biology 14(2014), 1 vom: 30. Juli volume:14 year:2014 number:1 day:30 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Co-divergence Evolution Phylogeny Rickettsiales bacteria Ticks Vectors
isfreeaccess_bool	true
container_title	BMC evolutionary biology
authorswithroles_txt_mv	Kang, Yan-Jun @@aut@@ Diao, Xiu-Nian @@aut@@ Zhao, Gao-Yu @@aut@@ Chen, Ming-Hui @@aut@@ Xiong, Yanwen @@aut@@ Shi, Mang @@aut@@ Fu, Wei-Ming @@aut@@ Guo, Yu-Jiang @@aut@@ Pan, Bao @@aut@@ Chen, Xiao-Ping @@aut@@ Holmes, Edward C @@aut@@ Gillespie, Joseph J @@aut@@ Dumler, Stephen J @@aut@@ Zhang, Yong-Zhen @@aut@@
publishDateDaySort_date	2014-07-30T00:00:00Z
hierarchy_top_id	32664489X
id	SPR026979810
language_de	englisch
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. 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author	Kang, Yan-Jun
spellingShingle	Kang, Yan-Jun misc Co-divergence misc Evolution misc Phylogeny misc Rickettsiales bacteria misc Ticks misc Vectors Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales
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topic_title	Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales Co-divergence (dpeaa)DE-He213 Evolution (dpeaa)DE-He213 Phylogeny (dpeaa)DE-He213 Rickettsiales bacteria (dpeaa)DE-He213 Ticks (dpeaa)DE-He213 Vectors (dpeaa)DE-He213
topic	misc Co-divergence misc Evolution misc Phylogeny misc Rickettsiales bacteria misc Ticks misc Vectors
topic_unstemmed	misc Co-divergence misc Evolution misc Phylogeny misc Rickettsiales bacteria misc Ticks misc Vectors
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title	Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales
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title_full	Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales
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author_browse	Kang, Yan-Jun Diao, Xiu-Nian Zhao, Gao-Yu Chen, Ming-Hui Xiong, Yanwen Shi, Mang Fu, Wei-Ming Guo, Yu-Jiang Pan, Bao Chen, Xiao-Ping Holmes, Edward C Gillespie, Joseph J Dumler, Stephen J Zhang, Yong-Zhen
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title_sort	extensive diversity of rickettsiales bacteria in two species of ticks from china and the evolution of the rickettsiales
title_auth	Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales
abstract	Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. Results Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. Conclusions Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. © Kang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales
url	https://dx.doi.org/10.1186/s12862-014-0167-2
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author2	Diao, Xiu-Nian Zhao, Gao-Yu Chen, Ming-Hui Xiong, Yanwen Shi, Mang Fu, Wei-Ming Guo, Yu-Jiang Pan, Bao Chen, Xiao-Ping Holmes, Edward C Gillespie, Joseph J Dumler, Stephen J Zhang, Yong-Zhen
author2Str	Diao, Xiu-Nian Zhao, Gao-Yu Chen, Ming-Hui Xiong, Yanwen Shi, Mang Fu, Wei-Ming Guo, Yu-Jiang Pan, Bao Chen, Xiao-Ping Holmes, Edward C Gillespie, Joseph J Dumler, Stephen J Zhang, Yong-Zhen
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Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales

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