Collective motions and specific effectors: a statistical mechanics perspective on biological regulation

Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of inv...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giuliani, Alessandro [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Gene Regulation Network Immune Related Gene Gene Expression Network Entire Transcriptome Cell Kind

Anmerkung:	© Giuliani; licensee BioMed Central Ltd. 2010

Übergeordnetes Werk:	Enthalten in: BMC genomics - London : BioMed Central, 2000, 11(2010), Suppl 1 vom: 10. Feb.
Übergeordnetes Werk:	volume:11 ; year:2010 ; number:Suppl 1 ; day:10 ; month:02

Links:	Volltext

DOI / URN:	10.1186/1471-2164-11-S1-S2

Katalog-ID:	SPR027057186

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allfields	10.1186/1471-2164-11-S1-S2 doi (DE-627)SPR027057186 (SPR)1471-2164-11-S1-S2-e DE-627 ger DE-627 rakwb eng Giuliani, Alessandro verfasserin aut Collective motions and specific effectors: a statistical mechanics perspective on biological regulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Giuliani; licensee BioMed Central Ltd. 2010 Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. Gene Regulation Network (dpeaa)DE-He213 Immune Related Gene (dpeaa)DE-He213 Gene Expression Network (dpeaa)DE-He213 Entire Transcriptome (dpeaa)DE-He213 Cell Kind (dpeaa)DE-He213 Enthalten in BMC genomics London : BioMed Central, 2000 11(2010), Suppl 1 vom: 10. Feb. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:11 year:2010 number:Suppl 1 day:10 month:02 https://dx.doi.org/10.1186/1471-2164-11-S1-S2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 Suppl 1 10 02
spelling	10.1186/1471-2164-11-S1-S2 doi (DE-627)SPR027057186 (SPR)1471-2164-11-S1-S2-e DE-627 ger DE-627 rakwb eng Giuliani, Alessandro verfasserin aut Collective motions and specific effectors: a statistical mechanics perspective on biological regulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Giuliani; licensee BioMed Central Ltd. 2010 Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. Gene Regulation Network (dpeaa)DE-He213 Immune Related Gene (dpeaa)DE-He213 Gene Expression Network (dpeaa)DE-He213 Entire Transcriptome (dpeaa)DE-He213 Cell Kind (dpeaa)DE-He213 Enthalten in BMC genomics London : BioMed Central, 2000 11(2010), Suppl 1 vom: 10. Feb. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:11 year:2010 number:Suppl 1 day:10 month:02 https://dx.doi.org/10.1186/1471-2164-11-S1-S2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 Suppl 1 10 02
allfields_unstemmed	10.1186/1471-2164-11-S1-S2 doi (DE-627)SPR027057186 (SPR)1471-2164-11-S1-S2-e DE-627 ger DE-627 rakwb eng Giuliani, Alessandro verfasserin aut Collective motions and specific effectors: a statistical mechanics perspective on biological regulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Giuliani; licensee BioMed Central Ltd. 2010 Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. Gene Regulation Network (dpeaa)DE-He213 Immune Related Gene (dpeaa)DE-He213 Gene Expression Network (dpeaa)DE-He213 Entire Transcriptome (dpeaa)DE-He213 Cell Kind (dpeaa)DE-He213 Enthalten in BMC genomics London : BioMed Central, 2000 11(2010), Suppl 1 vom: 10. Feb. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:11 year:2010 number:Suppl 1 day:10 month:02 https://dx.doi.org/10.1186/1471-2164-11-S1-S2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 Suppl 1 10 02
allfieldsGer	10.1186/1471-2164-11-S1-S2 doi (DE-627)SPR027057186 (SPR)1471-2164-11-S1-S2-e DE-627 ger DE-627 rakwb eng Giuliani, Alessandro verfasserin aut Collective motions and specific effectors: a statistical mechanics perspective on biological regulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Giuliani; licensee BioMed Central Ltd. 2010 Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. Gene Regulation Network (dpeaa)DE-He213 Immune Related Gene (dpeaa)DE-He213 Gene Expression Network (dpeaa)DE-He213 Entire Transcriptome (dpeaa)DE-He213 Cell Kind (dpeaa)DE-He213 Enthalten in BMC genomics London : BioMed Central, 2000 11(2010), Suppl 1 vom: 10. Feb. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:11 year:2010 number:Suppl 1 day:10 month:02 https://dx.doi.org/10.1186/1471-2164-11-S1-S2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 Suppl 1 10 02
allfieldsSound	10.1186/1471-2164-11-S1-S2 doi (DE-627)SPR027057186 (SPR)1471-2164-11-S1-S2-e DE-627 ger DE-627 rakwb eng Giuliani, Alessandro verfasserin aut Collective motions and specific effectors: a statistical mechanics perspective on biological regulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Giuliani; licensee BioMed Central Ltd. 2010 Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. Gene Regulation Network (dpeaa)DE-He213 Immune Related Gene (dpeaa)DE-He213 Gene Expression Network (dpeaa)DE-He213 Entire Transcriptome (dpeaa)DE-He213 Cell Kind (dpeaa)DE-He213 Enthalten in BMC genomics London : BioMed Central, 2000 11(2010), Suppl 1 vom: 10. Feb. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:11 year:2010 number:Suppl 1 day:10 month:02 https://dx.doi.org/10.1186/1471-2164-11-S1-S2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 Suppl 1 10 02
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title	Collective motions and specific effectors: a statistical mechanics perspective on biological regulation
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title_sort	collective motions and specific effectors: a statistical mechanics perspective on biological regulation
title_auth	Collective motions and specific effectors: a statistical mechanics perspective on biological regulation
abstract	Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. © Giuliani; licensee BioMed Central Ltd. 2010
abstractGer	Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. © Giuliani; licensee BioMed Central Ltd. 2010
abstract_unstemmed	Background The interaction of a multiplicity of scales in both time and space is a fundamental feature of biological systems. The complementation of macroscopic (entire organism) and microscopic (molecular biology) views with a mesoscopic level of analysis able to connect the different planes of investigation is urgently needed. This will allow to both obtain a general frame of reference for rationalizing the burden of data coming from high throughput technologies and to derive effective operational views on biological systems. Results The network paradigm in which microscopic level elements (nodes) are each other related by functional links so giving rise to both global (entire network) and local (specific) behavior is a promising metaphor to try and develop a statistical mechanics inspired approach for biological systems. Here we show the application of this paradigm to different systems going from yeast metabolism to murine macrophages response to immune stimulation. Conclusions The need to complement the purely molecular view with mesoscopic approaches is evident in all the studied examples that in turn demonstrate the untenability of the simple ergodic approach dominant in molecular biology in which the data coming from huge ensemble of cells are considered as relative to a single ‘average’ cell. © Giuliani; licensee BioMed Central Ltd. 2010
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title_short	Collective motions and specific effectors: a statistical mechanics perspective on biological regulation
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Collective motions and specific effectors: a statistical mechanics perspective on biological regulation

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