Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage i...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Knight, Jo [verfasserIn] North, Bernard V Sham, Pak C Curtis, David

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Schlagwörter:	Quantitative Trait Linkage Analysis Unlinked Locus Offspring Cohort Complex Pedigree

Anmerkung:	© Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC genetics - London : BioMed Central, 2000, 4(2003), Suppl 1 vom: 31. Dez.
Übergeordnetes Werk:	volume:4 ; year:2003 ; number:Suppl 1 ; day:31 ; month:12

Links:	Volltext

DOI / URN:	10.1186/1471-2156-4-S1-S74

Katalog-ID:	SPR026998572

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allfields	10.1186/1471-2156-4-S1-S74 doi (DE-627)SPR026998572 (SPR)1471-2156-4-S1-S74-e DE-627 ger DE-627 rakwb eng Knight, Jo verfasserin aut Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. Quantitative Trait (dpeaa)DE-He213 Linkage Analysis (dpeaa)DE-He213 Unlinked Locus (dpeaa)DE-He213 Offspring Cohort (dpeaa)DE-He213 Complex Pedigree (dpeaa)DE-He213 North, Bernard V aut Sham, Pak C aut Curtis, David aut Enthalten in BMC genetics London : BioMed Central, 2000 4(2003), Suppl 1 vom: 31. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:4 year:2003 number:Suppl 1 day:31 month:12 https://dx.doi.org/10.1186/1471-2156-4-S1-S74 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 Suppl 1 31 12
spelling	10.1186/1471-2156-4-S1-S74 doi (DE-627)SPR026998572 (SPR)1471-2156-4-S1-S74-e DE-627 ger DE-627 rakwb eng Knight, Jo verfasserin aut Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. Quantitative Trait (dpeaa)DE-He213 Linkage Analysis (dpeaa)DE-He213 Unlinked Locus (dpeaa)DE-He213 Offspring Cohort (dpeaa)DE-He213 Complex Pedigree (dpeaa)DE-He213 North, Bernard V aut Sham, Pak C aut Curtis, David aut Enthalten in BMC genetics London : BioMed Central, 2000 4(2003), Suppl 1 vom: 31. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:4 year:2003 number:Suppl 1 day:31 month:12 https://dx.doi.org/10.1186/1471-2156-4-S1-S74 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 Suppl 1 31 12
allfields_unstemmed	10.1186/1471-2156-4-S1-S74 doi (DE-627)SPR026998572 (SPR)1471-2156-4-S1-S74-e DE-627 ger DE-627 rakwb eng Knight, Jo verfasserin aut Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. Quantitative Trait (dpeaa)DE-He213 Linkage Analysis (dpeaa)DE-He213 Unlinked Locus (dpeaa)DE-He213 Offspring Cohort (dpeaa)DE-He213 Complex Pedigree (dpeaa)DE-He213 North, Bernard V aut Sham, Pak C aut Curtis, David aut Enthalten in BMC genetics London : BioMed Central, 2000 4(2003), Suppl 1 vom: 31. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:4 year:2003 number:Suppl 1 day:31 month:12 https://dx.doi.org/10.1186/1471-2156-4-S1-S74 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 Suppl 1 31 12
allfieldsGer	10.1186/1471-2156-4-S1-S74 doi (DE-627)SPR026998572 (SPR)1471-2156-4-S1-S74-e DE-627 ger DE-627 rakwb eng Knight, Jo verfasserin aut Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. Quantitative Trait (dpeaa)DE-He213 Linkage Analysis (dpeaa)DE-He213 Unlinked Locus (dpeaa)DE-He213 Offspring Cohort (dpeaa)DE-He213 Complex Pedigree (dpeaa)DE-He213 North, Bernard V aut Sham, Pak C aut Curtis, David aut Enthalten in BMC genetics London : BioMed Central, 2000 4(2003), Suppl 1 vom: 31. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:4 year:2003 number:Suppl 1 day:31 month:12 https://dx.doi.org/10.1186/1471-2156-4-S1-S74 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 Suppl 1 31 12
allfieldsSound	10.1186/1471-2156-4-S1-S74 doi (DE-627)SPR026998572 (SPR)1471-2156-4-S1-S74-e DE-627 ger DE-627 rakwb eng Knight, Jo verfasserin aut Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. Quantitative Trait (dpeaa)DE-He213 Linkage Analysis (dpeaa)DE-He213 Unlinked Locus (dpeaa)DE-He213 Offspring Cohort (dpeaa)DE-He213 Complex Pedigree (dpeaa)DE-He213 North, Bernard V aut Sham, Pak C aut Curtis, David aut Enthalten in BMC genetics London : BioMed Central, 2000 4(2003), Suppl 1 vom: 31. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:4 year:2003 number:Suppl 1 day:31 month:12 https://dx.doi.org/10.1186/1471-2156-4-S1-S74 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2003 Suppl 1 31 12
language	English
source	Enthalten in BMC genetics 4(2003), Suppl 1 vom: 31. Dez. volume:4 year:2003 number:Suppl 1 day:31 month:12
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topic_facet	Quantitative Trait Linkage Analysis Unlinked Locus Offspring Cohort Complex Pedigree
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authorswithroles_txt_mv	Knight, Jo @@aut@@ North, Bernard V @@aut@@ Sham, Pak C @@aut@@ Curtis, David @@aut@@
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author	Knight, Jo
spellingShingle	Knight, Jo misc Quantitative Trait misc Linkage Analysis misc Unlinked Locus misc Offspring Cohort misc Complex Pedigree Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
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topic_title	Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait Quantitative Trait (dpeaa)DE-He213 Linkage Analysis (dpeaa)DE-He213 Unlinked Locus (dpeaa)DE-He213 Offspring Cohort (dpeaa)DE-He213 Complex Pedigree (dpeaa)DE-He213
topic	misc Quantitative Trait misc Linkage Analysis misc Unlinked Locus misc Offspring Cohort misc Complex Pedigree
topic_unstemmed	misc Quantitative Trait misc Linkage Analysis misc Unlinked Locus misc Offspring Cohort misc Complex Pedigree
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title	Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
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title_full	Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
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author_browse	Knight, Jo North, Bernard V Sham, Pak C Curtis, David
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title_sort	mapping loci influencing blood pressure in the framingham pedigrees using model-free lod score analysis of a quantitative trait
title_auth	Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
abstract	Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Abstract This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits. © Knight et al; licensee BioMed Central Ltd 2003. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
url	https://dx.doi.org/10.1186/1471-2156-4-S1-S74
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up_date	2024-07-03T23:51:48.052Z
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Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

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