Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association

Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on...
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Autor*in:	Rosenberger, Albert [verfasserIn] Janicke, Nico Köhler, Karola Korb, Katrin Kulle, Bettina Bickeböller, Heike

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	Generalize Additive Model Unaffected Sibling False Discovery Rate Method Score Coefficient Generalize Additive Model Model

Anmerkung:	© Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC genetics - London : BioMed Central, 2000, 6(2005), Suppl 1 vom: 30. Dez.
Übergeordnetes Werk:	volume:6 ; year:2005 ; number:Suppl 1 ; day:30 ; month:12

Links:	Volltext

DOI / URN:	10.1186/1471-2156-6-S1-S55

Katalog-ID:	SPR027000923

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allfields	10.1186/1471-2156-6-S1-S55 doi (DE-627)SPR027000923 (SPR)1471-2156-6-S1-S55-e DE-627 ger DE-627 rakwb eng Rosenberger, Albert verfasserin aut Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. Generalize Additive Model (dpeaa)DE-He213 Unaffected Sibling (dpeaa)DE-He213 False Discovery Rate Method (dpeaa)DE-He213 Score Coefficient (dpeaa)DE-He213 Generalize Additive Model Model (dpeaa)DE-He213 Janicke, Nico aut Köhler, Karola aut Korb, Katrin aut Kulle, Bettina aut Bickeböller, Heike aut Enthalten in BMC genetics London : BioMed Central, 2000 6(2005), Suppl 1 vom: 30. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:6 year:2005 number:Suppl 1 day:30 month:12 https://dx.doi.org/10.1186/1471-2156-6-S1-S55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 Suppl 1 30 12
spelling	10.1186/1471-2156-6-S1-S55 doi (DE-627)SPR027000923 (SPR)1471-2156-6-S1-S55-e DE-627 ger DE-627 rakwb eng Rosenberger, Albert verfasserin aut Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. Generalize Additive Model (dpeaa)DE-He213 Unaffected Sibling (dpeaa)DE-He213 False Discovery Rate Method (dpeaa)DE-He213 Score Coefficient (dpeaa)DE-He213 Generalize Additive Model Model (dpeaa)DE-He213 Janicke, Nico aut Köhler, Karola aut Korb, Katrin aut Kulle, Bettina aut Bickeböller, Heike aut Enthalten in BMC genetics London : BioMed Central, 2000 6(2005), Suppl 1 vom: 30. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:6 year:2005 number:Suppl 1 day:30 month:12 https://dx.doi.org/10.1186/1471-2156-6-S1-S55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 Suppl 1 30 12
allfields_unstemmed	10.1186/1471-2156-6-S1-S55 doi (DE-627)SPR027000923 (SPR)1471-2156-6-S1-S55-e DE-627 ger DE-627 rakwb eng Rosenberger, Albert verfasserin aut Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. Generalize Additive Model (dpeaa)DE-He213 Unaffected Sibling (dpeaa)DE-He213 False Discovery Rate Method (dpeaa)DE-He213 Score Coefficient (dpeaa)DE-He213 Generalize Additive Model Model (dpeaa)DE-He213 Janicke, Nico aut Köhler, Karola aut Korb, Katrin aut Kulle, Bettina aut Bickeböller, Heike aut Enthalten in BMC genetics London : BioMed Central, 2000 6(2005), Suppl 1 vom: 30. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:6 year:2005 number:Suppl 1 day:30 month:12 https://dx.doi.org/10.1186/1471-2156-6-S1-S55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 Suppl 1 30 12
allfieldsGer	10.1186/1471-2156-6-S1-S55 doi (DE-627)SPR027000923 (SPR)1471-2156-6-S1-S55-e DE-627 ger DE-627 rakwb eng Rosenberger, Albert verfasserin aut Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. Generalize Additive Model (dpeaa)DE-He213 Unaffected Sibling (dpeaa)DE-He213 False Discovery Rate Method (dpeaa)DE-He213 Score Coefficient (dpeaa)DE-He213 Generalize Additive Model Model (dpeaa)DE-He213 Janicke, Nico aut Köhler, Karola aut Korb, Katrin aut Kulle, Bettina aut Bickeböller, Heike aut Enthalten in BMC genetics London : BioMed Central, 2000 6(2005), Suppl 1 vom: 30. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:6 year:2005 number:Suppl 1 day:30 month:12 https://dx.doi.org/10.1186/1471-2156-6-S1-S55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 Suppl 1 30 12
allfieldsSound	10.1186/1471-2156-6-S1-S55 doi (DE-627)SPR027000923 (SPR)1471-2156-6-S1-S55-e DE-627 ger DE-627 rakwb eng Rosenberger, Albert verfasserin aut Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. Generalize Additive Model (dpeaa)DE-He213 Unaffected Sibling (dpeaa)DE-He213 False Discovery Rate Method (dpeaa)DE-He213 Score Coefficient (dpeaa)DE-He213 Generalize Additive Model Model (dpeaa)DE-He213 Janicke, Nico aut Köhler, Karola aut Korb, Katrin aut Kulle, Bettina aut Bickeböller, Heike aut Enthalten in BMC genetics London : BioMed Central, 2000 6(2005), Suppl 1 vom: 30. Dez. (DE-627)326644938 (DE-600)2041497-3 1471-2156 nnns volume:6 year:2005 number:Suppl 1 day:30 month:12 https://dx.doi.org/10.1186/1471-2156-6-S1-S55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 Suppl 1 30 12
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topic_title	Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association Generalize Additive Model (dpeaa)DE-He213 Unaffected Sibling (dpeaa)DE-He213 False Discovery Rate Method (dpeaa)DE-He213 Score Coefficient (dpeaa)DE-He213 Generalize Additive Model Model (dpeaa)DE-He213
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title	Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association
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title_full	Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association
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title_sort	surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association
title_auth	Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association
abstract	Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. The genome-wide search for association using single-nucleotide polymorphisms did not yield interesting leads. © Rosenberger et al; licensee BioMed Central Ltd 2005. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for association related to three phenotypes for alcohol use disorder. These are a behavioral score BQ, based on a 12-item questionnaire about drinking behavior and the subject's report of drinking-related health problems, and ERP pattern and ERP magnitude, both derived from the eyes closed resting ERP measures to quantify brain activity. Overall, we were able to identify 11 candidate regions for linkage. Only two regions were found to be related to both BQ and one of the ERP phenotypes. 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Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association

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